3OTH

Crystal Structure of CalG1, Calicheamicin Glycostyltransferase, TDP and calicheamicin alpha3I bound form

Summary for 3OTH

• Entry DOI: 10.2210/pdb3oth/pdb
• Related: 3D0Q 3D0R 3OTG 3OTI
• Descriptor: CalG1, THYMIDINE-5'-DIPHOSPHATE, Calicheamicin alpha3I, ... (4 entities in total)
• Functional Keywords: calicheamicin, tdp, structural genomics, psi-2, protein structure initiative, center for eukaryotic structural genomics, cesg, gt-b fold, glycosyltransferase, transferase-antibiotic complex, enzyme discovery for natural product biosynthesis, natpro, transferase/antibiotic
• Biological source: Micromonospora echinospora (Micromonospora purpurea)
• Total number of polymer chains: 2
• Total formula weight: 90696.07

Authors

Chang, A.,Singh, S.,Bingman, C.A.,Thorson, J.S.,Phillips Jr., G.N.,Center for Eukaryotic Structural Genomics (CESG),Enzyme Discovery for Natural Product Biosynthesis (NatPro) (deposition date: 2010-09-11, release date: 2010-12-15, Last modification date: 2017-11-08)

• Primary citation: Chang, A.,Singh, S.,Helmich, K.E.,Goff, R.D.,Bingman, C.A.,Thorson, J.S.,Phillips, G.N.; Complete set of glycosyltransferase structures in the calicheamicin biosynthetic pathway reveals the origin of regiospecificity.; Proc.Natl.Acad.Sci.USA, 108:17649-17654, 2011; PubMed: 21987796; DOI: 10.1073/pnas.1108484108

Experimental method

X-RAY DIFFRACTION (2.301 Å)