6YXQ

Crystal structure of a DNA repair complex ASCC3-ASCC2

Summary for 6YXQ

Entry DOI	10.2210/pdb6yxq/pdb
Descriptor	Activating signal cointegrator 1 complex subunit 3, Activating signal cointegrator 1 complex subunit 2 (3 entities in total)
Functional Keywords	dna alkylation damage, dna repair, ubiquitin binding, helicase, structural protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	74474.83
Authors	Jia, J.,Absmeier, E.,Holton, N.,Bohnsack, K.E.,Pietrzyk-Brzezinska, A.J.,Bohnsack, M.T.,Wahl, M.C. (deposition date: 2020-05-03, release date: 2020-09-30, Last modification date: 2020-11-18)
Primary citation	Jia, J.,Absmeier, E.,Holton, N.,Pietrzyk-Brzezinska, A.J.,Hackert, P.,Bohnsack, K.E.,Bohnsack, M.T.,Wahl, M.C. The interaction of DNA repair factors ASCC2 and ASCC3 is affected by somatic cancer mutations. Nat Commun, 11:5535-5535, 2020 Cited by PubMed: 33139697 DOI: 10.1038/s41467-020-19221-x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation