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PDB: 89774 results

6QQT
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BU of 6qqt by Molmil
Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with inhibitor
Descriptor: 3-[1-[(4-methoxyphenyl)methyl]indol-6-yl]-1~{H}-pyrazol-5-amine, SULFATE ION, tRNA (guanine-N(1)-)-methyltransferase
Authors:Thomas, S.E, Whitehouse, A.J, Coyne, A.G, Abell, C, Mendes, V, Blundell, T.L.
Deposit date:2019-02-19
Release date:2019-09-18
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.673 Å)
Cite:Development of Inhibitors againstMycobacterium abscessustRNA (m1G37) Methyltransferase (TrmD) Using Fragment-Based Approaches.
J.Med.Chem., 62, 2019
6QR1
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BU of 6qr1 by Molmil
Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with inhibitor
Descriptor: 3-azanyl-5-[3-chloranyl-1-(pyridin-3-ylmethyl)indol-6-yl]-1~{H}-pyrazole-4-carbonitrile, tRNA (guanine-N(1)-)-methyltransferase
Authors:Thomas, S.E, Whitehouse, A.J, Coyne, A.G, Abell, C, Mendes, V, Blundell, T.L.
Deposit date:2019-02-19
Release date:2019-09-18
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Development of Inhibitors againstMycobacterium abscessustRNA (m1G37) Methyltransferase (TrmD) Using Fragment-Based Approaches.
J.Med.Chem., 62, 2019
1KFO
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BU of 1kfo by Molmil
CRYSTAL STRUCTURE OF AN RNA HELIX RECOGNIZED BY A ZINC-FINGER PROTEIN: AN 18 BASE PAIR DUPLEX AT 1.6 RESOLUTION
Descriptor: 5'-R(*GP*AP*AP*UP*GP*CP*CP*UP*GP*CP*GP*AP*GP*CP*AP*(5BU)P*CP*CP*C)-3'
Authors:Lima, S, Hildenbrand, J, Korostelev, A, Hattman, S, Li, H.
Deposit date:2001-11-21
Release date:2001-12-07
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of an RNA helix recognized by a zinc-finger protein: an 18-bp duplex at 1.6 A resolution.
RNA, 8, 2002
3NIR
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BU of 3nir by Molmil
Crystal structure of small protein crambin at 0.48 A resolution
Descriptor: Crambin, ETHANOL
Authors:Schmidt, A, Teeter, M, Weckert, E, Lamzin, V.S.
Deposit date:2010-06-16
Release date:2011-05-18
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (0.48 Å)
Cite:Crystal structure of small protein crambin at 0.48 A resolution
Acta Crystallogr.,Sect.F, 67, 2011
2DSF
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BU of 2dsf by Molmil
Structure of the complex of C-terminal lobe of bovine lactoferrin with xylose at 2.8A resolution
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CARBONATE ION, FE (III) ION, ...
Authors:Mir, R, Singh, N, Sinha, M, Sharma, S, Bhushan, A, Singh, T.P.
Deposit date:2006-06-29
Release date:2006-07-11
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of the complex of C-terminal lobe of bovine lactoferrin with xylose at 2.8A resolution
To be Published
3NL6
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BU of 3nl6 by Molmil
The Crystal Structure of Candida glabrata THI6, a Bifunctional Enzyme involved in Thiamin Biosyhthesis of Eukaryotes
Descriptor: MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, THIAMIN PHOSPHATE, ...
Authors:Paul, D, Chatterjee, A, Begley, T.P, Ealick, S.E.
Deposit date:2010-06-21
Release date:2010-11-10
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.612 Å)
Cite:Domain Organization in Candida glabrata THI6, a Bifunctional Enzyme Required for Thiamin Biosynthesis in Eukaryotes .
