3UDH
| Crystal Structure of BACE with Compound 1 | 分子名称: | (3S)-spiro[indole-3,3'-pyrrolidin]-2(1H)-one, 1,2-ETHANEDIOL, Beta-secretase 1, ... | 著者 | Efremov, I.V, Vajdos, F.F, Borzilleri, K, Capetta, S, Dorff, P, Dutra, J, Mansour, M, Oborski, C, O'Connell, T, O'Sullivan, T.J, Pandit, J, Wang, H, Withka, J. | 登録日 | 2011-10-28 | 公開日 | 2012-04-18 | 最終更新日 | 2017-11-08 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Discovery and optimization of a novel spiropyrrolidine inhibitor of {beta}-secretase (BACE1) through fragment-based drug design. J.Med.Chem., 55, 2012
|
|
3UDQ
| Crystal Structure of BACE with Compound 13 | 分子名称: | (4S)-6-bromo-1,1-dioxido-3,4-dihydro-2H-thiochromen-4-yl (3S,5'R)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxylate, Beta-secretase 1 | 著者 | Efremov, I.V, Vajdos, F.F, Borzilleri, K, Capetta, S, Dorff, P, Dutra, J, Mansour, M, Oborski, C, O'Connell, T, O'Sullivan, T.J, Pandit, J, Wang, H, Withka, J. | 登録日 | 2011-10-28 | 公開日 | 2012-04-18 | 最終更新日 | 2018-04-04 | 実験手法 | X-RAY DIFFRACTION (2.73 Å) | 主引用文献 | Discovery and optimization of a novel spiropyrrolidine inhibitor of {beta}-secretase (BACE1) through fragment-based drug design. J.Med.Chem., 55, 2012
|
|
3UDJ
| Crystal Structure of BACE with Compound 5 | 分子名称: | 1,2-ETHANEDIOL, Beta-secretase 1, DI(HYDROXYETHYL)ETHER, ... | 著者 | Efremov, I.V, Vajdos, F.F, Borzilleri, K, Capetta, S, Dorff, P, Dutra, J, Mansour, M, Oborski, C, O'Connell, T, O'Sullivan, T.J, Pandit, J, Wang, H, Withka, J. | 登録日 | 2011-10-28 | 公開日 | 2012-04-18 | 最終更新日 | 2013-06-19 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Discovery and optimization of a novel spiropyrrolidine inhibitor of {beta}-secretase (BACE1) through fragment-based drug design. J.Med.Chem., 55, 2012
|
|
3UDR
| Crystal Structure of BACE with Compound 14 | 分子名称: | 1,2-ETHANEDIOL, 1-cyanocyclohexyl (3S,5'R)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxylate, Beta-secretase 1, ... | 著者 | Efremov, I.V, Vajdos, F.F, Borzilleri, K, Capetta, S, Dorff, P, Dutra, J, Mansour, M, Oborski, C, O'Connell, T, O'Sullivan, T.J, Pandit, J, Wang, H, Withka, J. | 登録日 | 2011-10-28 | 公開日 | 2012-04-18 | 最終更新日 | 2018-04-04 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Discovery and optimization of a novel spiropyrrolidine inhibitor of {beta}-secretase (BACE1) through fragment-based drug design. J.Med.Chem., 55, 2012
|
|
2QGM
| Crystal structure of succinoglycan biosynthesis protein at the resolution 1.7 A. Northeast Structural Genomics Consortium target BcR136. | 分子名称: | Succinoglycan biosynthesis protein | 著者 | Kuzin, A.P, Abashidze, M, Jayaraman, S, Wang, H, Fang, Y, Maglaqui, M, Ma, L.-C, Xiao, R, Liu, J, Baran, M.C, Acton, T.B, Rost, B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2007-06-29 | 公開日 | 2007-07-24 | 最終更新日 | 2018-01-24 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Crystal structure of succinoglycan biosynthesis protein at the resolution 1.7 A. Northeast Structural Genomics Consortium target BcR136. To be Published
|
|
2RA2
