3BUS
 
 | | Crystal Structure of RebM | | 分子名称: | Methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE | | 著者 | McCoy, J.G, Singh, S, Bingman, C.A, Thorson, J.S, Phillips Jr, G.N. | | 登録日 | 2008-01-03 | | 公開日 | 2008-03-25 | | 最終更新日 | 2017-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Structure and mechanism of the rebeccamycin sugar 4'-O-methyltransferase RebM.
J.Biol.Chem., 283, 2008
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3TOS
 | | Crystal Structure of CalS11, Calicheamicin Methyltransferase | | 分子名称: | 1,2-ETHANEDIOL, CalS11, GLUTAMIC ACID, ... | | 著者 | Chang, A, Aceti, D.J, Beebe, E.T, Makino, S.-I, Wrobel, R.L, Bingman, C.A, Thorson, J.S, Phillips Jr, G.N, Center for Eukaryotic Structural Genomics (CESG), Enzyme Discovery for Natural Product Biosynthesis (NatPro) | | 登録日 | 2011-09-06 | | 公開日 | 2011-10-05 | | 最終更新日 | 2017-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Crystal Structure of CalS11, Calicheamicin methyltransferase
To be Published
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5JXM
 | | Crystal Structure of Prenyltransferase PriB Apo Form | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, MAGNESIUM ION, PriB | | 著者 | Cao, H, Elshahawi, S, Benach, J, Wasserman, S.R, Morisco, L.L, Koss, J.W, Thorson, J.S, Phillips Jr, G.N, Enzyme Discovery for Natural Product Biosynthesis (NatPro) | | 登録日 | 2016-05-13 | | 公開日 | 2016-06-08 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | | 主引用文献 | Structure and specificity of a permissive bacterial C-prenyltransferase.
Nat. Chem. Biol., 13, 2017
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5K9M
 | | Crystal Structure of PriB Binary Complex with Product Diphosphate | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, PYROPHOSPHATE 2-, PriB Prenyltransferase | | 著者 | Cao, H, Elshahawi, S, Benach, J, Wasserman, S.R, Morisco, L.L, Koss, J.W, Thorson, J.S, Phillips Jr, G.N, Enzyme Discovery for Natural Product Biosynthesis (NatPro) | | 登録日 | 2016-06-01 | | 公開日 | 2016-06-15 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Structure and specificity of a permissive bacterial C-prenyltransferase.
Nat. Chem. Biol., 13, 2017
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7MSY
 | | Structure of CalU17 from the Calicheamicin Biosynthesis Pathway of Micromonospora echinospora | | 分子名称: | CALCIUM ION, CHLORIDE ION, CalU17, ... | | 著者 | Kosgei, A.J, Miller, M.D, Xu, W, Van Lanen, S.G, Thorson, J.S, Phillips Jr, G.N. | | 登録日 | 2021-05-12 | | 公開日 | 2021-07-28 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | | 主引用文献 | The crystal structure of DynF from the dynemicin-biosynthesis pathway of Micromonospora chersina.
Acta Crystallogr.,Sect.F, 78, 2022
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7ML6
 | | Structure of CalU17 from the Calicheamicin Biosynthesis Pathway of Micromonospora echinospora | | 分子名称: | CalU17, GLYCEROL | | 著者 | Kosgei, A.J, Miller, M.D, Xu, W, Van Lanen, S.G, Thorson, J.S, Phillips Jr, G.N. | | 登録日 | 2021-04-27 | | 公開日 | 2021-07-28 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | The crystal structure of DynF from the dynemicin-biosynthesis pathway of Micromonospora chersina.
Acta Crystallogr.,Sect.F, 78, 2022
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6WF4
 | | Crystal Structure of TerC Co-crystallized with Polyporic Acid | | 分子名称: | (2~5~S)-2~3~,2~5~,2~6~-trihydroxy[1~1~,2~1~:2~4~,3~1~-terphenyl]-2~2~(2~5~H)-one, ISOPROPYL ALCOHOL, Terfestatin Biosyntheis Enzyme C | | 著者 | Clinger, J.A, Miller, M.D, Hall, R.E, Zhang, Y, Elshahawi, S.I, Thorson, J.S, Van Lanen, S.G, Phillips Jr, G.N, Enzyme Discovery for Natural Product Biosynthesis (NatPro) | | 登録日 | 2020-04-03 | | 公開日 | 2021-04-07 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | | 主引用文献 | Structural and functional characterization of two cooperative enzymes responsible for the stability
of p-terphenyls.
