8QZN
 
 | | DARPin-Armadillo fusion protein with a selected Tyrosin pocket binding to the fused target peptide | | Descriptor: | 1,2-ETHANEDIOL, DARPin-Armadillo fusion protein with Tyrosin pocket and linked target peptide, SULFATE ION | | Authors: | Stark, Y, Menard, F, Jeliazkov, J, Ernst, P, Chembath, A, Ashraf, M, Hine, A, Plueckthun, A. | | Deposit date: | 2023-10-27 | | Release date: | 2024-07-03 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Modular binder technology by NGS-aided, high-resolution selection in yeast of designed armadillo modules.
Proc.Natl.Acad.Sci.USA, 121, 2024
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8V39
 | | Crystal structure of active KRAS-G12C (GMPPNP-bound) in complex with BBO-8520 | | Descriptor: | BBO-8520 (bound form), GTPase KRas, MAGNESIUM ION, ... | | Authors: | Chan, A.H, Ashraf, M, Dharmaiah, S, Simanshu, D.K. | | Deposit date: | 2023-11-27 | | Release date: | 2024-12-18 | | Last modified: | 2025-03-12 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Discovery of BBO-8520, a First-In-Class Direct and Covalent Dual Inhibitor of GTP-Bound (ON) and GDP-Bound (OFF) KRASG12C.
Cancer Discov, 15, 2025
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