6CSD
 
 | | V308E mutant of cytochrome P450 2D6 complexed with prinomastat | | 分子名称: | 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, Cytochrome P450 2D6, PROTOPORPHYRIN IX CONTAINING FE, ... | | 著者 | Yang, Y.T, Fujita, K, Wang, P.F, Im, S.C, Pearl, N.M, Meagher, J, Stuckey, J, Waskell, L. | | 登録日 | 2018-03-20 | | 公開日 | 2019-03-27 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.391 Å) | | 主引用文献 | Characteristic conformational changes on the distal and proximal surfaces of cytochrome P450 2D6 in response to substrate binding
To Be Published
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6CSB
 | | V308E mutant of cytochrome P450 2D6 complexed with thioridazine | | 分子名称: | 10-{2-[(2R)-1-methylpiperidin-2-yl]ethyl}-2-(methylsulfanyl)-10H-phenothiazine, ACETATE ION, Cytochrome P450 2D6, ... | | 著者 | Yang, Y.T, Fujita, K, Wang, P.F, Im, S.C, Pearl, N.M, Meagher, J, Stuckey, J, Waskell, L. | | 登録日 | 2018-03-20 | | 公開日 | 2019-03-27 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.394 Å) | | 主引用文献 | Characteristic conformational changes on the distal and proximal surfaces of cytochrome P450 2D6 in response to substrate binding
To Be Published
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1MJN
 | | Crystal Structure of the intermediate affinity aL I domain mutant | | 分子名称: | Integrin alpha-L, MAGNESIUM ION | | 著者 | Shimaoka, M, Xiao, T, Liu, J.H, Yang, Y.T, Dong, Y.C, Jun, C.D, McCormack, A, Zhang, R.G, Wang, J.H, Springer, T.A. | | 登録日 | 2002-08-28 | | 公開日 | 2003-01-28 | | 最終更新日 | 2021-10-27 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Structures of the alphaL I Domain and its Complex with ICAM-1 reveal a Shape-shifting Pathway for Integrin Regulation
Cell(Cambridge,Mass.), 112, 2003
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1NPE
 | | Crystal structure of Nidogen/Laminin Complex | | 分子名称: | CADMIUM ION, Laminin gamma-1 chain, nidogen | | 著者 | Takagi, J, Yang, Y.T, Liu, J.-H, Wang, J.-H, Springer, T.A. | | 登録日 | 2003-01-17 | | 公開日 | 2003-08-12 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Complex between nidogen and laminin fragments reveals a paradigmatic
beta-propeller interface
Nature, 424, 2003
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1SJ0
 | | Human Estrogen Receptor Alpha Ligand-binding Domain in Complex with the Antagonist Ligand 4-D | | 分子名称: | (2S,3R)-2-(4-(2-(PIPERIDIN-1-YL)ETHOXY)PHENYL)-2,3-DIHYDRO-3-(4-HYDROXYPHENYL)BENZO[B][1,4]OXATHIIN-6-OL, Estrogen receptor | | 著者 | Kim, S, Wu, J.Y, Birzin, E.T, Chan, W, Pai, L.Y, Yang, Y.T, Mosley, R.T, Fitzgerald, P.M, Sharma, N, DiNinno, F, Rohrer, S.P, Schaeffer, J.M, Hammond, M.L. | | 登録日 | 2004-03-02 | | 公開日 | 2004-04-27 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Estrogen Receptor Ligands. II. Discovery of Benzoxathiins as Potent, Selective Estrogen Receptor alpha Modulators.
J.Med.Chem., 47, 2004
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3DBQ
 | | Crystal structure of TTK kinase domain | | 分子名称: | Dual specificity protein kinase TTK | | 著者 | Wang, W, Yang, Y.T, Gao, Y.F, Zhu, S.C, Wang, F, Old, W, Xu, Q.B, Resing, K, Ahn, N, Lei, M, Liu, X.D. | | 登録日 | 2008-06-02 | | 公開日 | 2009-02-10 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structural and Mechanistic Insights into Mps1 Kinase Activation
J.CELL.MOL.MED., 13, 2008
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6BWW
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3X0T
 | | Crystal structure of PirA | | 分子名称: | NITRATE ION, Uncharacterized protein | | 著者 | Wang, H.C, Ko, T.P, Wang, A.H.J, Lo, C.F. | | 登録日 | 2014-10-22 | | 公開日 | 2015-08-26 | | 最終更新日 | 2022-08-24 | | 実験手法 | X-RAY DIFFRACTION (1.17 Å) | | 主引用文献 | The opportunistic marine pathogen Vibrio parahaemolyticus becomes virulent by acquiring a plasmid that expresses a deadly toxin.
Proc.Natl.Acad.Sci.USA, 112, 2015
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3X0U
 | | Crystal structure of PirB | | 分子名称: | Uncharacterized protein | | 著者 | Wang, H.C, Ko, T.P, Wang, A.H.J, Lo, C.F. | | 登録日 | 2014-10-22 | | 公開日 | 2015-08-26 | | 最終更新日 | 2022-08-24 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | The opportunistic marine pathogen Vibrio parahaemolyticus becomes virulent by acquiring a plasmid that expresses a deadly toxin.
Proc.Natl.Acad.Sci.USA, 112, 2015
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1XP1
 | | HUMAN ESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH COMPOUND 15 | | 分子名称: | (2S,3R)-2-(4-{2-[(3R,4R)-3,4-DIMETHYLPYRROLIDIN-1-YL]ETHOXY}PHENYL)-3-(4-HYDROXYPHENYL)-2,3-DIHYDRO-1,4-BENZOXATHIIN-6- OL, Estrogen receptor | | 著者 | Fitzgerald, P.M.D, Sharma, N. | | 登録日 | 2004-10-07 | | 公開日 | 2004-12-07 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Estrogen receptor ligands. Part 9: Dihydrobenzoxathiin SERAMs with alkyl substituted pyrrolidine side chains and linkers.
