6FVF
The Structure of CK2alpha with CCh503 bound
Summary for 6FVF
Entry DOI | 10.2210/pdb6fvf/pdb |
Descriptor | Casein kinase II subunit alpha, [1-[2-(phenylsulfonylamino)ethyl]piperidin-4-yl]methyl 5-fluoranyl-2-methoxy-1~{H}-indole-3-carboxylate, ADENOSINE-5'-TRIPHOSPHATE, ... (4 entities in total) |
Functional Keywords | ck2alpha, ck2a, fragment based drug discovery, high concentration screening, selective atp competitive inhibitors, surface entrophy reduction, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 40028.13 |
Authors | Brear, P.,Prudent, R.,Laudet, B.,Filhol, O.,Cochet, C.,Sautel, C.,Moucadel, V.,Bestgen, B.,Engel, M.,Ettaoussi, M.,Lomberget, T.,Le Borgne, M.,Kufareva, I.,Abagyan, R.,Hyvonen, M. (deposition date: 2018-03-02, release date: 2019-06-19, Last modification date: 2024-01-17) |
Primary citation | Kufareva, I.,Bestgen, B.,Brear, P.,Prudent, R.,Laudet, B.,Moucadel, V.,Ettaoussi, M.,Sautel, C.F.,Krimm, I.,Engel, M.,Filhol, O.,Borgne, M.L.,Lomberget, T.,Cochet, C.,Abagyan, R. Discovery of holoenzyme-disrupting chemicals as substrate-selective CK2 inhibitors. Sci Rep, 9:15893-15893, 2019 Cited by PubMed: 31685885DOI: 10.1038/s41598-019-52141-5 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.47 Å) |
Structure validation
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