2A1Y
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![BU of 2a1y by Molmil](/molmil-images/mine/2a1y) | Crystal Structure of GuaC-GMP complex from Bacillus anthracis at 2.26 A Resolution. | Descriptor: | GMP reductase, GUANOSINE-5'-MONOPHOSPHATE | Authors: | Grenha, R, Levdikov, V.M, Blagova, E.V, Fogg, M.J, Brannigan, J.A, Wilkinson, A.J, Wilson, K.S, Structural Proteomics in Europe (SPINE) | Deposit date: | 2005-06-21 | Release date: | 2006-07-04 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.27 Å) | Cite: | Crystal structure of GuaC-GMP complex from Bacillus anthracis at 2.26 A resolution. To be Published
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4B11
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![BU of 4b11 by Molmil](/molmil-images/mine/4b11) | Plasmodium vivax N-myristoyltransferase with a bound benzofuran inhibitor (compound 13) | Descriptor: | 2-oxopentadecyl-CoA, 3-methyl-N-(naphthalen-1-ylmethyl)-4-piperidin-4-yloxy-1-benzofuran-2-carboxamide, CHLORIDE ION, ... | Authors: | Yu, Z, Brannigan, J.A, Moss, D.K, Brzozowski, A.M, Wilkinson, A.J, Holder, A.A, Tate, E.W, Leatherbarrow, R.J. | Deposit date: | 2012-07-06 | Release date: | 2012-10-17 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.59 Å) | Cite: | Design and Synthesis of Inhibitors of Plasmodium Falciparum N-Myristoyltransferase, a Promising Target for Anti-Malarial Drug Discovery. J.Med.Chem., 55, 2012
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4BBH
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![BU of 4bbh by Molmil](/molmil-images/mine/4bbh) | Plasmodium vivax N-myristoyltransferase with a bound benzothiophene inhibitor | Descriptor: | 2-oxopentadecyl-CoA, 3-methoxybenzyl 3-(piperidin-4-yloxy)-1-benzothiophene-2-carboxylate, CHLORIDE ION, ... | Authors: | Rackham, M.D, Brannigan, J.A, Moss, D.K, Yu, Z, Wilkinson, A.J, Holder, A.A, Tate, E.W, Leatherbarrow, R.J. | Deposit date: | 2012-09-23 | Release date: | 2012-12-05 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.63 Å) | Cite: | Discovery of Novel and Ligand-Efficient Inhibitors of Plasmodium Falciparum and Plasmodium Vivax N-Myristoyltransferase. J.Med.Chem., 56, 2013
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4B13
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![BU of 4b13 by Molmil](/molmil-images/mine/4b13) | Plasmodium vivax N-myristoyltransferase with a bound benzofuran inhibitor (compound 25) | Descriptor: | 2-oxopentadecyl-CoA, 4-{[2-(3-benzyl-1,2,4-oxadiazol-5-yl)-3-methyl-1-benzofuran-4-yl]oxy}piperidine, CHLORIDE ION, ... | Authors: | Yu, Z, Brannigan, J.A, Moss, D.K, Brzozowski, A.M, Wilkinson, A.J, Holder, A.A, Tate, E.W, Leatherbarrow, R.J. | Deposit date: | 2012-07-06 | Release date: | 2012-10-17 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Design and Synthesis of Inhibitors of Plasmodium Falciparum N-Myristoyltransferase, a Promising Target for Antimalarial Drug Discovery. J.Med.Chem., 55, 2012
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4B10
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![BU of 4b10 by Molmil](/molmil-images/mine/4b10) | Plasmodium vivax N-myristoyltransferase with a non-hydrolysable co- factor | Descriptor: | 2-oxopentadecyl-CoA, CHLORIDE ION, DIMETHYL SULFOXIDE, ... | Authors: | Yu, Z, Brannigan, J.A, Moss, D.K, Brzozowski, A.M, Wilkinson, A.J, Holder, A.A, Tate, E.W, Leatherbarrow, R.J. | Deposit date: | 2012-07-06 | Release date: | 2012-10-17 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.56 Å) | Cite: | Design and Synthesis of Inhibitors of Plasmodium Falciparum N-Myristoyltransferase, a Promising Target for Anti-Malarial Drug Discovery. J.Med.Chem., 55, 2012
