2B5B
 
 | | A reptilian defensin with anti-bacterial and anti-viral activity | | 分子名称: | Defensin | | 著者 | Chattopadhyay, S, Sinha, N.K, Banerjee, S, Roy, D, Chattopadhyay, D, Roy, S. | | 登録日 | 2005-09-28 | | 公開日 | 2006-06-27 | | 最終更新日 | 2022-03-09 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Small cationic protein from a marine turtle has beta-defensin-like fold and antibacterial and antiviral activity.
Proteins, 64, 2006
|
|
8HMS
 | | Crystal Structure of PKM2 mutant C474S | | 分子名称: | 1,2-ETHANEDIOL, 1,6-di-O-phosphono-beta-D-fructofuranose, GLYCEROL, ... | | 著者 | Upadhyay, S, Kumar, A, Patel, A.K. | | 登録日 | 2022-12-05 | | 公開日 | 2023-01-11 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural and mechanistic insights into cancer patient-derived mutations in Pyruvate Kinase muscle isoform 2
To Be Published
|
|
8HMQ
 | | Crystal Structure of PKM2 mutant P403A | | 分子名称: | 1,2-ETHANEDIOL, 1,6-di-O-phosphono-beta-D-fructofuranose, GLYCEROL, ... | | 著者 | Upadhyay, S, Kumar, A, Patel, A.K. | | 登録日 | 2022-12-05 | | 公開日 | 2023-01-11 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structural and mechanistic insights into cancer patient-derived mutations in Pyruvate Kinase muscle isoform 2
To Be Published
|
|
8HMR
 | | Crystal Structure of PKM2 mutant L144P | | 分子名称: | 1,2-ETHANEDIOL, 1,6-di-O-phosphono-beta-D-fructofuranose, MAGNESIUM ION, ... | | 著者 | Upadhyay, S, Kumar, A, Patel, A.K. | | 登録日 | 2022-12-05 | | 公開日 | 2023-01-11 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structural and mechanistic insights into cancer patient-derived mutations in Pyruvate Kinase muscle isoform 2
To Be Published
|
|
8HMU
 | | Crystal Structure of PKM2 mutant R516C | | 分子名称: | 1,2-ETHANEDIOL, 1,6-di-O-phosphono-beta-D-fructofuranose, GLYCEROL, ... | | 著者 | Upadhyay, S, Kumar, A, Patel, A.K. | | 登録日 | 2022-12-05 | | 公開日 | 2023-01-11 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structural and mechanistic insights into cancer patient-derived mutations in Pyruvate Kinase muscle isoform 2
To Be Published
|
|
4FRR
 | |
1Z8Y
 | | Mapping the E2 Glycoprotein of Alphaviruses | | 分子名称: | Capsid protein C, Spike glycoprotein E1, Spike glycoprotein E2 | | 著者 | Mukhopadhyay, S, Zhang, W, Gabler, S, Chipman, P.R, Strauss, E.G, Strauss, J.H, Baker, T.S, Kuhn, R.J, Rossmann, M.G. | | 登録日 | 2005-03-31 | | 公開日 | 2006-02-07 | | 最終更新日 | 2019-11-06 | | 実験手法 | ELECTRON MICROSCOPY (9 Å) | | 主引用文献 | Mapping the structure and function of the E1 and E2 glycoproteins in alphaviruses.
Structure, 14, 2006
|
|
2IIR
 | |
2O97
 | | Crystal Structure of E. coli HU heterodimer | | 分子名称: | CHLORIDE ION, DNA-binding protein HU-alpha, DNA-binding protein HU-beta, ... | | 著者 | Guo, F, Adhya, S. | | 登録日 | 2006-12-13 | | 公開日 | 2007-03-06 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | Spiral structure of Escherichia coli HU{alpha}beta provides foundation for DNA supercoiling.
Proc.Natl.Acad.Sci.Usa, 104, 2007
|
|
4YEX
 | | HUaa-19bp | | 分子名称: | DNA-binding protein HU-alpha, synthetic DNA strand | | 著者 | Hammel, M, Reyes, F.E, Parpana, R, Tainer, J.A, Adhya, S, Amlanjyoti, D. | | 登録日 | 2015-02-24 | | 公開日 | 2016-06-29 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | HU multimerization shift controls nucleoid compaction.
Sci Adv, 2, 2016
|
|
4YFT
 | | HUab-20bp | | 分子名称: | DNA-binding protein HU-alpha, DNA-binding protein HU-beta, synthetic DNA strand | | 著者 | Hammel, M, Reyes, F.E, Parpana, R, Tainer, J.A, Adhya, S, Amlanjyoti, D. | | 登録日 | 2015-02-25 | | 公開日 | 2016-06-29 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.914 Å) | | 主引用文献 | HU multimerization shift controls nucleoid compaction.
Sci Adv, 2, 2016
|
|
4YEW
 | | HUab-19bp | | 分子名称: | DNA-binding protein HU-alpha, DNA-binding protein HU-beta, synthetic DNA strand | | 著者 | Hammel, M, Reyes, F.E, Parpana, R, Tainer, J.A, Adhya, S, Amlanjyoti, D. | | 登録日 | 2015-02-24 | | 公開日 | 2016-06-29 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.683 Å) | | 主引用文献 | HU multimerization shift controls nucleoid compaction.
