2GX4
 
 | | Crystal structure of SARS coronavirus 3CL protease inhibitor complex | | Descriptor: | 3C-like proteinase, N-[(BENZYLOXY)CARBONYL]-O-(TERT-BUTYL)-L-THREONYL-3-CYCLOHEXYL-N-[(1S)-2-HYDROXY-1-{[(3S)-2-OXOPYRROLIDIN-3-YL]METHYL}ETHYL]-L-ALANINAMIDE | | Authors: | Hsu, M.F, Wang, A.H.-J. | | Deposit date: | 2006-05-08 | | Release date: | 2007-05-08 | | Last modified: | 2020-04-08 | | Method: | X-RAY DIFFRACTION (1.93 Å) | | Cite: | Synthesis, crystal structure, structure-activity relationships, and antiviral activity of a potent SARS coronavirus 3CL protease inhibitor.
J.Med.Chem., 49, 2006
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2IOB
 | | E. coli Bifunctional glutathionylspermidine synthetase/amidase Apo protein | | Descriptor: | Bifunctional glutathionylspermidine synthetase/amidase | | Authors: | Pai, C.H, Chiang, B.Y, Ko, T.P, Chou, C.C, Chong, C.M, Yen, F.J, Coward, J.K, Wang, A.H.-J, Lin, C.H. | | Deposit date: | 2006-10-10 | | Release date: | 2006-12-12 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Dual binding sites for translocation catalysis by Escherichia coli glutathionylspermidine synthetase
Embo J., 25, 2006
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2IO7
 | | E. coli Bifunctional glutathionylspermidine synthetase/amidase Incomplex with Mg2+ and AMPPNP | | Descriptor: | Bifunctional glutathionylspermidine synthetase/amidase, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | | Authors: | Pai, C.H, Chiang, B.Y, Ko, T.P, Chong, C.M, Yen, F.J, Coward, J.K, Wang, A.H.-J, Lin, C.H. | | Deposit date: | 2006-10-10 | | Release date: | 2006-12-12 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Dual binding sites for translocation catalysis by Escherichia coli glutathionylspermidine synthetase
Embo J., 25, 2006
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2VPS
 | | Structure Of The Bifunctional Leishmania Major Trypanothione Synthetase-Amidase | | Descriptor: | BROMIDE ION, CHLORIDE ION, TRYPANOTHIONE SYNTHETASE | | Authors: | Fyfe, P.K, Oza, S.L, Fairlamb, A.H, Hunter, W.N. | | Deposit date: | 2008-03-04 | | Release date: | 2008-05-06 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | Leishmania Trypanothione Synthetase-Amidase Structure Reveals a Basis for Regulation of Conflicting Synthetic and Hydrolytic Activities.
J.Biol.Chem., 283, 2008
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2VUP
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2ICV
 | | Kinetic and Crystallographic Studies of a Redesigned Manganese-Binding Site in Cytochrome c Peroxidase | | Descriptor: | COBALT (II) ION, Cytochrome c peroxidase, mitochondrial, ... | | Authors: | Pfister, T, Mirarefi, A.Y, Gengenbach, A.J, Zhao, X, Conaster, C.D.N, Gao, Y.G, Robinson, H, Zukoski, C.F, Wang, A.H.J, Lu, Y. | | Deposit date: | 2006-09-13 | | Release date: | 2007-08-28 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Kinetic and crystallographic studies of a redesigned manganese-binding site in cytochrome c peroxidase
J.Biol.Inorg.Chem., 12, 2007
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2VOK
 | | Murine TRIM21 | | Descriptor: | 52 KDA RO PROTEIN | | Authors: | Keeble, A.H, Khan, Z, Forster, A, James, L.C. | | Deposit date: | 2008-02-19 | | Release date: | 2008-04-15 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Trim21 is an Igg Receptor that is Structurally, Thermodynamically, and Kinetically Conserved.
