6NM4
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![BU of 6nm4 by Molmil](/molmil-images/mine/6nm4) | Crystal structure of SAM-bound PRDM9 in complex with MRK-740 inhibitor | Descriptor: | 4-[3-(3,5-dimethoxyphenyl)-1,2,4-oxadiazol-5-yl]-1-methyl-9-(2-methylpyridin-4-yl)-1,4,9-triazaspiro[5.5]undecane, Histone-lysine N-methyltransferase PRDM9, S-ADENOSYLMETHIONINE, ... | Authors: | Ivanochko, D, Halabelian, L, Fischer, C, Sanders, J.M, Kattar, S.D, Brown, P.J, Edwards, A.M, Bountra, C, Arrowsmith, C.H, Structural Genomics Consortium (SGC) | Deposit date: | 2019-01-10 | Release date: | 2019-02-13 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.58 Å) | Cite: | Discovery of a chemical probe for PRDM9. Nat Commun, 10, 2019
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6MIW
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![BU of 6miw by Molmil](/molmil-images/mine/6miw) | WWE domain of human HUWE1 | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, E3 ubiquitin-protein ligase HUWE1, UNKNOWN ATOM OR ION | Authors: | Halabelian, L, Loppnau, P, Tempel, W, Wong, F, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Tong, Y, Structural Genomics Consortium (SGC) | Deposit date: | 2018-09-20 | Release date: | 2018-10-17 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | WWE domain of human HUWE1 To Be Published
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3L42
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![BU of 3l42 by Molmil](/molmil-images/mine/3l42) | PWWP domain of human bromodomain and PHD finger containing protein 1 | Descriptor: | Peregrin, UNKNOWN ATOM OR ION | Authors: | Tempel, W, Zeng, H, Ni, S, Amaya, M.F, Dong, A, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Wu, H, Structural Genomics Consortium (SGC) | Deposit date: | 2009-12-18 | Release date: | 2010-01-12 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Structural and Histone Binding Ability Characterizations of Human PWWP Domains. Plos One, 6, 2011
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3KUF
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![BU of 3kuf by Molmil](/molmil-images/mine/3kuf) | The Crystal Structure of the Tudor Domains from FXR1 | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Fragile X mental retardation syndrome-related protein 1, GLYCEROL | Authors: | Bian, C, Guo, Y.H, Adams-Cioaba, M.A, Mackenzie, F, Kozieradzki, I, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2009-11-27 | Release date: | 2010-01-05 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal structure of the Tudor domains from Fragile X mental retardation syndrome-related protein 1 To be Published
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3L50
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![BU of 3l50 by Molmil](/molmil-images/mine/3l50) | The crystal structure of human Glia Maturation Factor, Gamma (GMFG) | Descriptor: | CHLORIDE ION, Glia maturation factor gamma | Authors: | Ugochukwu, E, Pilka, E, Krysztofinska, E, Hapka, E, Krojer, T, Muniz, J, Vollmar, M, Pike, A.C.W, von Delft, F, Bountra, C, Arrowsmith, C.H, Weigelt, J, Edwards, A, Kavanagh, K.L, Oppermann, U, Structural Genomics Consortium (SGC) | Deposit date: | 2009-12-21 | Release date: | 2010-02-02 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | The crystal structure of human Glia Maturation Factor, Gamma (GMFG) To be Published
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3LLR
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![BU of 3llr by Molmil](/molmil-images/mine/3llr) | Crystal structure of the PWWP domain of Human DNA (cytosine-5-)-methyltransferase 3 alpha | Descriptor: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DNA (cytosine-5)-methyltransferase 3A, SULFATE ION | Authors: | Qiu, W, Dombrovski, L, Ni, S, Weigelt, J, Boutra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Wu, H, Structural Genomics Consortium (SGC) | Deposit date: | 2010-01-29 | Release date: | 2010-03-23 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural and histone binding ability characterizations of human PWWP domains. Plos One, 6, 2011
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3LM0
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![BU of 3lm0 by Molmil](/molmil-images/mine/3lm0) | Crystal Structure of human Serine/Threonine Kinase 17B (STK17B) | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Serine/threonine-protein kinase 17B, ... | Authors: | Ugochukwu, E, Soundararajan, M, Rellos, P, Fedorov, O, Phillips, C, Wang, J, Hapka, E, Filippakopoulos, P, Chaikuad, A, Pike, A.C.W, von Delft, F, Bountra, C, Arrowsmith, C.H, Weigelt, J, Edwards, A, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2010-01-29 | Release date: | 2010-03-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: |
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3LX7
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![BU of 3lx7 by Molmil](/molmil-images/mine/3lx7) | Crystal structure of a Novel Tudor domain-containing protein SGF29 | Descriptor: | SAGA-associated factor 29 homolog, SULFATE ION, UNKNOWN ATOM OR ION | Authors: | Bian, C.B, Xu, C, Tempel, W, Lam, R, Bountra, C, Arrowsmith, C.H, Weigelt, J, Edwards, A.M, Bochkarev, A, Min, J. | Deposit date: | 2010-02-24 | Release date: | 2010-05-05 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation. Embo J., 30, 2011
