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PDB: 175 件
4CRO
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BU of 4cro by Molmil
PROTEIN-DNA CONFORMATIONAL CHANGES IN THE CRYSTAL STRUCTURE OF A LAMBDA CRO-OPERATOR COMPLEX
分子名称: DNA (5'-D(*TP*AP*TP*CP*AP*CP*CP*GP*CP*GP*GP*GP*TP*GP*AP*TP*A)-3'), PROTEIN (LAMBDA CRO)
著者Brennan, R.G, Roderick, S.L, Takeda, Y, Matthews, B.W.
登録日1992-01-15
公開日1992-01-15
最終更新日2022-11-23
実験手法X-RAY DIFFRACTION (3.9 Å)
主引用文献Protein-DNA conformational changes in the crystal structure of a lambda Cro-operator complex.
Proc.Natl.Acad.Sci.USA, 87, 1990
3ECO
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BU of 3eco by Molmil
Crystal structure of MepR, a transcription regulator of the Staphylococcus aureus multidrug efflux pump MepA
分子名称: MepR, SULFATE ION
著者Brennan, R.G, Kumaraswami, M.
登録日2008-09-01
公開日2009-02-10
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural and biochemical characterization of MepR, a multidrug binding transcription regulator of the Staphylococcus aureus multidrug efflux pump MepA.
Nucleic Acids Res., 37, 2009
1DN8
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BU of 1dn8 by Molmil
STRUCTURE OF A Z-DNA WITH TWO DIFFERENT BACKBONE CHAIN CONFORMATIONS. STABILIZATION OF THE DECADEOXYOLIGONUCLEOTIDE D(CGTACGTACG) BY (CO(NH3)6)3+ BINDING TO THE GUANINE
分子名称: COBALT HEXAMMINE(III), DNA (5'-D(*P*CP*GP*TP*AP*CP*GP*TP*AP*CP*G)-3')
著者Brennan, R.G, Westhof, E, Sundaralingam, M.
登録日1987-05-12
公開日1988-04-16
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structure of a Z-DNA with two different backbone chain conformations. Stabilization of the decadeoxyoligonucleotide d(CGTACGTACG) by [Co(NH3)6]3+ binding to the guanine.
J.Biomol.Struct.Dyn., 3, 1986
2PEX
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BU of 2pex by Molmil
Structure of reduced C22S OhrR from Xanthamonas Campestris
分子名称: FORMIC ACID, Transcriptional regulator OhrR
著者Brennan, R.G, Newberry, K.J.
登録日2007-04-03
公開日2007-12-11
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural Mechanism of Organic Hydroperoxide Induction of the Transcription Regulator OhrR.
Mol.Cell, 28, 2007
2PFB
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BU of 2pfb by Molmil
Structure of oxidized OhrR from Xanthamonas campestris
分子名称: Transcriptional regulator OhrR
著者Brennan, R.G, Newberry, K.J.
登録日2007-04-04
公開日2007-12-11
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献Structural Mechanism of Organic Hydroperoxide Induction of the Transcription Regulator OhrR.
Mol.Cell, 28, 2007
8SSH
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BU of 8ssh by Molmil
MtrR from Neisseria gonorrhoeae bound to Ethinyl Estradiol
分子名称: Ethinyl estradiol, HTH-type transcriptional regulator MtrR, PHOSPHATE ION
著者Hooks, G.M, Brennan, R.G.
登録日2023-05-08
公開日2024-02-14
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Hormonal steroids induce multidrug resistance and stress response genes in Neisseria gonorrhoeae by binding to MtrR.
Nat Commun, 15, 2024
6WMP
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BU of 6wmp by Molmil
F. tularensis RNAPs70-iglA DNA complex
分子名称: DNA NT-strand, DNA T-strand, DNA-directed RNA polymerase subunit alpha 1, ...
著者Travis, B.A, Brennan, R.G, Schumacher, M.A.
登録日2020-04-21
公開日2020-11-11
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (2.98 Å)
主引用文献Structural Basis for Virulence Activation of Francisella tularensis.
Mol.Cell, 81, 2021
1R8E
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BU of 1r8e by Molmil
Crystal Structure of BmrR Bound to DNA at 2.4A Resolution
分子名称: 5'-D(*GP*AP*CP*CP*CP*TP*CP*CP*CP*CP*TP*TP*AP*GP*GP*GP*GP*AP*GP*GP*GP*TP*C)-3', GLYCEROL, IMIDAZOLE, ...
著者Newberry, K.J, Brennan, R.G.
登録日2003-10-23
公開日2004-08-17
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献The structural mechanism for transcription activation by MerR family member multidrug transporter activation, N terminus.
J.Biol.Chem., 279, 2004
6WMR
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BU of 6wmr by Molmil
F. tularensis RNAPs70-(MglA-SspA)-iglA DNA complex
分子名称: DNA NT-strand, DNA NT-strand downstream, DNA T-strand, ...
