1Y43
 
 | | crystal structure of aspergilloglutamic peptidase from Aspergillus niger | | Descriptor: | Aspergillopepsin II heavy chain, Aspergillopepsin II light chain, SULFATE ION | | Authors: | Sasaki, H, Nakagawa, A, Iwata, S, Muramatsu, T, Suganuma, M, Sawano, Y, Kojima, M, Kubota, K, Takahashi, K. | | Deposit date: | 2004-11-30 | | Release date: | 2005-12-13 | | Last modified: | 2013-02-27 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | The three-dimensional structure of aspergilloglutamic peptidase from Aspergillus niger
Proc.Jpn.Acad.,Ser.B, 80, 2004
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3AP1
 | | Crystal structure of human tyrosylprotein sulfotransferase-2 complexed with PAP and C4 peptide | | Descriptor: | ADENOSINE-3'-5'-DIPHOSPHATE, C4 peptide, GLYCEROL, ... | | Authors: | Teramoto, T, Fujikawa, Y, Kawaguchi, Y, Kurogi, K, Soejima, M, Adachi, R, Nakanishi, Y, Mishiro-Sato, E, Liu, M.-C, Sakakibara, Y, Suiko, M, Kimura, M, Kakuta, Y. | | Deposit date: | 2010-10-09 | | Release date: | 2011-10-26 | | Last modified: | 2013-03-27 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal structure of human tyrosylprotein sulfotransferase-2 reveals the mechanism of protein tyrosine sulfation reaction.
Nat Commun, 4, 2013
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3VHE
 | | Crystal structure of human VEGFR2 kinase domain with a novel pyrrolopyrimidine inhibitor. | | Descriptor: | 1-{2-fluoro-4-[(5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yl)oxy]phenyl}-3-[3-(trifluoromethyl)phenyl]urea, Vascular endothelial growth factor receptor 2 | | Authors: | Oguro, Y, Miyamoto, N, Okada, K, Takagi, T, Iwata, H, Awazu, Y, Miki, H, Hori, A, Kamiyama, K, Imanura, S. | | Deposit date: | 2011-08-24 | | Release date: | 2011-11-02 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Design, synthesis, and evaluation of 5-methyl-4-phenoxy-5H-pyrrolo[3,2-d]pyrimidine derivatives: novel VEGFR2 kinase inhibitors binding to inactive kinase conformation.
Bioorg.Med.Chem., 18, 2010
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2PCK
 | | Crystal structure of PH0725 from Pyrococcus horikoshii OT3 | | Descriptor: | S-ADENOSYL-L-HOMOCYSTEINE, diphthine synthase | | Authors: | Yamamoto, H, Morikawa, Y, Matsuura, Y, Shimada, H, Kunishima, N, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2007-03-30 | | Release date: | 2007-10-02 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Crystal structure of PH0725 from Pyrococcus horikoshii OT3
To be Published
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3VQZ
 | | Crystal structure of metallo-beta-lactamase, SMB-1, in a complex with mercaptoacetic acid | | Descriptor: | Metallo-beta-lactamase, SODIUM ION, SULFANYLACETIC ACID, ... | | Authors: | Wachino, J, Yamaguchi, Y, Mori, S, Arakawa, Y, Shibayama, K. | | Deposit date: | 2012-04-02 | | Release date: | 2013-02-13 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural Insights into the Subclass B3 Metallo-beta-Lactamase SMB-1 and the Mode of Inhibition by the Common Metallo- -Lactamase Inhibitor Mercaptoacetate
Antimicrob.Agents Chemother., 57, 2013
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3V10
 | | Crystal structure of the collagen binding domain of Erysipelothrix rhusiopathiae surface protein RspB | | Descriptor: | Rhusiopathiae surface protein B | | Authors: | Ponnuraj, K, Swarmistha devi, A, Ogawa, Y, Shimoji, Y, Subramainan, B. | | Deposit date: | 2011-12-09 | | Release date: | 2012-10-24 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Collagen adhesin-nanoparticle interaction impairs adhesin's ligand binding mechanism
Biochim.Biophys.Acta, 1820, 2012
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3VPE
 | | Crystal Structure of Metallo-beta-Lactamase SMB-1 | | Descriptor: | ACETATE ION, GLYCEROL, Metallo-beta-lactamase, ... | | Authors: | Wachino, J, Yamaguchi, Y, Mori, S, Arakawa, Y, Shibayama, K. | | Deposit date: | 2012-02-29 | | Release date: | 2013-02-13 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Structural Insights into the Subclass B3 Metallo-beta-Lactamase SMB-1 and the Mode of Inhibition by the Common Metallo- -Lactamase Inhibitor Mercaptoacetate
Antimicrob.Agents Chemother., 57, 2013
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3W2S
 | | EGFR kinase domain with compound4 | | Descriptor: | 1-{3-[2-chloro-4-({5-[2-(2-hydroxyethoxy)ethyl]-5H-pyrrolo[3,2-d]pyrimidin-4-yl}amino)phenoxy]phenyl}-3-cyclohexylurea, Epidermal growth factor receptor, SULFATE ION | | Authors: | Sogabe, S, Kawakita, Y, Igaki, S. | | Deposit date: | 2012-12-03 | | Release date: | 2013-01-16 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structure-Based Approach for the Discovery of Pyrrolo[3,2-d]pyrimidine-Based EGFR T790M/L858R Mutant Inhibitors.