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4B12
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![BU of 4b12 by Molmil](/molmil-images/mine/4b12) | Plasmodium vivax N-myristoyltransferase with a bound benzofuran inhibitor (compound 23) | Descriptor: | 1-[3-methyl-4-(piperidin-4-yloxy)-1-benzofuran-2-yl]-3-phenylpropan-1-one, 2-oxopentadecyl-CoA, CHLORIDE ION, ... | Authors: | Yu, Z, Brannigan, J.A, Moss, D.K, Brzozowski, A.M, Wilkinson, A.J, Holder, A.A, Tate, E.W, Leatherbarrow, R.J. | Deposit date: | 2012-07-06 | Release date: | 2012-10-17 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | Design and Synthesis of Inhibitors of Plasmodium Falciparum N-Myristoyltransferase, a Promising Target for Anti-Malarial Drug Discovery. J.Med.Chem., 55, 2012
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258D
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![BU of 258d by Molmil](/molmil-images/mine/258d) | FACTORS AFFECTING SEQUENCE SELECTIVITY ON NOGALAMYCIN INTERCALATION: THE CRYSTAL STRUCTURE OF D(TGTACA)-NOGALAMYCIN | Descriptor: | ACETATE ION, DNA (5'-D(*TP*GP*TP*AP*CP*A)-3'), NOGALAMYCIN, ... | Authors: | Smith, C.K, Brannigan, J.A, Moore, M.H. | Deposit date: | 1996-05-12 | Release date: | 1996-06-20 | Last modified: | 2023-08-02 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Factors affecting DNA sequence selectivity of nogalamycin intercalation: the crystal structure of d(TGTACA)2-nogalamycin2. J.Mol.Biol., 263, 1996
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4C2Z
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![BU of 4c2z by Molmil](/molmil-images/mine/4c2z) | Human N-myristoyltransferase (NMT1) with Myristoyl-CoA and inhibitor bound | Descriptor: | 2,6-dichloro-4-(2-piperazin-1-ylpyridin-4-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide, CHLORIDE ION, CITRIC ACID, ... | Authors: | Thinon, E, Serwa, R.A, Brannigan, J.A, Brassat, U, Wright, M.H, Heal, W.P, Wilkinson, A.J, Mann, D.J, Tate, E.W. | Deposit date: | 2013-08-20 | Release date: | 2014-10-01 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.08 Å) | Cite: | Chemical Proteomics Defines the Mammalian N- Myristoylated Proteome in Live Cells Global Profiling of Co- and Post-Translationally N-Myristoylated Proteomes in Human Cells. Nat.Commun., 5, 2014
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4C2X
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![BU of 4c2x by Molmil](/molmil-images/mine/4c2x) | Human N-myristoyltransferase isoform 2 (NMT2) | Descriptor: | 2-oxopentadecyl-CoA, GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE 2, MAGNESIUM ION | Authors: | Thinon, E, Serwa, R.A, Brannigan, J.A, Brassat, U, Wright, M.H, Heal, W.P, Wilkinson, A.J, Mann, D.J, Tate, E.W. | Deposit date: | 2013-08-20 | Release date: | 2014-10-01 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.33 Å) | Cite: | Global Profiling of Co- and Post-Translationally N-Myristoylated Proteomes in Human Cells. Nat.Commun., 5, 2014
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1EYV
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![BU of 1eyv by Molmil](/molmil-images/mine/1eyv) | THE CRYSTAL STRUCTURE OF NUSB FROM MYCOBACTERIUM TUBERCULOSIS | Descriptor: | N-UTILIZING SUBSTANCE PROTEIN B HOMOLOG, PHOSPHATE ION | Authors: | Gopal, B, Haire, L.F, Cox, R.A, Colston, M.J, Major, S, Brannigan, J.A, Smerdon, S.J, Dodson, G.G, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2000-05-09 | Release date: | 2000-05-18 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | The crystal structure of NusB from Mycobacterium tuberculosis. Nat.Struct.Biol., 7, 2000
