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2HD6
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BU of 2hd6 by Molmil
Crystal structure of the human carbonic anhydrase II in complex with a hypoxia-activatable sulfonamide.
Descriptor: CHLORIDE ION, Carbonic anhydrase 2, GLYCEROL, ...
Authors:De Simone, G, Vitale, R.M, Di Fiore, A, Pedone, C.
Deposit date:2006-06-20
Release date:2006-10-03
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Carbonic anhydrase inhibitors: Hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX.
J.Med.Chem., 49, 2006
3IBL
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BU of 3ibl by Molmil
The crystal structure of the human carbonic anhydrase II in complex with an aliphatic bis-sulfamate inhibitor
Descriptor: 4-(HYDROXYMERCURY)BENZOIC ACID, CHLORIDE ION, Carbonic anhydrase 2, ...
Authors:Alterio, V, De Simone, G.
Deposit date:2009-07-16
Release date:2009-09-22
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors
J.Med.Chem., 52, 2009
3IBI
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BU of 3ibi by Molmil
The crystal structure of the human carbonic anhydrase II in complex with an aliphatic sulfamate inhibitor
Descriptor: 4-(HYDROXYMERCURY)BENZOIC ACID, CHLORIDE ION, Carbonic anhydrase 2, ...
Authors:Alterio, V, De Simone, G.
Deposit date:2009-07-16
Release date:2009-09-22
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors
J.Med.Chem., 52, 2009
3IBN
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BU of 3ibn by Molmil
The crystal structure of the human carbonic anhydrase II in complex with an aliphatic bis-sulfamate inhibitor
Descriptor: 4-(HYDROXYMERCURY)BENZOIC ACID, CHLORIDE ION, Carbonic anhydrase 2, ...
Authors:Alterio, V, De Simone, G.
Deposit date:2009-07-16
Release date:2009-09-22
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors
J.Med.Chem., 52, 2009
3IBU
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BU of 3ibu by Molmil
The crystal structure of the human carbonic anhydrase II in complex with an aliphatic sulfamate inhibitor
Descriptor: 4-(HYDROXYMERCURY)BENZOIC ACID, CHLORIDE ION, Carbonic anhydrase 2, ...
Authors:Alterio, V, De Simone, G.
Deposit date:2009-07-17
Release date:2009-09-22
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.41 Å)
Cite:Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors
J.Med.Chem., 52, 2009
2JXZ
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BU of 2jxz by Molmil
Solution Conformation of A Non-Amyloidogenic Analogue of Human Calcitonin in Sodium Dodecyl Sulfate Micelles
Descriptor: Calcitonin
Authors:Andreotti, G, Vitale, R, Avidan-Shpalter, C, Amodeo, P, Gazit, E, Motta, A.
Deposit date:2007-12-03
Release date:2008-11-25
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Converting the highly amyloidogenic human calcitonin into a powerful fibril inhibitor by 3D structure homology with a non-amyloidogenic analogue
J.Biol.Chem., 286, 2011
3F3X
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BU of 3f3x by Molmil
Crystal structure of the transcriptional regulator BldR from Sulfolobus Solfataricus
Descriptor: SULFATE ION, Transcriptional regulator, marR family, ...
Authors:Di Fiore, A, De Simone, G.
Deposit date:2008-10-31
Release date:2009-05-05
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural analysis of BldR from Sulfolobus solfataricus provides insights into the molecular basis of transcriptional activation in archaea by MarR family proteins.
J.Mol.Biol., 388, 2009
2F14
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BU of 2f14 by Molmil
Tne Crystal Structure of the Human Carbonic Anhydrase II in Complex with a Fluorescent Inhibitor
Descriptor: 4-(HYDROXYMERCURY)BENZOIC ACID, 5-{[({2-[4-(AMINOSULFONYL)PHENYL]ETHYL}AMINO)CARBONOTHIOYL]AMINO}-2-(6-HYDROXY-3-OXO-3H-XANTHEN-9-YL)BENZOIC ACID, Carbonic anhydrase 2, ...
Authors:Alterio, V, Pedone, C, De Simone, G.
Deposit date:2005-11-14
Release date:2006-10-24
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Carbonic anhydrase inhibitors: X-ray and molecular modeling study for the interaction of a fluorescent antitumor sulfonamide with isozyme II and IX.
J.Am.Chem.Soc., 128, 2006
2QP6
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BU of 2qp6 by Molmil
The crystal structure of the complex of hcaII with a bioreductive antitumor derivative
Descriptor: 2-chloro-5-nitrobenzenesulfonamide, CHLORIDE ION, Carbonic anhydrase 2, ...
Authors:D'Ambrosio, K, De Simone, G.
Deposit date:2007-07-23
Release date:2008-06-03
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Carbonic Anhydrase Inhibitors: Bioreductive Nitro-Containing Sulfonamides with Selectivity for Targeting the Tumor Associated Isoforms IX and XII.
J.Med.Chem., 51, 2008

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