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3LJU
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![BU of 3lju by Molmil](/molmil-images/mine/3lju) | Crystal structure of full length centaurin alpha-1 bound with the head group of PIP3 | Descriptor: | (2R)-3-{[(R)-{[(1S,2S,3R,4S,5S,6S)-2,6-dihydroxy-3,4,5-tris(phosphonooxy)cyclohexyl]oxy}(hydroxy)phosphoryl]oxy}propane -1,2-diyl dioctanoate, Arf-GAP with dual PH domain-containing protein 1, ZINC ION | Authors: | Shen, L, Tong, Y, Tempel, W, MacKenzie, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) | Deposit date: | 2010-01-26 | Release date: | 2010-11-24 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.702 Å) | Cite: | Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin alpha1. Proc.Natl.Acad.Sci.USA, 107, 2010
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3LD6
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![BU of 3ld6 by Molmil](/molmil-images/mine/3ld6) | Crystal structure of human lanosterol 14alpha-demethylase (CYP51) in complex with ketoconazole | Descriptor: | 1-acetyl-4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine, Cycloheptakis-(1-4)-(alpha-D-glucopyranose), Lanosterol 14-alpha demethylase, ... | Authors: | Strushkevich, N, Tempel, W, MacKenzie, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Park, H, Structural Genomics Consortium (SGC) | Deposit date: | 2010-01-12 | Release date: | 2010-02-02 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural basis of human CYP51 inhibition by antifungal azoles. J.Mol.Biol., 397, 2010
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1HYW
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![BU of 1hyw by Molmil](/molmil-images/mine/1hyw) | SOLUTION STRUCTURE OF BACTERIOPHAGE LAMBDA GPW | Descriptor: | HEAD-TO-TAIL JOINING PROTEIN W | Authors: | Maxwell, K.L, Yee, A.A, Booth, V, Arrowsmith, C.H, Gold, M, Davidson, A.R. | Deposit date: | 2001-01-22 | Release date: | 2001-04-25 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | The solution structure of bacteriophage lambda protein W, a small morphogenetic protein possessing a novel fold. J.Mol.Biol., 308, 2001
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1WPI
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![BU of 1wpi by Molmil](/molmil-images/mine/1wpi) | Solution NMR Structure of Protein YKR049C from Saccharomyces cerevisiae. Ontario Centre for Structural Proteomics target YST0250_1_133; Northeast Structural Genomics Consortium YTYst250 | Descriptor: | Hypothetical 15.6 kDa protein in NAP1-TRK2 intergenic region | Authors: | Jung, J.W, Yee, A, Arrowsmith, C.H, Lee, W, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2004-09-03 | Release date: | 2005-09-13 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution structure of YKR049C, a putative redox protein from Saccharomyces cerevisiae J.Biochem.Mol.Biol., 38, 2005
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1IIO
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![BU of 1iio by Molmil](/molmil-images/mine/1iio) | |
1K0H
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![BU of 1k0h by Molmil](/molmil-images/mine/1k0h) | Solution structure of bacteriophage lambda gpFII | Descriptor: | gpFII | Authors: | Maxwell, K.L, Yee, A.A, Arrowsmith, C.H, Gold, M, Davidson, A.R. | Deposit date: | 2001-09-19 | Release date: | 2002-07-17 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | The solution structure of the bacteriophage lambda head-tail joining protein, gpFII. J.Mol.Biol., 318, 2002
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1YWY
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![BU of 1ywy by Molmil](/molmil-images/mine/1ywy) | Solution Structure of Pseudomonas aeruginosa Protein PA2021. The Northeast Structural Genomics Consortium Target Pat85. | Descriptor: | hypothetical protein PA2021 | Authors: | Lin, Y.C, Liu, G, Shen, Y, Yee, A, Arrowsmith, C.H, Szyperski, T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2005-02-18 | Release date: | 2005-04-12 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Solution Structure of Pseudomonas aeruginosa Protein PA2021. To be Published
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1K3R
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![BU of 1k3r by Molmil](/molmil-images/mine/1k3r) | Crystal Structure of the Methyltransferase with a Knot from Methanobacterium thermoautotrophicum | Descriptor: | conserved protein MT0001 | Authors: | Zarembinski, T.I, Kim, Y, Peterson, K, Christendat, D, Dharamsi, A, Arrowsmith, C.H, Edwards, A.M, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2001-10-03 | Release date: | 2002-05-15 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Deep trefoil knot implicated in RNA binding found in an archaebacterial protein. Proteins, 50, 2003
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1HS5
