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PDB: 523 件
5JCT
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Crystal Structure of Human Pirin in complex with a Chemical Probe pyrrolidine 24
分子名称: DIMETHYL SULFOXIDE, FE (III) ION, GLYCEROL, ...
著者Ali, S, van Montfort, R.
登録日2016-04-15
公開日2017-01-11
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.73 Å)
主引用文献Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen.
J. Med. Chem., 60, 2017
6H1H
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BU of 6h1h by Molmil
Crystal structure of human Pirin in complex with compound 7 (PLX4720)
分子名称: 1,2-ETHANEDIOL, FE (III) ION, GLYCEROL, ...
著者Ali, S, Le Bihan, Y.V, van Montfort, R.L.M.
登録日2018-07-11
公開日2018-11-28
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.54 Å)
主引用文献Privileged Structures and Polypharmacology within and between Protein Families.
ACS Med Chem Lett, 9, 2018
6H1I
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BU of 6h1i by Molmil
Crystal structure of human Pirin in complex with bisamide compound 2
分子名称: FE (III) ION, GLYCEROL, Pirin, ...
著者Ali, S, Le Bihan, Y.V, van Montfort, R.L.M.
登録日2018-07-11
公開日2018-11-28
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.69 Å)
主引用文献Privileged Structures and Polypharmacology within and between Protein Families.
ACS Med Chem Lett, 9, 2018
4ICG
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BU of 4icg by Molmil
N-terminal dimerization domain of H-NS in complex with Hha (Salmonella Typhimurium)
分子名称: DNA-binding protein H-NS, Hemolysin expression modulating protein (Involved in environmental regulation of virulence factors)
著者Ali, S.S, Whitney, J.C, Stevenson, J, Robinson, H, Howell, P.L, Navarre, W.W.
登録日2012-12-10
公開日2013-03-27
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.9217 Å)
主引用文献Structural Insights into the Regulation of Foreign Genes in Salmonella by the Hha/H-NS Complex.
J.Biol.Chem., 288, 2013
2QRO
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BU of 2qro by Molmil
Human Deoxycytidine kinase dAMP, UDP, Mg ion product complex
分子名称: 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, Deoxycytidine kinase, MAGNESIUM ION, ...
著者Ealick, S.E, Soriano, E.V.
登録日2007-07-28
公開日2007-12-11
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (3.45 Å)
主引用文献Structures of human deoxycytidine kinase product complexes.
Acta Crystallogr.,Sect.D, 63, 2007
1QCZ
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BU of 1qcz by Molmil
CRYSTAL STRUCTURE OF E. COLI PURE, AN UNUSUAL MUTASE THAT CATALYZES THE CONVERSION OF N5-CARBOXYAMINOIMIDAZOLE RIBONUCLEOTIDE (N5-CAIR) TO 4-CARBOXYAMINOIMIDAZOLE RIBONUCLEOTIDE (CAIR) IN THE PURINE BIOSYNTHETIC PATHWAY
分子名称: N5-CARBOXYAMINOIMIDAZOLE RIBONUCLEOTIDE MUTASE
著者Ealick, S.E, Mathews, I.I.
登録日1999-05-10
公開日1999-11-10
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Crystal structure of Escherichia coli PurE, an unusual mutase in the purine biosynthetic pathway.
Structure Fold.Des., 7, 1999
2QJI
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BU of 2qji by Molmil
M. jannaschii ADH synthase complexed with dihydroxyacetone phosphate and glycerol
分子名称: 1,3-DIHYDROXYACETONEPHOSPHATE, GLYCEROL, Putative aldolase MJ0400
著者Ealick, S.E, Morar, M.
登録日2007-07-07
公開日2007-10-30
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structure of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid synthase, a catalyst in the archaeal pathway for the biosynthesis of aromatic amino acids.
Biochemistry, 46, 2007
2QQD
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BU of 2qqd by Molmil
N47A mutant of Pyruvoyl-dependent Arginine Decarboxylase from Methanococcus jannashii
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, AGMATINE, PYRUVIC ACID, ...
著者Ealick, S.E, Soriano, E.S.
登録日2007-07-26
公開日2008-03-18
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structures of the N47A and E109Q mutant proteins of pyruvoyl-dependent arginine decarboxylase from Methanococcus jannaschii.
Acta Crystallogr.,Sect.D, 64, 2008
2NSJ
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BU of 2nsj by Molmil
E. coli PurE H45Q mutant complexed with CAIR
分子名称: 5-AMINO-1-(5-O-PHOSPHONO-BETA-D-RIBOFURANOSYL)-1H-IMIDAZOLE-4-CARBOXYLIC ACID, Phosphoribosylaminoimidazole carboxylase catalytic subunit
著者Ealick, S.E, Morar, M.
