7KG1
| Structure of human PARG complexed with PARG-002 | 分子名称: | 1,3-dimethyl-8-{[2-(morpholin-4-yl)ethyl]amino}-3,7-dihydro-1H-purine-2,6-dione, CACODYLATE ION, DIMETHYL SULFOXIDE, ... | 著者 | Brosey, C.A, Balapiti-Modarage, L.P.F, Warden, L.S, Jones, D.E, Ahmed, Z, Tainer, J.A. | 登録日 | 2020-10-15 | 公開日 | 2021-03-10 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors. Prog.Biophys.Mol.Biol., 163, 2021
|
|
7T28
| Structure of phage Bsp38 anti-Pycsar nuclease Apyc1 in apo state | 分子名称: | Putative metal-dependent hydrolase, ZINC ION | 著者 | Hobbs, S.J, Wein, T, Lu, A, Morehouse, B.R, Schnabel, J, Sorek, R, Kranzusch, P.J. | 登録日 | 2021-12-03 | 公開日 | 2022-04-20 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.68 Å) | 主引用文献 | Phage anti-CBASS and anti-Pycsar nucleases subvert bacterial immunity. Nature, 605, 2022
|
|
5MQH
| |
5M7K
| Blastochloris viridis photosynthetic reaction center - RC_vir_xfel | 分子名称: | (2E,6E,10E,14E,18E,22E,26E)-3,7,11,15,19,23,27,31-OCTAMETHYLDOTRIACONTA-2,6,10,14,18,22,26,30-OCTAENYL TRIHYDROGEN DIPHOSPHATE, 15-cis-1,2-dihydroneurosporene, BACTERIOCHLOROPHYLL A, ... | 著者 | Sharma, A.S, Johansson, L, Dunevall, E, Wahlgren, W.Y, Neutze, R, Katona, G. | 登録日 | 2016-10-28 | 公開日 | 2017-02-08 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Asymmetry in serial femtosecond crystallography data. Acta Crystallogr A Found Adv, 73, 2017
|
|
5C7M
| CRYSTAL STRUCTURE OF E3 LIGASE ITCH WITH A UB VARIANT | 分子名称: | E3 ubiquitin-protein ligase Itchy homolog, Polyubiquitin-C | 著者 | Walker, J.R, Hu, J, Dong, A, Wernimont, A, Zhang, W, Sidhu, S, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Tong, Y, Structural Genomics Consortium (SGC) | 登録日 | 2015-06-24 | 公開日 | 2016-03-16 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.03 Å) | 主引用文献 | System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes. Mol.Cell, 62, 2016
|
|
8Q96
| P301S Tau Filaments from the Brains of Tg2541 Transgenic Mouse Line | 分子名称: | Isoform Tau-E of Microtubule-associated protein tau, Unknown protein | 著者 | Schweighauser, M, Murzin, A.G, Macdonald, J, Lavenir, I, Crowther, R.A, Scheres, S.H.W, Goedert, M. | 登録日 | 2023-08-19 | 公開日 | 2023-10-11 | 最終更新日 | 2023-10-18 | 実験手法 | ELECTRON MICROSCOPY (3.09 Å) | 主引用文献 | Cryo-EM structures of tau filaments from the brains of mice transgenic for human mutant P301S Tau. Acta Neuropathol Commun, 11, 2023
|
|
5MQQ
| |
7KG7
| Structure of human PARG complexed with PARG-292 | 分子名称: | 8-{[2-(1,1-dioxo-1lambda~6~,4-thiazinan-4-yl)ethyl]sulfanyl}-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione, DIMETHYL SULFOXIDE, Poly(ADP-ribose) glycohydrolase, ... | 著者 | Brosey, C.A, Balapiti-Modarage, L.P.F, Warden, L.S, Jones, D.E, Ahmed, Z, Tainer, J.A. | 登録日 | 2020-10-16 | 公開日 | 2021-03-10 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors. Prog.Biophys.Mol.Biol., 163, 2021
|
|
8T9Y
| Structure of VHH-Fab complex with engineered Elbow FNQIKG and Crystal Kappa regions | 分子名称: | DI(HYDROXYETHYL)ETHER, Fab heavy chain, Fab light chain, ... | 著者 | Filippova, E.V, Thompson, I, Kossiakoff, A.A. | 登録日 | 2023-06-26 | 公開日 | 2023-11-29 | 最終更新日 | 2024-01-03 | 実験手法 | X-RAY DIFFRACTION (2.52 Å) | 主引用文献 | Engineered antigen-binding fragments for enhanced crystallization of antibody:antigen complexes. Protein Sci., 33, 2024
