2IOK
Human estrogen receptor alpha ligand-binding domain in complex with compound 1D
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE IOK A 600 |
| Chain | Residue |
| A | MET343 |
| A | LEU428 |
| A | HIS524 |
| A | LEU525 |
| A | LEU349 |
| A | ALA350 |
| A | GLU353 |
| A | LEU384 |
| A | MET388 |
| A | PHE404 |
| A | VAL418 |
| A | MET421 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE IOK B 1600 |
| Chain | Residue |
| B | LEU1349 |
| B | GLU1353 |
| B | LEU1384 |
| B | MET1388 |
| B | GLU1419 |
| B | ILE1424 |
| B | LEU1428 |
| B | GLY1521 |
| B | HIS1524 |
| B | LEU1525 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:9338790, ECO:0000269|PubMed:9600906, ECO:0007744|PDB:1A52, ECO:0007744|PDB:1ERE |
| Chain | Residue | Details |
| A | GLU353 | |
| A | ARG394 | |
| A | HIS524 | |
| B | GLU1353 | |
| B | ARG1394 | |
| B | HIS1524 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine; by Tyr-kinases => ECO:0000269|PubMed:7539106 |
| Chain | Residue | Details |
| A | TYR537 | |
| B | TYR1537 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000250 |
| Chain | Residue | Details |
| A | CYS447 | |
| B | CYS1447 |
