4HLU
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![BU of 4hlu by Molmil](/molmil-images/mine/4hlu) | Structure of the EcfA-A' heterodimer bound to ADP | Descriptor: | ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, Energy-coupling factor transporter ATP-binding protein EcfA, ... | Authors: | Wang, D.N, Karpowich, N.K. | Deposit date: | 2012-10-17 | Release date: | 2013-02-06 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.7003 Å) | Cite: | Assembly and mechanism of a group II ECF transporter. Proc.Natl.Acad.Sci.USA, 110, 2013
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7LO8
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![BU of 7lo8 by Molmil](/molmil-images/mine/7lo8) | NorA in complex with Fab36 | Descriptor: | Fab36 Heavy Chain, Fab36 Light Chain, Quinolone resistance protein NorA | Authors: | Brawley, D.N, Sauer, D.B, Song, J.M, Koide, A, Koide, S, Traaseth, N.J, Wang, D.N. | Deposit date: | 2021-02-09 | Release date: | 2022-04-20 | Last modified: | 2022-07-13 | Method: | ELECTRON MICROSCOPY (3.16 Å) | Cite: | Structural basis for inhibition of the drug efflux pump NorA from Staphylococcus aureus. Nat.Chem.Biol., 18, 2022
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7LO7
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![BU of 7lo7 by Molmil](/molmil-images/mine/7lo7) | NorA in complex with Fab25 | Descriptor: | Fab25 Heavy Chain, Fab25 Light Chain, Quinolone resistance protein NorA | Authors: | Brawley, D.N, Sauer, D.B, Song, J.M, Koide, A, Koide, S, Traaseth, N.J, Wang, D.N. | Deposit date: | 2021-02-09 | Release date: | 2022-04-20 | Last modified: | 2022-07-13 | Method: | ELECTRON MICROSCOPY (3.74 Å) | Cite: | Structural basis for inhibition of the drug efflux pump NorA from Staphylococcus aureus. Nat.Chem.Biol., 18, 2022
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7EW5
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![BU of 7ew5 by Molmil](/molmil-images/mine/7ew5) | |
7F8I
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![BU of 7f8i by Molmil](/molmil-images/mine/7f8i) | |
7JSK
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![BU of 7jsk by Molmil](/molmil-images/mine/7jsk) | Structure of the NaCT-Citrate complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CITRIC ACID, SODIUM ION, ... | Authors: | Sauer, D.B, Wang, B, Song, J, Rice, W.J, Wang, D.N. | Deposit date: | 2020-08-14 | Release date: | 2021-02-24 | Last modified: | 2021-03-10 | Method: | ELECTRON MICROSCOPY (3.04 Å) | Cite: | Structure and inhibition mechanism of the human citrate transporter NaCT. Nature, 591, 2021
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7JSJ
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![BU of 7jsj by Molmil](/molmil-images/mine/7jsj) | Structure of the NaCT-PF2 complex | Descriptor: | (2R)-2-[2-(4-tert-butylphenyl)ethyl]-2-hydroxybutanedioic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, SODIUM ION, ... | Authors: | Sauer, D.B, Wang, B, Song, J, Rice, W.J, Wang, D.N. | Deposit date: | 2020-08-14 | Release date: | 2021-02-24 | Last modified: | 2021-03-10 | Method: | ELECTRON MICROSCOPY (3.12 Å) | Cite: | Structure and inhibition mechanism of the human citrate transporter NaCT. Nature, 591, 2021
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4ZIR
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![BU of 4zir by Molmil](/molmil-images/mine/4zir) | Crystal structure of EcfAA' heterodimer bound to AMPPNP | Descriptor: | CHLORIDE ION, Energy-coupling factor transporter ATP-binding protein EcfA1, Energy-coupling factor transporter ATP-binding protein EcfA2, ... | Authors: | Karpowich, N.K, Cocco, N, Song, J.M, Wang, D.N. | Deposit date: | 2015-04-28 | Release date: | 2015-06-10 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | ATP binding drives substrate capture in an ECF transporter by a release-and-catch mechanism. Nat.Struct.Mol.Biol., 22, 2015
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7T9F
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![BU of 7t9f by Molmil](/molmil-images/mine/7t9f) | Structure of VcINDY-apo | Descriptor: | DASS family sodium-coupled anion symporter | Authors: | Sauer, D.B, Marden, J.J, Song, J.M, Wang, D.N. | Deposit date: | 2021-12-19 | Release date: | 2022-05-25 | Last modified: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (3.23 Å) | Cite: | Structural basis of ion - substrate coupling in the Na + -dependent dicarboxylate transporter VcINDY. Nat Commun, 13, 2022
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7T9G
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![BU of 7t9g by Molmil](/molmil-images/mine/7t9g) | Structure of VcINDY-Na+ | Descriptor: | DASS family sodium-coupled anion symporter, SODIUM ION | Authors: | Sauer, D.B, Marden, J.J, Song, J.M, Wang, D.N. | Deposit date: | 2021-12-19 | Release date: | 2022-05-25 | Last modified: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (2.83 Å) | Cite: | Structural basis of ion - substrate coupling in the Na + -dependent dicarboxylate transporter VcINDY. Nat Commun, 13, 2022
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5KBW
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![BU of 5kbw by Molmil](/molmil-images/mine/5kbw) | |
5KC4
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![BU of 5kc4 by Molmil](/molmil-images/mine/5kc4) | Structure of TmRibU, orthorhombic crystal form | Descriptor: | RIBOFLAVIN, Riboflavin transporter RibU, nonyl beta-D-glucopyranoside | Authors: | Karpowich, N.K, Wang, D.N, Song, J.M. | Deposit date: | 2016-06-04 | Release date: | 2016-06-29 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | An Aromatic Cap Seals the Substrate Binding Site in an ECF-Type S Subunit for Riboflavin. J.Mol.Biol., 428, 2016