著者Travis, B.A, Brennan, R.G, Schumacher, M.A.
登録日2020-04-21
公開日2020-11-11
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.46 Å)
主引用文献Structural Basis for Virulence Activation of Francisella tularensis.
Mol.Cell, 81, 2021
6WMU
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BU of 6wmu by Molmil
E. coli RNAPs70-SspA-gadA DNA complex
分子名称: DNA NT-strand, DNA NT-strand downstream, DNA T-strand, ...
著者Travis, B.A, Brennan, R.G, Schumacher, M.A.
登録日2020-04-21
公開日2020-11-11
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.18 Å)
主引用文献Structural Basis for Virulence Activation of Francisella tularensis.
Mol.Cell, 81, 2021
1RPW
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BU of 1rpw by Molmil
Crystal Structure Of The Multidrug Binding Protein Qacr Bound To The Diamidine Hexamidine
分子名称: 4,4'[1,6-HEXANEDIYLBIS(OXY)]BISBENZENECARBOXIMIDAMIDE, SULFATE ION, Transcriptional regulator qacR
著者Murray, D.S, Schumacher, M.A, Brennan, R.G.
登録日2003-12-03
公開日2004-06-01
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Crystal structures of QacR-diamidine complexes reveal additional multidrug-binding modes and a novel mechanism of drug charge neutralization.
J.Biol.Chem., 279, 2004
1RKW
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BU of 1rkw by Molmil
CRYSTAL STRUCTURE OF THE MULTIDRUG BINDING TRANSCRIPTIONAL REPRESSOR QACR BOUND TO PENTAMADINE
分子名称: 1,5-BIS(4-AMIDINOPHENOXY)PENTANE, SULFATE ION, Transcriptional regulator qacR
著者Murray, D.S, Schumacher, M.A, Brennan, R.G.
登録日2003-11-23
公開日2004-06-01
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.62 Å)
主引用文献Crystal structures of QacR-diamidine complexes reveal additional multidrug-binding modes and a novel mechanism of drug charge neutralization.
J.Biol.Chem., 279, 2004
6WMT
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BU of 6wmt by Molmil
F. tularensis RNAPs70-(MglA-SspA)-ppGpp-PigR-iglA DNA complex
分子名称: DNA NT-strand, DNA NT-strand downstream, DNA T-strand, ...
著者Travis, B.A, Brennan, R.G, Schumacher, M.A.
登録日2020-04-21
公開日2020-11-11
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (4.43 Å)
主引用文献Structural Basis for Virulence Activation of Francisella tularensis.
Mol.Cell, 81, 2021
8FHW
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BU of 8fhw by Molmil
Cryo-EM structure of Cryptococcus neoformans trehalose-6-phosphate synthase homotetramer in complex with uridine diphosphate and glucose-6-phosphate
分子名称: 6-O-phosphono-alpha-D-glucopyranose, Alpha,alpha-trehalose-phosphate synthase (UDP-forming), URIDINE-5'-DIPHOSPHATE
著者Washington, E.J, Brennan, R.G.
登録日2022-12-15
公開日2023-12-20
最終更新日2024-06-26
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structures of trehalose-6-phosphate synthase, Tps1, from the fungal pathogen Cryptococcus neoformans : a target for novel antifungals.
Biorxiv, 2024
8FO1
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BU of 8fo1 by Molmil
Cryo-EM structure of Cryptococcus neoformans trehalose-6-phosphate synthase homotetramer in apo form
分子名称: Alpha,alpha-trehalose-phosphate synthase (UDP-forming)
著者Washington, E.J, Brennan, R.G.
登録日2022-12-29
公開日2024-01-10
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Cryo-EM structure of Cryptococcus neoformans trehalose-6-phosphate synthase homotetramer in apo form
To Be Published
8FW0
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BU of 8fw0 by Molmil
MtrR from Neisseria gonorrhoeae bound to beta-Estradiol
分子名称: ESTRADIOL, GLYCEROL, HTH-type transcriptional regulator MtrR, ...
著者Hooks, G.H, Brennan, R.G.
登録日2023-01-20
公開日2024-01-24
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.37 Å)
主引用文献Hormonal steroids induce multidrug resistance and stress response genes in Neisseria gonorrhoeae by binding to MtrR.
Nat Commun, 15, 2024
8FW8
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BU of 8fw8 by Molmil
MtrR from Neisseria gonorrhoeae bound to Progesterone
分子名称: 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, HTH-type transcriptional regulator MtrR, PHOSPHATE ION, ...
著者Hooks, G.H, Brennan, R.G.
登録日2023-01-20
公開日2024-01-24
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献Hormonal steroids induce multidrug resistance and stress response genes in Neisseria gonorrhoeae by binding to MtrR.