|
|
6P7M
| Cryo-EM structure of LbCas12a-crRNA: AcrVA4 (1:2 complex) | 分子名称: | Cas12a, MAGNESIUM ION, anti-CRISPR VA4, ... | 著者 | Knott, G.J, Liu, J.J, Doudna, J.A. | 登録日 | 2019-06-06 | 公開日 | 2019-08-21 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural basis for AcrVA4 inhibition of specific CRISPR-Cas12a. Elife, 8, 2019
|
|
7KG0
| Structure of human PARG complexed with PARG-131 | 分子名称: | 1,2-ETHANEDIOL, 5-({4-[(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)methyl]phenyl}methyl)pyrimidine-2,4,6(1H,3H,5H)-trione, Poly(ADP-ribose) glycohydrolase, ... | 著者 | Arvai, A, Bommagani, S, Brosey, C.A, Jones, D.E, Warden, L.S, Ahmed, Z, Tainer, J.A. | 登録日 | 2020-10-15 | 公開日 | 2021-03-10 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | 主引用文献 | Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors. Prog.Biophys.Mol.Biol., 163, 2021
|
|
6SME
| |
5CEZ
| |
3C6Z
| HNL from Hevea brasiliensis to atomic resolution | 分子名称: | BETA-MERCAPTOETHANOL, DI(HYDROXYETHYL)ETHER, Hydroxynitrilase, ... | 著者 | Schmidt, A. | 登録日 | 2008-02-06 | 公開日 | 2008-06-03 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.05 Å) | 主引用文献 | Atomic resolution crystal structures and quantum chemistry meet to reveal subtleties of hydroxynitrile lyase catalysis J.Biol.Chem., 283, 2008
|
|
7KG6
| Structure of human PARG complexed with PARG-322 | 分子名称: | 1-{2-[(1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)sulfanyl]ethyl}piperidine-4-carboxylic acid, Poly(ADP-ribose) glycohydrolase | 著者 | Brosey, C.A, Balapiti-Modarage, L.P.F, Warden, L.S, Jones, D.E, Ahmed, Z, Tainer, J.A. | 登録日 | 2020-10-16 | 公開日 | 2021-03-10 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | 主引用文献 | Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors. Prog.Biophys.Mol.Biol., 163, 2021
|
|
8T8I
| Structure of VHH-Fab complex with engineered Elbow FNQIKG, Crystal Kappa and SER substitutions | 分子名称: | CHLORIDE ION, DI(HYDROXYETHYL)ETHER, Fab heavy chain, ... | 著者 | Filippova, E.V, Thompson, I, Kossiakoff, A.A. | 登録日 | 2023-06-22 | 公開日 | 2023-11-29 | 最終更新日 | 2024-01-03 | 実験手法 | X-RAY DIFFRACTION (2.52 Å) | 主引用文献 | Engineered antigen-binding fragments for enhanced crystallization of antibody:antigen complexes. Protein Sci., 33, 2024
|
|
8THI
| Cryo-EM structure of the Tripartite ATP-independent Periplasmic (TRAP) transporter SiaQM from Haemophilus influenzae (parallel dimer) | 分子名称: | (1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, SODIUM ION, Sialic acid TRAP transporter permease protein SiaT | 著者 | Davies, J.S, Currie, M.C, Dobson, R.C.J, North, R.A. | 登録日 | 2023-07-16 | 公開日 | 2023-11-22 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (3.36 Å) | 主引用文献 | Structural and biophysical analysis of a Haemophilus influenzae tripartite ATP-independent periplasmic (TRAP) transporter. Elife, 12, 2024
|
|
6PJD
