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6FVF

The Structure of CK2alpha with CCh503 bound

Summary for 6FVF
Entry DOI10.2210/pdb6fvf/pdb
DescriptorCasein kinase II subunit alpha, [1-[2-(phenylsulfonylamino)ethyl]piperidin-4-yl]methyl 5-fluoranyl-2-methoxy-1~{H}-indole-3-carboxylate, ADENOSINE-5'-TRIPHOSPHATE, ... (4 entities in total)
Functional Keywordsck2alpha, ck2a, fragment based drug discovery, high concentration screening, selective atp competitive inhibitors, surface entrophy reduction, transferase
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight40028.13
Authors
Primary citationKufareva, I.,Bestgen, B.,Brear, P.,Prudent, R.,Laudet, B.,Moucadel, V.,Ettaoussi, M.,Sautel, C.F.,Krimm, I.,Engel, M.,Filhol, O.,Borgne, M.L.,Lomberget, T.,Cochet, C.,Abagyan, R.
Discovery of holoenzyme-disrupting chemicals as substrate-selective CK2 inhibitors.
Sci Rep, 9:15893-15893, 2019
Cited by
PubMed: 31685885
DOI: 10.1038/s41598-019-52141-5
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.47 Å)
Structure validation

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