1EKQ
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1F0Z
| SOLUTION STRUCTURE OF THIS, THE SULFUR CARRIER PROTEIN IN E.COLI THIAMIN BIOSYNTHESIS | Descriptor: | THIS PROTEIN | Authors: | Wang, C, Xi, J, Begley, T.P, Nicholson, L.K. | Deposit date: | 2000-05-17 | Release date: | 2001-01-10 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution structure of ThiS and implications for the evolutionary roots of ubiquitin. Nat.Struct.Biol., 8, 2001
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3RP6
| Crystal Structure of Klebsiella pneumoniae HpxO complexed with FAD | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, flavoprotein monooxygenase | Authors: | Hicks, K.A, O'Leary, S.E, Begley, T.P, Ealick, S.E. | Deposit date: | 2011-04-26 | Release date: | 2012-05-16 | Last modified: | 2013-02-06 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural and Mechanistic Studies of HpxO, a Novel Flavin Adenine Dinucleotide-Dependent Urate Oxidase from Klebsiella pneumoniae. Biochemistry, 52, 2013
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3RM5
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3RP7
| Crystal Structure of Klebsiella pneumoniae HpxO complexed with FAD and uric acid | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, URIC ACID, flavoprotein monooxygenase | Authors: | Hicks, K.A, O'Leary, S.E, Begley, T.P, Ealick, S.E. | Deposit date: | 2011-04-26 | Release date: | 2012-05-16 | Last modified: | 2013-02-06 | Method: | X-RAY DIFFRACTION (2.042 Å) | Cite: | Structural and Mechanistic Studies of HpxO, a Novel Flavin Adenine Dinucleotide-Dependent Urate Oxidase from Klebsiella pneumoniae. Biochemistry, 52, 2013
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3KVV
| Trapping of an oxocarbenium ion intermediate in UP crystals | Descriptor: | 1,4-anhydro-D-erythro-pent-1-enitol, 5-FLUOROURACIL, SULFATE ION, ... | Authors: | Paul, D, O'Leary, S, Rajashankar, K, Bu, W, Toms, A, Settembre, E, Sanders, J, Begley, T.P, Ealick, S.E. | Deposit date: | 2009-11-30 | Release date: | 2010-04-28 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Glycal formation in crystals of uridine phosphorylase. Biochemistry, 49, 2010
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3RP8
| Crystal Structure of Klebsiella pneumoniae R204Q HpxO complexed with FAD | Descriptor: | CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, flavoprotein monooxygenase | Authors: | Hicks, K.A, O'Leary, S.E, Begley, T.P, Ealick, S.E. | Deposit date: | 2011-04-26 | Release date: | 2012-05-16 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.968 Å) | Cite: | Structural and Mechanistic Studies of HpxO, a Novel Flavin Adenine Dinucleotide-Dependent Urate Oxidase from Klebsiella pneumoniae. Biochemistry, 52, 2013
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3QH2
| Crystal structure of TenI from Bacillus subtilis complexed with product cThz-P | Descriptor: | 4-methyl-5-[2-(phosphonooxy)ethyl]-1,3-thiazole-2-carboxylic acid, Regulatory protein tenI, SULFATE ION | Authors: | Han, Y, Zhang, Y, Hazra, A, Chatterjee, A, Lai, R, Begley, T.P, Ealick, S.E. | Deposit date: | 2011-01-25 | Release date: | 2011-05-25 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.231 Å) | Cite: | A Missing Enzyme in Thiamin Thiazole Biosynthesis: Identification of TenI as a Thiazole Tautomerase. J.Am.Chem.Soc., 133, 2011
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3IX1
| Periplasmic N-formyl-4-amino-5-aminomethyl-2-methylpyrimidine binding protein from Bacillus halodurans | Descriptor: | N-[(4-amino-2-methylpyrimidin-5-yl)methyl]formamide, N-formyl-4-amino-5-aminomethyl-2-methylpyrimidine binding protein | Authors: | Bale, S, Rajashankar, K.R, Perry, K, Begley, T.P, Ealick, S.E. | Deposit date: | 2009-09-03 | Release date: | 2010-10-13 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | HMP Binding Protein ThiY and HMP-P Synthase THI5 Are Structural Homologues. Biochemistry, 49, 2010
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4ESX
| Crystal structure of C. albicans Thi5 complexed with PLP | Descriptor: | Pyrimidine biosynthesis enzyme THI13 | Authors: | Huang, S, Fenwick, M.K, Zhang, Y, Lai, R, Hazra, A, Rajashankar, K, Philmus, B, Kinsland, C, Sanders, J, Begley, T.P, Ealick, S.E. | Deposit date: | 2012-04-23 | Release date: | 2012-09-19 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Thiamin pyrimidine biosynthesis in Candida albicans : a remarkable reaction between histidine and pyridoxal phosphate. J.Am.Chem.Soc., 134, 2012
