1E50
 
 | | AML1/CBFbeta complex | | 分子名称: | CORE-BINDING FACTOR ALPHA SUBUNIT, CORE-BINDING FACTOR CBF-BETA | | 著者 | Warren, A.J, Bravo, J, Williams, R.L, Rabbits, T.H. | | 登録日 | 2000-07-13 | | 公開日 | 2001-07-12 | | 最終更新日 | 2018-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structural Basis for the Heterodimeric Interaction between the Acute Leukaemia-Associated Transcription Factors Aml1 and Cbfbeta
Embo J., 19, 2000
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4ZXR
 | | Structure of Thaumatin wrapped in graphene within vacuum | | 分子名称: | GLYCEROL, L(+)-TARTARIC ACID, Thaumatin-1 | | 著者 | Aller, P, Warren, A.J, Trincao, J, Evans, G. | | 登録日 | 2015-05-20 | | 公開日 | 2015-10-14 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | | 主引用文献 | In vacuo X-ray data collection from graphene-wrapped protein crystals.
Acta Crystallogr.,Sect.D, 71, 2015
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6QKL
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7QH6
 | | Cryo-EM structure of the human mtLSU assembly intermediate upon MRM2 depletion - class 1 | | 分子名称: | 16S ribosomal RNA, 39S ribosomal protein L13, mitochondrial, ... | | 著者 | Rebelo-Guiomar, P, Pellegrino, S, Dent, K.C, Warren, A.J, Minczuk, M. | | 登録日 | 2021-12-10 | | 公開日 | 2022-03-02 | | 実験手法 | ELECTRON MICROSCOPY (3.08 Å) | | 主引用文献 | A late-stage assembly checkpoint of the human mitochondrial ribosome large subunit.
Nat Commun, 13, 2022
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7QH7
 | | Cryo-EM structure of the human mtLSU assembly intermediate upon MRM2 depletion - class 4 | | 分子名称: | 16S ribosomal RNA, 39S ribosomal protein L10, mitochondrial, ... | | 著者 | Rebelo-Guiomar, P, Pellegrino, S, Dent, K.C, Warren, A.J, Minczuk, M. | | 登録日 | 2021-12-10 | | 公開日 | 2022-05-18 | | 実験手法 | ELECTRON MICROSCOPY (2.89 Å) | | 主引用文献 | A late-stage assembly checkpoint of the human mitochondrial ribosome large subunit.
Nat Commun, 13, 2022
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7R4X
 | | Cryo-EM reconstruction of the human 40S ribosomal subunit - Full map | | 分子名称: | 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | | 著者 | Pellegrino, S, Dent, K.C, Spikes, T, Warren, A.J. | | 登録日 | 2022-02-09 | | 公開日 | 2023-02-22 | | 最終更新日 | 2024-04-24 | | 実験手法 | ELECTRON MICROSCOPY (2.15 Å) | | 主引用文献 | Cryo-EM reconstruction of the human 40S ribosomal subunit at 2.15 angstrom resolution.
Nucleic Acids Res., 51, 2023
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8BP2
 | | 2.8A STRUCTURE OF ZOLIFLODACIN WITH S.AUREUS DNA GYRASE AND DNA | | 分子名称: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DNA (20-MER), DNA gyrase subunit A, ... | | 著者 | Bax, B.D, Morgan, H, Warren, A.J. | | 登録日 | 2022-11-15 | | 公開日 | 2023-02-08 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | A 2.8 angstrom Structure of Zoliflodacin in a DNA Cleavage Complex with Staphylococcus aureus DNA Gyrase.
Int J Mol Sci, 24, 2023
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8A3D
 | | Human mature large subunit of the ribosome with eIF6 and homoharringtonine bound | | 分子名称: | (3beta)-O~3~-[(2R)-2,6-dihydroxy-2-(2-methoxy-2-oxoethyl)-6-methylheptanoyl]cephalotaxine, 28S ribosomal RNA, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | | 著者 | Faille, A, Warren, A.J, Dent, K.C. | | 登録日 | 2022-06-08 | | 公開日 | 2023-03-08 | | 最終更新日 | 2023-03-22 | | 実験手法 | ELECTRON MICROSCOPY (1.67 Å) | | 主引用文献 | The chemical landscape of the human ribosome at 1.67 angstrom resolution.
Biorxiv, 2023
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7OW7
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4H7W
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8B2T
 | | SARS-CoV-2 Main Protease (Mpro) in complex with nirmatrelvir alkyne | | 分子名称: | 3C-like proteinase nsp5, Nirmatrelvir (reacted form) | | 著者 | Owen, C.D, Crawshaw, A.D, Warren, A.J, Trincao, J, Zhao, Y, Brewitz, L, Malla, T.R, Salah, E, Petra, L, Strain-Damerell, C, Schofield, C.J, Walsh, M.A. | | 登録日 | 2022-09-14 | | 公開日 | 2023-02-22 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.893 Å) | | 主引用文献 | Alkyne Derivatives of SARS-CoV-2 Main Protease Inhibitors Including Nirmatrelvir Inhibit by Reacting Covalently with the Nucleophilic Cysteine.