Proc.Natl.Acad.Sci.USA, 105, 2008
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2R25
 | | Complex of YPD1 and SLN1-R1 with bound Mg2+ and BeF3- | | Descriptor: | BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, Osmosensing histidine protein kinase SLN1, ... | | Authors: | Copeland, D.M, Zhao, X, Soares, A.S, West, A.H. | | Deposit date: | 2007-08-24 | | Release date: | 2008-01-15 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Crystal structure of a complex between the phosphorelay protein YPD1 and
the response regulator domain of SLN1 bound to a phosphoryl analog
J.Mol.Biol., 375, 2008
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2R5P
 | | Crystal Structure Analysis of HIV-1 Subtype C Protease Complexed with Indinavir | | Descriptor: | CHLORIDE ION, N-[2(R)-HYDROXY-1(S)-INDANYL]-5-[(2(S)-TERTIARY BUTYLAMINOCARBONYL)-4(3-PYRIDYLMETHYL)PIPERAZINO]-4(S)-HYDROXY-2(R)-PHENYLMETHYLPENTANAMIDE, Protease, ... | | Authors: | Coman, R.M, Robbins, A.H, McKenna, R, Dunn, B.M. | | Deposit date: | 2007-09-04 | | Release date: | 2007-11-20 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | The Contribution of Naturally Occurring Polymorphisms in Altering the Biochemical and Structural Characteristics of HIV-1 Subtype C Protease
Biochemistry, 47, 2008
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2VOB
 | | TRYPANOTHIONE SYNTHETASE | | Descriptor: | CHLORIDE ION, TRYPANOTHIONE SYNTHETASE | | Authors: | Fyfe, P.K, Oza, S.L, Fairlamb, A.H, Hunter, W.N. | | Deposit date: | 2008-02-13 | | Release date: | 2008-05-06 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Leishmania Trypanothione Synthetase-Amidase Structure Reveals a Basis for Regulation of Conflicting Synthetic and Hydrolytic Activities.
J.Biol.Chem., 283, 2008
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2QRJ
 | | Crystal Structure of Sulfate-bound Saccharopine Dehydrogenase (L-Lys Forming) from Saccharomyces cerevisiae | | Descriptor: | CHLORIDE ION, SULFATE ION, Saccharopine dehydrogenase, ... | | Authors: | Andi, B, Xu, H, Cook, P.F, West, A.H. | | Deposit date: | 2007-07-28 | | Release date: | 2007-10-30 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Crystal Structures of Ligand-Bound Saccharopine Dehydrogenase from Saccharomyces cerevisiae
Biochemistry, 46, 2007
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2WO5
 | | Structure of wild type E. coli N-acetylneuraminic acid lyase in space group P21 crystal form I | | Descriptor: | N-ACETYLNEURAMINATE LYASE | | Authors: | Campeotto, I, Bolt, A.H, Harman, T.A, Trinh, C.H, Dennis, C.A, Phillips, S.E.V, Pearson, A.R, Nelson, A, Berry, A. | | Deposit date: | 2009-07-21 | | Release date: | 2010-08-25 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural Insights Into Substrate Specificity in Variants of N-Acetylneuraminic Acid Lyase Produced by Directed Evolution.
J.Mol.Biol., 404, 2010
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2WOI
 | | Trypanothione reductase from Trypanosoma brucei | | Descriptor: | CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, SODIUM ION, ... | | Authors: | Alphey, M.S, Fairlamb, A.H. | | Deposit date: | 2009-07-24 | | Release date: | 2010-08-04 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Dihydroquinazolines as a Novel Class of Trypanosoma Brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of Their Binding Mode by Protein Crystallography.
J.Med.Chem., 54, 2011
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2FA5
 | | The crystal structure of an unliganded multiple antibiotic-resistance repressor (MarR) from Xanthomonas campestris | | Descriptor: | CHLORIDE ION, transcriptional regulator marR/emrR family | | Authors: | Chin, K.H, Tu, Z.L, Li, J.N, Chou, C.C, Wang, A.H.J, Chou, S.H. | | Deposit date: | 2005-12-06 | | Release date: | 2006-11-14 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | The crystal structure of XC1739: a putative multiple antibiotic-resistance repressor (MarR) from Xanthomonas campestris at 1.8 A resolution
Proteins, 65, 2006
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2QIV
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2FMC
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2Q8B
 | | Structure of the malaria antigen AMA1 in complex with a growth-inhibitory antibody | | Descriptor: | 1F9 heavy chain, 1F9 light chain, Apical membrane antigen 1 | | Authors: | Gupta, A, Murphy, V.J, Anders, R.F, Batchelor, A.H. | | Deposit date: | 2007-06-10 | | Release date: | 2007-10-09 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structure of the Malaria Antigen AMA1 in Complex with a Growth-Inhibitory Antibody
Plos Pathog., 3, 2007
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2JYD
 | | Structure of the fifth zinc finger of Myelin Transcription Factor 1 | | Descriptor: | F5 domain of Myelin transcription factor 1, ZINC ION | | Authors: | Gamsjaeger, R, Swanton, M.K, Kobus, F.J, Lehtomaki, E, Lowry, J.A, Kwan, A.H, Matthews, J.M, Mackay, J.P. | | Deposit date: | 2007-12-12 | | Release date: | 2008-01-15 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Structural and biophysical analysis of the DNA binding properties of myelin transcription factor 1.