To be published
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6D2V
 | | Apo Structure of TerB, an NADP Dependent Oxidoreductase in the Terfestatin Biosynthesis Pathway | | 分子名称: | CHLORIDE ION, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, THIOCYANATE ION, ... | | 著者 | Clinger, J.A, Elshahawi, S.I, Zhang, Y, Hall, R.P, Liu, Y, Thorson, J.S, Phillips Jr, G.N. | | 登録日 | 2018-04-14 | | 公開日 | 2018-06-13 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.901 Å) | | 主引用文献 | Structure and Function of Terfestatin Biosynthesis Enzymes TerB and TerC
To Be Published
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6D34
 | | Apo Crystal Structure of TerC, a Terfestatin Biosynthesis Enzyme | | 分子名称: | ISOPROPYL ALCOHOL, TerC | | 著者 | Clinger, J.A, Elshahawi, S.I, Zhang, Y, Hall, R.P, Liu, Y, Thorson, J.S, Phillips Jr, G.N. | | 登録日 | 2018-04-14 | | 公開日 | 2018-06-13 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structure and Function of Terfestatin Biosynthesis Enzymes TerB and TerC
To Be Published
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5HOQ
 | | Apo structure of CalS11, TDP-rhamnose 3'-o-methyltransferase, an enzyme in Calicheamicin biosynthesis | | 分子名称: | SULFATE ION, TDP-rhamnose 3'-O-methyltransferase (CalS11) | | 著者 | Han, L, Helmich, K.E, Singh, S, Thorson, J.S, Bingman, C.A, Phillips Jr, G.N, Enzyme Discovery for Natural Product Biosynthesis | | 登録日 | 2016-01-19 | | 公開日 | 2016-03-30 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.793 Å) | | 主引用文献 | Loop dynamics of thymidine diphosphate-rhamnose 3'-O-methyltransferase (CalS11), an enzyme in calicheamicin biosynthesis.
Struct Dyn., 3, 2016
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5INJ
 | | Crystal Structure of Prenyltransferase PriB Ternary Complex with L-Tryptophan and Dimethylallyl thiolodiphosphate (DMSPP) | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DIMETHYLALLYL S-THIOLODIPHOSPHATE, Prenyltransferase, ... | | 著者 | Cao, H, Elshahawi, S, Benach, J, Wasserman, S.R, Morisco, L.L, Koss, J.W, Thorson, J.S, Phillips Jr, G.N, Enzyme Discovery for Natural Product Biosynthesis (NatPro) | | 登録日 | 2016-03-07 | | 公開日 | 2016-05-11 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Structure and specificity of a permissive bacterial C-prenyltransferase.
Nat. Chem. Biol., 13, 2017
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5JR3
 | | Crystal structure of carminomycin-4-O-methyltransferase DnrK in complex with SAH and 4-methylumbelliferone | | 分子名称: | 7-hydroxy-4-methyl-2H-chromen-2-one, Carminomycin 4-O-methyltransferase DnrK, S-ADENOSYL-L-HOMOCYSTEINE, ... | | 著者 | Wang, F, Johnson, B.R, Huber, T.D, Singh, S, Thorson, J.S, Phillips Jr, G.N, Enzyme Discovery for Natural Product Biosynthesis (NatPro) | | 登録日 | 2016-05-05 | | 公開日 | 2016-06-01 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | | 主引用文献 | Crystal structure of carminomycin-4-O-methyltransferase DnrK in complex with SAH and 4-methylumbelliferone (to be published)
To Be Published
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4WS9
 | | Crystal structure of sMAT N159G from Sulfolobus solfataricus | | 分子名称: | PHOSPHATE ION, S-adenosylmethionine synthase | | 著者 | Wang, F, Brady, E.L, Singh, S, Clinger, J.A, Huber, T.D, Thorson, J.S, Phillips Jr, G.N. | | 登録日 | 2014-10-26 | | 公開日 | 2014-11-05 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.803 Å) | | 主引用文献 | Crystal structure of sMAT N159G from Sulfolobus solfataricus.