Bioorg.Med.Chem.Lett., 15, 2005
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1XPC
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1XP9
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1XP6
 | | HUMAN ESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH COMPOUND 16 | | 分子名称: | (2S,3R)-2-(4-{2-[(3S,4S)-3,4-DIMETHYLPYRROLIDIN-1-YL]ETHOXY}PHENYL)-3-(4-HYDROXYPHENYL)-2,3-DIHYDRO-1,4-BENZOXATHIIN-6-OL, Estrogen receptor | | 著者 | Fitzgerald, P.M.D, Sharma, N. | | 登録日 | 2004-10-08 | | 公開日 | 2004-12-07 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Estrogen receptor ligands. Part 9: Dihydrobenzoxathiin SERAMs with alkyl substituted pyrrolidine side chains and linkers.
Bioorg.Med.Chem.Lett., 15, 2005
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1YIM
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1YIN
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3L82
 | | X-ray Crystal structure of TRF1 and Fbx4 complex | | 分子名称: | F-box only protein 4, Telomeric repeat-binding factor 1 | | 著者 | Zeng, Z.X, Wang, W, Yang, Y.T, Chen, Y, Yang, X.M, Diehl, J.A, Liu, X.D, Lei, M. | | 登録日 | 2009-12-29 | | 公開日 | 2010-03-09 | | 最終更新日 | 2013-09-25 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural Basis of Selective Ubiquitination of TRF1 by SCF(Fbx4)
Dev.Cell, 18, 2010
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3K6G
 | | Crystal structure of Rap1 and TRF2 complex | | 分子名称: | Telomeric repeat-binding factor 2, Telomeric repeat-binding factor 2-interacting protein 1 | | 著者 | Chen, Y, Rai, R, Yang, Y.T, Zheng, H, Chang, S, Lei, M. | | 登録日 | 2009-10-08 | | 公開日 | 2010-10-13 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms.
Nat.Struct.Mol.Biol., 18, 2011
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3KF6
 | | Crystal structure of S. pombe Stn1-ten1 complex | | 分子名称: | Protein stn1, Protein ten1 | | 著者 | Sun, J, Yu, E.Y, Yang, Y.T, Confer, L.A, Sun, S.H, Wan, K, Lue, N.F, Lei, M. | | 登録日 | 2009-10-27 | | 公開日 | 2009-12-22 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Stn1-Ten1 is an Rpa2-Rpa3-like complex at telomeres.
Genes Dev., 23, 2009
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3KEY
 | | Crystal structure of S. cerevisiae Stn1 C-terminal | | 分子名称: | Protein STN1 | | 著者 | Sun, J, Yu, E.Y, Yang, Y.T, Confer, L.A, Sun, S.H, Wan, K, Lue, N.F, Lei, M. | | 登録日 | 2009-10-26 | | 公開日 | 2009-12-22 | | 最終更新日 | 2017-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Stn1-Ten1 is an Rpa2-Rpa3-like complex at telomeres.
Genes Dev., 23, 2009
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3KF8
 | | Crystal structure of C. tropicalis Stn1-ten1 complex | | 分子名称: | Protein stn1, Protein ten1 | | 著者 | Sun, J, Yu, E.Y, Yang, Y.T, Confer, L.A, Sun, S.H, Wan, K, Lue, N.F, Lei, M. | | 登録日 | 2009-10-27 | | 公開日 | 2009-12-22 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Stn1-Ten1 is an Rpa2-Rpa3-like complex at telomeres.
Genes Dev., 23, 2009
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1T0P
 | | Structural Basis of ICAM recognition by integrin alpahLbeta2 revealed in the complex structure of binding domains of ICAM-3 and alphaLbeta2 at 1.65 A | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Integrin alpha-L, Intercellular adhesion molecule-3, ... | | 著者 | Song, G, Yang, Y.T, Liu, J.H, Shimaoko, M, Springer, T.A, Wang, J.H. | | 登録日 | 2004-04-12 | | 公開日 | 2005-03-08 | | 最終更新日 | 2021-10-27 | | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | | 主引用文献 | An atomic resolution view of ICAM recognition in a complex between the binding domains of ICAM-3 and integrin alphaLbeta2.
Proc.Natl.Acad.Sci.Usa, 102, 2005
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2IOG
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2IOK
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2HKO
 | | Crystal structure of LSD1 | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, Lysine-specific histone demethylase 1 | | 著者 | Chen, Y, Yang, Y.T, Wang, F, Yanane, K, Zhang, Y, Lei, M. | | 登録日 | 2006-07-05 | | 公開日 | 2006-08-29 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Crystal structure of human histone lysine-specific demethylase 1 (LSD1).
Proc.Natl.Acad.Sci.Usa, 103, 2006
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2I46
 | | Crystal structure of human TPP1 | | 分子名称: | Adrenocortical dysplasia protein homolog | | 著者 | Wang, F, Podell, E.R, Zaug, A.J, Yang, Y.T, Baciu, P, Else, T, Hammer, G.D, Cech, T.R, Lei, M. | | 登録日 | 2006-08-21 | | 公開日 | 2006-11-28 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | The POT1-TPP1 telomere complex is a telomerase processivity factor.
Nature, 445, 2007
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