2WP6
Trypanosoma brucei trypanothione reductase in complex with 3,4- dihydroquinazoline inhibitor (DDD00071494)
Summary for 2WP6
| Entry DOI | 10.2210/pdb2wp6/pdb |
| Related | 2WOI 2WOV 2WOW 2WP5 2WPC 2WPE 2WPF |
| Descriptor | TRYPANOTHIONE REDUCTASE, FLAVIN-ADENINE DINUCLEOTIDE, (4S)-3-BENZYL-6-CHLORO-2-METHYL-4-PHENYL-3,4-DIHYDROQUINAZOLINE, ... (5 entities in total) |
| Functional Keywords | oxidoreductase, trypanosomiasis, sleeping sickness, flavoprotein, redox-active center |
| Biological source | TRYPANOSOMA BRUCEI |
| Total number of polymer chains | 4 |
| Total formula weight | 218698.75 |
| Authors | Alphey, M.S.,Patterson, S.,Fairlamb, A.H. (deposition date: 2009-08-03, release date: 2010-10-13, Last modification date: 2023-12-20) |
| Primary citation | Patterson, S.,Alphey, M.S.,Jones, D.C.,Shanks, E.J.,Street, I.P.,Frearson, J.A.,Wyatt, P.G.,Gilbert, I.H.,Fairlamb, A.H. Dihydroquinazolines as a Novel Class of Trypanosoma Brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of Their Binding Mode by Protein Crystallography. J.Med.Chem., 54:6514-, 2011 Cited by PubMed: 21851087DOI: 10.1021/JM200312V PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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