Nat Commun, 15, 2024
3ZQL
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BU of 3zql by Molmil
DNA-bound form of TetR-like repressor SimR
分子名称: 5'-D(*DTP*TP*CP*GP*TP*AP*CP*GP*CP*CP*GP*TP*AP*DCP *GP*AP*A)-3', 5'-D(*DTP*TP*CP*GP*TP*AP*CP*GP*GP*CP*GP*TP*AP*DCP *GP*AP*A)-3', PUTATIVE REPRESSOR SIMREG2
著者Le, T.B.K, Schumacher, M.A, Lawson, D.M, Brennan, R.G, Buttner, M.J.
登録日2011-06-10
公開日2011-08-31
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.99 Å)
主引用文献The Crystal Structure of the Tetr Family Transcriptional Repressor Simr Bound to DNA and the Role of a Flexible N-Terminal Extension in Minor Groove Binding.
Nucleic Acids Res., 39, 2011
3VIB
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BU of 3vib by Molmil
Structural basis for multidrug recognition and antimicrobial resistance by MTRR, an efflux pump regulator from Neisseria Gonorrhoeae
分子名称: 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, MtrR, PHOSPHATE ION
著者Kumaraswami, M, Shafer, W.M, Brennan, R.G.
登録日2011-09-27
公開日2012-10-03
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural basis for multidrug recognitionand antimicrobial resistance by MTRR, an efflux pump regulator from Neisseria Gonorrhoeae
TO BE PUBLISHED
7JU3
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BU of 7ju3 by Molmil
MtrR bound to the mtrCDE operator from Neisseria gonorrhoeae
分子名称: CALCIUM ION, DNA (5'-D(*AP*CP*AP*TP*AP*CP*AP*CP*GP*AP*TP*TP*GP*CP*AP*CP*GP*GP*AP*TP*A)-3'), DNA (5'-D(*TP*AP*TP*CP*CP*GP*TP*GP*CP*AP*AP*TP*CP*GP*TP*GP*TP*AP*TP*GP*T)-3'), ...
著者Beggs, G.A, Shafer, W.M, Brennan, R.G.
登録日2020-08-19
公開日2021-03-24
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structures of Neisseria gonorrhoeae MtrR-operator complexes reveal molecular mechanisms of DNA recognition and antibiotic resistance-conferring clinical mutations.
Nucleic Acids Res., 49, 2021
7JNP
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BU of 7jnp by Molmil
MtrR bound to the rpoH operator from Neisseria gonorrhoeae
分子名称: CALCIUM ION, DNA (5'-D(*TP*AP*CP*AP*TP*AP*CP*GP*TP*GP*GP*TP*TP*GP*TP*AP*TP*GP*TP*AP*A)-3'), DNA (5'-D(*TP*TP*AP*CP*AP*TP*AP*CP*AP*AP*CP*CP*AP*CP*GP*TP*AP*TP*GP*TP*A)-3'), ...
著者Beggs, G.A, Shafer, W.M, Brennan, R.G.
登録日2020-08-05
公開日2021-03-24
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structures of Neisseria gonorrhoeae MtrR-operator complexes reveal molecular mechanisms of DNA recognition and antibiotic resistance-conferring clinical mutations.
Nucleic Acids Res., 49, 2021
8FW3
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BU of 8fw3 by Molmil
MtrR from Neisseria gonorrhoeae bound to Testosterone
分子名称: HTH-type transcriptional regulator MtrR, PHOSPHATE ION, TESTOSTERONE
著者Hooks, G.H, Brennan, R.G.
登録日2023-01-20
公開日2024-01-24
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.22 Å)
主引用文献Hormonal steroids induce multidrug resistance and stress response genes in Neisseria gonorrhoeae by binding to MtrR.
Nat Commun, 15, 2024
7LQ4
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BU of 7lq4 by Molmil
Rr (RsiG)2-(c-di-GMP)2-WhiG complex
分子名称: 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), RsiG, WhiG
著者Schumacher, M.A, Brennan, R.G.
登録日2021-02-12
公開日2021-07-14
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Evolution of a sigma-(c-di-GMP)-anti-sigma switch.
Proc.Natl.Acad.Sci.USA, 118, 2021
7LQ2
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BU of 7lq2 by Molmil
Apo Rr RsiG- crystal form 1
分子名称: ISOPROPYL ALCOHOL, MAGNESIUM ION, RR RsiG
著者Schumacher, M.A, Brennan, R.G.
登録日2021-02-12
公開日2021-07-14
最終更新日2021-08-25
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Evolution of a sigma-(c-di-GMP)-anti-sigma switch.
Proc.Natl.Acad.Sci.USA, 118, 2021
7LQ3
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BU of 7lq3 by Molmil
Evolution of a sigma-(c-di-GMP)-antisigma switch
分子名称: MAGNESIUM ION, RsiG, SULFATE ION
著者Schumacher, M.A, Brennan, R.G.
登録日2021-02-12
公開日2021-07-14
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Evolution of a sigma-(c-di-GMP)-anti-sigma switch.
Proc.Natl.Acad.Sci.USA, 118, 2021

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