5LWN

Crystal structure of JAK3 in complex with Compound 5 (FM409)

Summary for 5LWN

Entry DOI	10.2210/pdb5lwn/pdb
Descriptor	Tyrosine-protein kinase JAK3, 1-phenylurea, 1,2-ETHANEDIOL, ... (6 entities in total)
Functional Keywords	transferase, jak3, covalent inhibitor, reversible covalent inhibitor, induced pocket, arginine pocket, structural genomics, structural genomics consortium, sgc
Biological source	Homo sapiens (Human)
Cellular location	Endomembrane system ; Peripheral membrane protein : P52333
Total number of polymer chains	1
Total formula weight	34812.88
Authors	Chaikuad, A.,Forster, M.,Mukhopadhyay, S.,Kupinska, K.,Ellis, K.,Mahajan, P.,Burgess-Brown, N.,Edwards, A.M.,Arrowsmith, C.H.,Bountra, C.,Laufer, S.A.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2016-09-18, release date: 2016-10-26, Last modification date: 2016-11-30)
Primary citation	Forster, M.,Chaikuad, A.,Bauer, S.M.,Holstein, J.,Robers, M.B.,Corona, C.R.,Gehringer, M.,Pfaffenrot, E.,Ghoreschi, K.,Knapp, S.,Laufer, S.A. Selective JAK3 Inhibitors with a Covalent Reversible Binding Mode Targeting a New Induced Fit Binding Pocket. Cell Chem Biol, 23:1335-1340, 2016 Cited by PubMed: 27840070 DOI: 10.1016/j.chembiol.2016.10.008 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation