2IOK
Human estrogen receptor alpha ligand-binding domain in complex with compound 1D
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE IOK A 600 |
| Chain | Residue |
| A | MET343 |
| A | LEU428 |
| A | HIS524 |
| A | LEU525 |
| A | LEU349 |
| A | ALA350 |
| A | GLU353 |
| A | LEU384 |
| A | MET388 |
| A | PHE404 |
| A | VAL418 |
| A | MET421 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE IOK B 1600 |
| Chain | Residue |
| B | LEU1349 |
| B | GLU1353 |
| B | LEU1384 |
| B | MET1388 |
| B | GLU1419 |
| B | ILE1424 |
| B | LEU1428 |
| B | GLY1521 |
| B | HIS1524 |
| B | LEU1525 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"9338790","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9600906","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1A52","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ERE","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphotyrosine; by Tyr-kinases","evidences":[{"source":"PubMed","id":"7539106","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