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5KC0
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![BU of 5kc0 by Molmil](/molmil-images/mine/5kc0) | Crystal structure of TmRibU, hexagonal crystal form | Descriptor: | RIBOFLAVIN, Riboflavin transporter RibU, nonyl beta-D-glucopyranoside | Authors: | Karpowich, N.K, Wang, D.N, Song, J.M. | Deposit date: | 2016-06-03 | Release date: | 2016-06-29 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.2001 Å) | Cite: | An Aromatic Cap Seals the Substrate Binding Site in an ECF-Type S Subunit for Riboflavin. J.Mol.Biol., 428, 2016
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6WTX
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![BU of 6wtx by Molmil](/molmil-images/mine/6wtx) | |
6WU3
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![BU of 6wu3 by Molmil](/molmil-images/mine/6wu3) | |
3KLY
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6WU4
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![BU of 6wu4 by Molmil](/molmil-images/mine/6wu4) | Structure of the LaINDY-alpha-ketoglutarate complex | Descriptor: | DASS family sodium-coupled anion symporter | Authors: | Sauer, D.B, Marden, J.J, Cocco, N, Song, J.M, Wang, D.N, New York Consortium on Membrane Protein Structure (NYCOMPS) | Deposit date: | 2020-05-04 | Release date: | 2020-09-16 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.71 Å) | Cite: | Structural basis for the reaction cycle of DASS dicarboxylate transporters. Elife, 9, 2020
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1PW4
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![BU of 1pw4 by Molmil](/molmil-images/mine/1pw4) | Crystal Structure of the Glycerol-3-Phosphate Transporter from E.Coli | Descriptor: | Glycerol-3-phosphate transporter | Authors: | Huang, Y, Lemieux, M.J, Song, J, Auer, M, Wang, D.N. | Deposit date: | 2003-06-30 | Release date: | 2003-08-05 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Structure and Mechanism of the Glycerol-3-Phosphate Transporter from Escherichia Coli Science, 301, 2003
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3KLZ
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8TTH
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![BU of 8tth by Molmil](/molmil-images/mine/8tth) | NorA single mutant - D307N at pH 7.5 | Descriptor: | Heavy Chain of FabDA1 Variable Domain, Light Chain of FabDA1 Variable Domain, Quinolone resistance protein NorA | Authors: | Li, J.P, Li, Y, Koide, A, Kuang, H.H, Torres, V.J, Koide, S, Wang, D.N, Traaseth, N.J. | Deposit date: | 2023-08-13 | Release date: | 2024-05-29 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.54 Å) | Cite: | Proton-coupled transport mechanism of the efflux pump NorA. Nat Commun, 15, 2024
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8TTF
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![BU of 8ttf by Molmil](/molmil-images/mine/8ttf) | NorA double mutant - E222QD307N at pH 7.5 | Descriptor: | Heavy Chain of FabDA1 Variable Domain, Light Chain of FabDA1 Variable Domain, Quinolone resistance protein NorA | Authors: | Li, J.P, Li, Y, Koide, A, Kuang, H.H, Torres, V.J, Koide, S, Wang, D.N, Traaseth, N.J. | Deposit date: | 2023-08-13 | Release date: | 2024-05-29 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.61 Å) | Cite: | Proton-coupled transport mechanism of the efflux pump NorA. Nat Commun, 15, 2024
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8TTE
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![BU of 8tte by Molmil](/molmil-images/mine/8tte) | Protonated state of NorA at pH 5.0 | Descriptor: | FabDA1 CDRH3 loop, Quinolone resistance protein NorA | Authors: | Li, J.P, Li, Y, Koide, A, Kuang, H.H, Torres, V.J, Koide, S, Wang, D.N, Traaseth, N.J. | Deposit date: | 2023-08-13 | Release date: | 2024-05-29 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.26 Å) | Cite: | Proton-coupled transport mechanism of the efflux pump NorA. Nat Commun, 15, 2024
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8TTG
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![BU of 8ttg by Molmil](/molmil-images/mine/8ttg) | NorA single mutant - E222Q at pH 7.5 | Descriptor: | FabDA1 CDRH3 loop, Quinolone resistance protein NorA | Authors: | Li, J.P, Li, Y, Koide, A, Kuang, H.H, Torres, V.J, Koide, S, Wang, D.N, Traaseth, N.J. | Deposit date: | 2023-08-13 | Release date: | 2024-05-29 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.35 Å) | Cite: | Proton-coupled transport mechanism of the efflux pump NorA. Nat Commun, 15, 2024
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3GWU
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![BU of 3gwu by Molmil](/molmil-images/mine/3gwu) | Leucine transporter LeuT in complex with sertraline | Descriptor: | (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine, LEUCINE, SODIUM ION, ... | Authors: | Zhou, Z, Zhen, J, Karpowich, N.K, Law, C.J, Reith, M.E.A, Wang, D.N. | Deposit date: | 2009-04-01 | Release date: | 2009-05-12 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.14 Å) | Cite: | Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures. Nat.Struct.Mol.Biol., 16, 2009
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3GWV
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![BU of 3gwv by Molmil](/molmil-images/mine/3gwv) | Leucine transporter LeuT in complex with R-fluoxetine | Descriptor: | (3R)-N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine, LEUCINE, SODIUM ION, ... | Authors: | Zhou, Z, Zhen, J, Karpowich, N.K, Law, C.J, Reith, M.E.A, Wang, D.N. | Deposit date: | 2009-04-01 | Release date: | 2009-05-12 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures. Nat.Struct.Mol.Biol., 16, 2009
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