J.Med.Chem., 66, 2023
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6EZO
 | | Eukaryotic initiation factor EIF2B in complex with ISRIB | | 分子名称: | 2-(4-chloranylphenoxy)-~{N}-[4-[2-(4-chloranylphenoxy)ethanoylamino]cyclohexyl]ethanamide, Human eukaryotic initiation factor EIF2B epsilon subunits, Translation initiation factor eIF-2B subunit alpha, ... | | 著者 | Faille, A, Weis, F, Zyryanova, A, Warren, A.J, Ron, D. | | 登録日 | 2017-11-16 | | 公開日 | 2018-03-28 | | 最終更新日 | 2019-12-11 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B.
Science, 359, 2018
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6QIK
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6QT0
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6QTZ
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6S05
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6RI5
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6RZZ
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3QRL
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5ANC
 | | Mechanism of eIF6 release from the nascent 60S ribosomal subunit | | 分子名称: | 26S RIBOSOMAL RNA, 60S ACIDIC RIBOSOMAL PROTEIN P0, 60S RIBOSOMAL PROTEIN L10, ... | | 著者 | Weis, F, Giudice, E, Churcher, M, Jin, L, Hilcenko, C, Wong, C.C, Traynor, D, Kay, R.R, Warren, A.J. | | 登録日 | 2015-09-06 | | 公開日 | 2015-10-21 | | 最終更新日 | 2017-08-02 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | Mechanism of Eif6 Release from the Nascent 60S Ribosomal Subunit
Nat.Struct.Mol.Biol., 22, 2015
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5ANB
 | | Mechanism of eIF6 release from the nascent 60S ribosomal subunit | | 分子名称: | 26S RIBOSOMAL RNA, 60S ACIDIC RIBOSOMAL PROTEIN P0, 60S RIBOSOMAL PROTEIN L10, ... | | 著者 | Weis, F, Giudice, E, Churcher, M, Jin, L, Hilcenko, C, Wong, C.C, Traynor, D, Kay, R.R, Warren, A.J. | | 登録日 | 2015-09-06 | | 公開日 | 2015-10-21 | | 最終更新日 | 2017-08-02 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Mechanism of Eif6 Release from the Nascent 60S Ribosomal Subunit
Nat.Struct.Mol.Biol., 22, 2015
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5AN9
 | | Mechanism of eIF6 release from the nascent 60S ribosomal subunit | | 分子名称: | 26S RIBOSOMAL RNA, 60S ACIDIC RIBOSOMAL PROTEIN P0, 60S RIBOSOMAL PROTEIN L10, ... | | 著者 | Weis, F, Giudice, E, Churcher, M, Jin, L, Hilcenko, C, Wong, C.C, Traynor, D, Kay, R.R, Warren, A.J. | | 登録日 | 2015-09-06 | | 公開日 | 2015-10-21 | | 最終更新日 | 2017-08-02 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Mechanism of Eif6 Release from the Nascent 60S Ribosomal Subunit
Nat.Struct.Mol.Biol., 22, 2015
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2L9N
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2J2S
 | | Solution structure of the nonmethyl-CpG-binding CXXC domain of the leukaemia-associated MLL histone methyltransferase | | 分子名称: | ZINC FINGER PROTEIN HRX, ZINC ION | | 著者 | Allen, M.D, Grummitt, C.G, Hilcenko, C, Young-Min, S, Tonkin, L.M, Johnson, C.M, Bycroft, M, Warren, A.J. | | 登録日 | 2006-08-17 | | 公開日 | 2006-08-21 | | 最終更新日 | 2017-04-19 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution Structure of the Nonmethyl-Cpg-Binding Cxxc Domain of the Leukaemia-Associated Mll Histone Methyltransferase
Embo J., 25, 2006
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1H9D
 | | Aml1/cbf-beta/dna complex | | 分子名称: | CORE-BINDING FACTOR ALPHA SUBUNIT1, CORE-BINDING FACTOR CBF-BETA, DNA (5'-(*CP*AP*AP*CP*CP*GP*CP*AP*AP*C)-3'), ... | | 著者 | Bravo, J, Warren, A.J. | | 登録日 | 2001-03-07 | | 公開日 | 2001-03-31 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | The Leukemia-Associated Aml1 (Runx1)-Cbfbeta Complex Functions as a DNA-Induced Molecular Clamp
Nat.Struct.Biol., 8, 2001
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