To Be Published
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4XQ2
 | | Ensemble refinement of cystathione gamma lyase (CalE6) D7G from Micromonospora echinospora | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, CalE6, ... | | 著者 | Wang, F, Yennamalli, R.M, Singh, S, Tan, K, Thorson, J.S, Phillips Jr, G.N, Enzyme Discovery for Natural Product Biosynthesis (NatPro) | | 登録日 | 2015-01-18 | | 公開日 | 2015-04-15 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | The crystal structure of cystathione gamma lyase (CalE6) from Micromonospora echinospora
To Be Published
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4XR9
 | | Crystal structure of CalS8 from Micromonospora echinospora cocrystallized with NAD and TDP-glucose | | 分子名称: | CalS8, GLYCEROL, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | | 著者 | Michalska, K, Bigelow, L, Endres, M, Babnigg, G, Bingman, C.A, Yennamalli, R.M, Singh, S, Kharel, M.K, Thorson, J.S, Phillips Jr, G.N, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro) | | 登録日 | 2015-01-20 | | 公開日 | 2015-02-11 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Crystal structure of CalS8 from Micromonospora echinospora
To Be Published
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4XRR
 | | Crystal structure of cals8 from micromonospora echinospora (P294S mutant) | | 分子名称: | CalS8, GLYCEROL | | 著者 | Michalska, K, Bigelow, L, Endres, M, Babnigg, G, Bingman, C.A, Yennamalli, R.M, Singh, S, Kharel, M.K, Thorson, J.S, Phillips Jr, G.N, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro) | | 登録日 | 2015-01-21 | | 公開日 | 2015-02-11 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Structural Characterization of CalS8, a TDP-alpha-D-Glucose Dehydrogenase Involved in Calicheamicin Aminodideoxypentose Biosynthesis.
J. Biol. Chem., 290, 2015
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4XAU
 | | Crystal structure of AtS13 from Actinomadura melliaura | | 分子名称: | PYRIDOXAL-5'-PHOSPHATE, Putative aminotransferase | | 著者 | Wang, F, Singh, S, Xu, W, Thorson, J.S, Phillips Jr, G.N, Enzyme Discovery for Natural Product Biosynthesis (NatPro) | | 登録日 | 2014-12-15 | | 公開日 | 2014-12-24 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (3.0012 Å) | | 主引用文献 | Structural characterization of AtmS13, a putative sugar aminotransferase involved in indolocarbazole AT2433 aminopentose biosynthesis.
Proteins, 83, 2015
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1ZXF
 | | Solution structure of a self-sacrificing resistance protein, CalC from Micromonospora echinospora | | 分子名称: | CalC | | 著者 | Singh, S, Hager, M.H, Zhang, C, Griffith, B.R, Lee, M.S, Hallenga, K, Markley, J.L, Thorson, J.S, Center for Eukaryotic Structural Genomics (CESG) | | 登録日 | 2005-06-08 | | 公開日 | 2005-12-13 | | 最終更新日 | 2022-03-02 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural insight into the self-sacrifice mechanism of enediyne resistance.
Acs Chem.Biol., 1, 2006
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3LST
 | | Crystal Structure of CalO1, Methyltransferase in Calicheamicin Biosynthesis, SAH bound form | | 分子名称: | 1,2-ETHANEDIOL, CalO1 Methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE | | 著者 | Chang, A, Singh, S, Bingman, C.A, Thorson, J.S, Phillips Jr, G.N, Center for Eukaryotic Structural Genomics (CESG) | | 登録日 | 2010-02-12 | | 公開日 | 2010-03-02 | | 最終更新日 | 2017-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural characterization of CalO1: a putative orsellinic acid methyltransferase in the calicheamicin-biosynthetic pathway.