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1GKF
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![BU of 1gkf by Molmil](/molmil-images/mine/1gkf) | Crystal structures of penicillin acylase enzyme-substrate complexes: Structural insights into the catalytic mechanism | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, PENICILLIN G ACYLASE ALPHA SUBUNIT, ... | Authors: | McVey, C.E, Walsh, M.A, Dodson, G.G, Wilson, K.S, Brannigan, J.A. | Deposit date: | 2001-08-13 | Release date: | 2002-01-04 | Last modified: | 2019-07-24 | Method: | X-RAY DIFFRACTION (1.41 Å) | Cite: | Crystal Structures of Penicillin Acylase Enzyme- Substrate Complexes: Structural Insights Into the Catalytic Mechanism J.Mol.Biol., 313, 2001
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1GK9
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![BU of 1gk9 by Molmil](/molmil-images/mine/1gk9) | Crystal structures of penicillin acylase enzyme-substrate complexes: Structural insights into the catalytic mechanism | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, PENICILLIN G ACYLASE ALPHA SUBUNIT, ... | Authors: | McVey, C.E, Walsh, M.A, Dodson, G.G, Wilson, K.S, Brannigan, J.A. | Deposit date: | 2001-08-10 | Release date: | 2002-01-04 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Crystal Structures of Penicillin Acylase Enzyme-Substrate Complexes: Structural Insights Into the Catalytic Mechanism J.Mol.Biol., 313, 2001
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1GM7
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![BU of 1gm7 by Molmil](/molmil-images/mine/1gm7) | Crystal structures of penicillin acylase enzyme-substrate complexes: Structural insights into the catalytic mechanism | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, PENICILLIN G, ... | Authors: | McVey, C.E, Walsh, M.A, Dodson, G.G, Wilson, K.S, Brannigan, J.A. | Deposit date: | 2001-09-11 | Release date: | 2001-11-28 | Last modified: | 2019-07-24 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Crystal Structures of Penicillin Acylase Enzyme- Substrate Complexes: Structural Insights Into the Catalytic Mechanism J.Mol.Biol., 313, 2001
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1GM9
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![BU of 1gm9 by Molmil](/molmil-images/mine/1gm9) | Crystal structures of penicillin acylase enzyme-substrate complexes: Structural insights into the catalytic mechanism | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, N-[(2S,4S,6R)-2-(DIHYDROXYMETHYL)-4-HYDROXY-3,3-DIMETHYL-7-OXO-4LAMBDA~4~-THIA-1-AZABICYCLO[3.2.0]HEPT-6-YL]-2-PHENYLAC ETAMIDE, ... | Authors: | McVey, C.E, Walsh, M.A, Dodson, G.G, Wilson, K.S, Brannigan, J.A. | Deposit date: | 2001-09-12 | Release date: | 2001-11-28 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal Structures of Penicillin Acylase Enzyme- Substrate Complexes: Structural Insights Into the Catalytic Mechanism J.Mol.Biol., 313, 2001
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1GM8
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![BU of 1gm8 by Molmil](/molmil-images/mine/1gm8) | Crystal structures of penicillin acylase enzyme-substrate complexes: Structural insights into the catalytic mechanism | Descriptor: | CALCIUM ION, N-[(2S,4S,6R)-2-(DIHYDROXYMETHYL)-4-HYDROXY-3,3-DIMETHYL-7-OXO-4LAMBDA~4~-THIA-1-AZABICYCLO[3.2.0]HEPT-6-YL]-2-PHENYLAC ETAMIDE, PENICILLIN G ACYLASE ALPHA SUBUNIT, ... | Authors: | McVey, C.E, Walsh, M.A, Dodson, G.G, Wilson, K.S, Brannigan, J.A. | Deposit date: | 2001-09-11 | Release date: | 2001-11-28 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal Structures of Penicillin Acylase Enzyme- Substrate Complexes: Structural Insights Into the Catalytic Mechanism J.Mol.Biol., 313, 2001
