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1JN3
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BU of 1jn3 by Molmil
FIDELITY PROPERTIES AND STRUCTURE OF M282L MUTATOR MUTANT OF DNA POLYMERASE: SUBTLE STRUCTURAL CHANGES INFLUENCE THE MECHANISM OF NUCLEOTIDE DISCRIMINATION
Descriptor: DNA POLYMERASE BETA
Authors:Conn, D.A, Sweasy, J.B, Jaeger, J.
Deposit date:2001-07-22
Release date:2001-08-03
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:A DNA polymerase beta mutator mutant with reduced nucleotide discrimination and increased protein stability
Biochemistry, 40, 2001
4PPX
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BU of 4ppx by Molmil
DNA Polymerase Beta E295K with Spiroiminodihydantoin in Templating Position
Descriptor: 5'-D(*CP*CP*GP*AP*CP*(SDH)P*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3', 5'-D(*GP*TP*CP*GP*G)-3', ...
Authors:Eckenroth, B.E, Doublie, S.
Deposit date:2014-02-27
Release date:2014-04-02
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Crystal Structure of DNA Polymerase beta with DNA Containing the Base Lesion Spiroiminodihydantoin in a Templating Position.
Biochemistry, 53, 2014
6UOL
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BU of 6uol by Molmil
Y271G DNA polymerase beta substrate complex with a templating cytosine and incoming rGTP
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, DNA (5'-D(*CP*CP*GP*AP*CP*CP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ...
Authors:Smith, M.R, Freudenthal, B.D.
Deposit date:2019-10-15
Release date:2020-01-08
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.936 Å)
Cite:Molecular and structural characterization of oxidized ribonucleotide insertion into DNA by human DNA polymerase beta.
J.Biol.Chem., 295, 2020
6UOK
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BU of 6uok by Molmil
Y271G DNA polymerase beta substrate complex with templating cytosine and incoming r8-oxo-GTP
Descriptor: 1,2-ETHANEDIOL, 8-OXO-GUANOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, ...
Authors:Smith, M.R, Freudenthal, B.D.
Deposit date:2019-10-15
Release date:2020-01-08
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Molecular and structural characterization of oxidized ribonucleotide insertion into DNA by human DNA polymerase beta.
J.Biol.Chem., 295, 2020
6UOM
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BU of 6uom by Molmil
Y271G DNA polymerase beta ternary complex with templating adenine and incoming r8-oxo-GTP
Descriptor: 1,2-ETHANEDIOL, 2',3'-DIDEOXYCYTIDINE-5'-MONOPHOSPHATE, 8-OXO-GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Smith, M.R, Freudenthal, B.D.
Deposit date:2019-10-15
Release date:2020-01-08
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Molecular and structural characterization of oxidized ribonucleotide insertion into DNA by human DNA polymerase beta.
J.Biol.Chem., 295, 2020
3UXO
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BU of 3uxo by Molmil
Crystal Structure of Rat DNA Polymerase Beta Mutator I260Q Apoenzyme
Descriptor: DNA polymerase beta
Authors:Gridley, C.L, Jaeger, J.
Deposit date:2011-12-05
Release date:2012-12-05
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Changes in the Hydrophobic Hinge Region Adversely Affect the Activity and Fidelity of the I260Q Mutator DNA Polymerase beta.
Biochemistry, 52, 2013
3UXP
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BU of 3uxp by Molmil
Co-crystal Structure of Rat DNA polymerase beta Mutator I260Q: Enzyme-DNA-ddTTP
Descriptor: 2',3'-DIDEOXY-THYMIDINE-5'-TRIPHOSPHATE, DNA 5'-D(P*AP*CP*TP*CP*AP*CP*AP*TP*A)-3', DNA 5'-D(P*AP*TP*GP*TP*GP*AP*G)-3', ...
Authors:Gridley, C.L, Jaeger, J.
Deposit date:2011-12-05
Release date:2012-12-05
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.723 Å)
Cite:Structural Changes in the Hydrophobic Hinge Region Adversely Affect the Activity and Fidelity of the I260Q Mutator DNA Polymerase beta.
Biochemistry, 52, 2013
3V7J
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BU of 3v7j by Molmil
Co-crystal structure of Wild Type Rat polymerase beta: Enzyme-DNA binary complex
Descriptor: CHLORIDE ION, DNA (5'-D(P*AP*TP*GP*TP*GP*AP*GP*T)-3'), DNA (5'-D(P*CP*AP*AP*AP*CP*TP*CP*AP*CP*AP*TP*A)-3'), ...
Authors:Rangarajan, S, Jaeger, J.
Deposit date:2011-12-21
Release date:2013-01-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystallographic studies of K72E mutant DNA polymerase explain loss of lyase function and reveal changes in the overall conformational state of the polymerase domain
To be Published
3V7K
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BU of 3v7k by Molmil
Co-crystal structure of K72E variant of rat polymerase beta: Enzyme-DNA binary complex
Descriptor: DNA (5'-D(P*AP*TP*GP*TP*GP*AP*GP*T)-3'), DNA (5'-D(P*CP*AP*AP*AP*CP*TP*CP*AP*CP*AP*A)-3'), DNA polymerase beta, ...
Authors:Rangarajan, S, Jaeger, J.
Deposit date:2011-12-21
Release date:2013-01-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.271 Å)
Cite:Crystallographic studies of K72E mutant DNA polymerase explain loss of lyase function and reveal changes in the overall conformational state of the polymerase domain
To be Published
3V7L
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BU of 3v7l by Molmil
Apo Structure of Rat DNA polymerase beta K72E variant
Descriptor: CHLORIDE ION, DNA polymerase beta, SODIUM ION, ...