J.Biol.Chem., 283, 2008
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2WKL
 | | Velaglucerase alfa | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLUCOSYLCERAMIDASE, ... | | Authors: | Brumshtein, B, Salinas, P, Peterson, B, Chan, V, Silman, I, Sussman, J.L, Savickas, P.J, Robinson, G.S, Futerman, A.H. | | Deposit date: | 2009-06-15 | | Release date: | 2009-09-22 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Characterization of Gene-Activated Human Acid-Beta-Glucosidase: Crystal Structure, Glycan Composition and Internalization Into Macrophages.
Glycobiology, 20, 2010
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2WNN
 | | Structure of wild type E. coli N-acetylneuraminic acid lyase in complex with pyruvate in space group P21 | | Descriptor: | N-ACETYLNEURAMINATE LYASE, PENTAETHYLENE GLYCOL, SODIUM ION | | Authors: | Campeotto, I, Bolt, A.H, Harman, T.A, Trinh, C.H, Dennis, C.A, Phillips, S.E.V, Pearson, A.R, Nelson, A, Berry, A. | | Deposit date: | 2009-07-13 | | Release date: | 2010-08-25 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Structural Insights Into Substrate Specificity in Variants of N-Acetylneuraminic Acid Lyase Produced by Directed Evolution.
J.Mol.Biol., 404, 2010
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2GBZ
 | | The Crystal Structure of XC847 from Xanthomonas campestris: a 3-5 Oligoribonuclease of DnaQ fold family with a Novel Opposingly-Shifted Helix | | Descriptor: | MAGNESIUM ION, Oligoribonuclease | | Authors: | Chin, K.H, Yang, C.Y, Chou, C.C, Wang, A.H.J, Chou, S.H. | | Deposit date: | 2006-03-12 | | Release date: | 2007-01-16 | | Last modified: | 2017-10-18 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | The crystal structure of XC847 from Xanthomonas campestris: a 3'-5' oligoribonuclease of DnaQ fold family with a novel opposingly shifted helix
Proteins, 65, 2006
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2WNZ
 | | Structure of the E192N mutant of E. coli N-acetylneuraminic acid lyase in complex with pyruvate in space group P21 crystal form I | | Descriptor: | (2S)-2-HYDROXYPROPANOIC ACID, 2-ETHOXYETHANOL, LACTIC ACID, ... | | Authors: | Campeotto, I, Bolt, A.H, Harman, T.A, Trinh, C.H, Dennis, C.A, Phillips, S.E.V, Pearson, A.R, Nelson, A, Berry, A. | | Deposit date: | 2009-07-21 | | Release date: | 2010-08-25 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Structural Insights Into Substrate Specificity in Variants of N-Acetylneuraminic Acid Lyase Produced by Directed Evolution.
J.Mol.Biol., 404, 2010
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2JX1
 | | Structure of the fifth zinc finger of Myelin Transcription Factor 1 in complex with RARE DNA | | Descriptor: | DNA (5'-D(*DAP*DCP*DCP*DGP*DAP*DAP*DAP*DGP*DTP*DTP*DCP*DAP*DC)-3'), DNA (5'-D(*DGP*DTP*DGP*DAP*DAP*DCP*DTP*DTP*DTP*DCP*DGP*DGP*DT)-3'), Myelin transcription factor 1 | | Authors: | Gamsjaeger, R, Swanton, M.K, Kobus, F.J, Lehtomaki, E, Lowry, J.A, Kwan, A.H, Matthews, J.M, Mackay, J.P. | | Deposit date: | 2007-11-01 | | Release date: | 2007-12-11 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Structure of the fifth zinc finger of Myelin Transcription Factor 1 in complex with RARE DNA
To be Published
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2WNQ
 | | Structure of the E192N mutant of E. coli N-acetylneuraminic acid lyase in space group P21 | | Descriptor: | CHLORIDE ION, N-ACETYLNEURAMINATE LYASE | | Authors: | Campeotto, I, Bolt, A.H, Harman, T.A, Trinh, C.H, Dennis, C.A, Phillips, S.E.V, Pearson, A.R, Nelson, A, Berry, A. | | Deposit date: | 2009-07-17 | | Release date: | 2010-08-25 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structural Insights Into Substrate Specificity in Variants of N-Acetylneuraminic Acid Lyase Produced by Directed Evolution.
J.Mol.Biol., 404, 2010
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2WP6
 | | Trypanosoma brucei trypanothione reductase in complex with 3,4- dihydroquinazoline inhibitor (DDD00071494) | | Descriptor: | (4S)-3-BENZYL-6-CHLORO-2-METHYL-4-PHENYL-3,4-DIHYDROQUINAZOLINE, CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, ... | | Authors: | Alphey, M.S, Patterson, S, Fairlamb, A.H. | | Deposit date: | 2009-08-03 | | Release date: | 2010-10-13 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Dihydroquinazolines as a Novel Class of Trypanosoma Brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of Their Binding Mode by Protein Crystallography.
J.Med.Chem., 54, 2011
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