4IOU
 
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4XXO
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7TCZ
 | | Human cytomegalovirus protease mutant (C84A, C87A, C138A, C202A) in complex with inhibitor | | 分子名称: | Assemblin, [1-(2-oxopropyl)-4-phenyl-1H-1,2,3-triazol-5-yl]methyl benzylcarbamate | | 著者 | Hulce, K.R, Bohn, M, Ongpipattanakul, C, Jaishankar, P, Renslo, A.R, Craik, C.S. | | 登録日 | 2021-12-29 | | 公開日 | 2022-01-12 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.67 Å) | | 主引用文献 | Inhibiting a dynamic viral protease by targeting a non-catalytic cysteine.
Cell Chem Biol, 29, 2022
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6NSV
 | | Crystal structure of the human CHIP TPR domain in complex with a 5mer acetylated optimized peptide | | 分子名称: | ACE-LEU-TRP-TRP-PRO-ASP, CHLORIDE ION, E3 ubiquitin-protein ligase CHIP, ... | | 著者 | Basu, K, Ravalin, M, Bohn, M.-F, Craik, C.S, Gestwicki, J.E. | | 登録日 | 2019-01-25 | | 公開日 | 2019-07-31 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.305 Å) | | 主引用文献 | Specificity for latent C termini links the E3 ubiquitin ligase CHIP to caspases.
Nat.Chem.Biol., 15, 2019
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6EFK
 | | Crystal structure of the human CHIP TPR domain in complex with a 5mer acetylated HSP70 peptide | | 分子名称: | ACE-ILE-GLU-GLU-VAL-ASP, E3 ubiquitin-protein ligase CHIP, SODIUM ION | | 著者 | Basu, K, Ravalin, M, Bohn, M.-F, Craik, C.S, Gestwicki, J.E. | | 登録日 | 2018-08-16 | | 公開日 | 2019-07-31 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Specificity for latent C termini links the E3 ubiquitin ligase CHIP to caspases.
Nat.Chem.Biol., 15, 2019
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7KKH
 | | P1A4 Fab in complex with ARS1620 | | 分子名称: | (S)-1-{4-[6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl] piperazin-1-yl}propan-1-one, P1A4 Fab Heavy Chain, P1A4 Fab Light Chain, ... | | 著者 | Basu, K, Rohweder, P.J, Zhang, Z, Bohn, M.-F, Shokat, K, Craik, C.S. | | 登録日 | 2020-10-27 | | 公開日 | 2022-04-27 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | A covalent inhibitor of K-Ras(G12C) induces MHC class I presentation of haptenated peptide neoepitopes targetable by immunotherapy.
Cancer Cell, 40, 2022
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8FYU
 | | Crystal structure of the human CHIP-TPR domain in complex with a 10mer acetylated tau peptide | | 分子名称: | ACE-SER-SER-THR-GLY-SER-ILE-ASP-MET-VAL-ASP, E3 ubiquitin-protein ligase CHIP | | 著者 | Wucherer, K, Bohn, M.F, Basu, K, Nadel, C.M, Gestwicki, J.E, Craik, C.S. | | 登録日 | 2023-01-26 | | 公開日 | 2023-08-30 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.84839141 Å) | | 主引用文献 | Phosphorylation of a Cleaved Tau Proteoform at a Single Residue Inhibits Binding to the E3 Ubiquitin Ligase, CHIP.
Biorxiv, 2023
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8GCK
 | | Crystal structure of the human CHIP-TPR domain in complex with a 6mer acetylated tau peptide | | 分子名称: | ACE-SER-ILE-ASP-MET-VAL-ASP, E3 ubiquitin-protein ligase CHIP | | 著者 | Wucherer, K, Bohn, M.F, Basu, K, Nadel, C.M, Gestwicki, J.E, Craik, C.S. | | 登録日 | 2023-03-02 | | 公開日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.36823535 Å) | | 主引用文献 | Intersecting PTMs regulate clearance of pathogenic tau by the ubiquitin ligase CHIP.
To Be Published
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5UTE
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5UR3
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5UTN
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5UV3
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5UVP
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7KYD
 | | Drosophila melanogaster long-chain fatty-acyl-CoA synthetase CG6178 | | 分子名称: | 1,2-ETHANEDIOL, 5'-O-[(S)-hydroxy(octanoyloxy)phosphoryl]adenosine, Long-chain fatty-acyl-CoA synthetase CG6178 | | 著者 | Adams, S.T, Zephyr, J, Bohn, M.F, Schiffer, C.A, Miller, S.C. | | 登録日 | 2020-12-07 | | 公開日 | 2022-01-05 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | FruitFire: a luciferase based on a fruit fly metabolic enzyme.
Biorxiv, 2023
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6YXQ
 | | Crystal structure of a DNA repair complex ASCC3-ASCC2 | | 分子名称: | Activating signal cointegrator 1 complex subunit 2, Activating signal cointegrator 1 complex subunit 3 | | 著者 | Jia, J, Absmeier, E, Holton, N, Bohnsack, K.E, Pietrzyk-Brzezinska, A.J, Bohnsack, M.T, Wahl, M.C. | | 登録日 | 2020-05-03 | | 公開日 | 2020-09-30 | | 最終更新日 | 2020-11-18 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | The interaction of DNA repair factors ASCC2 and ASCC3 is affected by somatic cancer mutations.
Nat Commun, 11, 2020
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2V3J
 | | The yeast ribosome synthesis factor Emg1 alpha beta knot fold methyltransferase | | 分子名称: | ESSENTIAL FOR MITOTIC GROWTH 1, SULFATE ION | | 著者 | Leulliot, N, Bohnsack, M.T, Graille, M, Tollervey, D, Van Tilbeurgh, H. | | 登録日 | 2007-06-18 | | 公開日 | 2007-12-04 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | The Yeast Ribosome Synthesis Factor Emg1 is a Novel Member of the Superfamily of Alpha/Beta Knot Fold Methyltransferases.
Nucleic Acids Res., 36, 2008
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2V3K
 | | The yeast ribosome synthesis factor Emg1 alpha beta knot fold methyltransferase | | 分子名称: | ESSENTIAL FOR MITOTIC GROWTH 1, S-ADENOSYLMETHIONINE, SULFATE ION | | 著者 | Leulliot, N, Bohnsack, M.T, Graille, M, Tollervey, D, VanTilbeurgh, H. | | 登録日 | 2007-06-18 | | 公開日 | 2007-07-10 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | The Yeast Ribosome Synthesis Factor Emg1 is a Novel Member of the Superfamily of Alpha/Beta Knot Fold Methyltransferases.
Nucleic Acids Res., 36, 2008
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2LCQ
 | | Solution structure of the endonuclease Nob1 from P.horikoshii | | 分子名称: | Putative toxin VapC6, ZINC ION | | 著者 | Veith, T, Martin, R, Wurm, J.P, Weis, B, Duchardt-Ferner, E, Safferthal, C, Hennig, R, Mirus, O, Bohnsack, M.T, Woehnert, J, Schleiff, E. | | 登録日 | 2011-05-05 | | 公開日 | 2011-12-14 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural and functional analysis of the archaeal endonuclease Nob1.
Nucleic Acids Res., 40, 2012
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