| X-Ray structure of the Q7CPV8 protein from Salmonella typhimurium at the resolution 1.9 A. Northeast Structural Genomics Consortium target StR88A | 分子名称: | Putative lipoprotein | 著者 | Kuzin, A.P, Su, M, Seetharaman, J, Vorobiev, S.M, Wang, H, Mao, L, Cunningham, K, Xiao, R, Liu, J, Baran, M.C, Acton, T.B, Rost, B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2007-09-14 | 公開日 | 2007-10-09 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | X-Ray structure of the Q7CPV8 protein from Salmonella typhimurium at the resolution 1.9 A. To be Published
|
|
2RAD
| Crystal structure of the succinoglycan biosynthesis protein. Northeast structural Genomics Consortium target BcR135 | 分子名称: | Succinoglycan biosynthesis protein | 著者 | Kuzin, A.P, Abashidze, M, Seetharaman, J, Wang, H, Mao, L, Cunningham, K, Xiao, R, Liu, J, Baran, M.C, Acton, T.B, Rost, B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2007-09-14 | 公開日 | 2007-10-02 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Crystal structure of the succinoglycan biosynthesis protein. To be Published
|
|
2RB6
| X-Ray structure of the protein Q8EI81. Northeast Structural Genomics Consortium target SoR78A | 分子名称: | Uncharacterized protein | 著者 | Kuzin, A.P, Su, M, Seetharaman, J, Vorobiev, S.M, Wang, H, Mao, L, Cunningham, K, Xiao, R, Liu, J, Baran, M.C, Acton, T.B, Rost, B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2007-09-18 | 公開日 | 2007-10-23 | 最終更新日 | 2017-10-25 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | X-Ray structure of the protein Q8EI81. To be Published
|
|
6JAS
| |
2HD1
| Crystal structure of PDE9 in complex with IBMX | 分子名称: | 3-ISOBUTYL-1-METHYLXANTHINE, MAGNESIUM ION, Phosphodiesterase 9A, ... | 著者 | Huai, Q, Wang, H, Zhang, W, Colman, R.W, Robinson, H, Ke, H. | 登録日 | 2006-06-19 | 公開日 | 2006-06-27 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.23 Å) | 主引用文献 | Crystal structure of phosphodiesterase 9 shows orientation variation of inhibitor IBMX binding Proc.Natl.Acad.Sci.USA, 101, 2004
|
|
6KH4
| Design and crystal structure of protein MOFs with ferritin nanocages as linkers and nickel clusters as nodes | 分子名称: | FE (III) ION, Ferritin, NICKEL (II) ION | 著者 | Gu, C, Chen, H, Wang, Y, Zhang, T, Wang, H, Zhao, G. | 登録日 | 2019-07-12 | 公開日 | 2020-01-29 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.302 Å) | 主引用文献 | Structural Insight into Binary Protein Metal-Organic Frameworks with Ferritin Nanocages as Linkers and Nickel Clusters as Nodes. Chemistry, 26, 2020
|
|
6KH3
| Design and crystal structure of protein MOFs with ferritin nanocages as linkers and nickel clusters as nodes | 分子名称: | FE (III) ION, Ferritin, NICKEL (II) ION | 著者 | Gu, C, Chen, H, Wang, Y, Zhang, T, Wang, H, Zhao, G. | 登録日 | 2019-07-12 | 公開日 | 2020-01-29 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural Insight into Binary Protein Metal-Organic Frameworks with Ferritin Nanocages as Linkers and Nickel Clusters as Nodes. Chemistry, 26, 2020
|
|
6KH5
| Design and crystal structure of protein MOFs with ferritin nanocages as linkers and nickel clusters as nodes | 分子名称: | FE (III) ION, Ferritin, NICKEL (II) ION | 著者 | Gu, C, Chen, H, Wang, Y, Zhang, T, Wang, H, Zhao, G. | 登録日 | 2019-07-12 | 公開日 | 2020-01-29 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.294 Å) | 主引用文献 | Structural Insight into Binary Protein Metal-Organic Frameworks with Ferritin Nanocages as Linkers and Nickel Clusters as Nodes. Chemistry, 26, 2020
