7NRC
| Structure of the yeast Gcn1 bound to a leading stalled 80S ribosome with Rbg2, Gir2, A- and P-tRNA and eIF5A | 分子名称: | 18S rRNA (1771-MER), 25S rRNA (3184-MER), 40S ribosomal protein S0-A, ... | 著者 | Pochopien, A.A, Beckert, B, Wilson, D.N. | 登録日 | 2021-03-03 | 公開日 | 2021-05-05 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Structure of Gcn1 bound to stalled and colliding 80S ribosomes. Proc.Natl.Acad.Sci.USA, 118, 2021
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5ND8
| Hibernating ribosome from Staphylococcus aureus (Unrotated state) | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | 著者 | Khusainov, I, Vicens, Q, Ayupov, R, Usachev, K, Myasnikov, A, Simonetti, A, Validov, S, Kieffer, B, Yusupova, G, Yusupov, M, Hashem, Y. | 登録日 | 2017-03-07 | 公開日 | 2017-06-28 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Structures and dynamics of hibernating ribosomes from Staphylococcus aureus mediated by intermolecular interactions of HPF. EMBO J., 36, 2017
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6WEO
| IL-22 Signaling Complex with IL-22R1 and IL-10Rbeta | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Saxton, R.A, Jude, K.M, Henneberg, L.T, Garcia, K.C. | 登録日 | 2020-04-02 | 公開日 | 2021-04-28 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | The tissue protective functions of interleukin-22 can be decoupled from pro-inflammatory actions through structure-based design. Immunity, 54, 2021
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6WPM
| Crystal structure of a putative oligosaccharide periplasmic-binding protein from Synechococcus sp. MITs9220 in complex with zinc | 分子名称: | 1,2-ETHANEDIOL, GLYCEROL, SULFATE ION, ... | 著者 | Ford, B.A, Michie, K.A, Paulsen, I.T, Mabbutt, B.C, Shah, B.S. | 登録日 | 2020-04-27 | 公開日 | 2021-05-12 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (2.88 Å) | 主引用文献 | Novel functional insights into a modified sugar-binding protein from Synechococcus MITS9220. Sci Rep, 12, 2022
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5NO4
| RsgA-GDPNP bound to the 30S ribosomal subunit (RsgA assembly intermediate with uS3) | 分子名称: | 16S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | 著者 | Lopez-Alonso, J.P, Kaminishi, T, Kikuchi, T, Hirata, Y, Iturrioz, I, Dhimole, N, Schedlbauer, A, Hase, Y, Goto, S, Kurita, D, Muto, A, Zhou, S, Naoe, C, Mills, D.J, Gil-Carton, D, Takemoto, C, Himeno, H, Fucini, P, Connell, S.R. | 登録日 | 2017-04-10 | 公開日 | 2017-05-31 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (5.16 Å) | 主引用文献 | RsgA couples the maturation state of the 30S ribosomal decoding center to activation of its GTPase pocket. Nucleic Acids Res., 45, 2017
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8P8M
| Yeast 60S ribosomal subunit, RPL39 deletion | 分子名称: | 25S rRNA, 5.8S rRNA, 5S rRNA, ... | 著者 | Rabl, J, Banerjee, A, Boehringer, D, Zavolan, M. | 登録日 | 2023-06-01 | 公開日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (2.66 Å) | 主引用文献 | Yeast 60S ribosomal subunit, RPL39 deletion To Be Published
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8P8U
| Yeast 60S ribosomal subunit | 分子名称: | 25S rRNA, 5.8S rRNA, 5S rRNA, ... | 著者 | Rabl, J, Banerjee, A, Boehringer, D, Zavolan, M. | 登録日 | 2023-06-02 | 公開日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (2.23 Å) | 主引用文献 | Yeast 60S ribosomal subunit To Be Published
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7ABU
