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8QX8
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BU of 8qx8 by Molmil
Endosomal membrane tethering complex CORVET
Descriptor: E3 ubiquitin-protein ligase PEP5, Vacuolar membrane protein PEP3, Vacuolar protein sorting-associated protein 16, ...
Authors:Shvarev, D, Ungermann, C, Moeller, A.
Deposit date:2023-10-23
Release date:2024-07-03
Last modified:2024-07-24
Method:ELECTRON MICROSCOPY (4.6 Å)
Cite:Structure of the endosomal CORVET tethering complex.
Nat Commun, 15, 2024
7ZU0
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BU of 7zu0 by Molmil
HOPS tethering complex from yeast
Descriptor: E3 ubiquitin-protein ligase PEP5, Vacuolar membrane protein PEP3, Vacuolar morphogenesis protein 6, ...
Authors:Shvarev, D, Schoppe, J, Koenig, C, Perz, A, Fuellbrunn, N, Kiontke, S, Langemeyer, L, Januliene, D, Schnelle, K, Kuemmel, D, Froehlich, F, Moeller, A, Ungermann, C.
Deposit date:2022-05-11
Release date:2022-09-28
Last modified:2024-07-24
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Structure of the endosomal CORVET tethering complex.
Nat Commun, 15, 2024
7QLA
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BU of 7qla by Molmil
Structure of the Rab GEF complex Mon1-Ccz1
Descriptor: Ccz1, Vacuolar fusion protein MON1
Authors:Klink, B.U, Herrmann, E, Antoni, C, Langemeyer, L, Kiontke, S, Gatsogiannis, C, Ungermann, C, Raunser, S, Kuemmel, D.
Deposit date:2021-12-20
Release date:2022-02-09
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (3.85 Å)
Cite:Structure of the Mon1-Ccz1 complex reveals molecular basis of membrane binding for Rab7 activation.
Proc.Natl.Acad.Sci.USA, 119, 2022
7ZTY
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BU of 7zty by Molmil
Structure of Vps39 N-terminal domain from Chaetomium thermophilum
Descriptor: CNH domain-containing protein
Authors:Kiontke, S, Ungermann, C, Kuemmel, D.
Deposit date:2022-05-11
Release date:2022-09-21
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:Structure of the HOPS tethering complex, a lysosomal membrane fusion machinery.
Elife, 11, 2022
3BW6
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BU of 3bw6 by Molmil
Crystal structure of the longin domain of yeast Ykt6
Descriptor: SULFATE ION, Synaptobrevin homolog YKT6
Authors:Pylypenko, O, Schonichen, A, Ludwig, D, Ungermann, C, Goody, R.S, Rak, A, Geyer, M.
Deposit date:2008-01-08
Release date:2008-04-01
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Farnesylation of the SNARE protein Ykt6 increases its stability and helical folding.
J.Mol.Biol., 377, 2008
4UUY
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BU of 4uuy by Molmil
Structural Identification of the Vps18 beta-propeller reveals a critical role in the HOPS complex stability and function.
Descriptor: 1,2-ETHANEDIOL, GLYCEROL, SULFATE ION, ...
Authors:Behrmann, H, Gohlke, U, Heinemann, U.
Deposit date:2014-08-01
Release date:2014-10-29
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Structural Identification of the Vps18 Beta-Propeller Reveals a Critical Role in the Hops Complex Stability and Function.
J.Biol.Chem., 289, 2014
7A0N
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BU of 7a0n by Molmil
Structure of TSC1 NTD and linker domain
Descriptor: Uncharacterized protein,Uncharacterized protein
Authors:Fitzian, K, Kuemmel, D.
Deposit date:2020-08-10
Release date:2021-05-26
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (4.3 Å)
Cite:TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation.
Mol.Cell, 81, 2021
7A0M
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BU of 7a0m by Molmil
TSC1 N-terminal domain
Descriptor: SULFATE ION, TSC1 N-terminal domain
Authors:Zech, R, Kiontke, S, Kuemmel, D.
Deposit date:2020-08-10
Release date:2021-05-26
Last modified:2021-07-14
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation.
Mol.Cell, 81, 2021
5LDD
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BU of 5ldd by Molmil
Crystal structure of the heterodimeric GEF Mon1-Ccz1 in complex with Ypt7
Descriptor: Ccz1, Mon1, Rab small monomeric GTPase-like protein, ...
Authors:Kiontke, S, Kuemmel, D.
Deposit date:2016-06-24
Release date:2017-01-18
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (2.496 Å)
Cite:Architecture and mechanism of the late endosomal Rab7-like Ypt7 guanine nucleotide exchange factor complex Mon1-Ccz1.
Nat Commun, 8, 2017
8C7G
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BU of 8c7g by Molmil
Drosophila melanogaster Rab7 GEF complex Mon1-Ccz1-Bulli
Descriptor: Caffeine, calcium, zinc sensitivity 1, ...
Authors:Schaefer, J, Herrmann, E, Kuemmel, D, Moeller, A.
Deposit date:2023-01-15
Release date:2023-05-17
Last modified:2024-07-24
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structure of the metazoan Rab7 GEF complex Mon1-Ccz1-Bulli.
Proc.Natl.Acad.Sci.USA, 120, 2023
7P3Y
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BU of 7p3y by Molmil
Homology model of the full-length AP-3 complex in an intermediate open conformation
Descriptor: AP complex subunit sigma, AP-3 complex subunit delta, AP-3 complex subunit mu, ...
Authors:Schubert, E, Raunser, S.
Deposit date:2021-07-09
Release date:2021-09-29
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (10.1 Å)
Cite:Flexible open conformation of the AP-3 complex explains its role in cargo recruitment at the Golgi.
J.Biol.Chem., 297, 2021
7P3X
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BU of 7p3x by Molmil
Homology model of the full-length AP-3 complex in a compact open conformation
Descriptor: AP complex subunit sigma, AP-3 complex subunit delta, AP-3 complex subunit mu, ...
Authors:Schubert, E, Raunser, S.
Deposit date:2021-07-09
Release date:2021-09-29
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (9.1 Å)
Cite:Flexible open conformation of the AP-3 complex explains its role in cargo recruitment at the Golgi.
J.Biol.Chem., 297, 2021
7P3Z
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BU of 7p3z by Molmil
Homology model of the full-length AP-3 complex in a stretched open conformation
Descriptor: AP complex subunit sigma, AP-3 complex subunit delta, AP-3 complex subunit mu, ...
Authors:Schubert, E, Raunser, S.
Deposit date:2021-07-09
Release date:2021-09-29
Last modified:2021-12-08
Method:ELECTRON MICROSCOPY (10.5 Å)
Cite:Flexible open conformation of the AP-3 complex explains its role in cargo recruitment at the Golgi.
J.Biol.Chem., 297, 2021

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