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1XOB
| THIOREDOXIN (REDUCED DITHIO FORM), NMR, 20 STRUCTURES | Descriptor: | THIOREDOXIN | Authors: | Jeng, M.-F, Campbell, A.P, Begley, T, Holmgren, A, Case, D.A, Wright, P.E, Dyson, H.J. | Deposit date: | 1995-11-28 | Release date: | 1996-06-10 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | High-resolution solution structures of oxidized and reduced Escherichia coli thioredoxin. Structure, 2, 1994
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4ESW
| Crystal structure of C. albicans Thi5 H66G mutant | Descriptor: | CITRIC ACID, Pyrimidine biosynthesis enzyme THI13 | Authors: | Fenwick, M.K, Huang, S, Zhang, Y, Lai, R, Hazra, A, Rajashankar, K, Philmus, B, Kinsland, C, Sanders, J, Begley, T.P, Ealick, S.E. | Deposit date: | 2012-04-23 | Release date: | 2012-09-19 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Thiamin pyrimidine biosynthesis in Candida albicans : a remarkable reaction between histidine and pyridoxal phosphate. J.Am.Chem.Soc., 134, 2012
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1YAD
| Structure of TenI from Bacillus subtilis | Descriptor: | Regulatory protein tenI, SULFATE ION, TRIS-HYDROXYMETHYL-METHYL-AMMONIUM | Authors: | Toms, A.V, Haas, A.L, Park, J.-H, Begley, T.P, Ealick, S.E. | Deposit date: | 2004-12-17 | Release date: | 2005-02-22 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural characterization of the regulatory proteins TenA and TenI from Bacillus subtilis and identification of TenA as a thiaminase II. Biochemistry, 44, 2005
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1YFU
| Crystal structure of 3-hydroxyanthranilate-3,4-dioxygenase from Ralstonia metallidurans | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3-hydroxyanthranilate-3,4-dioxygenase, CHLORIDE ION, ... | Authors: | Zhang, Y, Colabroy, K.L, Begley, T.P, Ealick, S.E. | Deposit date: | 2005-01-04 | Release date: | 2005-05-31 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural Studies on 3-Hydroxyanthranilate-3,4-dioxygenase: The Catalytic Mechanism of a Complex Oxidation Involved in NAD Biosynthesis. Biochemistry, 44, 2005
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1YAK
| Complex of Bacillus subtilis TenA with 4-amino-2-methyl-5-hydroxymethylpyrimidine | Descriptor: | 4-AMINO-5-HYDROXYMETHYL-2-METHYLPYRIMIDINE, Transcriptional activator tenA | Authors: | Toms, A.V, Haas, A.L, Park, J.-H, Begley, T.P, Ealick, S.E. | Deposit date: | 2004-12-17 | Release date: | 2005-02-22 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural characterization of the regulatory proteins TenA and TenI from Bacillus subtilis and identification of TenA as a thiaminase II. Biochemistry, 44, 2005
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1XOA
| THIOREDOXIN (OXIDIZED DISULFIDE FORM), NMR, 20 STRUCTURES | Descriptor: | THIOREDOXIN | Authors: | Jeng, M.-F, Campbell, A.P, Begley, T, Holmgren, A, Case, D.A, Wright, P.E, Dyson, H.J. | Deposit date: | 1995-11-28 | Release date: | 1996-06-10 | Last modified: | 2017-11-29 | Method: | SOLUTION NMR | Cite: | High-resolution solution structures of oxidized and reduced Escherichia coli thioredoxin. Structure, 2, 1994
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1YFW
| Crystal structure of 3-hydroxyanthranilate-3,4-dioxygenase from Ralstonia metallidurans complexed with 4-chloro-3-hydroxyanthranilic acid and O2 | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3-hydroxyanthranilate-3,4-dioxygenase, 4-CHLORO-3-HYDROXYANTHRANILIC ACID, ... | Authors: | Zhang, Y, Colabroy, K.L, Begley, T.P, Ealick, S.E. | Deposit date: | 2005-01-04 | Release date: | 2005-05-31 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural Studies on 3-Hydroxyanthranilate-3,4-dioxygenase: The Catalytic Mechanism of a Complex Oxidation Involved in NAD Biosynthesis. Biochemistry, 44, 2005
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1YFX