Acs Med.Chem.Lett., 4, 2013
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3W32
 | | EGFR kinase domain complexed with compound 20a | | Descriptor: | 4-({3-chloro-4-[3-(trifluoromethyl)phenoxy]phenyl}amino)-N-[2-(methylsulfonyl)ethyl]-8,9-dihydro-7H-pyrimido[4,5-b]azepine-6-carboxamide, Epidermal growth factor receptor, SULFATE ION | | Authors: | Sogabe, S, Kawakita, Y. | | Deposit date: | 2012-12-07 | | Release date: | 2013-03-06 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Design and synthesis of novel pyrimido[4,5-b]azepine derivatives as HER2/EGFR dual inhibitors
Bioorg.Med.Chem., 21, 2013
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3W2O
 | | EGFR Kinase domain T790M/L858R Mutant with TAK-285 | | Descriptor: | Epidermal growth factor receptor, N-{2-[4-({3-chloro-4-[3-(trifluoromethyl)phenoxy]phenyl}amino)-5H-pyrrolo[3,2-d]pyrimidin-5-yl]ethyl}-3-hydroxy-3-methylbutanamide | | Authors: | Sogabe, S, Kawakita, Y, Igaki, S. | | Deposit date: | 2012-12-03 | | Release date: | 2013-01-16 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Structure-Based Approach for the Discovery of Pyrrolo[3,2-d]pyrimidine-Based EGFR T790M/L858R Mutant Inhibitors.
Acs Med.Chem.Lett., 4, 2013
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3W2P
 | | EGFR Kinase domain T790M/L858R mutant with compound 2 | | Descriptor: | Epidermal growth factor receptor, N-{2-[4-({3-chloro-4-[3-(trifluoromethyl)phenoxy]phenyl}amino)-5H-pyrrolo[3,2-d]pyrimidin-5-yl]ethyl}-4-(dimethylamino)butanamide | | Authors: | Sogabe, S, Kawakita, Y, Igaki, S. | | Deposit date: | 2012-12-03 | | Release date: | 2013-01-16 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Structure-Based Approach for the Discovery of Pyrrolo[3,2-d]pyrimidine-Based EGFR T790M/L858R Mutant Inhibitors.
Acs Med.Chem.Lett., 4, 2013
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3W2R
 | | EGFR Kinase domain T790M/L858R mutant with compound 4 | | Descriptor: | 1,2-ETHANEDIOL, 1-{3-[2-chloro-4-({5-[2-(2-hydroxyethoxy)ethyl]-5H-pyrrolo[3,2-d]pyrimidin-4-yl}amino)phenoxy]phenyl}-3-cyclohexylurea, Epidermal growth factor receptor | | Authors: | Sogabe, S, Kawakita, Y, Igaki, S. | | Deposit date: | 2012-12-03 | | Release date: | 2013-01-16 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Structure-Based Approach for the Discovery of Pyrrolo[3,2-d]pyrimidine-Based EGFR T790M/L858R Mutant Inhibitors.
Acs Med.Chem.Lett., 4, 2013
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7C0M
 | | Human cGAS-nucleosome complex | | Descriptor: | Cyclic GMP-AMP synthase, DNA (145-MER), Histone H2A type 1-B/E, ... | | Authors: | Kujirai, T, Zierhut, C, Takizawa, Y, Kim, R, Negishi, L, Uruma, N, Hirai, S, Funabiki, H, Kurumizaka, H. | | Deposit date: | 2020-05-01 | | Release date: | 2020-09-16 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Structural basis for the inhibition of cGAS by nucleosomes.
