6UUC
| E. coli sigma-S transcription initiation complex with a 3-nt RNA and a mismatching ATP ("Fresh" crystal soaked with ATP for 2 hours) | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | Authors: | Zuo, Y, De, S, Steitz, T.A. | Deposit date: | 2019-10-30 | Release date: | 2020-08-26 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (4.096 Å) | Cite: | Structural Insights into Transcription Initiation from De Novo RNA Synthesis to Transitioning into Elongation. Iscience, 23, 2020
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5TPR
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7S14
| Crystal structure of putative NAD(P)H-flavin oxidoreductase from Haemophilus influenzae 86-028NP | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, CHLORIDE ION, ... | Authors: | Kim, Y, Maltseva, N, Endres, M, Crofts, T, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2021-08-31 | Release date: | 2021-10-06 | Last modified: | 2024-07-17 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Functional and Structural Characterization of Diverse NfsB Chloramphenicol Reductase Enzymes from Human Pathogens. Microbiol Spectr, 10, 2022
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5CPQ
| Disproportionating enzyme 1 from Arabidopsis - apo form | Descriptor: | 1,2-ETHANEDIOL, 4-alpha-glucanotransferase DPE1, chloroplastic/amyloplastic | Authors: | O'Neill, E.C, Stevenson, C.E.M, Tantanarat, K, Latousakis, D, Donaldson, M.I, Rejzek, M, Limpaseni, T, Smith, A.M, Field, R.A, Lawson, D.M. | Deposit date: | 2015-07-21 | Release date: | 2015-11-04 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.13 Å) | Cite: | Structural Dissection of the Maltodextrin Disproportionation Cycle of the Arabidopsis Plastidial Disproportionating Enzyme 1 (DPE1). J.Biol.Chem., 290, 2015
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6F8C
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6I7X
| Crystal Structure of the first bromodomain of BRD4 in complex with RT53 | Descriptor: | 1,2-ETHANEDIOL, 2-[(4~{S})-6-(4-chlorophenyl)-8-methoxy-1-methyl-4~{H}-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-1-[4-(dimethylamino)piperidin-1-yl]ethanone, Bromodomain-containing protein 4 | Authors: | Picaud, S, Traquete, R, Bernardes, G.J.L, Newman, J, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Filippakopoulos, P, Structural Genomics Consortium (SGC) | Deposit date: | 2018-11-19 | Release date: | 2019-11-27 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Crystal Structure of the first bromodomain of BRD4 in complex with RT53 To Be Published
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7L0B
| Crystal structure of hydroxyacyl glutathione hydrolase (GloB) from Staphylococcus aureus, apoenzyme | Descriptor: | Hydroxyacylglutathione hydrolase, SULFATE ION, ZINC ION | Authors: | Miller, J.J, Jez, J.M, Odom John, A.R. | Deposit date: | 2020-12-11 | Release date: | 2020-12-30 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Structure-guided microbial targeting of antistaphylococcal prodrugs. Elife, 10, 2021
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5NHI
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6ANG
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4RZT
| Lac repressor engineered to bind sucralose, sucralose-bound tetramer | Descriptor: | 4-chloro-4-deoxy-alpha-D-galactopyranose-(1-2)-1,6-dichloro-1,6-dideoxy-beta-D-fructofuranose, Lac repressor | Authors: | Arbing, M.A, Cascio, D, Sawaya, M.R, Kosuri, S, Church, G.M. | Deposit date: | 2014-12-24 | Release date: | 2015-12-23 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Engineering an allosteric transcription factor to respond to new ligands. Nat.Methods, 13, 2016
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6AQB
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5CS1
| The structure of the NK1 fragment of HGF/SF | Descriptor: | Hepatocyte growth factor | Authors: | Sigurdardottir, A.G, Winter, A, Sobkowicz, A, Fragai, M, Chirgadze, D.Y, Ascher, D.B, Blundell, T.L, Gherardi, E. | Deposit date: | 2015-07-23 | Release date: | 2015-08-12 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding. Chem Sci, 6, 2015
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4YOE
| Structure of UP1 bound to RNA 5'-AGU-3' | Descriptor: | ACETATE ION, Heterogeneous nuclear ribonucleoprotein A1, RNA AGU, ... | Authors: | Meagher, J.L, Stuckey, J.A. | Deposit date: | 2015-03-11 | Release date: | 2015-06-10 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | The First Crystal Structure of the UP1 Domain of hnRNP A1 Bound to RNA Reveals a New Look for an Old RNA Binding Protein. J.Mol.Biol., 427, 2015