Biochemistry, 49, 2010
6QYK
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BU of 6qyk by Molmil
Structure of MBP-Mcl-1 in complex with compound 7a
Descriptor: (2~{R})-2-[6-ethyl-5-(1~{H}-indol-5-yl)thieno[2,3-d]pyrimidin-4-yl]oxypropanoic acid, Maltose/maltodextrin-binding periplasmic protein,Induced myeloid leukemia cell differentiation protein Mcl-1, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose
Authors:Dokurno, P, Szlavik, Z, Ondi, L, Csekei, M, Paczal, A, Szabo, Z.B, Radics, G, Murray, J, Davidson, J, Chen, I, Davis, B, Hubbard, R.E, Pedder, C, Surgenor, A.E, Smith, J, Robertson, A, LeToumelin-Braizat, G, Cauquil, N, Zarka, M, Demarles, D, Perron-Sierra, F, Geneste, O, Kotschy, A.
Deposit date:2019-03-09
Release date:2019-08-07
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure-Guided Discovery of a Selective Mcl-1 Inhibitor with Cellular Activity.
J.Med.Chem., 62, 2019
1UB8
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BU of 1ub8 by Molmil
Crystal structure of d(GCGAAGC), bending duplex with a bulge-in residue
Descriptor: 5'-D(*GP*CP*GP*AP*AP*GP*C)-3', COBALT HEXAMMINE(III)
Authors:Sunami, T, Kondo, J, Hirao, I, Watanabe, K, Miura, K, Takenaka, A.
Deposit date:2003-03-31
Release date:2004-03-09
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structures of d(GCGAAGC) and d(GCGAAAGC) (tetragonal form): a switching of partners of the sheared G.A pairs to form a functional G.AxA.G crossing.
Acta Crystallogr.,Sect.D, 60, 2004
3NA7
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BU of 3na7 by Molmil
2.2 Angstrom Structure of the HP0958 Protein from Helicobacter pylori CCUG 17874
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, HP0958, MAGNESIUM ION, ...
Authors:Caly, D.L, O'Toole, P.W, Moore, S.A.
Deposit date:2010-06-01
Release date:2010-09-22
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The 2.2-A Structure of the HP0958 Protein from Helicobacter pylori Reveals a Kinked Anti-Parallel Coiled-Coil Hairpin Domain and a Highly Conserved Zn-Ribbon Domain
J.Mol.Biol., 403, 2010
6QXV
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BU of 6qxv by Molmil
Pink beam serial crystallography: Proteinase K, 1 us exposure, 1585 patterns merged (2 chips)
Descriptor: CALCIUM ION, CHLORIDE ION, Proteinase K, ...
Authors:Tolstikova, A, Oberthuer, D, Meents, A.
Deposit date:2019-03-08
Release date:2019-09-25
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:1 kHz fixed-target serial crystallography using a multilayer monochromator and an integrating pixel detector.
Iucrj, 6, 2019
3NCA
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BU of 3nca by Molmil
X-ray structure of ketohexokinase in complex with a thieno pyridinol compound
Descriptor: Ketohexokinase, SULFATE ION, thieno[3,2-b]pyridin-7-ol
Authors:Abad, M.C, Gibbs, A.C, Spurlino, J.C.
Deposit date:2010-06-04
Release date:2010-12-22
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.602 Å)
Cite:Electron density guided fragment-based lead discovery of ketohexokinase inhibitors.
J.Med.Chem., 53, 2010
6QYN
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BU of 6qyn by Molmil
Structure of MBP-Mcl-1 in complex with compound 10d
Descriptor: (2~{R})-2-[5-(3-chloranyl-2-methyl-4-oxidanyl-phenyl)-6-ethyl-thieno[2,3-d]pyrimidin-4-yl]oxy-3-phenyl-propanoic acid, Maltose/maltodextrin-binding periplasmic protein,Induced myeloid leukemia cell differentiation protein Mcl-1, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose
Authors:Dokurno, P, Szlavik, Z, Ondi, L, Csekei, M, Paczal, A, Szabo, Z.B, Radics, G, Murray, J, Davidson, J, Chen, I, Davis, B, Hubbard, R.E, Pedder, C, Surgenor, A.E, Smith, J, Robertson, A, LeToumelin-Braizat, G, Cauquil, N, Zarka, M, Demarles, D, Perron-Sierra, F, Geneste, O, Kotschy, A.
