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PDB: 13 件
8K3O
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BU of 8k3o by Molmil
Cryo-EM structure of 30S ribosome with cleaved AP-mRNA bound complex I
分子名称: 16S rRNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ...
著者Afsar, M, Shukla, A, Ramachandran, R.
登録日2023-07-16
公開日2024-07-24
実験手法ELECTRON MICROSCOPY (3.88 Å)
主引用文献Cryo-EM structure of 30S ribosome with cleaved AP-mRNA bound complex I
To Be Published
8SE9
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BU of 8se9 by Molmil
Cryo-EM structure of a double loaded human UBA7-UBE2L6-ISG15 thioester mimetic complex (Form 2)
分子名称: ADENOSINE MONOPHOSPHATE, Ubiquitin-like modifier-activating enzyme 7, Ubiquitin-like protein ISG15, ...
著者Afsar, M, Jia, L, Ruben, E.A, Olsen, S.K.
登録日2023-04-08
公開日2023-10-11
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Cryo-EM structures of Uba7 reveal the molecular basis for ISG15 activation and E1-E2 thioester transfer.
Nat Commun, 14, 2023
8SV8
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BU of 8sv8 by Molmil
Cryo-EM structure of a double loaded human UBA7-UBE2L6-ISG15 thioester mimetic complex from a composite map
分子名称: ADENOSINE MONOPHOSPHATE, Ubiquitin-like modifier-activating enzyme 7, Ubiquitin-like protein ISG15, ...
著者Afsar, M, Jia, L, Ruben, E.A, Olsen, S.K.
登録日2023-05-15
公開日2023-10-11
実験手法ELECTRON MICROSCOPY (3.38 Å)
主引用文献Cryo-EM structures of Uba7 reveal the molecular basis for ISG15 activation and E1-E2 thioester transfer.
Nat Commun, 14, 2023
8SEA
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BU of 8sea by Molmil
Cryo-EM structure of a double loaded human UBA7-UBE2L6-ISG15 thioester mimetic complex (Form 1)
分子名称: ADENOSINE MONOPHOSPHATE, Ubiquitin-like modifier-activating enzyme 7, Ubiquitin-like protein ISG15, ...
著者Afsar, M, Jia, L, Ruben, E.A, Olsen, S.K.
登録日2023-04-08
公開日2023-10-11
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Cryo-EM structures of Uba7 reveal the molecular basis for ISG15 activation and E1-E2 thioester transfer.
Nat Commun, 14, 2023
8SEB
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BU of 8seb by Molmil
Cryo-EM structure of a single loaded human UBA7-UBE2L6-ISG15 adenylate complex
分子名称: ADENOSINE MONOPHOSPHATE, Ubiquitin-like modifier-activating enzyme 7, Ubiquitin-like protein ISG15, ...
著者Afsar, M, Jia, L, Ruben, E.A, Olsen, S.K.
登録日2023-04-08
公開日2023-10-11
最終更新日2024-10-23
実験手法ELECTRON MICROSCOPY (3.24 Å)
主引用文献Cryo-EM structures of Uba7 reveal the molecular basis for ISG15 activation and E1-E2 thioester transfer.
Nat Commun, 14, 2023
6LW8
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BU of 6lw8 by Molmil
Structural basis for domain rotation during adenylation of active site K123 and fragment library screening against NAD+ -dependent DNA ligase from Mycobacterium tuberculosis
分子名称: (4R)-4-(4-fluorophenyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine, DNA ligase A, GLYCEROL, ...
著者Ramachandran, R, Afsar, M, Shukla, A.
登録日2020-02-07
公開日2021-02-10
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.401 Å)
主引用文献Structure based identification of first-in-class fragment inhibitors that target the NMN pocket of M. tuberculosis NAD + -dependent DNA ligase A.
J.Struct.Biol., 213, 2021
8K4E
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BU of 8k4e by Molmil
Cryo-EM structure of 30S ribosome with cleaved AP-mRNA bound complex-II
分子名称: 16S rRNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ...
著者Ramachandran, R, Afsar, M, Shukla, A.