|
|
7VP8
| Crystal structure of ferritin from Ureaplasma urealyticum | 分子名称: | CHLORIDE ION, FE (III) ION, Ferritin-like diiron domain-containing protein | 著者 | Wang, W, Liu, X, Wang, Y, Fu, D, Wang, H. | 登録日 | 2021-10-15 | 公開日 | 2022-08-24 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.002 Å) | 主引用文献 | Distinct structural characteristics define a new subfamily of Mycoplasma ferritin Chin.Chem.Lett., 33, 2022
|
|
2LG3
| Structure of the duplex containing HNE derived (6S,8R,11S) gamma-HO-PdG when placed opposite dT | 分子名称: | (4S)-nonane-1,4-diol, DNA (5'-D(*GP*CP*TP*AP*GP*CP*GP*AP*GP*TP*CP*C)-3'), DNA (5'-D(*GP*GP*AP*CP*TP*TP*GP*CP*TP*AP*GP*C)-3') | 著者 | Huang, H, Wang, H, Kozekova, A, Lloyd, R.S, Rizzo, C.J, Stone, M.P. | 登録日 | 2011-07-19 | 公開日 | 2012-08-01 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Ring-chain tautomerization of trans-4-hydroxynonenal derived (6S,8R,11S) gamma-hydroxy-1,N2-propano-deoxyguanosine adduct when placed opposite 2'-deoxythymidine in duplex To be Published
|
|
2L7K
| Solution NMR Structure of protein CD1104.2 from Clostridium difficile, Northeast Structural Genomics Consortium Target CfR130 | 分子名称: | Uncharacterized protein | 著者 | Pulavarti, S.V.S.R.K, Eletsky, A, Mills, J.L, Sukumaran, D.K, Wang, H, Ciccosanti, C, Janjua, H, Acton, T.B, Xiao, R, Everett, J.K, Lee, H, Prestegard, J.H, Montelione, G.T, Szyperski, T, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2010-12-13 | 公開日 | 2011-02-02 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution NMR Structure of CfR130 from Clostridium difficile, Northeast Structural Genomics Consortium Target CfR130 To be Published
|
|
2LG2
| Structure of the duplex containing HNE derived (6S,8R,11S) N2-dG cyclic hemiacetal when placed opposite dT | 分子名称: | (2R,5S)-5-pentyltetrahydrofuran-2-ol, DNA (5'-D(*GP*CP*TP*AP*GP*CP*GP*AP*GP*TP*CP*C)-3'), DNA (5'-D(*GP*GP*AP*CP*TP*TP*GP*CP*TP*AP*GP*C)-3') | 著者 | Huang, H, Wang, H, Kozekova, A, Lloyd, R.S, Rizzo, C.J, Stone, M.P. | 登録日 | 2011-07-19 | 公開日 | 2012-08-01 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Ring-chain tautomerization of trans-4-hydroxynonenal derived (6S,8R,11S) gamma-hydroxy-1,N2-propano-deoxyguanosine adduct when placed opposite 2'-deoxythymidine in duplex To be Published
|
|
7EVP
| Cryo-EM structure of the Gp168-beta-clamp complex | 分子名称: | Beta sliding clamp, Sliding clamp inhibitor | 著者 | Liu, B, Li, S, Liu, Y, Chen, H, Hu, Z, Wang, Z, Gou, L, Zhang, L, Ma, B, Wang, H, Matthews, S, Wang, Y, Zhang, K. | 登録日 | 2021-05-21 | 公開日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Bacteriophage Twort protein Gp168 is a beta-clamp inhibitor by occupying the DNA sliding channel. Nucleic Acids Res., 49, 2021
|
|
3NV6
| Crystal Structure of Camphor-Bound CYP101D2 | 分子名称: | CAMPHOR, Cytochrome P450, DI(HYDROXYETHYL)ETHER, ... | 著者 | Yang, W, Bell, S.G, Wang, H, Zhou, W.H, Bartlam, M, Wong, L.L, Rao, Z. | 登録日 | 2010-07-08 | 公開日 | 2010-11-03 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | The structure of CYP101D2 unveils a potential path for substrate entry into the active site Biochem.J., 433, 2011