| Structure of SARS-CoV-2 Main Protease bound to RS102895 | 分子名称: | 1'-[2-[4-(trifluoromethyl)phenyl]ethyl]spiro[1~{H}-3,1-benzoxazine-4,4'-piperidine]-2-one, 3C-like proteinase, DIMETHYL SULFOXIDE, ... | 著者 | Guenther, S, Reinke, P.Y.A, Oberthuer, D, Yefanov, O, Gelisio, L, Ginn, H, Lieske, J, Domaracky, M, Brehm, W, Rahmani Mashour, A, White, T.A, Knoska, J, Pena Esperanza, G, Koua, F, Tolstikova, A, Groessler, M, Fischer, P, Hennicke, V, Fleckenstein, H, Trost, F, Galchenkova, M, Gevorkov, Y, Li, C, Awel, S, Paulraj, L.X, Ullah, N, Falke, S, Alves Franca, B, Schwinzer, M, Brognaro, H, Werner, N, Perbandt, M, Tidow, H, Seychell, B, Beck, T, Meier, S, Doyle, J.J, Giseler, H, Melo, D, Lane, T.J, Dunkel, I, Peck, A, Saouane, S, Hakanpaeae, J, Meyer, J, Noei, H, Gribbon, P, Ellinger, B, Kuzikov, M, Wolf, M, Zhang, L, Ehrt, C, Pletzer-Zelgert, J, Wollenhaupt, J, Feiler, C, Weiss, M, Schulz, E.C, Mehrabi, P, Norton-Baker, B, Schmidt, C, Lorenzen, K, Schubert, R, Han, H, Chari, A, Fernandez Garcia, Y, Turk, D, Hilgenfeld, R, Rarey, M, Zaliani, A, Chapman, H.N, Pearson, A, Betzel, C, Meents, A. | 登録日 | 2020-09-08 | 公開日 | 2020-12-02 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease. Science, 372, 2021
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8PFR
| Mouse RPL39L integrated into the yeast 60S ribosomal subunit | 分子名称: | 25S rRNA, 5.8S rRNA, 5S rRNA, ... | 著者 | Rabl, J, Banerjee, A, Boehringer, D, Zavolan, M. | 登録日 | 2023-06-16 | 公開日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (2.15 Å) | 主引用文献 | Mouse RPL39L integrated into the yeast 60S ribosomal subunit To Be Published
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8DKV
| PPARg bound to JTP-426467 and Co-R peptide | 分子名称: | 2-chloro-N-[4-(5-methyl-1,3-benzoxazol-2-yl)phenyl]-5-nitrobenzamide, 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, Nuclear receptor corepressor 1, ... | 著者 | Larsen, N.A. | 登録日 | 2022-07-06 | 公開日 | 2022-09-07 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | 主引用文献 | Biochemical and structural basis for the pharmacological inhibition of nuclear hormone receptor PPAR gamma by inverse agonists. J.Biol.Chem., 298, 2022
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6US6
| Artificial Iron Proteins: Modelling the Active Sites in Non-Heme Dioxygenases | 分子名称: | ACETATE ION, Streptavidin, {N-(2-{bis[(pyridin-2-yl-kappaN)methyl]amino-kappaN}ethyl)-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide}iron(3+) | 著者 | Miller, K.R, Paretsky, J.D, Follmer, A.H, Heinisch, T, Mittra, K, Gul, S, Kim, I.-S, Fuller, F.D, Batyuk, A, Sutherlin, K.D, Brewster, A.S, Bhowmick, A, Sauter, N.K, Kern, J, Yano, J, Green, M.T, Ward, T.R, Borovik, A.S. | 登録日 | 2019-10-24 | 公開日 | 2020-05-06 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Artificial Iron Proteins: Modeling the Active Sites in Non-Heme Dioxygenases. Inorg.Chem., 59, 2020
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8DX4
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8USR
| IL17A homodimer complexed to Compound 23 | 分子名称: | Interleukin-17A, ~{N}-[(2~{S})-1-[[(1~{S})-1-(8~{a}~{H}-imidazo[1,2-a]pyrimidin-2-yl)ethyl]amino]-1-oxidanylidene-4-phenyl-butan-2-yl]-4,5-bis(chloranyl)-1~{H}-pyrrole-2-carboxamide | 著者 | Argiriadi, M.A, Ramos, A.L. | 登録日 | 2023-10-29 | 公開日 | 2024-04-03 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | 主引用文献 | Discovery of Small Molecule Interleukin 17A Inhibitors with Novel Binding Mode and Stoichiometry: Optimization of DNA-Encoded Chemical Library Hits to In Vivo Active Compounds. J.Med.Chem., 67, 2024