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1GWF
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![BU of 1gwf by Molmil](/molmil-images/mine/1gwf) | Compound II structure of Micrococcus Lysodeikticus catalase | Descriptor: | ACETATE ION, Catalase, OXYGEN ATOM, ... | Authors: | Murshudov, G.N, Grebenko, A.I, Brannigan, J.A, Antson, A.A, Barynin, V.V, Dodson, G.G, Dauter, Z, Wilson, K.S, Melik-Adamyan, W.R. | Deposit date: | 2002-03-15 | Release date: | 2002-04-26 | Last modified: | 2018-06-20 | Method: | X-RAY DIFFRACTION (1.96 Å) | Cite: | The Structures of Micrococcus Lysodeikticus Catalase, its Ferryl Intermediate (Compound II) and Nadph Complex. Acta Crystallogr.,Sect.D, 58, 2002
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1GWE
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![BU of 1gwe by Molmil](/molmil-images/mine/1gwe) | Atomic resolution structure of Micrococcus Lysodeikticus catalase | Descriptor: | Catalase, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION | Authors: | Murshudov, G.N, Grebenko, A.I, Brannigan, J.A, Antson, A.A, Barynin, V.V, Dodson, G.G, Dauter, Z, Wilson, K.S, Melik-Adamyan, W.R. | Deposit date: | 2002-03-15 | Release date: | 2002-04-26 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (0.88 Å) | Cite: | The Structures of Micrococcus Lysodeikticus Catalase, its Ferryl Intermediate (Compound II) and Nadph Complex. Acta Crystallogr.,Sect.D, 58, 2002
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1H4Z
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![BU of 1h4z by Molmil](/molmil-images/mine/1h4z) | Structure of the Anti-Sigma Factor Antagonist SpoIIAA in its Unphosphorylated Form | Descriptor: | ANTI-SIGMA F FACTOR ANTAGONIST | Authors: | Seavers, P.R, Lewis, R.J, Brannigan, J.A, Verschueren, K.H.G, Murshudov, G.N, Wilkinson, A.J. | Deposit date: | 2001-05-16 | Release date: | 2001-07-06 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.74 Å) | Cite: | Structure of the Bacillus Cell Fate Determinant Spoiiaa in Phosphorylated and Unphosphorylated Forms Structure, 9, 2001
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1GWH
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![BU of 1gwh by Molmil](/molmil-images/mine/1gwh) | Atomic resolution structure of Micrococcus Lysodeikticus catalase complexed with NADPH | Descriptor: | ACETATE ION, Catalase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | Authors: | Murshudov, G.N, Grebenko, A.I, Brannigan, J.A, Antson, A.A, Barynin, V.V, Dodson, G.G, Dauter, Z, Wilson, K.S, Melik-Adamyan, W.R. | Deposit date: | 2002-03-15 | Release date: | 2002-03-19 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.74 Å) | Cite: | The Structures of Micrococcus Lysodeikticus Catalase, its Ferryl Intermediate (Compound II) and Nadph Complex. Acta Crystallogr.,Sect.D, 58, 2002
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1H4Y
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![BU of 1h4y by Molmil](/molmil-images/mine/1h4y) | Structure of the Anti-Sigma Factor Antagonist SpoIIAA in its Unphosphorylated Form | Descriptor: | ANTI-SIGMA F FACTOR ANTAGONIST | Authors: | Seavers, P.R, Lewis, R.J, Brannigan, J.A, Verschueren, K.H.G, Murshudov, G.N, Wilkinson, A.J. | Deposit date: | 2001-05-16 | Release date: | 2001-07-06 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.61 Å) | Cite: | Structure of the Bacillus Cell Fate Determinant Spoiiaa in Phosphorylated and Unphosphorylated Forms Structure, 9, 2001
