7WM4
 
 | | Cryo-EM structure of tetrameric TLR3 in complex with dsRNA (90 bp) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, RNA (81-MER), ... | | Authors: | Sakaniwa, K, Ohto, U, Shimizu, T. | | Deposit date: | 2022-01-14 | | Release date: | 2023-01-25 | | Last modified: | 2023-08-30 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | TLR3 forms a laterally aligned multimeric complex along double-stranded RNA for efficient signal transduction.
Nat Commun, 14, 2023
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7WSI
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7VES
 | | Crystal Structure of nucleotide-free Irgb6 | | Descriptor: | T-cell-specific guanine nucleotide triphosphate-binding protein 2 | | Authors: | Saijo-Hamano, Y, Sakai, N, Nitta, R. | | Deposit date: | 2021-09-10 | | Release date: | 2021-11-03 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural basis of membrane recognition of Toxoplasma gondii vacuole by Irgb6.
Life Sci Alliance, 5, 2022
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7VEX
 | | Crystal Structure of GTP-bound Irgb6 | | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, T-cell-specific guanine nucleotide triphosphate-binding protein 2 | | Authors: | Saijo-Hamano, Y, Sakai, N, Nitta, R. | | Deposit date: | 2021-09-10 | | Release date: | 2021-11-03 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.51 Å) | | Cite: | Structural basis of membrane recognition of Toxoplasma gondii vacuole by Irgb6.
Life Sci Alliance, 5, 2022
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1ZAB
 | | Crystal Structure of Mouse Cytidine Deaminase Complexed with 3-Deazauridine | | Descriptor: | 1-((2R,3R,4S,5R)-TETRAHYDRO-3,4-DIHYDROXY-5-(HYDROXYMETHYL)FURAN-2-YL)PYRIDINE-2,4(1H,3H)-DIONE, Cytidine deaminase, SULFATE ION, ... | | Authors: | Teh, A.H. | | Deposit date: | 2005-04-06 | | Release date: | 2006-04-11 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.36 Å) | | Cite: | The 1.48 A Resolution Crystal Structure of the Homotetrameric Cytidine Deaminase from Mouse
Biochemistry, 45, 2006
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8Q4L
 | | GBP1 bound by 14-3-3sigma | | Descriptor: | 14-3-3 protein sigma, Guanylate-binding protein 1 | | Authors: | Pfleiderer, M.M, Liu, X, Fisch, D, Anastasakou, E, Frickel, E.M, Galej, W.P. | | Deposit date: | 2023-08-07 | | Release date: | 2023-10-11 | | Last modified: | 2023-10-18 | | Method: | ELECTRON MICROSCOPY (5.12 Å) | | Cite: | PIM1 controls GBP1 activity to limit self-damage and to guard against pathogen infection.
Science, 382, 2023
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3TDC
 | | Crystal Structure of Human Acetyl-CoA carboxylase 2 | | Descriptor: | 1-[3-({4-[(5S)-3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl]piperidin-1-yl}carbonyl)-1-benzothiophen-2-yl]-3-ethylurea, Acetyl-CoA carboxylase 2 variant | | Authors: | Dougan, D.R, Mol, C.D. | | Deposit date: | 2011-08-10 | | Release date: | 2011-10-12 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.41 Å) | | Cite: | Design, synthesis, and structure-activity relationships of spirolactones bearing 2-ureidobenzothiophene as acetyl-CoA carboxylases inhibitors.
Bioorg.Med.Chem.Lett., 21, 2011
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3WTW
 | | Crystal structure of the complex comprised of ETS1(K167A), RUNX1, CBFBETA, and the tcralpha gene enhancer DNA | | Descriptor: | Core-binding factor subunit beta, DNA (5'-D(*AP*GP*AP*GP*GP*AP*TP*GP*TP*GP*GP*CP*TP*TP*C)-3'), DNA (5'-D(*GP*AP*AP*GP*CP*CP*AP*CP*AP*TP*CP*CP*TP*CP*T)-3'), ... | | Authors: | Shiina, M, Hamada, K, Ogata, K. | | Deposit date: | 2014-04-21 | | Release date: | 2014-08-20 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | A novel allosteric mechanism on protein-DNA interactions underlying the phosphorylation-dependent regulation of Ets1 target gene expressions.