Sci Adv, 2, 2016
|
|
4YEY
 | | HUaa-20bp | | 分子名称: | DNA-binding protein HU-alpha, synthetic DNA strand | | 著者 | Hammel, M, Reyes, F.E, Parpana, R, Tainer, J.A, Adhya, S, Amlanjyoti, D. | | 登録日 | 2015-02-24 | | 公開日 | 2016-06-29 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (3.354 Å) | | 主引用文献 | HU multimerization shift controls nucleoid compaction.
Sci Adv, 2, 2016
|
|
4YFH
 | | HU38-20bp | | 分子名称: | DNA-binding protein HU-alpha, synthetic DNA strand | | 著者 | Hammel, M, Reyes, F.E, Parpana, R, Tainer, J.A, Adhya, S, Amlanjyoti, D. | | 登録日 | 2015-02-25 | | 公開日 | 2016-06-29 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (3.49 Å) | | 主引用文献 | HU multimerization shift controls nucleoid compaction.
Sci Adv, 2, 2016
|
|
4YF0
 | | HU38-19bp | | 分子名称: | DNA-binding protein HU-alpha, synthetic DNA strand | | 著者 | Hammel, M, Reyes, F.E, Parpana, R, Tainer, J.A, Adhya, S, Amlanjyoti, D. | | 登録日 | 2015-02-24 | | 公開日 | 2016-06-29 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.79 Å) | | 主引用文献 | HU multimerization shift controls nucleoid compaction.
Sci Adv, 2, 2016
|
|
7A1F
 | | Crystal structure of human 5' exonuclease Appollo in complex with 5'dAMP | | 分子名称: | 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, 5' exonuclease Apollo, FE (III) ION, ... | | 著者 | Newman, J.A, Baddock, H.T, Mukhopadhyay, S.M.M, Burgess-Brown, N.A, von Delft, F, Arrowshmith, C.H, Edwards, A, Bountra, C, Gileadi, O. | | 登録日 | 2020-08-12 | | 公開日 | 2021-01-20 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | A phosphate binding pocket is a key determinant of exo- versus endo-nucleolytic activity in the SNM1 nuclease family.
Nucleic Acids Res., 49, 2021
|
|
5LEV
 | | Crystal structure of human UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase (DPAGT1) (V264G mutant) | | 分子名称: | UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, UNKNOWN LIGAND | | 著者 | Pike, A.C.W, Dong, Y.Y, Chu, A, Tessitore, A, Goubin, S, Dong, L, Mukhopadhyay, S, Mahajan, P, Chalk, R, Berridge, G, Wang, D, Kupinska, K, Belaya, K, Beeson, D, Burgess-Brown, N, Edwards, A.M, Arrowsmith, C.H, Bountra, C, Carpenter, E.P, Structural Genomics Consortium (SGC) | | 登録日 | 2016-06-30 | | 公開日 | 2016-12-28 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Structures of DPAGT1 Explain Glycosylation Disease Mechanisms and Advance TB Antibiotic Design.
Cell, 175, 2018
|
|
5LWN
 | | Crystal structure of JAK3 in complex with Compound 5 (FM409) | | 分子名称: | (2~{S})-2-cyano-~{N},~{N}-dimethyl-3-[5-[3-[(1~{S},2~{R})-2-methylcyclohexyl]-3,5,8,10-tetrazatricyclo[7.3.0.0^{2,6}]dodeca-1,4,6,8,11-pentaen-4-yl]furan-2-yl]propanamide, (~{Z})-2-cyano-~{N},~{N}-dimethyl-3-[5-[3-[(1~{S},2~{R})-2-methylcyclohexyl]-3,5,8,10-tetrazatricyclo[7.3.0.0^{2,6}]dodeca-1,4,6,8,11-pentaen-4-yl]furan-2-yl]prop-2-enamide, 1,2-ETHANEDIOL, ... | | 著者 | Chaikuad, A, Forster, M, Mukhopadhyay, S, Kupinska, K, Ellis, K, Mahajan, P, Burgess-Brown, N, Edwards, A.M, Arrowsmith, C.H, Bountra, C, Laufer, S.A, Knapp, S, Structural Genomics Consortium (SGC) | | 登録日 | 2016-09-18 | | 公開日 | 2016-10-26 | | 最終更新日 | 2016-11-30 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Selective JAK3 Inhibitors with a Covalent Reversible Binding Mode Targeting a New Induced Fit Binding Pocket.