登録日2023-07-18
公開日2024-07-24
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Cryo-EM structure of 30S ribosome with cleaved AP-mRNA bound complex-II
To Be Published
6KJM
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BU of 6kjm by Molmil
Structural basis for domain rotation during adenylation of active site K123 and fragment library screening against NAD+ -dependent DNA ligase from Mycobacterium tuberculosis
分子名称: ADENOSINE MONOPHOSPHATE, BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, DNA ligase A, ...
著者Ramachandran, R, Shukla, A, Afsar, M.
登録日2019-07-22
公開日2020-07-22
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structure based identification of first-in-class fragment inhibitors that target the NMN pocket of M. tuberculosis NAD + -dependent DNA ligase A.
J.Struct.Biol., 213, 2021
6KKV
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BU of 6kkv by Molmil
Structural basis for domain rotation during adenylation of active site K123 and fragment library screening against NAD+ -dependent DNA ligase from Mycobacterium tuberculosis
分子名称: DNA ligase A, N-[(4-methylphenyl)methyl]-1H-pyrrole-2-carboxamide, SULFATE ION
著者Ramachandran, R, Shukla, A, Afsar, M.
登録日2019-07-27
公開日2020-07-29
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.56 Å)
主引用文献Structure based identification of first-in-class fragment inhibitors that target the NMN pocket of M. tuberculosis NAD + -dependent DNA ligase A.
J.Struct.Biol., 213, 2021
6KSD
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BU of 6ksd by Molmil
Structural basis for domain rotation during adenylation of active site K123 and fragment library screening against NAD+ -dependent DNA ligase from Mycobacterium tuberculosis
分子名称: BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, DNA ligase A, SULFATE ION
著者Ramachandran, R, Shukla, A, Afsar, M.
登録日2019-08-23
公開日2020-08-26
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Salt bridges at the subdomain interfaces of the adenylation domain and active-site residues of Mycobacterium tuberculosis NAD + -dependent DNA ligase A (MtbLigA) are important for the initial steps of nick-sealing activity.
Acta Crystallogr D Struct Biol, 77, 2021
6KRH
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BU of 6krh by Molmil
Structural basis for domain rotation during adenylation of active site K123 and fragment library screening against NAD+ -dependent DNA ligase from Mycobacterium tuberculosis
分子名称: ADENOSINE MONOPHOSPHATE, BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, DNA ligase A, ...
著者Ramachandran, R, Shukla, A, Afsar, M.
登録日2019-08-21
公開日2020-08-26
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Salt bridges at the subdomain interfaces of the adenylation domain and active-site residues of Mycobacterium tuberculosis NAD + -dependent DNA ligase A (MtbLigA) are important for the initial steps of nick-sealing activity.
Acta Crystallogr D Struct Biol, 77, 2021
6KSC
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BU of 6ksc by Molmil
Structural basis for domain rotation during adenylation of active site K123 and fragment library screening against NAD+ -dependent DNA ligase from Mycobacterium tuberculosis
分子名称: ADENOSINE MONOPHOSPHATE, DNA ligase A, SULFATE ION
著者Ramachandran, R, Shukla, A, Afsar, M.
登録日2019-08-23
公開日2020-08-26
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Salt bridges at the subdomain interfaces of the adenylation domain and active-site residues of Mycobacterium tuberculosis NAD + -dependent DNA ligase A (MtbLigA) are important for the initial steps of nick-sealing activity.
Acta Crystallogr D Struct Biol, 77, 2021
6KDU
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BU of 6kdu by Molmil
Structural basis for domain rotation during adenylation of active site K123 and fragment library screening against NAD+ -dependent DNA ligase from Mycobacterium tuberculosis
分子名称: ADENOSINE MONOPHOSPHATE, BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, DNA ligase A, ...
著者Ramachandran, R, Shukla, A, Afsar, M.
登録日2019-07-02
公開日2020-07-01
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Salt bridges at the subdomain interfaces of the adenylation domain and active-site residues of Mycobacterium tuberculosis NAD + -dependent DNA ligase A (MtbLigA) are important for the initial steps of nick-sealing activity.
Acta Crystallogr D Struct Biol, 77, 2021

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件を2024-10-30に公開中

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