Acta Crystallogr.,Sect.D, 67, 2011
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3OTI
 | | Crystal Structure of CalG3, Calicheamicin Glycostyltransferase, TDP and calicheamicin T0 bound form | | 分子名称: | CHLORIDE ION, CalG3, Calicheamicin T0, ... | | 著者 | Chang, A, Singh, S, Bingman, C.A, Thorson, J.S, Phillips Jr, G.N, Center for Eukaryotic Structural Genomics (CESG), Enzyme Discovery for Natural Product Biosynthesis (NatPro) | | 登録日 | 2010-09-11 | | 公開日 | 2010-12-15 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.597 Å) | | 主引用文献 | Complete set of glycosyltransferase structures in the calicheamicin biosynthetic pathway reveals the origin of regiospecificity.
Proc.Natl.Acad.Sci.USA, 108, 2011
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3OTH
 | | Crystal Structure of CalG1, Calicheamicin Glycostyltransferase, TDP and calicheamicin alpha3I bound form | | 分子名称: | CalG1, Calicheamicin alpha3I, THYMIDINE-5'-DIPHOSPHATE | | 著者 | Chang, A, Singh, S, Bingman, C.A, Thorson, J.S, Phillips Jr, G.N, Center for Eukaryotic Structural Genomics (CESG), Enzyme Discovery for Natural Product Biosynthesis (NatPro) | | 登録日 | 2010-09-11 | | 公開日 | 2010-12-15 | | 最終更新日 | 2017-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.301 Å) | | 主引用文献 | Complete set of glycosyltransferase structures in the calicheamicin biosynthetic pathway reveals the origin of regiospecificity.
Proc.Natl.Acad.Sci.USA, 108, 2011
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3GWZ
 | | Structure of the Mitomycin 7-O-methyltransferase MmcR | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, CALCIUM ION, MmcR, ... | | 著者 | Singh, S, Chang, A, Bingman, C.A, Phillips Jr, G.N, Thorson, J.S. | | 登録日 | 2009-04-01 | | 公開日 | 2010-04-07 | | 最終更新日 | 2017-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | | 主引用文献 | Structural characterization of the mitomycin 7-O-methyltransferase.
Proteins, 79, 2011
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3GXO
 | | Structure of the Mitomycin 7-O-methyltransferase MmcR with bound Mitomycin A | | 分子名称: | CALCIUM ION, MmcR, S-ADENOSYL-L-HOMOCYSTEINE, ... | | 著者 | Singh, S, Chang, A, Bingman, C.A, Phillips Jr, G.N, Thorson, J.S. | | 登録日 | 2009-04-02 | | 公開日 | 2010-04-21 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structural characterization of the mitomycin 7-O-methyltransferase.
Proteins, 79, 2011
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3IAA
 | | Crystal Structure of CalG2, Calicheamicin Glycosyltransferase, TDP bound form | | 分子名称: | CalG2, THYMIDINE-5'-DIPHOSPHATE | | 著者 | Chang, A, Singh, S, Bingman, C.A, Thorson, J.S, Phillips Jr, G.N. | | 登録日 | 2009-07-13 | | 公開日 | 2010-06-02 | | 最終更新日 | 2017-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.505 Å) | | 主引用文献 | Complete set of glycosyltransferase structures in the calicheamicin biosynthetic pathway reveals the origin of regiospecificity.
Proc.Natl.Acad.Sci.USA, 108, 2011
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3IA7
 | | Crystal Structure of CalG4, the Calicheamicin Glycosyltransferase | | 分子名称: | CALCIUM ION, CHLORIDE ION, CalG4 | | 著者 | Chang, A, Singh, S, Bingman, C.A, Thorson, J.S, Phillips Jr, G.N. | | 登録日 | 2009-07-13 | | 公開日 | 2010-06-02 | | 最終更新日 | 2017-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | | 主引用文献 | Complete set of glycosyltransferase structures in the calicheamicin biosynthetic pathway reveals the origin of regiospecificity.
Proc.Natl.Acad.Sci.USA, 108, 2011
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