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![BU of 1hs5 by Molmil](/molmil-images/mine/1hs5) | NMR SOLUTION STRUCTURE OF DESIGNED P53 DIMER | Descriptor: | CELLULAR TUMOR ANTIGEN P53 | Authors: | Davison, T.S, Nie, X, Ma, W, Li, Y, Kay, C, Benchimol, S, Arrowsmith, C.H. | Deposit date: | 2000-12-22 | Release date: | 2001-01-10 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structure and functionality of a designed p53 dimer. J.Mol.Biol., 307, 2001
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1K77
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![BU of 1k77 by Molmil](/molmil-images/mine/1k77) | Crystal Structure of EC1530, a Putative Oxygenase from Escherichia coli | Descriptor: | FORMIC ACID, GLYCEROL, Hypothetical protein ygbM, ... | Authors: | Kim, Y, Skarina, T, Beasley, S, Laskowski, R, Arrowsmith, C.H, Joachimiak, A, Edwards, A.M, Savchenko, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2001-10-18 | Release date: | 2002-03-13 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.63 Å) | Cite: | Crystal structure of Escherichia coli EC1530, a glyoxylate induced protein YgbM. Proteins, 48, 2002
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1YWS
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![BU of 1yws by Molmil](/molmil-images/mine/1yws) | |
1KUU
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![BU of 1kuu by Molmil](/molmil-images/mine/1kuu) | CRYSTAL STRUCTURE OF METHANOBACTERIUM THERMOAUTOTROPHICUM CONSERVED PROTEIN MTH1020 REVEALS AN NTN-HYDROLASE FOLD | Descriptor: | conserved protein | Authors: | Saridakis, V, Christendat, D, Thygesen, A, Arrowsmith, C.H, Edwards, A.M, Pai, E.F. | Deposit date: | 2002-01-22 | Release date: | 2002-05-29 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | CRYSTAL STRUCTURE OF METHANOBACTERIUM THERMOAUTOTROPHICUM CONSERVED PROTEIN MTH1020 REVEALS AN NTN-HYDROLASE FOLD PROTEINS: STRUCT.,FUNCT.,GENET., 48, 2002
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1ZKH
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![BU of 1zkh by Molmil](/molmil-images/mine/1zkh) | Solution structure of a human ubiquitin-like domain in SF3A1 | Descriptor: | Splicing factor 3 subunit 1 | Authors: | Lukin, J.A, Dhe-Paganon, S, Guido, V, Lemak, A, Avvakumov, G.V, Xue, S, Newman, E.M, Mackenzie, F, Sundstrom, M, Edwards, A, Arrowsmith, C.H, Structural Genomics Consortium (SGC) | Deposit date: | 2005-05-02 | Release date: | 2005-05-10 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution structure of a human ubiquitin-like domain in SF3A1 To be Published
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1YY6
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![BU of 1yy6 by Molmil](/molmil-images/mine/1yy6) | The Crystal Structure of the N-terminal domain of HAUSP/USP7 complexed with an EBNA1 peptide | Descriptor: | Epstein-Barr nuclear antigen-1, SODIUM ION, Ubiquitin carboxyl-terminal hydrolase 7 | Authors: | Saridakis, V, Sheng, Y, Sarkari, F, Holowaty, M, Shire, K, Nguyen, T, Zhang, R, Liao, J, Lee, W, Edwards, A.M, Arrowsmith, C.H, Frappier, L. | Deposit date: | 2005-02-23 | Release date: | 2005-04-05 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structure of the p53 binding domain of HAUSP/USP7 bound to Epstein-Barr nuclear antigen 1 implications for EBV-mediated immortalization. Mol.Cell, 18, 2005
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1YZE
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![BU of 1yze by Molmil](/molmil-images/mine/1yze) | Crystal structure of the N-terminal domain of USP7/HAUSP. | Descriptor: | Ubiquitin carboxyl-terminal hydrolase 7 | Authors: | Saridakis, V, Sheng, Y, Sarkari, F, Holowaty, M.N, Shire, K, Nguyen, T, Zhang, R.G, Liao, J, Lee, W, Edwards, A.M, Arrowsmith, C.H, Frappier, L. | Deposit date: | 2005-02-28 | Release date: | 2005-04-05 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure of the p53 binding domain of HAUSP/USP7 bound to Epstein-Barr nuclear antigen 1 implications for EBV-mediated immortalization. Mol.Cell, 18, 2005
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1YWU
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![BU of 1ywu by Molmil](/molmil-images/mine/1ywu) | Solution NMR structure of Pseudomonas Aeruginosa protein PA4608. Northeast Structural Genomics target PaT7 | Descriptor: | hypothetical protein PA4608 | Authors: | Ramelot, T.A, Yee, A.A, Cort, J.R, Semesi, A, Arrowsmith, C.H, Kennedy, M.A, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2005-02-18 | Release date: | 2005-03-29 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | NMR structure and binding studies confirm that PA4608 from Pseudomonas aeruginosa is a PilZ domain and a c-di-GMP binding protein. Proteins, 66, 2007
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1Z9V
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![BU of 1z9v by Molmil](/molmil-images/mine/1z9v) | Solution Structure of MTH0776 from Methanobacterium thermoautotrophicum (strain H) | Descriptor: | conserved hypothetical protein MTH0776 | Authors: | Amegbey, G, Stothard, P, Iakounine, A, Yee, A, Arrowsmith, C.H, Wishart, D.S. | Deposit date: | 2005-04-04 | Release date: | 2005-11-22 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Solution Structure of MTH0776 from Methanobacterium Thermoautotrophicum. J.Biomol.Nmr, 33, 2005
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