| Crystal structure of 3-hydroxyanthranilate-3,4-dioxygenase from Ralstonia metallidurans complexed with 4-chloro-3-hydroxyanthranilic acid and NO | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3-hydroxyanthranilate-3,4-dioxygenase, 4-CHLORO-3-HYDROXYANTHRANILIC ACID, ... | Authors: | Zhang, Y, Colabroy, K.L, Begley, T.P, Ealick, S.E. | Deposit date: | 2005-01-04 | Release date: | 2005-05-31 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural Studies on 3-Hydroxyanthranilate-3,4-dioxygenase: The Catalytic Mechanism of a Complex Oxidation Involved in NAD Biosynthesis. Biochemistry, 44, 2005
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1YFY
| Crystal structure of 3-hydroxyanthranilate-3,4-dioxygenase from Ralstonia metallidurans complexed with 3-hydroxyanthranilic acid | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3-HYDROXYANTHRANILIC ACID, 3-hydroxyanthranilate-3,4-dioxygenase, ... | Authors: | Zhang, Y, Colabroy, K.L, Begley, T.P, Ealick, S.E. | Deposit date: | 2005-01-04 | Release date: | 2005-05-31 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural Studies on 3-Hydroxyanthranilate-3,4-dioxygenase: The Catalytic Mechanism of a Complex Oxidation Involved in NAD Biosynthesis. Biochemistry, 44, 2005
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1YAF
| Structure of TenA from Bacillus subtilis | Descriptor: | Transcriptional activator tenA | Authors: | Toms, A.V, Haas, A.L, Park, J.-H, Begley, T.P, Ealick, S.E. | Deposit date: | 2004-12-17 | Release date: | 2005-02-22 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural characterization of the regulatory proteins TenA and TenI from Bacillus subtilis and identification of TenA as a thiaminase II. Biochemistry, 44, 2005
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2B5H
| 1.5 A Resolution Crystal Structure of Recombinant R. Norvegicus Cysteine Dioxygenase | Descriptor: | Cysteine dioxygenase type I, FE (III) ION | Authors: | Simmons, C.R, Liu, Q, Huang, Q, Hao, Q, Begley, T.P, Karplus, P.A, Stipanuk, M.H. | Deposit date: | 2005-09-28 | Release date: | 2006-04-11 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Crystal Structure of Mammalian Cysteine Dioxygenase: A NOVEL MONONUCLEAR IRON CENTER FOR CYSTEINE THIOL OXIDATION. J.Biol.Chem., 281, 2006
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3GMC
| Crystal Structure of 2-Methyl-3-hydroxypyridine-5-carboxylic acid Oxygenase with substrate bound | Descriptor: | 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase, 5-hydroxy-6-methylpyridine-3-carboxylic acid, FLAVIN-ADENINE DINUCLEOTIDE | Authors: | McCulloch, K.M, Mukherjee, T, Begley, T.P, Ealick, S.E. | Deposit date: | 2009-03-13 | Release date: | 2009-04-14 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure of the PLP degradative enzyme 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase from Mesorhizobium loti MAFF303099 and its mechanistic implications. Biochemistry, 48, 2009
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3GMB
| Crystal Structure of 2-Methyl-3-hydroxypyridine-5-carboxylic acid Oxygenase | Descriptor: | 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase, FLAVIN-ADENINE DINUCLEOTIDE | Authors: | McCulloch, K.M, Mukherjee, T, Begley, T.P, Ealick, S.E. | Deposit date: | 2009-03-13 | Release date: | 2009-04-14 | Last modified: | 2017-11-01 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure of the PLP degradative enzyme 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase from Mesorhizobium loti MAFF303099 and its mechanistic implications. Biochemistry, 48, 2009
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3KUK
| Trapping of an oxocarbenium ion intermediate in UP crystals | Descriptor: | 2'-DEOXYURIDINE, SULFATE ION, Uridine phosphorylase | Authors: | Paul, D, O'Leary, S, Rajashankar, K, Bu, W, Toms, A, Settembre, E, Sanders, J, Begley, T.P, Ealick, S.E. | Deposit date: | 2009-11-27 | Release date: | 2010-04-28 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.783 Å) | Cite: | Glycal formation in crystals of uridine phosphorylase. Biochemistry, 49, 2010
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3KVY
| Trapping of an oxocarbenium ion intermediate in UP crystals | Descriptor: | 1,4-anhydro-D-erythro-pent-1-enitol, SULFATE ION, URACIL, ... | Authors: | Paul, D, O'Leary, S, Rajashankar, K, Bu, W, Toms, A, Settembre, E, Sanders, J, Begley, T.P, Ealick, S.E. | Deposit date: | 2009-11-30 | Release date: | 2010-04-28 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Glycal formation in crystals of uridine phosphorylase. Biochemistry, 49, 2010
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