2WOI

Trypanothione reductase from Trypanosoma brucei

Summary for 2WOI

Entry DOI	10.2210/pdb2woi/pdb
Descriptor	TRYPANOTHIONE REDUCTASE, FLAVIN-ADENINE DINUCLEOTIDE, CHLORIDE ION, ... (5 entities in total)
Functional Keywords	trypanosomiasis, sleeping sickness, flavoprotein, trypanothione, oxidoreductase, fad, nadp, reductase, redox-active center
Biological source	TRYPANOSOMA BRUCEI
Total number of polymer chains	4
Total formula weight	217461.74
Authors	Alphey, M.S.,Fairlamb, A.H. (deposition date: 2009-07-24, release date: 2010-08-04, Last modification date: 2023-12-20)
Primary citation	Patterson, S.,Alphey, M.S.,Jones, D.C.,Shanks, E.J.,Street, I.P.,Frearson, J.A.,Wyatt, P.G.,Gilbert, I.H.,Fairlamb, A.H. Dihydroquinazolines as a Novel Class of Trypanosoma Brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of Their Binding Mode by Protein Crystallography. J.Med.Chem., 54:6514-, 2011 Cited by PubMed: 21851087 DOI: 10.1021/JM200312V PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation