5KYK
 
 | | Covalent GTP-competitive inhibitors of KRAS G12C: Guanosine bisphosphonate Analogs | | 分子名称: | 5'-O-[(R)-[({2-[(chloroacetyl)amino]ethyl}sulfamoyl)methyl](hydroxy)phosphoryl]guanosine, GTPase KRas | | 著者 | Xiong, Y, Lu, J, Hunter, J, Li, L, Scott, D, Manandhar, A, Gondi, S, Westover, K.D, Gray, N.S. | | 登録日 | 2016-07-21 | | 公開日 | 2017-04-12 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.702 Å) | | 主引用文献 | Covalent Guanosine Mimetic Inhibitors of G12C KRAS.
ACS Med Chem Lett, 8, 2017
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1DQH
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1DQF
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2PFF
 | | Structural Insights of Yeast Fatty Acid Synthase | | 分子名称: | Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta, Tail protein | | 著者 | Xiong, Y, Lomakin, I.B, Steitz, T.A. | | 登録日 | 2007-04-04 | | 公開日 | 2007-07-10 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (4 Å) | | 主引用文献 | Structural Insights of Yeast Fatty Acid Synthase
Cell(Cambridge,Mass.), 129, 2007
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1R89
 | | Crystal Structures of an Archaeal Class I CCA-Adding Enzyme and Its Nucleotide Complexes | | 分子名称: | CHLORIDE ION, CYTIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Xiong, Y, Li, F, Wang, J, Weiner, A.M, Steitz, T.A. | | 登録日 | 2003-10-23 | | 公開日 | 2003-12-16 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Crystal structures of an archaeal class I CCA-adding enzyme and its nucleotide complexes
Mol.Cell, 12, 2003
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1R8C
 | | Crystal Structures of an Archaeal Class I CCA-Adding Enzyme and Its Nucleotide | | 分子名称: | MANGANESE (II) ION, SODIUM ION, URIDINE 5'-TRIPHOSPHATE, ... | | 著者 | Xiong, Y, Li, F, Wang, J, Weiner, A.M, Steitz, T.A. | | 登録日 | 2003-10-23 | | 公開日 | 2003-12-16 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Crystal structures of an archaeal class I CCA-adding enzyme and its nucleotide complexes
Mol.Cell, 12, 2003
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1R8A
 | | Crystal Structures of an Archaeal Class I CCA-Adding Enzyme and Its Nucleotide Complexes | | 分子名称: | MANGANESE (II) ION, SODIUM ION, tRNA nucleotidyltransferase | | 著者 | Xiong, Y, Li, F, Wang, J, Weiner, A.M, Steitz, T.A. | | 登録日 | 2003-10-23 | | 公開日 | 2003-12-16 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystal structures of an archaeal class I CCA-adding enzyme and its nucleotide complexes
Mol.Cell, 12, 2003
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1R8B
 | | Crystal Structures of an Archaeal Class I CCA-Adding Enzyme and Its Nucleotide | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, MAGNESIUM ION, ... | | 著者 | Xiong, Y, Li, F, Wang, J, Weiner, A.M, Steitz, T.A. | | 登録日 | 2003-10-23 | | 公開日 | 2003-12-16 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal structures of an archaeal class I CCA-adding enzyme and its nucleotide complexes
Mol.Cell, 12, 2003
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1TFW
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1SZ1
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1TFY
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1J9H
 | | Crystal Structure of an RNA Duplex with Uridine Bulges | | 分子名称: | 5'-R(*GP*UP*GP*UP*CP*GP*(CBR)P*AP*C)-3', CALCIUM ION | | 著者 | Xiong, Y, Deng, J, Sudarsanakumar, C, Sundaralingam, M. | | 登録日 | 2001-05-25 | | 公開日 | 2001-10-26 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Crystal structure of an RNA duplex r(gugucgcac)(2) with uridine bulges.
J.Mol.Biol., 313, 2001
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1JZV
 | | Crystal structure of a bulged RNA from the SL2 stem-loop of the HIV-1 psi-RNA | | 分子名称: | 5'-R(*CP*AP*GP*UP*AP*CP*GP*(5IC)P*C)-3', 5'-R(*GP*GP*CP*GP*AP*CP*(5BU)P*G)-3', MAGNESIUM ION | | 著者 | Xiong, Y, Sudarsanakumar, C, Deng, J, Pan, B, Sundaralingam, M. | | 登録日 | 2001-09-17 | | 公開日 | 2003-11-11 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Crystal Structure of a Bulged RNA from the SL2 Stem-loop of the HIV-1 psi-RNA
To be Published
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479D
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421D
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4WHJ
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8WW2
 | | GPR3/Gs complex | | 分子名称: | CHOLESTEROL HEMISUCCINATE, G-protein coupled receptor 3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | He, Y, Xiong, Y. | | 登録日 | 2023-10-24 | | 公開日 | 2024-02-14 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (2.79 Å) | | 主引用文献 | Identification of oleic acid as an endogenous ligand of GPR3.
Cell Res., 34, 2024
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6QPL
 | | Crystal structure of Spindlin1 in complex with the inhibitor MS31 | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, DIMETHYL SULFOXIDE, GLYCEROL, ... | | 著者 | Johansson, C, Krojer, T, Xiong, Y, Jin, J, Arrowsmith, C.H, Bountra, C, Edwards, A, Oppermann, U.C.T. | | 登録日 | 2019-02-14 | | 公開日 | 2019-07-17 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1 (SPIN1).
J.Med.Chem., 62, 2019
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3G8Q
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3MQB
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3MQ7
 | | Crystal Structure of Ectodomain Mutant of BST-2/Tetherin/CD317 | | 分子名称: | Bone marrow stromal antigen 2, CALCIUM ION | | 著者 | Xiong, Y, Yang, H, Wang, J, Meng, W. | | 登録日 | 2010-04-27 | | 公開日 | 2010-10-27 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | | 主引用文献 | Structural insight into the mechanisms of enveloped virus tethering by tetherin.
Proc.Natl.Acad.Sci.USA, 107, 2010
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3MQ9
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3MQC
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5TTF
 | | Crystal structure of catalytic domain of G9a with MS012 | | 分子名称: | CHLORIDE ION, Histone-lysine N-methyltransferase EHMT2, N4-(1-methylpiperidin-4-yl)-N2-hexyl-6,7-dimethoxyquinazoline-2,4-diamine, ... | | 著者 | DONG, A, ZENG, H, LIU, J, XIONG, Y, BABAULT, N, JIN, J, TEMPEL, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, WU, H, BROWN, P.J, Structural Genomics Consortium (SGC) | | 登録日 | 2016-11-03 | | 公開日 | 2016-12-21 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | | 主引用文献 | Discovery of Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase.
J. Med. Chem., 60, 2017
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5TUY
 | | Structure of human G9a SET-domain (EHMT2) in complex with inhibitor MS0124 | | 分子名称: | 6,7-dimethoxy-N-(1-methylpiperidin-4-yl)-2-(morpholin-4-yl)quinazolin-4-amine, Histone-lysine N-methyltransferase EHMT2, S-ADENOSYLMETHIONINE, ... | | 著者 | Babault, N, Xiong, Y, Liu, J, Jin, J. | | 登録日 | 2016-11-07 | | 公開日 | 2017-02-22 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Discovery of Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase.
J. Med. Chem., 60, 2017
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