J.Mol.Biol., 427, 2015
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6AK3
 | | Crystal structure of the human prostaglandin E receptor EP3 bound to prostaglandin E2 | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, (Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxo-cyclopentyl]hept-5-enoic acid, Prostaglandin E2 receptor EP3 subtype,Soluble cytochrome b562 | | Authors: | Morimoto, K, Suno, R, Iwata, S, Kobayashi, T. | | Deposit date: | 2018-08-29 | | Release date: | 2018-12-05 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Crystal structure of the endogenous agonist-bound prostanoid receptor EP3.
Nat. Chem. Biol., 15, 2019
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1DDZ
 | | X-RAY STRUCTURE OF A BETA-CARBONIC ANHYDRASE FROM THE RED ALGA, PORPHYRIDIUM PURPUREUM R-1 | | Descriptor: | CARBONIC ANHYDRASE, ZINC ION | | Authors: | Mitsuhashi, S, Mizushima, T, Yamashita, E, Miyachi, S, Tsukihara, T. | | Deposit date: | 1999-11-12 | | Release date: | 2000-03-08 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | X-ray structure of beta-carbonic anhydrase from the red alga, Porphyridium purpureum, reveals a novel catalytic site for CO(2) hydration.
J.Biol.Chem., 275, 2000
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1EWT
 | | CRYSTAL STRUCTURE OF METABOTROPIC GLUTAMATE RECEPTOR SUBTYPE 1 LIGAND FREE FORM I | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, METABOTROPIC GLUTAMATE RECEPTOR SUBTYPE 1, SULFATE ION | | Authors: | Kunishima, N, Shimada, Y, Tsuji, Y, Jingami, H, Morikawa, K. | | Deposit date: | 2000-04-27 | | Release date: | 2000-12-18 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (3.7 Å) | | Cite: | Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor.
Nature, 407, 2000
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2EFL
 | | Crystal structure of the EFC domain of formin-binding protein 17 | | Descriptor: | Formin-binding protein 1 | | Authors: | Shimada, A, Niwa, H, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2007-02-23 | | Release date: | 2007-05-29 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.61 Å) | | Cite: | Curved EFC/F-BAR-Domain Dimers Are Joined End to End into a Filament for Membrane Invagination in Endocytosis
Cell(Cambridge,Mass.), 129, 2007
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5B2G
 | | Crystal structure of human claudin-4 in complex with C-terminal fragment of Clostridium perfringens enterotoxin | | Descriptor: | Endolysin,Claudin-4, Heat-labile enterotoxin B chain | | Authors: | Shinoda, T, Kimura-Someya, T, Shirouzu, M, Yokoyama, S. | | Deposit date: | 2016-01-15 | | Release date: | 2016-10-05 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Structural basis for disruption of claudin assembly in tight junctions by an enterotoxin
Sci Rep, 6, 2016
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3VU3
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2EFK
 | | Crystal structure of the EFC domain of Cdc42-interacting protein 4 | | Descriptor: | Cdc42-interacting protein 4 | | Authors: | Shimada, A, Niwa, H, Chen, L, Liu, Z.-J, Wang, B.-C, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2007-02-23 | | Release date: | 2007-05-29 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Curved EFC/F-BAR-Domain Dimers Are Joined End to End into a Filament for Membrane Invagination in Endocytosis
Cell(Cambridge,Mass.), 129, 2007
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5BOH
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1EWV
 | | CRYSTAL STRUCTURE OF METABOTROPIC GLUTAMATE RECEPTOR SUBTYPE 1 LIGAND FREE FORM II | | Descriptor: | METABOTROPIC GLUTAMATE RECEPTOR SUBTYPE 1 | | Authors: | Kunishima, N, Shimada, Y, Tsuji, Y, Jingami, H, Morikawa, K. | | Deposit date: | 2000-04-27 | | Release date: | 2000-12-18 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (4 Å) | | Cite: | Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor.