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8FMW
| The structure of a hibernating ribosome in the Lyme disease pathogen | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | 著者 | Sharma, M.R, Manjari, S.R, Agrawal, E.K, Keshavan, P, Koripella, R.K, Majumdar, S, Marcinkiewicz, A.L, Lin, Y.P, Agrawal, R.K, Banavali, N.K. | 登録日 | 2022-12-25 | 公開日 | 2023-11-08 | 実験手法 | ELECTRON MICROSCOPY (2.86 Å) | 主引用文献 | The structure of a hibernating ribosome in a Lyme disease pathogen. Nat Commun, 14, 2023
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5LYV
| The crystal structure of 7SK 5'-hairpin - Osmium derivative | 分子名称: | 7SK RNA, CHLORIDE ION, MAGNESIUM ION, ... | 著者 | Martinez-Zapien, D, Legrand, P, McEwen, A.G, Pasquali, S, Dock-Bregeon, A.-C. | 登録日 | 2016-09-28 | 公開日 | 2017-01-25 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | The crystal structure of the 5 functional domain of the transcription riboregulator 7SK. Nucleic Acids Res., 45, 2017
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8FN2
| The structure of a 50S ribosomal subunit in the Lyme disease pathogen Borreliella burgdorferi | 分子名称: | 23S ribosomal RNA, 50S ribosomal protein L10, 50S ribosomal protein L11, ... | 著者 | Sharma, M.R, Manjari, S.R, Agrawal, E.K, Keshavan, P, Koripella, R.K, Majumdar, S, Marcinkiewicz, A.L, Lin, Y.P, Agrawal, R.K, Banavali, N.K. | 登録日 | 2022-12-26 | 公開日 | 2023-11-08 | 最終更新日 | 2024-10-09 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | The structure of a hibernating ribosome in a Lyme disease pathogen. Nat Commun, 14, 2023
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6ZN8
| Crystal structure of the H. influenzae VapXD toxin-antitoxin complex | 分子名称: | Endoribonuclease VapD, VapX | 著者 | Bertelsen, M.B, Senissar, M, Nielsen, M.H, Bisiak, F, Cunha, M.V, Molinaro, A.L, Daines, D.A, Brodersen, D.E. | 登録日 | 2020-07-06 | 公開日 | 2020-11-04 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (3.211 Å) | 主引用文献 | Structural Basis for Toxin Inhibition in the VapXD Toxin-Antitoxin System. Structure, 29, 2021
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6UTM
| Native E. coli Glyceraldehyde 3-phosphate dehydrogenase | 分子名称: | GLYCEROL, Glyceraldehyde-3-phosphate dehydrogenase, SN-GLYCEROL-3-PHOSPHATE, ... | 著者 | Rodriguez-Hernandez, A, Romo-Arevalo, E, Rodriguez-Romero, A. | 登録日 | 2019-10-29 | 公開日 | 2019-12-11 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.14 Å) | 主引用文献 | A Novel Substrate-Binding Site in the X-Ray Structure of an Oxidized E. coli Glyceraldehyde 3-Phosphate Dehydrogenase Elucidated by Single-Wavelength Anomalous Dispersion Crystals, 9, 2019
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721P
| THREE-DIMENSIONAL STRUCTURES OF H-RAS P21 MUTANTS: MOLECULAR BASIS FOR THEIR INABILITY TO FUNCTION AS SIGNAL SWITCH MOLECULES | 分子名称: | H-RAS P21 PROTEIN, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | 著者 | Krengel, U, Scherer, A, Kabsch, W, Wittinghofer, A, Pai, E.F. | 登録日 | 1991-06-06 | 公開日 | 1994-01-31 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules. Cell(Cambridge,Mass.), 62, 1990
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8DSY
| PPARg bound to inverse agonist H3B-343 | 分子名称: | Peroxisome proliferator-activated receptor gamma, {5-[(5-{[(4-tert-butylphenyl)methyl]carbamoyl}-2,3-dimethyl-1H-indol-1-yl)methyl]-2-chlorophenoxy}acetic acid | 著者 | Larsen, N.A. | 登録日 | 2022-07-24 | 公開日 | 2022-09-07 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | 主引用文献 | Biochemical and structural basis for the pharmacological inhibition of nuclear hormone receptor PPAR gamma by inverse agonists. J.Biol.Chem., 298, 2022