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3LO7
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7XKX
| Crystal structure of Tpn2 | Descriptor: | SQHop_cyclase_C domain-containing protein | Authors: | Chang, C.Y, Stowell, E.A, Lin, Y.L, Ehrenberger, M.A, Rudolf, J.D. | Deposit date: | 2022-04-20 | Release date: | 2023-03-01 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.57 Å) | Cite: | Structure-guided product determination of the bacterial type II diterpene synthase Tpn2. Commun Chem, 5, 2022
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5FO5
| Structure of the DNA-binding domain of Escherichia coli methionine biosynthesis regulator MetR | Descriptor: | 1,2-ETHANEDIOL, HTH-TYPE TRANSCRIPTIONAL REGULATOR METR, MAGNESIUM ION | Authors: | Punekar, A.S, Porter, J, Urbanowski, M.L, Stauffer, G.V, Carr, S.B, Phillips, S.E. | Deposit date: | 2015-11-18 | Release date: | 2016-06-08 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.16 Å) | Cite: | Structural Basis for DNA Recognition by the Transcription Regulator Metr. Acta Crystallogr.,Sect.F, 72, 2016
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3LY2
| Catalytic Domain of Human Phosphodiesterase 4B in Complex with A Coumarin-Based Inhibitor | Descriptor: | 8-(cyclopentyloxy)-4-[(3,5-dichloropyridin-4-yl)amino]-7-methoxy-2H-chromen-2-one, MAGNESIUM ION, SULFATE ION, ... | Authors: | Shiau, A.K, Coyle, A.R, Hsien, J.H, Staszewski, L.M. | Deposit date: | 2010-02-26 | Release date: | 2010-04-28 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Water-soluble PDE4 inhibitors for the treatment of dry eye. Bioorg.Med.Chem.Lett., 20, 2010
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4YLJ
| Crystal structure of DYRK1A in complex with 10-Iodo-substituted 11H-indolo[3,2-c]quinoline-6-carboxylic acid inhibitor 5j | Descriptor: | 10-iodo-11H-indolo[3,2-c]quinoline-6-carboxylic acid, Dual specificity tyrosine-phosphorylation-regulated kinase 1A, SULFATE ION, ... | Authors: | Chaikuad, A, Falke, H, Nowak, R, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Kunick, C, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2015-03-05 | Release date: | 2015-03-25 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.58 Å) | Cite: | 10-Iodo-11H-indolo[3,2-c]quinoline-6-carboxylic Acids Are Selective Inhibitors of DYRK1A. J.Med.Chem., 58, 2015
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6AU0
| Crystal structure of PPK2 (Class III) in complex with bisphosphonate inhibitor (2-((3,5-dichlorophenyl)amino)ethane-1,1-diyl)diphosphonic acid | Descriptor: | GLYCEROL, Polyphosphate:AMP phosphotransferase, {[(3,5-dichlorophenyl)amino]methylene}bis(phosphonic acid) | Authors: | Nocek, B, Ruszkowski, M, Joachimiak, A, Berlicki, L, Yakunin, A. | Deposit date: | 2017-08-29 | Release date: | 2019-01-16 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural Insights into Substrate Selectivity and Activity of Bacterial Polyphosphate Kinases Acs Catalysis, 8, 2018
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7X56
| A CBg-ParM filament with ADP | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ParM/StbA family protein | Authors: | Koh, A, Ali, S, Robinson, R, Narita, A. | Deposit date: | 2022-03-04 | Release date: | 2023-03-08 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | A new actin-like filament from Clostridium botulinum exhibits a new system of filament turn over To Be Published
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4YQP
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8W1N
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8DZD
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5FE5
| Crystal structure of human PCAF bromodomain in complex with fragment MB093 (fragment 7) | Descriptor: | 1,2-ETHANEDIOL, 1-[4-(1,2,3-thiadiazol-4-yl)phenyl]methanamine, DIMETHYL SULFOXIDE, ... | Authors: | Chaikuad, A, von Delft, F, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2015-12-16 | Release date: | 2016-01-13 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.12 Å) | Cite: | Structure-Based Identification of Inhibitory Fragments Targeting the p300/CBP-Associated Factor Bromodomain. J.Med.Chem., 59, 2016
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7X59
| A CBg-ParM filament with GTP or GDPPi | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, ParM/StbA family protein | Authors: | Koh, A, Ali, S, Robinson, R, Narita, A. | Deposit date: | 2022-03-04 | Release date: | 2023-03-08 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (6.5 Å) | Cite: | A new actin-like filament from Clostridium botulinum exhibits a new system of filament turn over To Be Published
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