Nature, 407, 2000
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1EWK
 | | CRYSTAL STRUCTURE OF METABOTROPIC GLUTAMATE RECEPTOR SUBTYPE 1 COMPLEXED WITH GLUTAMATE | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLUTAMIC ACID, ... | | Authors: | Kunishima, N, Shimada, Y, Jingami, H, Morikawa, K. | | Deposit date: | 2000-04-26 | | Release date: | 2000-12-18 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor.
Nature, 407, 2000
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4ZWB
 | | Crystal structure of maltose-bound human GLUT3 in the outward-occluded conformation at 2.4 angstrom | | Descriptor: | Solute carrier family 2, facilitated glucose transporter member 3, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | | Authors: | Deng, D, Sun, P.C, Yan, C.Y, Yan, N. | | Deposit date: | 2015-05-19 | | Release date: | 2015-07-22 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Molecular basis of ligand recognition and transport by glucose transporters
Nature, 526, 2015
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4ZWC
 | | Crystal structure of maltose-bound human GLUT3 in the outward-open conformation at 2.6 angstrom | | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Solute carrier family 2, facilitated glucose transporter member 3, ... | | Authors: | Deng, D, Sun, P.C, Yan, C.Y, Yan, N. | | Deposit date: | 2015-05-19 | | Release date: | 2015-07-22 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Molecular basis of ligand recognition and transport by glucose transporters
Nature, 526, 2015
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4ZW9
 | | Crystal structure of human GLUT3 bound to D-glucose in the outward-occluded conformation at 1.5 angstrom | | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Solute carrier family 2, facilitated glucose transporter member 3, ... | | Authors: | Deng, D, Sun, P.C, Yan, C.Y, Yan, N. | | Deposit date: | 2015-05-19 | | Release date: | 2015-07-22 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.502 Å) | | Cite: | Molecular basis of ligand recognition and transport by glucose transporters
Nature, 526, 2015
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1WQS
 | | Crystal structure of Norovirus 3C-like protease | | Descriptor: | 3C-like protease, D(-)-TARTARIC ACID, L(+)-TARTARIC ACID, ... | | Authors: | Nakamura, K, Someya, Y, Kumasaka, T, Tanaka, N. | | Deposit date: | 2004-10-01 | | Release date: | 2005-10-04 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | A norovirus protease structure provides insights into active and substrate binding site integrity
J.Virol., 79, 2005
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8JS5
 | | Dimeric PAS domains of oxygen sensor FixL with ferric unliganded heme | | Descriptor: | GLYCEROL, PROTOPORPHYRIN IX CONTAINING FE, Sensor protein FixL | | Authors: | Kamaya, M, Koteishi, H, Sawai, H, Sugimoto, H, Shiro, Y. | | Deposit date: | 2023-06-19 | | Release date: | 2024-06-26 | | Method: | X-RAY DIFFRACTION (2.95 Å) | | Cite: | Dimeric PAS domains of oxygen sensor FixL in complex with imidazole-bound heme.
To be published
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8JS7
 | | Dimeric PAS domains of oxygen sensor FixL in complex with imidazole-bound heme | | Descriptor: | GLYCEROL, IMIDAZOLE, PROTOPORPHYRIN IX CONTAINING FE, ... | | Authors: | Kamaya, M, Koteishi, H, Sawai, H, Sugimoto, H, Shiro, Y. | | Deposit date: | 2023-06-19 | | Release date: | 2024-06-26 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | Dimeric PAS domains of oxygen sensor FixL in complex with imidazole-bound heme.
To be published
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8JS6
 | | Dimeric PAS domains of oxygen sensor FixL in complex with cyanide-bound ferric heme | | Descriptor: | CYANIDE ION, GLYCEROL, PROTOPORPHYRIN IX CONTAINING FE, ... | | Authors: | Kamaya, M, Koteishi, H, Sawai, H, Sugimoto, H, Shiro, Y. | | Deposit date: | 2023-06-19 | | Release date: | 2024-06-26 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Dimeric PAS domains of oxygen sensor FixL in complex with imidazole-bound heme.
To be published
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