6PW5
| Cryo-EM Structure of Thermo-Sensitive TRP Channel TRP1 from the Alga Chlamydomonas reinhardtii in Nanodiscs | 分子名称: | (2S)-3-{[(R)-hydroxy{[(1R,2R,3S,4R,5R,6S)-2,3,6-trihydroxy-4,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dihexadecanoate, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, TRP-like ion channel, ... | 著者 | McGoldrick, L.L, Singh, A.K, Sobolevsky, A.I. | 登録日 | 2019-07-22 | 公開日 | 2019-09-25 | 最終更新日 | 2019-12-04 | 実験手法 | ELECTRON MICROSCOPY (3.45 Å) | 主引用文献 | Structure of the thermo-sensitive TRP channel TRP1 from the alga Chlamydomonas reinhardtii. Nat Commun, 10, 2019
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8FL6
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6PX8
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7Q2J
| Quaternary Complex of human WDR5 and pVHL:ElonginC:ElonginB bound to PROTAC Homer | 分子名称: | Elongin-B, Elongin-C, N-[5-[4-[[5-[[(2S)-3,3-dimethyl-1-[(2S,4R)-2-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methylcarbamoyl]-4-oxidanyl-pyrrolidin-1-yl]-1-oxidanylidene-butan-2-yl]amino]-5-oxidanylidene-pentyl]carbamoyl]phenyl]-2-(4-methylpiperazin-1-yl)phenyl]-6-oxidanylidene-4-(trifluoromethyl)-1H-pyridine-3-carboxamide, ... | 著者 | Kraemer, A, Doelle, A, Schwalm, M.P, Adhikari, B, Wolf, E, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2021-10-25 | 公開日 | 2021-11-24 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Tracking the PROTAC degradation pathway in living cells highlights the importance of ternary complex measurement for PROTAC optimization. Cell Chem Biol, 30, 2023
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7O9U
| Solution structure of oxidized cytochrome c552 from Thioalkalivibrio paradoxus | 分子名称: | Cytochrome c552, HEME C | 著者 | Britikov, V.V, Britikova, E.V, Altukhov, D.A, Timofeev, V.I, Dergousova, N.I, Rakitina, T.V, Tikhonova, T.V, Usanov, S.A, Popov, V.O, Bocharov, E.V. | 登録日 | 2021-04-17 | 公開日 | 2021-05-05 | 最終更新日 | 2023-06-14 | 実験手法 | SOLUTION NMR | 主引用文献 | Unusual Cytochrome c 552 from Thioalkalivibrio paradoxus : Solution NMR Structure and Interaction with Thiocyanate Dehydrogenase. Int J Mol Sci, 23, 2022
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6NXZ
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8FLC
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7PCY
| THE CRYSTAL STRUCTURE OF PLASTOCYANIN FROM A GREEN ALGA, ENTEROMORPHA PROLIFERA | 分子名称: | COPPER (II) ION, PLASTOCYANIN | 著者 | Collyer, C.A, Guss, J.M, Freeman, H.C. | 登録日 | 1989-09-22 | 公開日 | 1990-07-15 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystal structure of plastocyanin from a green alga, Enteromorpha prolifera. J.Mol.Biol., 211, 1990
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8FLD
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7ALU
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7OO9
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7B6A
| BK Polyomavirus VP1 pentamer core (residues 30-299) | 分子名称: | CALCIUM ION, DIMETHYL SULFOXIDE, IODIDE ION, ... | 著者 | Osipov, E.M, Munawar, A, Beelen, S, Strelkov, S.V. | 登録日 | 2020-12-07 | 公開日 | 2022-06-22 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.44 Å) | 主引用文献 | Discovery of novel druggable pockets on polyomavirus VP1 through crystallographic fragment-based screening to develop capsid assembly inhibitors. Rsc Chem Biol, 3, 2022
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7Q65
| Cryo-em structure of the Nup98 fibril polymorph 2 | 分子名称: | Nuclear pore complex protein Nup98 | 著者 | Ibanez de Opakua, A, Geraets, J.A, Frieg, B, Dienemann, C, Savastano, A, Rankovic, M, Cima-Omori, M.-S, Schroeder, G.F, Zweckstetter, M. | 登録日 | 2021-11-05 | 公開日 | 2022-10-12 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (3.32 Å) | 主引用文献 | Molecular interactions of FG nucleoporin repeats at high resolution. Nat.Chem., 14, 2022
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7Q67
| Cryo-em structure of the Nup98 fibril polymorph 4 | 分子名称: | Nuclear pore complex protein Nup98 | 著者 | Ibanez de Opakua, A, Geraets, J.A, Frieg, B, Dienemann, C, Savastano, A, Rankovic, M, Cima-Omori, M.-S, Schroeder, G.F, Zweckstetter, M. | 登録日 | 2021-11-05 | 公開日 | 2022-10-12 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (3.37 Å) | 主引用文献 | Molecular interactions of FG nucleoporin repeats at high resolution. Nat.Chem., 14, 2022
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7TZU
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7B72
| DNA duplex with phosphoryl guanidine moiety, Rp-diastereomer | 分子名称: | DNA (5'-D(*CP*AP*CP*GP*CP*CP*GP*CP*TP*G)-3'), DNA (5'-D(*CP*AP*GP*CP*GP*GP*CP*GP*(RGT)P*G)-3') | 著者 | Lomzov, A.A, Pyshnyi, D.V, Shernuykov, A.V, Apukhtina, V.S. | 登録日 | 2020-12-09 | 公開日 | 2021-01-13 | 最終更新日 | 2023-08-23 | 実験手法 | SOLUTION NMR | 主引用文献 | DNA duplex with phosphoryl guanidine moiety, Rp-diastereomer To Be Published
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8G0O
