4FN9
 
 | | X-ray Crystal structure of the Ancestral 3-keto steroid receptor - Progesterone complex | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, GLYCEROL, ... | | 著者 | Colucci, J.K, Ortlund, E.A, Thornton, J.W. | | 登録日 | 2012-06-19 | | 公開日 | 2012-12-26 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Evolution of minimal specificity and promiscuity in steroid hormone receptors.
PLoS Genet., 8, 2012
|
|
1YOW
 | | human Steroidogenic Factor 1 LBD with bound Co-factor Peptide | | 分子名称: | PHOSPHATIDYL ETHANOL, Steroidogenic factor 1, TIF2 peptide | | 著者 | Krylova, I.N, Sablin, E.P, Xu, R.X, Waitt, G.M, Juzumiene, D, Williams, J.D, Ingraham, H.A, Willson, T.M, Williams, S.P, Montana, V, Madauss, K.P, Moore, J, Bynum, J.M, Lebedeva, L, MacKay, J.A, Suzawa, M, Guy, R.K, Thornton, J.W. | | 登録日 | 2005-01-28 | | 公開日 | 2005-05-10 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1
Cell(Cambridge,Mass.), 120, 2005
|
|
1YOK
 | | crystal structure of human LRH-1 bound with TIF-2 peptide and phosphatidylglycerol | | 分子名称: | (2S)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(6E)-HEXADEC-6-ENOYLOXY]PROPYL (8E)-OCTADEC-8-ENOATE, Nuclear receptor coactivator 2, Orphan nuclear receptor NR5A2 | | 著者 | Krylova, I.N, Sablin, E.P, Moore, J, Xu, R.X, Waitt, G.M, MacKay, J.A, Juzumiene, D, Bynum, J.M, Madauss, K, Montana, V, Lebedeva, L, Suzawa, M, Williams, J.D, Williams, S.P, Guy, R.K, Thornton, J.W, Fletterick, R.J, Willson, T.M, Ingraham, H.A. | | 登録日 | 2005-01-27 | | 公開日 | 2005-07-19 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1.
Cell(Cambridge,Mass.), 120, 2005
|
|
4LY7
 | | Ancestral RNase H | | 分子名称: | Ribonuclease H, SULFATE ION | | 著者 | Hart, K.M, Harms, M.J, Schmidt, B.H, Elya, C, Thornton, J.W, Marqusee, S. | | 登録日 | 2013-07-30 | | 公開日 | 2014-11-19 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.36 Å) | | 主引用文献 | Thermodynamic system drift in protein evolution.
Plos Biol., 12, 2014
|
|
2Q1H
 | | Ancestral Corticoid Receptor in Complex with Aldosterone | | 分子名称: | ALDOSTERONE, AncCR, GLYCEROL, ... | | 著者 | Ortlund, E.A, Bridgham, J.T, Redinbo, M.R, Thornton, J.W. | | 登録日 | 2007-05-24 | | 公開日 | 2007-09-04 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Crystal structure of an ancient protein: evolution by conformational epistasis.
Science, 317, 2007
|
|
2Q3Y
 | | Ancestral Corticiod Receptor in Complex with DOC | | 分子名称: | Ancestral Corticiod Receptor, DESOXYCORTICOSTERONE, GLYCEROL, ... | | 著者 | Ortlund, E.A, Bridgham, J.T, Redinbo, M.R, Thornton, J.W. | | 登録日 | 2007-05-30 | | 公開日 | 2007-09-04 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Crystal structure of an ancient protein: evolution by conformational epistasis
Science, 317, 2007
|
|
4FNE
 | | X-ray Crystal structure of the Ancestral 3-keto steroid receptor - DOC complex | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, DESOXYCORTICOSTERONE, ... | | 著者 | Ortlund, E.A, Colucci, J.K, Thornton, J, Eick, G, Harms, M. | | 登録日 | 2012-06-19 | | 公開日 | 2012-12-12 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.78 Å) | | 主引用文献 | Evolution of minimal specificity and promiscuity in steroid hormone receptors.