Science, 370, 2020
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2KE4
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2P6I
 | | Crystal structure of PH0725 from Pyrococcus horikoshii OT3 | | Descriptor: | S-ADENOSYL-L-HOMOCYSTEINE, diphthine synthase | | Authors: | Yamamoto, H, Matsuura, Y, Morikawa, Y, Shimada, H, Kunishima, N, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2007-03-18 | | Release date: | 2007-09-18 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystal structure of PH0725 from Pyrococcus horikoshii OT3
To be Published
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2PCI
 | | Crystal structure of PH0725 from Pyrococcus horikoshii OT3 | | Descriptor: | Probable diphthine synthase, S-ADENOSYL-L-HOMOCYSTEINE | | Authors: | Yamamoto, H, Matsuura, Y, Morikawa, Y, Nakamoto, T, Kunishima, N, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2007-03-29 | | Release date: | 2007-10-02 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structure of PH0725 from Pyrococcus horikoshii OT3
To be Published
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1IY4
 | | Solution structure of the human lysozyme at 35 degree C | | Descriptor: | Lysozyme | | Authors: | Kumeta, H, Miura, A, Kobashigawa, Y, Miura, K, Oka, C, Nitta, K, Nemoto, N, Tsuda, S. | | Deposit date: | 2002-07-15 | | Release date: | 2002-07-31 | | Last modified: | 2023-12-27 | | Method: | SOLUTION NMR | | Cite: | Low-temperature-induced structural changes in human lysozyme elucidated by three-dimensional NMR spectroscopy
Biochemistry, 42, 2003
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1J32
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2KBT
 | | Attachment of an NMR-invisible solubility enhancement tag (INSET) using a sortase-mediated protein ligation method | | Descriptor: | Proto-oncogene vav,Immunoglobulin G-binding protein G | | Authors: | Kumeta, H, Kobashigawa, Y, Ogura, K, Inagaki, F. | | Deposit date: | 2008-12-07 | | Release date: | 2009-02-03 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Attachment of an NMR-invisible solubility enhancement tag using a sortase-mediated protein ligation method
J.Biomol.Nmr, 43, 2009
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1IY3
 | | Solution Structure of the Human lysozyme at 4 degree C | | Descriptor: | Lysozyme | | Authors: | Kumeta, H, Miura, A, Kobashigawa, Y, Miura, K, Oka, C, Nitta, K, Nemoto, N, Tsuda, S. | | Deposit date: | 2002-07-15 | | Release date: | 2002-07-31 | | Last modified: | 2023-12-27 | | Method: | SOLUTION NMR | | Cite: | Low-temperature-induced structural changes in human lysozyme elucidated by three-dimensional NMR spectroscopy
Biochemistry, 42, 2003
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3VGV
 | | E134A mutant nucleoside diphosphate kinase derived from Halomonas sp. 593 | | Descriptor: | Nucleoside diphosphate kinase | | Authors: | Okazaki, N, Yonezawa, Y, Arai, S, Matsumoto, F, Tamada, T, Tokunaga, H, Ishibashi, M, Tokunaga, M, Kuroki, R. | | Deposit date: | 2011-08-21 | | Release date: | 2012-07-11 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | A structural mechanism for dimeric to tetrameric oligomer conversion in Halomonas sp. nucleoside diphosphate kinase
Protein Sci., 21, 2012
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2ZZD
 | | Recombinant thiocyanate hydrolase, air-oxidized form of holo-enzyme | | Descriptor: | COBALT (III) ION, L(+)-TARTARIC ACID, Thiocyanate hydrolase subunit alpha, ... | | Authors: | Arakawa, T, Kawano, Y, Katayama, Y, Yohda, M, Odaka, M. | | Deposit date: | 2009-02-09 | | Release date: | 2009-10-13 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.78 Å) | | Cite: | Structural Basis for Catalytic Activation of Thiocyanate Hydrolase Involving Metal-Ligated Cysteine Modification
J.Am.Chem.Soc., 131, 2009
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3VGT
 | | Wild-type nucleoside diphosphate kinase derived from Halomonas sp. 593 | | Descriptor: | Nucleoside diphosphate kinase | | Authors: | Okazaki, N, Yonezawa, Y, Arai, S, Matsumoto, F, Tamada, T, Tokunaga, H, Ishibashi, M, Tokunaga, M, Kuroki, R. | | Deposit date: | 2011-08-21 | | Release date: | 2012-07-11 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | A structural mechanism for dimeric to tetrameric oligomer conversion in Halomonas sp. nucleoside diphosphate kinase
Protein Sci., 21, 2012
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3WO5
 | | Crystal structure of S147Q of Rv2613c from Mycobacterium tuberculosis | | Descriptor: | AP-4-A phosphorylase, GLYCEROL, PHOSPHATE ION, ... | | Authors: | Mori, S, Wachino, J, Arakawa, Y, Shibayama, K. | | Deposit date: | 2013-12-20 | | Release date: | 2014-12-24 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.79 Å) | | Cite: | Role of Ser-147 and Ala-149 in catalytic activity of diadenosine tetraphosphate phosphorylase from Mycobacterium tuberculosis H37Rv
To be Published
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2RPV
 | | Solution Structure of GB1 with LBT probe | | Descriptor: | Immunoglobulin G-binding protein G, LANTHANUM (III) ION | | Authors: | Saio, T, Ogura, K, Yokochi, M, Kobashigawa, Y, Inagaki, F. | | Deposit date: | 2008-10-28 | | Release date: | 2009-09-15 | | Last modified: | 2021-11-10 | | Method: | SOLUTION NMR | | Cite: | Two-point anchoring of a lanthanide-binding peptide to a target protein enhances the paramagnetic anisotropic effect
J.Biomol.Nmr, 44, 2009
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