6OA3
 
 | | Structure of human PARG complexed with JA2131 | | 分子名称: | (8S)-1,3-dimethyl-8-{[2-(morpholin-4-yl)ethyl]sulfanyl}-6-sulfanylidene-1,3,6,7,8,9-hexahydro-2H-purin-2-one, Poly(ADP-ribose) glycohydrolase | | 著者 | Stegeman, R.A, Jones, D.E, Ellenberger, T, Kim, I.K, Tainer, J.A. | | 登録日 | 2019-03-15 | | 公開日 | 2019-12-25 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death.
Nat Commun, 10, 2019
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3BOR
 | | Crystal structure of the DEADc domain of human translation initiation factor 4A-2 | | 分子名称: | Human initiation factor 4A-II | | 著者 | Dimov, S, Hong, B, Tempel, W, MacKenzie, F, Karlberg, T, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) | | 登録日 | 2007-12-17 | | 公開日 | 2008-01-01 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Comparative Structural Analysis of Human DEAD-Box RNA Helicases.
Plos One, 5, 2010
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8S7F
 | | Crystal structure of Escherichia coli LpxH in complex with EBL-2805 | | 分子名称: | MANGANESE (II) ION, N-[4-[4-[3,5-bis(chloranyl)phenyl]piperazin-1-yl]sulfonylphenyl]-2-[methyl(methylsulfonyl)amino]benzamide, UDP-2,3-diacylglucosamine hydrolase | | 著者 | Sooriyaarachchi, S, Mowbray, S.L, Bergfors, T, Jones, T.A. | | 登録日 | 2024-03-01 | | 公開日 | 2024-09-18 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Design, synthesis, and in vitro biological evaluation of meta-sulfonamidobenzamide-based antibacterial LpxH inhibitors.
Eur.J.Med.Chem., 278, 2024
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2A1I
 | | Crystal Structure of the Central Domain of Human ERCC1 | | 分子名称: | DNA excision repair protein ERCC-1, MERCURY (II) ION | | 著者 | Tsodikov, O.V, Enzlin, J.H, Scharer, O.D, Ellenberger, T. | | 登録日 | 2005-06-20 | | 公開日 | 2005-08-02 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Crystal structure and DNA binding functions of ERCC1, a subunit of the DNA structure-specific endonuclease XPF-ERCC1.
Proc.Natl.Acad.Sci.Usa, 102, 2005
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2AC4
 | | Crystal structure of the His183Cys mutant variant of Bacillus subtilis Ferrochelatase | | 分子名称: | Ferrochelatase | | 著者 | Shipovskov, S, Karlberg, T, Fodje, M, Hansson, M.D, Ferreira, G.C, Hansson, M, Reimann, C.T, Al-Karadaghi, S. | | 登録日 | 2005-07-18 | | 公開日 | 2005-09-20 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Metallation of the Transition-state Inhibitor N-methyl Mesoporphyrin by Ferrochelatase: Implications for the Catalytic Reaction Mechanism.
J.Mol.Biol., 352, 2005
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2B2C
 | | Cloning, expression, characterisation and three- dimensional structure determination of the Caenorhabditis elegans spermidine synthase | | 分子名称: | spermidine synthase | | 著者 | Dufe, V.T, Luersen, K, Eschbach, M.L, Haider, N, Karlberg, T, Walter, R.D, Al-Karadaghi, S. | | 登録日 | 2005-09-19 | | 公開日 | 2005-11-15 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Cloning, expression, characterisation and three-dimensional structure determination of Caenorhabditis elegans spermidine synthase
FEBS LETT., 579, 2005
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2B4J
 | | Structural basis for the recognition between HIV-1 integrase and LEDGF/p75 | | 分子名称: | GLYCEROL, Integrase (IN), PC4 and SFRS1 interacting protein, ... | | 著者 | Cherepanov, P, Ambrosio, A.L, Rahman, S, Ellenberger, T, Engelman, A. | | 登録日 | 2005-09-24 | | 公開日 | 2005-10-25 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | | 主引用文献 | Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75
Proc.Natl.Acad.Sci.Usa, 102, 2005
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2AJQ
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6FVG
 | | The Structure of CK2alpha with CCh507 bound | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Casein kinase II subunit alpha, [1-[2-(phenylsulfonylamino)ethyl]piperidin-4-yl]methyl 1~{H}-indole-3-carboxylate | | 著者 | Brear, P, Prudent, R, Laudet, B, Filhol, O, Cochet, C, Sautel, C, Moucadel, V, Bestgen, B, Engel, M, Ettaoussi, M, Lomberget, T, Le Borgne, M, Kufareva, I, Abagyan, R, Hyvonen, M. | | 登録日 | 2018-03-02 | | 公開日 | 2019-06-19 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Discovery of holoenzyme-disrupting chemicals as substrate-selective CK2 inhibitors.
Sci Rep, 9, 2019
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6FVF
 | | The Structure of CK2alpha with CCh503 bound | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Casein kinase II subunit alpha, [1-[2-(phenylsulfonylamino)ethyl]piperidin-4-yl]methyl 5-fluoranyl-2-methoxy-1~{H}-indole-3-carboxylate | | 著者 | Brear, P, Prudent, R, Laudet, B, Filhol, O, Cochet, C, Sautel, C, Moucadel, V, Bestgen, B, Engel, M, Ettaoussi, M, Lomberget, T, Le Borgne, M, Kufareva, I, Abagyan, R, Hyvonen, M. | | 登録日 | 2018-03-02 | | 公開日 | 2019-06-19 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | | 主引用文献 | Discovery of holoenzyme-disrupting chemicals as substrate-selective CK2 inhibitors.
Sci Rep, 9, 2019
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6FUY
 | | Crystal structure of human full-length vinculin-T12-A974K (residues 1-1066) | | 分子名称: | CALCIUM ION, Vinculin | | 著者 | Chorev, D.S, Volberg, T, Livne, A, Eisenstein, M, Martins, B, Kam, Z, Jockusch, B.M, Medalia, O, Sharon, M, Geiger, B. | | 登録日 | 2018-02-28 | | 公開日 | 2018-03-14 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Conformational states during vinculin unlocking differentially regulate focal adhesion properties.
Sci Rep, 8, 2018
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7BBN
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3OPY
 | | Crystal structure of Pichia pastoris phosphofructokinase in the T-state | | 分子名称: | 6-phosphofructo-1-kinase alpha-subunit, 6-phosphofructo-1-kinase beta-subunit, 6-phosphofructo-1-kinase gamma-subunit, ... | | 著者 | Strater, N, Marek, S, Kuettner, E.B, Kloos, M, Keim, A, Bruser, A, Kirchberger, J, Schoneberg, T. | | 登録日 | 2010-09-02 | | 公開日 | 2010-10-06 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | | 主引用文献 | Molecular architecture and structural basis of allosteric regulation of eukaryotic phosphofructokinases.
Faseb J., 25, 2011
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3PNT
 | | Crystal Structure of the Streptococcus pyogenes NAD+ glycohydrolase SPN in complex with IFS, the Immunity Factor for SPN | | 分子名称: | Immunity factor for SPN, NAD+-glycohydrolase | | 著者 | Smith, C.L, Stine Elam, J, Ellenberger, T, Ghosh, J, Pinkner, J.S, Hultgren, S.J, Caparon, M.G. | | 登録日 | 2010-11-19 | | 公開日 | 2011-03-02 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structural Basis of Streptococcus pyogenes Immunity to Its NAD(+) Glycohydrolase Toxin.
Structure, 19, 2011
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3QB2
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