PLoS Genet, 8, 2012
|
|
1YMT
 | | Mouse SF-1 LBD | | 分子名称: | 1-CIS-9-OCTADECANOYL-2-CIS-9-HEXADECANOYL PHOSPHATIDYL GLYCEROL, Nuclear receptor 0B2, Steroidogenic factor 1 | | 著者 | Krylova, I.N, Sablin, E.P, Moore, J, Xu, R.X, Waitt, G.M, Juzumiene, D, Bynum, J.M, Fletterick, R.J, Willson, T.M, Ingraham, H.A. | | 登録日 | 2005-01-21 | | 公開日 | 2005-03-15 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1
Cell(Cambridge,Mass.), 120, 2005
|
|
3GN8
 | |
3RY9
 | |
7LTW
 | | Crystal structure of the mouse Kirrel2 D1 homodimer | | 分子名称: | Kin of IRRE-like protein 2, SODIUM ION | | 著者 | Roman, C.A, Pak, J.S, Wang, J, Ozkan, E. | | 登録日 | 2021-02-20 | | 公開日 | 2021-11-24 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Molecular and structural basis of olfactory sensory neuron axon coalescence by Kirrel receptors.
Cell Rep, 37, 2021
|
|
6ONB
 | | Crystal Structure of the ZIG-8-RIG-5 IG1-IG1 heterodimer, monoclinic form | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, NeuRonal IgCAM-5, ... | | 著者 | Cheng, S, Kurleto, J.D, Ozkan, E. | | 登録日 | 2019-04-20 | | 公開日 | 2019-05-15 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.696 Å) | | 主引用文献 | Family of neural wiring receptors in bilaterians defined by phylogenetic, biochemical, and structural evidence.
Proc.Natl.Acad.Sci.USA, 116, 2019
|
|
6ON9
 | | Crystal Structure of the ZIG-8-RIG-5 IG1-IG1 heterodimer, tetragonal form | | 分子名称: | NeuRonal IgCAM-5, SODIUM ION, SULFATE ION, ... | | 著者 | Cheng, S, Kurleto, J.D, Ozkan, E. | | 登録日 | 2019-04-20 | | 公開日 | 2019-05-15 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.995 Å) | | 主引用文献 | Family of neural wiring receptors in bilaterians defined by phylogenetic, biochemical, and structural evidence.
Proc.Natl.Acad.Sci.USA, 116, 2019
|
|
6ON6
 | | Crystal Structure of the RIG-5 IG1 homodimer | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, NeuRonal IgCAM-5 | | 著者 | Cheng, S, Kurleto, J.D, Ozkan, E. | | 登録日 | 2019-04-20 | | 公開日 | 2019-05-15 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.423 Å) | | 主引用文献 | Family of neural wiring receptors in bilaterians defined by phylogenetic, biochemical, and structural evidence.
Proc.Natl.Acad.Sci.USA, 116, 2019
|
|
6PLL
 | | Crystal structure of the ZIG-8 IG1 homodimer | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, Zwei Ig domain protein zig-8 | | 著者 | Cheng, S, Ozkan, E. | | 登録日 | 2019-07-01 | | 公開日 | 2020-07-08 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.693 Å) | | 主引用文献 | Family of neural wiring receptors in bilaterians defined by phylogenetic, biochemical, and structural evidence.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
|
|
5CC1
 | | S425G Glucocorticoid receptor DNA binding domain - (+)GRE complex | | 分子名称: | DNA (5'-D(*CP*CP*AP*GP*AP*AP*CP*AP*GP*AP*GP*TP*GP*TP*TP*CP*TP*G)-3'), DNA (5'-D(*TP*CP*AP*GP*AP*AP*CP*AP*CP*TP*CP*TP*GP*TP*TP*CP*TP*G)-3'), Glucocorticoid receptor, ... | | 著者 | Hudson, W.H, Weikum, E.A, Ortlund, E.A. | | 登録日 | 2015-07-01 | | 公開日 | 2015-12-23 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.302 Å) | | 主引用文献 | Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space.