Deposit date:2019-03-09
Release date:2019-08-07
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure-Guided Discovery of a Selective Mcl-1 Inhibitor with Cellular Activity.
J.Med.Chem., 62, 2019
6QYW
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BU of 6qyw by Molmil
Solution NMR of synthetic analogues of nisin and mutacin ring A and ring B - nisin ring A
Descriptor: ILE-DBU-DAL-ILE-DHA-LEU-CYS-ALA
Authors:Dickman, R, Mitchell, S.A, Figueiredo, A, Hansen, D.F, Tabor, A.B.
Deposit date:2019-03-09
Release date:2019-09-11
Last modified:2019-10-02
Method:SOLUTION NMR
Cite:Molecular Recognition of Lipid II by Lantibiotics: Synthesis and Conformational Studies of Analogues of Nisin and Mutacin Rings A and B.
J.Org.Chem., 84, 2019
1UH0
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BU of 1uh0 by Molmil
Crystal structure of jacalin- Me-alpha-GalNAc complex
Descriptor: Agglutinin alpha chain, Agglutinin beta-3 chain, methyl 2-acetamido-2-deoxy-alpha-D-galactopyranoside
Authors:Jeyaprakash, A.A, Katiyar, S, Swaminathan, C.P, Sekar, K, Surolia, A, Vijayan, M.
Deposit date:2003-06-23
Release date:2003-09-23
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Basis of the Carbohydrate Specificities of Jacalin: An X-ray and Modeling Study
J.MOL.BIOL., 332, 2003
3NDI
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BU of 3ndi by Molmil
X-ray Structure of a C-3'-Methyltransferase in Complex with S-adenosylmethionine and dTMP
Descriptor: Methyltransferase, PHOSPHATE ION, S-ADENOSYLMETHIONINE, ...
Authors:Bruender, N.A, Thoden, J.B, Kaur, M, Avey, M.K, Holden, H.M.
Deposit date:2010-06-07
Release date:2010-06-30
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Molecular Architecture of a C-3'-Methyltransferase Involved in the Biosynthesis of d-Tetronitrose.
Biochemistry, 49, 2010
3NFI
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BU of 3nfi by Molmil
Crystal structure of tandem winged helix domain of RNA polymerase I subunit A49
Descriptor: 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, DNA-directed RNA polymerase I subunit RPA49
Authors:Geiger, S.R, Lorenzen, K, Schreieck, A, Hanecker, P, Kostrewa, D, Heck, A.J.R, Cramer, P.
Deposit date:2010-06-10
Release date:2010-09-08
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:RNA Polymerase I Contains a TFIIF-Related DNA-Binding Subcomplex.
Mol.Cell, 39, 2010
6QMU
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BU of 6qmu by Molmil
A tetrahedral boronic acid diester formed by a non-natural amino acid in the ligand pocket of an engineered lipocalin
Descriptor: 3-nitrophenol, Neutrophil gelatinase-associated lipocalin
Authors:Skerra, A, Eichinger, A.
Deposit date:2019-02-08
Release date:2019-08-28
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:A Tetrahedral Boronic Acid Diester Formed by an Unnatural Amino Acid in the Ligand Pocket of an Engineered Lipocalin.