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1H4X
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![BU of 1h4x by Molmil](/molmil-images/mine/1h4x) | Structure of the Bacillus Cell Fate Determinant SpoIIAA in the Phosphorylated Form | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ANTI-SIGMA F FACTOR ANTAGONIST | Authors: | Seavers, P.R, Lewis, R.J, Brannigan, J.A, Verschueren, K.H.G, Murshudov, G.N, Wilkinson, A.J. | Deposit date: | 2001-05-15 | Release date: | 2001-07-06 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.16 Å) | Cite: | Structure of the Bacillus Cell Fate Determinant Spoiiaa in Phosphorylated and Unphosphorylated Forms Structure, 9, 2001
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2HF0
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![BU of 2hf0 by Molmil](/molmil-images/mine/2hf0) | Bifidobacterium longum bile salt hydrolase | Descriptor: | Bile salt hydrolase | Authors: | Suresh, C.G, Kumar, R.S, Brannigan, J.A. | Deposit date: | 2006-06-22 | Release date: | 2006-09-19 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural and Functional Analysis of a Conjugated Bile Salt Hydrolase from Bifidobacterium longum Reveals an Evolutionary Relationship with Penicillin V Acylase. J.Biol.Chem., 281, 2006
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2HEZ
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![BU of 2hez by Molmil](/molmil-images/mine/2hez) | Bifidobacterium longum bile salt hydrolase | Descriptor: | Bile salt hydrolase, SULFATE ION | Authors: | Suresh, C.G, Kumar, R.S, Brannigan, J.A. | Deposit date: | 2006-06-22 | Release date: | 2006-09-19 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural and Functional Analysis of a Conjugated Bile Salt Hydrolase from Bifidobacterium longum Reveals an Evolutionary Relationship with Penicillin V Acylase. J.Biol.Chem., 281, 2006
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2PVA
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![BU of 2pva by Molmil](/molmil-images/mine/2pva) | OXIDIZED PENICILLIN V ACYLASE FROM B. SPHAERICUS | Descriptor: | DITHIANE DIOL, PENICILLIN V ACYLASE | Authors: | Suresh, C.G, Pundle, A.V, Rao, K.N, SivaRaman, H, Brannigan, J.A, McVey, C.E, Verma, C.S, Dauter, Z, Dodson, E.J, Dodson, G.G. | Deposit date: | 1998-11-13 | Release date: | 2000-07-26 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Penicillin V acylase crystal structure reveals new Ntn-hydrolase family members. Nat.Struct.Biol., 6, 1999
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3T60
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![BU of 3t60 by Molmil](/molmil-images/mine/3t60) | 5'-Diphenyl Nucleoside Inhibitors of Plasmodium falciparum dUTPase | Descriptor: | 2',5'-dideoxy-5'-(tritylamino)uridine, Deoxyuridine 5'-triphosphate nucleotidohydrolase, putative, ... | Authors: | Hampton, S.E, Baragana, B, Schipani, A, Bosch-Navarrete, C, Musso-Buendia, A, Recio, E, Kaiser, M, Whittingham, J.L, Roberts, S.M, Shevtsov, M, Brannigan, J.A, Kahnberg, P, Brun, R, Wilson, K.S, Gonzalez-Pacanowska, D, Johansson, N.G, Gilbert, I.H. | Deposit date: | 2011-07-28 | Release date: | 2012-08-29 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.396 Å) | Cite: | Design, synthesis, and evaluation of 5'-diphenyl nucleoside analogues as inhibitors of the Plasmodium falciparum dUTPase. Chemmedchem, 6, 2011
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