登録日2006-11-04
公開日2007-04-24
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献N(5)-CAIR Mutase: Role of a CO(2) Binding Site and Substrate Movement in Catalysis.
Biochemistry, 46, 2007
2NSL
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BU of 2nsl by Molmil
E. coli PurE H45N mutant complexed with CAIR
分子名称: 5-AMINO-1-(5-O-PHOSPHONO-BETA-D-RIBOFURANOSYL)-1H-IMIDAZOLE-4-CARBOXYLIC ACID, Phosphoribosylaminoimidazole carboxylase catalytic subunit
著者Ealick, S.E, Morar, M.
登録日2006-11-04
公開日2007-04-24
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献N(5)-CAIR Mutase: Role of a CO(2) Binding Site and Substrate Movement in Catalysis.
Biochemistry, 46, 2007
2NSH
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BU of 2nsh by Molmil
E. coli PurE H45Q mutant complexed with nitro-AIR
分子名称: ((2R,3S,4R,5R)-5-(5-AMINO-4-NITRO-1H-IMIDAZOL-1-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL)METHYL DIHYDROGEN PHOSPHATE, Phosphoribosylaminoimidazole carboxylase catalytic subunit
著者Ealick, S.E, Morar, M.
登録日2006-11-04
公開日2007-04-24
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献N(5)-CAIR Mutase: Role of a CO(2) Binding Site and Substrate Movement in Catalysis.
Biochemistry, 46, 2007
2QRN
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BU of 2qrn by Molmil
Human Deoxycytidine kinase dCMP, UDP, Mg ion product complex
分子名称: 2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE, Deoxycytidine kinase, MAGNESIUM ION, ...
著者Ealick, S.E, Soriano, E.V.
登録日2007-07-28
公開日2007-12-11
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Structures of human deoxycytidine kinase product complexes.
Acta Crystallogr.,Sect.D, 63, 2007
2PRU
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BU of 2pru by Molmil
NMR Structure of Human apoS100B at 10C
分子名称: Protein S100-B
著者Malik, S, Shaw, G.S, Revington, M.
登録日2007-05-04
公開日2008-04-15
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Analysis of the structure of human apo-S100B at low temperature indicates a unimodal conformational distribution is adopted by calcium-free S100 proteins.
Proteins, 73, 2008
8U8O
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BU of 8u8o by Molmil
Human retinal variant phosphomimetic IMPDH1(546)-S477D filament bound by ATP, IMP, and NAD+, octamer-centered
分子名称: ADENOSINE-5'-TRIPHOSPHATE, INOSINIC ACID, Inosine-5'-monophosphate dehydrogenase 1, ...
著者Calise, S.J, Kollman, J.M.
登録日2023-09-18
公開日2024-01-31
最終更新日2024-02-14
実験手法ELECTRON MICROSCOPY (2.4 Å)
主引用文献Light-sensitive phosphorylation regulates retinal IMPDH1 activity and filament assembly.
J.Cell Biol., 223, 2024
8U8Y
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Human retinal variant phosphomimetic IMPDH1(546)-S477D filament bound by ATP, IMP, and NAD+, interface-centered
分子名称: INOSINIC ACID, Inosine-5'-monophosphate dehydrogenase 1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
著者Calise, S.J, Kollman, J.M.
登録日2023-09-18
公開日2024-01-31
最終更新日2024-02-14
実験手法ELECTRON MICROSCOPY (2.1 Å)
主引用文献Light-sensitive phosphorylation regulates retinal IMPDH1 activity and filament assembly.
J.Cell Biol., 223, 2024
5HFT
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BU of 5hft by Molmil
Crystal structure of HpxW
分子名称: Gamma-glutamyltranspeptidase
著者Ealick, S.E, Hicks, K.A.
登録日2016-01-07
公開日2016-06-29
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.646 Å)
主引用文献Biochemical and structural characterization of Klebsiella pneumoniae oxamate amidohydrolase in the uric acid degradation pathway.
Acta Crystallogr D Struct Biol, 72, 2016
8U7Q
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BU of 8u7q by Molmil
Human retinal variant phosphomimetic IMPDH1(546)-S477D filament bound by GTP, ATP, IMP, and NAD+, octamer-centered
分子名称: ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, INOSINIC ACID, ...
著者Calise, S.J, Kollman, J.M.
登録日2023-09-15
公開日2024-01-31
最終更新日2024-02-14
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Light-sensitive phosphorylation regulates retinal IMPDH1 activity and filament assembly.