| HIV-1 Protease NL4-3 WT in Complex with LR2-32 | 分子名称: | (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(2S,4S,5S)-4-hydroxy-5-{[N-(methoxycarbonyl)-3-methyl-L-valyl]amino}-1,6-diphenylhexan-2-yl]carbamate, Protease NL4-3, SULFATE ION | 著者 | Lockbaum, G.J, Rusere, L.N, Henes, M, Kosovrasti, K, Lee, S.K, Spielvogel, E, Nalivaika, E.A, Swanstrom, R, KurtYilmaz, N, Schiffer, C.A, Ali, A. | 登録日 | 2019-06-28 | 公開日 | 2020-07-01 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.892 Å) | 主引用文献 | Structural Analysis of Potent Hybrid HIV-1 Protease Inhibitors Containing Bis-tetrahydrofuran in a Pseudosymmetric Dipeptide Isostere. J.Med.Chem., 63, 2020
|
|
4Y1M
| |
5C9O
| Crystal structure of recombinant PLL lectin from Photorhabdus luminescens at 1.5 A resolution | 分子名称: | GLYCEROL, PLL lectin | 著者 | Kumar, A, Sykorova, P, Demo, G, Dobes, P, Hyrsl, P, Wimmerova, M. | 登録日 | 2015-06-28 | 公開日 | 2016-10-19 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | A Novel Fucose-binding Lectin from Photorhabdus luminescens (PLL) with an Unusual Heptabladed beta-Propeller Tetrameric Structure. J.Biol.Chem., 291, 2016
|
|
6FZ8
| Crystal Structure of lipase from Geobacillus stearothermophilus T6 methanol stable variant L184F/A187F | 分子名称: | CALCIUM ION, Lipase, ZINC ION | 著者 | Gihaz, S, Kanteev, M, Pazy, Y, Fishman, A. | 登録日 | 2018-03-14 | 公開日 | 2018-10-17 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Filling the Void: Introducing Aromatic Interactions into Solvent Tunnels To Enhance Lipase Stability in Methanol. Appl.Environ.Microbiol., 84, 2018
|
|
3CA7
| |
5MTQ
| Crystal structure of M. tuberculosis InhA inhibited by PT511 | 分子名称: | 2-[4-[(4-cyclohexyl-1,2,3-triazol-1-yl)methyl]-2-oxidanyl-phenoxy]benzenecarbonitrile, Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE | 著者 | Eltschkner, S, Pschibul, A, Spagnuolo, L.A, Yu, W, Tonge, P.J, Kisker, C. | 登録日 | 2017-01-10 | 公開日 | 2017-02-15 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Evaluating the Contribution of Transition-State Destabilization to Changes in the Residence Time of Triazole-Based InhA Inhibitors. J. Am. Chem. Soc., 139, 2017
|
|
6FZD
| Crystal Structure of lipase from Geobacillus stearothermophilus T6 variant L184F/A187F/L360F | 分子名称: | CALCIUM ION, Lipase, ZINC ION | 著者 | Gihaz, S, Kanteev, M, Pazy, Y, Fishman, A. | 登録日 | 2018-03-14 | 公開日 | 2018-10-17 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Filling the Void: Introducing Aromatic Interactions into Solvent Tunnels To Enhance Lipase Stability in Methanol. Appl.Environ.Microbiol., 84, 2018
|
|
8THJ
| Cryo-EM structure of the Tripartite ATP-independent Periplasmic (TRAP) transporter SiaQM from Haemophilus influenzae (antiparallel dimer) | 分子名称: | (1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, PHOSPHATIDYLETHANOLAMINE, SODIUM ION, ... | 著者 | Davies, J.S, Currie, M.C, Dobson, R.C.J, North, R.A. | 登録日 | 2023-07-16 | 公開日 | 2023-11-22 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (2.99 Å) | 主引用文献 | Structural and biophysical analysis of a Haemophilus influenzae tripartite ATP-independent periplasmic (TRAP) transporter. Elife, 12, 2024
|
|