Cell Chem Biol, 23, 2016
|
|
7OQZ
 | | Cryo-EM structure of human TMEM45A | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Transmembrane protein 45A | | 著者 | Grieben, M, Pike, A.C.W, Evans, A, Shrestha, L, Venkaya, S, Mukhopadhyay, S.M.M, Moreira, T, Chalk, R, MacLean, E.M, Marsden, B.D, Burgess-Brown, N.A, Bountra, C, Carpenter, E.P. | | 登録日 | 2021-06-04 | | 公開日 | 2021-06-16 | | 最終更新日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (3.27 Å) | | 主引用文献 | CryoEM structure of human TMEM45A
To Be Published
|
|
7NSG
 | | Structure of human excitatory amino acid transporter 3 (EAAT3) in complex with HIP-B | | 分子名称: | (+)-3-Hydroxy-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole-6-carboxylic acid, (-)-3-Hydroxy-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole-6-carboxylic acid, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... | | 著者 | Baronina, A, Pike, A.C.W, Yu, X, Dong, Y.Y, Shintre, C.A, Tessitore, A, Chu, A, Rotty, B, Venkaya, S, Mukhopadhyay, S.M.M, Borkowska, O, Chalk, R, Shrestha, L, Burgess-Brown, N.A, Edwards, A.M, Arrowsmith, C.H, Bountra, C, Han, S, Carpenter, E.P, Structural Genomics Consortium (SGC) | | 登録日 | 2021-03-05 | | 公開日 | 2022-03-16 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (3.34 Å) | | 主引用文献 | Structure of human excitatory amino acid transporter 3 (EAAT3) in complex with HIP-B
TO BE PUBLISHED
|
|
8FH3
 | | Human IFT-A complex structures provide molecular insights into ciliary transport | | 分子名称: | Intraflagellar transport protein 122 homolog, Intraflagellar transport protein 140 homolog, Tubby-related protein 3, ... | | 著者 | Jiang, M, Palicharla, V.R, Miller, D, Hwang, S.H, Zhu, H, Hixson, P, Mukhopadhyay, S, Sun, J. | | 登録日 | 2022-12-13 | | 公開日 | 2023-02-22 | | 最終更新日 | 2023-04-12 | | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | | 主引用文献 | Human IFT-A complex structures provide molecular insights into ciliary transport.
Cell Res., 33, 2023
|
|
8FGW
 | | Human IFT-A complex structures provide molecular insights into ciliary transport | | 分子名称: | Intraflagellar transport protein 122 homolog, Intraflagellar transport protein 140 homolog, Intraflagellar transport protein 43 homolog, ... | | 著者 | Jiang, M, Palicharla, V.R, Miller, D, Hwang, S.H, Zhu, H, Hixson, P, Mukhopadhyay, S, Sun, J. | | 登録日 | 2022-12-12 | | 公開日 | 2023-02-22 | | 最終更新日 | 2023-04-12 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Human IFT-A complex structures provide molecular insights into ciliary transport.
Cell Res., 33, 2023
|
|
5O5E
 | | Crystal structure of human UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase (DPAGT1) (V264G mutant) in complex with tunicamycin | | 分子名称: | (2S)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(6E)-HEXADEC-6-ENOYLOXY]PROPYL (8E)-OCTADEC-8-ENOATE, Tunicamycin, UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, ... | | 著者 | Pike, A.C.W, Dong, Y.Y, Chu, A, Tessitore, A, Goubin, S, Dong, L, Mukhopadhyay, S, Mahajan, P, Chalk, R, Berridge, G, Wang, D, Kupinska, K, Belaya, K, Beeson, D, Burgess-Brown, N, Edwards, A.M, Arrowsmith, C.H, Bountra, C, Carpenter, E.P, Structural Genomics Consortium (SGC) | | 登録日 | 2017-06-01 | | 公開日 | 2018-02-28 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | Structures of DPAGT1 Explain Glycosylation Disease Mechanisms and Advance TB Antibiotic Design.
Cell, 175, 2018
|
|
8OUO
 | | Human TPC2 in Complex with Antagonist (S)-SG-094 | | 分子名称: | (1S)-6-methoxy-2-methyl-7-phenoxy-1-[(4-phenoxyphenyl)methyl]-3,4-dihydro-1H-isoquinoline, 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE, 2-{[(4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranosyl)oxy]methyl}-4-{[(3beta,9beta,14beta,17beta,25R)-spirost-5-en-3-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranoside, ... | | 著者 | Chi, G, Pike, A.C.W, Maclean, E.M, Li, H, Mukhopadhyay, S.M.M, Bohstedt, T, Wang, D, McKinley, G, Fernandez-Cid, A, Duerr, K. | | 登録日 | 2023-04-24 | | 公開日 | 2024-06-12 | | 最終更新日 | 2024-08-21 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structural basis for inhibition of the lysosomal two-pore channel TPC2 by a small molecule antagonist.
Structure, 32, 2024
|
|
7PHL
 | | Human voltage-gated potassium channel Kv3.1 (with EDTA) | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE, POTASSIUM ION, Potassium voltage-gated channel, ... | | 著者 | Chi, G, Qian, P, Castro-Hartmann, P, Venkaya, S, Singh, N.K, McKinley, G, Mukhopadhyay, S.M.M, Fernandez-Cid, A, Pike, A.C.W, Marsden, B, MacLean, E.M, Sader, K, Burgess-Brown, N.A, Duerr, K.L. | | 登録日 | 2021-08-17 | | 公開日 | 2022-03-02 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Cryo-EM structure of the human Kv3.1 channel reveals gating control by the cytoplasmic T1 domain.
Nat Commun, 13, 2022
|
|