J.Cell Biol., 223, 2024
8U7V
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BU of 8u7v by Molmil
Human retinal variant phosphomimetic IMPDH1(546)-S477D filament bound by GTP, ATP, IMP, and NAD+, interface-centered
分子名称: ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, INOSINIC ACID, ...
著者Calise, S.J, Kollman, J.M.
登録日2023-09-15
公開日2024-01-31
最終更新日2024-02-14
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Light-sensitive phosphorylation regulates retinal IMPDH1 activity and filament assembly.
J.Cell Biol., 223, 2024
8U7M
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BU of 8u7m by Molmil
Human retinal variant phosphomimetic IMPDH1(595)-S477D free octamer bound by GTP, ATP, IMP, and NAD+
分子名称: ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, INOSINIC ACID, ...
著者Calise, S.J, Kollman, J.M.
登録日2023-09-15
公開日2024-01-31
最終更新日2024-02-14
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Light-sensitive phosphorylation regulates retinal IMPDH1 activity and filament assembly.
J.Cell Biol., 223, 2024
284D
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BU of 284d by Molmil
THE BI-LOOP, A NEW GENERAL FOUR-STRANDED DNA MOTIF
分子名称: BARIUM ION, DNA (5'-CD(*P*AP*TP*TP*CP*AP*TP*TP*C)-3'), SODIUM ION
著者Salisbury, S.A, Wilson, S.E, Powell, H.R, Kennard, O, Lubini, P, Sheldrick, G.M, Escaja, N, Alazzouzi, E, Grandas, A, Pedroso, E.
登録日1996-09-11
公開日1997-06-11
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.1 Å)
主引用文献The bi-loop, a new general four-stranded DNA motif.
Proc.Natl.Acad.Sci.USA, 94, 1997
6XH3
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BU of 6xh3 by Molmil
Co-crystal structure of HIV-1 TAR RNA in complex with lab-evolved RRM TBP6.3
分子名称: TAR BINDING PROTEIN TBP 6.3, TRANS-ACTIVATION RESPONSE ELEMENT
著者Chavali, S.S, Jenkins, J.L, Wedekind, J.E.
登録日2020-06-18
公開日2020-10-14
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.353 Å)
主引用文献Co-crystal structures of HIV TAR RNA bound to lab-evolved proteins show key roles for arginine relevant to the design of cyclic peptide TAR inhibitors.
J.Biol.Chem., 295, 2020
6XH0
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BU of 6xh0 by Molmil
Co-crystal structure of HIV-1 TAR RNA in complex with lab-evolved RRM TBP6.9
分子名称: MAGNESIUM ION, TAR binding protein 6.9, TRANS-ACTIVATION RESPONSE ELEMENT
著者Chavali, S.S, Jenkins, J.L, Wedekind, J.E.
登録日2020-06-18
公開日2020-10-14
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Co-crystal structures of HIV TAR RNA bound to lab-evolved proteins show key roles for arginine relevant to the design of cyclic peptide TAR inhibitors.
J.Biol.Chem., 295, 2020
6XH2
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BU of 6xh2 by Molmil
Co-crystal structure of HIV-1 TAR RNA in complex with lab-evolved RRM 6.6
分子名称: TAR-BINDING PROTEIN 6.6, TRANS-ACTIVATION RESPONSE ELEMENT
著者Chavali, S.S, Jenkins, J.L, Wedekind, J.E.
登録日2020-06-18
公開日2020-10-14
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.71 Å)
主引用文献Co-crystal structures of HIV TAR RNA bound to lab-evolved proteins show key roles for arginine relevant to the design of cyclic peptide TAR inhibitors.
J.Biol.Chem., 295, 2020
6XH1
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BU of 6xh1 by Molmil
Co-crystal structure of HIV-1 TAR RNA in complex with lab-evolved RRM TBP6.7 mutant
分子名称: TAR binding protein mutant 6.7 Q48R/T50R, TRANS-ACTIVATION RESPONSE ELEMENT
著者Chavali, S.S, Jenkins, J.L, Wedekind, J.E.
登録日2020-06-18
公開日2020-10-14
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.601 Å)
主引用文献Co-crystal structures of HIV TAR RNA bound to lab-evolved proteins show key roles for arginine relevant to the design of cyclic peptide TAR inhibitors.
J.Biol.Chem., 295, 2020
2HS0
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T. maritima PurL complexed with ATP
分子名称: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Phosphoribosylformylglycinamidine synthase II
著者Ealick, S.E, Morar, M.
登録日2006-07-20
公開日2007-01-09
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.52 Å)
主引用文献Complexed Structures of Formylglycinamide Ribonucleotide Amidotransferase from Thermotoga maritima Describe a Novel ATP Binding Protein Superfamily
Biochemistry, 45, 2006

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