Proc.Natl.Acad.Sci.USA, 113, 2016
|
|
5CBX
 | | AncGR DNA Binding Domain - (+)GRE Complex | | 分子名称: | AncGR DNA Binding Domain, DNA (5'-D(*CP*CP*AP*GP*AP*AP*CP*AP*GP*AP*GP*TP*GP*TP*TP*CP*TP*G)-3'), DNA (5'-D(*TP*CP*AP*GP*AP*AP*CP*AP*CP*TP*CP*TP*GP*TP*TP*CP*TP*G)-3'), ... | | 著者 | Hudson, W.H, Ortlund, E.A. | | 登録日 | 2015-07-01 | | 公開日 | 2015-12-23 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space.
Proc.Natl.Acad.Sci.USA, 113, 2016
|
|
5CBY
 | | AncGR2 DNA Binding Domain - (+)GRE Complex | | 分子名称: | AncGR2 DNA Binding Domain, DNA (5'-D(*CP*CP*AP*GP*AP*AP*CP*AP*GP*AP*GP*TP*GP*TP*TP*CP*TP*G)-3'), DNA (5'-D(*TP*CP*AP*GP*AP*AP*CP*AP*CP*TP*CP*TP*GP*TP*TP*CP*TP*G)-3'), ... | | 著者 | Hudson, W.H, Ortlund, E.A. | | 登録日 | 2015-07-01 | | 公開日 | 2015-12-23 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.997 Å) | | 主引用文献 | Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space.
Proc.Natl.Acad.Sci.USA, 113, 2016
|
|
5CBZ
 | | AncMR DNA Binding Domain - (+)GRE Complex | | 分子名称: | AncMR DNA Binding Domain, DNA (5'-D(*CP*CP*AP*GP*AP*AP*CP*AP*CP*TP*CP*TP*GP*TP*TP*CP*TP*G)-3'), DNA (5'-D(*TP*CP*AP*GP*AP*AP*CP*AP*GP*AP*GP*TP*GP*TP*TP*CP*TP*G)-3'), ... | | 著者 | Hudson, W.H, Ortlund, E.A. | | 登録日 | 2015-07-01 | | 公開日 | 2015-12-23 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space.
Proc.Natl.Acad.Sci.USA, 113, 2016
|
|
5CC0
 | | AncSR2 - TSLP nGRE complex | | 分子名称: | AncSR2 DNA Binding Domain, DNA (5'-D(*AP*GP*CP*TP*CP*TP*CP*CP*CP*GP*GP*AP*GP*GP*CP*G)-3'), DNA (5'-D(*CP*GP*CP*CP*TP*CP*CP*GP*GP*GP*AP*GP*AP*GP*CP*T)-3'), ... | | 著者 | Hudson, W.H, Ortlund, E.A. | | 登録日 | 2015-07-01 | | 公開日 | 2015-12-23 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.405 Å) | | 主引用文献 | Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space.
Proc.Natl.Acad.Sci.USA, 113, 2016
|
|
7LU6
 | | Crystal structure of the mouse Kirrel3 D1 homodimer | | 分子名称: | Kin of IRRE-like protein 3, SODIUM ION | | 著者 | Roman, C.A, Pak, J.S, Wang, J, Ozkan, E. | | 登録日 | 2021-02-21 | | 公開日 | 2021-11-24 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Molecular and structural basis of olfactory sensory neuron axon coalescence by Kirrel receptors.
Cell Rep, 37, 2021
|
|
4N1Y
 | |
4OND
 | | Ancestral Steroid Receptor 2 DBD helix mutant - ERE DNA complex | | 分子名称: | 5'-D(*CP*CP*AP*GP*GP*TP*CP*AP*GP*AP*GP*TP*GP*AP*CP*CP*TP*G)-3', 5'-D(*TP*CP*AP*GP*GP*TP*CP*AP*CP*TP*CP*TP*GP*AP*CP*CP*TP*G)-3', Ancestral SR2 Helix Mutant, ... | | 著者 | Ortlund, E.O, Murphy, M.N. | | 登録日 | 2014-01-28 | | 公開日 | 2014-10-29 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.253 Å) | | 主引用文献 | Evolution of DNA specificity in a transcription factor family produced a new gene regulatory module.
Cell(Cambridge,Mass.), 159, 2014
|
|
4OOR
 | |
4OLN
 | |