Chembiochem, 21, 2020
3NI8
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BU of 3ni8 by Molmil
Crystal Structure of PFC0360w, an HSP90 activator from plasmodium falciparum
Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, PFC0360w protein
Authors:Wernimont, A.K, Hutchinson, A, Sullivan, H, MacKenzie, F, Kozieradzki, I, Cossar, D, Bochkarev, A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Hui, R, Pizzaro, J.C, Hills, T, Structural Genomics Consortium (SGC)
Deposit date:2010-06-15
Release date:2010-08-11
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structure of PFC0360w, an HSP90 activator from plasmodium falciparum
To be Published
3NIE
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BU of 3nie by Molmil
Crystal Structure of PF11_0147
Descriptor: MAP2 kinase, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Wernimont, A.K, Hutchinson, A, Sullivan, H, MacKenzie, F, Kozieradzki, I, Chau, I, Lew, J, Senisterra, G, Cossar, D, Amani, M, Artz, J.D, Bochkarev, A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Hui, R, Hills, T, Structural Genomics Consortium (SGC)
Deposit date:2010-06-15
Release date:2010-08-11
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structure of PF11_0147
To be Published
6QO2
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BU of 6qo2 by Molmil
Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 1 (1H-Indole-5-carboxamide)
Descriptor: 1~{H}-indole-5-carboxamide, tRNA (guanine-N(1)-)-methyltransferase
Authors:Thomas, S.E, Whitehouse, A.J, Coyne, A.G, Abell, C, Mendes, V, Blundell, T.L.
Deposit date:2019-02-12
Release date:2020-03-04
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification.
Nucleic Acids Res., 48, 2020
6QOI
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BU of 6qoi by Molmil
Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 12 (2-Aminobenzothiazole)
Descriptor: 1,3-benzothiazol-2-amine, tRNA (guanine-N(1)-)-methyltransferase
Authors:Thomas, S.E, Whitehouse, A.J, Coyne, A.G, Abell, C, Mendes, V, Blundell, T.L.
Deposit date:2019-02-12
Release date:2020-02-26
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification.
Nucleic Acids Res., 48, 2020
6QNQ
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BU of 6qnq by Molmil
70S ribosome initiation complex (IC) with experimentally assigned potassium ions
Descriptor: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Rozov, A, Khusainov, I, Yusupov, M, Yusupova, G.
Deposit date:2019-02-11
Release date:2019-06-19
Last modified:2024-04-24
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Importance of potassium ions for ribosome structure and function revealed by long-wavelength X-ray diffraction.
Nat Commun, 10, 2019
6QP8
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BU of 6qp8 by Molmil
Drosophila Semaphorin 2b
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CITRATE ANION, ...
Authors:Robinson, R.A, Rozbesky, D, Harlos, K, Siebold, C, Jones, E.Y.
Deposit date:2019-02-13
Release date:2019-08-21
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Diversity of oligomerization in Drosophila semaphorins suggests a mechanism of functional fine-tuning.
Nat Commun, 10, 2019
6QPO
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BU of 6qpo by Molmil
Adenovirus species D serotype 49 Fiber-Knob KO1 mutant
Descriptor: Fiber, SULFATE ION
Authors:Baker, A.T, Rizkallah, P.J.
Deposit date:2019-02-14
Release date:2020-08-26
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:The Fiber Knob Protein of Human Adenovirus Type 49 Mediates Highly Efficient and Promiscuous Infection of Cancer Cell Lines Using a Novel Cell Entry Mechanism.
J.Virol., 95, 2021
6QQN
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BU of 6qqn by Molmil
Tubulin-TH588 complex
Descriptor: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ...
Authors:Patterson, J.C, Joughin, B.A, Prota, A.E, Muehlethaler, T, Jonas, O.H, Whitman, M.A, Varmeh, S, Chen, S, Balk, S.P, Steinmetz, M.O, Lauffenburger, D.A, Yaffe, M.B.
Deposit date:2019-02-18
Release date:2019-07-24
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.301 Å)
Cite:VISAGE Reveals a Targetable Mitotic Spindle Vulnerability in Cancer Cells.
Cell Syst, 9, 2019

227111

数据于2024-11-06公开中

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