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7OP7
| Bacteroides thetaiotaomicron mannosidase GH2 with beta-manno-configured N-alkyl cyclophellitol aziridine | 分子名称: | (1R,2S,3R,4S,5R,6R)-5-(8-azidooctylamino)-6-(hydroxymethyl)cyclohexane-1,2,3,4-tetrol, 1,2-ETHANEDIOL, BROMIDE ION, ... | 著者 | McGregor, N.G.S, Beenakker, T.J.M, Kuo, C, Wong, C, Offen, W.A, Armstrong, Z, Codee, J.D.C, Aerts, J.M.F.G, Florea, B.I, Overkleeft, H.S, Davies, G.J. | 登録日 | 2021-05-29 | 公開日 | 2022-02-02 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Synthesis of broad-specificity activity-based probes for exo -beta-mannosidases. Org.Biomol.Chem., 20, 2022
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8E5X
| Crystal structure of SARS-CoV-2 3CL protease in complex with a dimethyl sulfinyl benzene inhibitor | 分子名称: | (2~{S})-2-[[(2~{S})-4-methyl-2-[[2-methyl-2-[oxidanyl(phenyl)-$l^{3}-sulfanyl]propoxy]carbonylamino]pentanoyl]amino]-1-oxidanyl-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propane-1-sulfonic acid, 3C-like proteinase, N~2~-(ethoxycarbonyl)-N-{(1S,2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]-1-sulfanylpropan-2-yl}-L-leucinamide, ... | 著者 | Lovell, S, Machen, A.J, Battaile, K.P, Dampalla, C.S, Groutas, W.C. | 登録日 | 2022-08-22 | 公開日 | 2022-09-07 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structure-guided design of direct-acting antivirals that exploit the gem-dimethyl effect and potently inhibit 3CL proteases of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) and middle east respiratory syndrome coronavirus (MERS-CoV). Eur.J.Med.Chem., 254, 2023
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6ZOY
| Structure of Disulphide-stabilized SARS-CoV-2 Spike Protein Trimer (x1 disulphide-bond mutant, S383C, D985C, K986P, V987P, single Arg S1/S2 cleavage site) in Closed State | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | 著者 | Xiong, X, Qu, K, Scheres, S.H.W, Briggs, J.A.G. | 登録日 | 2020-07-08 | 公開日 | 2020-07-22 | 最終更新日 | 2021-06-02 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | A thermostable, closed SARS-CoV-2 spike protein trimer. Nat.Struct.Mol.Biol., 27, 2020
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8E9N
| Crystal structure of E. coli aspartate aminotransferase mutant VFIY in the ligand-free form at 278 K | 分子名称: | Aspartate aminotransferase, PYRIDOXAL-5'-PHOSPHATE, SULFATE ION | 著者 | Chica, R.A, St-Jacques, A.D, Rodriguez, J.M, Thompson, M.C. | 登録日 | 2022-08-26 | 公開日 | 2022-10-05 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | 主引用文献 | Computational remodeling of an enzyme conformational landscape for altered substrate selectivity. Nat Commun, 14, 2023
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8E9R
| Crystal structure of E. coli aspartate aminotransferase mutant VFCS in the ligand-free form at 278 K | 分子名称: | Aspartate aminotransferase, PYRIDOXAL-5'-PHOSPHATE, SULFATE ION | 著者 | Chica, R.A, St-Jacques, A.D, Rodriguez, J.M, Thompson, M.C. | 登録日 | 2022-08-26 | 公開日 | 2022-10-05 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Computational remodeling of an enzyme conformational landscape for altered substrate selectivity. Nat Commun, 14, 2023
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