| Crystal structure of Y281F mutant of Hyaluronate lyase B from Cutibacterium acnes | 分子名称: | Hyaluronate lyase | 著者 | Katiki, M, McNally, R, Chatterjee, A, Hajam, I.A, Liu, G.Y, Murali, R. | 登録日 | 2023-02-01 | 公開日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Functional divergence of a bacterial enzyme promotes healthy or acneic skin. Nat Commun, 14, 2023
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7O2W
| Structure of the C9orf72-SMCR8 complex | 分子名称: | Guanine nucleotide exchange protein SMCR8,Guanine nucleotide exchange protein SMCR8,Maltose/maltodextrin-binding periplasmic protein, Ubiquitin-like protein SMT3,Guanine nucleotide exchange C9orf72 | 著者 | Noerpel, J, Cavadini, S, Schenk, A.D, Graff-Meyer, A, Chao, J, Bhaskar, V. | 登録日 | 2021-03-31 | 公開日 | 2021-07-21 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY | 主引用文献 | Structure of the human C9orf72-SMCR8 complex reveals a multivalent protein interaction architecture. Plos Biol., 19, 2021
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8CXJ
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7Q66
| Cryo-em structure of the Nup98 fibril polymorph 3 | 分子名称: | Nuclear pore complex protein Nup98 | 著者 | Ibanez de Opakua, A, Geraets, J.A, Frieg, B, Dienemann, C, Savastano, A, Rankovic, M, Cima-Omori, M.-S, Schroeder, G.F, Zweckstetter, M. | 登録日 | 2021-11-05 | 公開日 | 2022-10-12 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (2.79 Å) | 主引用文献 | Molecular interactions of FG nucleoporin repeats at high resolution. Nat.Chem., 14, 2022
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6QAT
| Crystal structure of ULK2 in complexed with hesperadin | 分子名称: | N-{(3Z)-2-oxo-3-[phenyl({4-[(piperidin-1-yl)methyl]phenyl}amino)methylidene]-2,3-dihydro-1H-indol-5-yl}ethanesulfonamide, Serine/threonine-protein kinase ULK2 | 著者 | Chaikuad, A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium, Structural Genomics Consortium (SGC) | 登録日 | 2018-12-19 | 公開日 | 2019-02-27 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.77 Å) | 主引用文献 | Conservation of structure, function and inhibitor binding in UNC-51-like kinase 1 and 2 (ULK1/2). Biochem.J., 476, 2019
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7AAY
| Crystal structure of MerTK kinase domain in complex with Merestinib | 分子名称: | CHLORIDE ION, N-(3-fluoro-4-{[1-methyl-6-(1H-pyrazol-4-yl)-1H-indazol-5-yl]oxy}phenyl)-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide, Tyrosine-protein kinase Mer | 著者 | Schimpl, M, Pflug, A, McCoull, W, Nissink, J.W.M, Overman, R.C, Rawlins, P.B, Truman, C, Underwood, E, Warwicker, J, Winter-Holt, J. | 登録日 | 2020-09-05 | 公開日 | 2020-10-28 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.87 Å) | 主引用文献 | A-loop interactions in Mer tyrosine kinase give rise to inhibitors with two-step mechanism and long residence time of binding. Biochem.J., 477, 2020
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6Q87
| Structure of Fucosylated D-antimicrobial peptide SB10 in complex with the Fucose-binding lectin PA-IIL at 2.541 Angstrom resolution | 分子名称: | 3,7-anhydro-2,8-dideoxy-L-glycero-D-gluco-octonic acid, AMINO GROUP, CALCIUM ION, ... | 著者 | Baeriswyl, S, Stocker, A, Reymond, J.-L. | 登録日 | 2018-12-14 | 公開日 | 2019-03-20 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.541 Å) | 主引用文献 | X-ray Crystal Structures of Short Antimicrobial Peptides as Pseudomonas aeruginosa Lectin B Complexes. Acs Chem.Biol., 14, 2019
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7AB2
| Crystal structure of MerTK kinase domain in complex with UNC2025 | 分子名称: | 4-[2-(butylamino)-5-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-ol, CHLORIDE ION, DIMETHYL SULFOXIDE, ... | 著者 | Pflug, A, Schimpl, M, McCoull, W, Nissink, J.W.M, Overman, R.C, Rawlins, P.B, Truman, C, Underwood, E, Warwicker, J, Winter-Holt, J. | 登録日 | 2020-09-05 | 公開日 | 2020-10-28 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | 主引用文献 | A-loop interactions in Mer tyrosine kinase give rise to inhibitors with two-step mechanism and long residence time of binding. Biochem.J., 477, 2020
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7A8P
| Structure of human mitochondrial RNA polymerase in complex with IMT inhibitor. | 分子名称: | (3~{R})-1-[(2~{R})-2-[4-(2-chloranyl-4-fluoranyl-phenyl)-2-oxidanylidene-chromen-7-yl]oxypropanoyl]piperidine-3-carboxylic acid, DNA-directed RNA polymerase, mitochondrial | 著者 | Hillen, H.S, Bonekamp, N, Peter, B, Felser, A, Bergbrede, T, Choidas, A, Horn, M, Unger, A, di Lucrezia, R, Atanassov, I, Li, X, Koch, U, Menninger, S, Boros, J, Habenberger, P, Giavalisco, P, Cramer, P, Denzel, M, Nussbaumer, P, Klebl, B, Falkenberg, M, Gustafsson, C.M, Larsson, N.G. | 登録日 | 2020-08-30 | 公開日 | 2020-12-30 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Small-molecule inhibitors of human mitochondrial DNA transcription. Nature, 588, 2020
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