|
|
3NRN
| Crystal Structure of PF1083 protein from Pyrococcus furiosus, Northeast Structural Genomics Consortium Target PfR223 | 分子名称: | ADENOSINE MONOPHOSPHATE, uncharacterized protein PF1083 | 著者 | Seetharaman, J, Su, M, Patel, P, Xiao, R, Ciccosanti, C, Wang, H, Everett, J.K, Nair, R, Acton, T.B, Rost, B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2010-06-30 | 公開日 | 2010-11-03 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Northeast Structural Genomics Consortium Target PfR223 To be Published
|
|
3O6U
| Crystal Structure of CPE2226 protein from Clostridium perfringens. Northeast Structural Genomics Consortium Target CpR195 | 分子名称: | uncharacterized protein CPE2226 | 著者 | Vorobiev, S, Su, M, Seetharaman, J, Patel, P, Xiao, R, Ciccosanti, C, Wang, H, Everett, J.K, Nair, R, Acton, T.B, Rost, B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2010-07-29 | 公開日 | 2010-08-11 | 最終更新日 | 2017-11-08 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Crystal Structure of CPE2226 protein from Clostridium perfringens. To be Published
|
|
3NV5
| Crystal Structure of Cytochrome P450 CYP101D2 | 分子名称: | Cytochrome P450, DI(HYDROXYETHYL)ETHER, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Yang, W, Bell, S.G, Wang, H, Zhou, W.H, Bartlam, M, Wong, L.L, Rao, Z. | 登録日 | 2010-07-08 | 公開日 | 2010-11-03 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | 主引用文献 | The structure of CYP101D2 unveils a potential path for substrate entry into the active site Biochem.J., 433, 2011
|
|
3OH8
| Crystal structure of the nucleoside-diphosphate sugar epimerase from Corynebacterium glutamicum. Northeast Structural Genomics Consortium Target CgR91 | 分子名称: | Nucleoside-diphosphate sugar epimerase (SulA family) | 著者 | Vorobiev, S, Lew, S, Kuzin, A, Mao, M, Xiao, R, Ciccosanti, C, Wang, H, Everett, J.K, Nair, R, Acton, T.B, Rost, B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2010-08-17 | 公開日 | 2010-09-01 | 最終更新日 | 2017-11-08 | 実験手法 | X-RAY DIFFRACTION (1.997 Å) | 主引用文献 | Crystal structure of the nucleoside-diphosphate sugar epimerase from Corynebacterium glutamicum. Northeast Structural Genomics Consortium Target CgR91. To be Published
|
|
8HZW
| The NMR structure of noursinH11W peptide | 分子名称: | noursinH11W | 著者 | Yao, H, Li, Y, Zhang, T, Gao, J, Wang, H. | 登録日 | 2023-01-09 | 公開日 | 2023-05-31 | 最終更新日 | 2024-05-08 | 実験手法 | SOLUTION NMR | 主引用文献 | Discovery and biosynthesis of tricyclic copper-binding ribosomal peptides containing histidine-to-butyrine crosslinks. Nat Commun, 14, 2023
|
|
3P9V
| High Resolution Crystal Structure of protein Maqu_3174 from Marinobacter aquaeolei, Northeast Structural Genomics Consortium Target MqR197 | 分子名称: | Uncharacterized protein | 著者 | Kuzin, A, Chen, Y, Seetharaman, J, Mao, M, Xiao, R, Ciccosanti, C, Wang, H, Everett, J.K, Nair, R, Acton, T.B, Rost, B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2010-10-18 | 公開日 | 2010-10-27 | 最終更新日 | 2012-02-22 | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | 主引用文献 | Northeast Structural Genomics Consortium Target MqR197 To be published
|
|