2IOK
Human estrogen receptor alpha ligand-binding domain in complex with compound 1D
Summary for 2IOK
Entry DOI | 10.2210/pdb2iok/pdb |
Related | 2IOG |
Descriptor | Estrogen receptor, N-[(1R)-3-(4-HYDROXYPHENYL)-1-METHYLPROPYL]-2-(2-PHENYL-1H-INDOL-3-YL)ACETAMIDE (3 entities in total) |
Functional Keywords | nuclear receptor, transcription factor, er-alpha, antagonist, transcription |
Biological source | Homo sapiens (human) |
Cellular location | Isoform 1: Nucleus. Isoform 3: Nucleus: P03372 |
Total number of polymer chains | 2 |
Total formula weight | 58749.19 |
Authors | Fitzgerald, P.M.D.,Sharma, N. (deposition date: 2006-10-10, release date: 2007-10-09, Last modification date: 2023-08-30) |
Primary citation | Dykstra, K.D.,Guo, L.,Birzin, E.T.,Chan, W.,Yang, Y.T.,Hayes, E.C.,DaSilva, C.A.,Pai, L.-Y.,Mosley, R.T.,Kraker, B.,Fitzgerald, P.M.D.,DiNinno, F.,Rohrer, S.P.,Schaeffer, J.M.,Hammond, M.L. Estrogen receptor ligands. Part 16: 2-Aryl indoles as highly subtype selective ligands for ERalpha Bioorg.Med.Chem.Lett., 17:2322-2328, 2007 Cited by PubMed: 17289385DOI: 10.1016/j.bmcl.2007.01.054 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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