Authors:Rangarajan, S, Jaeger, J.
Deposit date:2011-12-21
Release date:2013-01-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.66 Å)
Cite:Crystallographic studies of K72E mutant DNA polymerase explain loss of lyase function and reveal changes in the overall conformational state of the polymerase domain
To be Published
3UXN
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BU of 3uxn by Molmil
Crystal Structure of Rat DNA Polymerase Beta, Wild Type Apoenzyme
Descriptor: DNA polymerase beta
Authors:Gridley, C.L, Firbank, S, Jaeger, J.
Deposit date:2011-12-05
Release date:2012-12-05
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Changes in the Hydrophobic Hinge Region Adversely Affect the Activity and Fidelity of the I260Q Mutator DNA Polymerase beta.
Biochemistry, 52, 2013
3V72
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BU of 3v72 by Molmil
Crystal Structure of Rat DNA polymerase beta Mutator E295K: Enzyme-dsDNA
Descriptor: CHLORIDE ION, DNA 5'-D(P*AP*AP*AP*CP*TP*CP*AP*CP*AP*T)-3', DNA 5'-D(P*AP*TP*GP*TP*GP*AP*GP*T)-3', ...
Authors:Gridley, C.L, Jaeger, J.
Deposit date:2011-12-20
Release date:2012-07-04
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Unfavorable Electrostatic and Steric Interactions in DNA Polymerase beta E295K Mutant Interfere with the Enzyme s Pathway
J.Am.Chem.Soc., 134, 2012
5U8G
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BU of 5u8g by Molmil
DNA Polymerase Beta crystallized in PEG 400
Descriptor: CHLORIDE ION, DNA (5'-D(*CP*CP*GP*AP*CP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3'), ...
Authors:Eckenroth, B.E, Doublie, S.
Deposit date:2016-12-14
Release date:2017-04-26
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.166 Å)
Cite:Remote Mutations Induce Functional Changes in Active Site Residues of Human DNA Polymerase beta.
Biochemistry, 56, 2017
5U8I
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BU of 5u8i by Molmil
DNA Polymerase Beta S229L crystallized in PEG 400
Descriptor: DNA (5'-D(*CP*CP*GP*AP*CP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3'), DNA (5'-D(*GP*TP*CP*GP*G)-3'), ...
Authors:Eckenroth, B.E, Doublie, S.
Deposit date:2016-12-14
Release date:2017-04-26
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Remote Mutations Induce Functional Changes in Active Site Residues of Human DNA Polymerase beta.
Biochemistry, 56, 2017
5U8H
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BU of 5u8h by Molmil
DNA Polymerase Beta G231D crystallized in PEG 400
Descriptor: DNA (5'-D(*CP*CP*GP*AP*CP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3'), DNA (5'-D(*GP*TP*CP*GP*G)-3'), ...
Authors:Eckenroth, B.E, Doublie, S.
Deposit date:2016-12-14
Release date:2017-04-26
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.155 Å)
Cite:Remote Mutations Induce Functional Changes in Active Site Residues of Human DNA Polymerase beta.
Biochemistry, 56, 2017
6BTF
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BU of 6btf by Molmil
DNA Polymerase Beta I260Q Ternary Complex
Descriptor: 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, DNA Downstream Strand, DNA Primer Strand, ...
Authors:Eckenroth, B.E, Doublie, S.
Deposit date:2017-12-06
Release date:2018-09-26
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:I260Q DNA polymerase beta highlights precatalytic conformational rearrangements critical for fidelity.
Nucleic Acids Res., 46, 2018
6BTE
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BU of 6bte by Molmil
DNA Polymerase Beta I260Q Binary Complex
Descriptor: CHLORIDE ION, DNA Downstream Strand, DNA Primer Strand, ...
Authors:Eckenroth, B.E, Doublie, S.
Deposit date:2017-12-06
Release date:2018-09-26
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:I260Q DNA polymerase beta highlights precatalytic conformational rearrangements critical for fidelity.
Nucleic Acids Res., 46, 2018
6NKZ
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BU of 6nkz by Molmil
Ternary complex crystal structure of K289M variant of DNA polymerase Beta with "hot-spot sequence" with beta-gamma methylene dGTP
Descriptor: 2'-DEOXY-5'-O-(HYDROXY{[HYDROXY(PHOSPHONOMETHYL)PHOSPHORYL]OXY}PHOSPHORYL)GUANOSINE, DNA (5'-D(*CP*CP*GP*AP*AP*CP*AP*AP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*TP*(2DT))-3'), ...
Authors:Batra, V.K, Wilson, S.H.
Deposit date:2019-01-07
Release date:2020-01-08
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Revealing an Internal Stabilization Deficiency in the DNA Polymerase beta K289M Cancer Variant through the Combined Use of Chemical Biology and X-ray Crystallography.
Biochemistry, 59, 2020
6NKX
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BU of 6nkx by Molmil
Ternary complex crystal structure of K289M variant of DNA polymerase Beta with "hot-spot sequence" with dGTP
Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, DNA (5'-D(*CP*CP*GP*AP*AP*CP*AP*AP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ...
Authors:Batra, V.K, Wilson, S.H.
Deposit date:2019-01-07
Release date:2020-01-08
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Revealing an Internal Stabilization Deficiency in the DNA Polymerase beta K289M Cancer Variant through the Combined Use of Chemical Biology and X-ray Crystallography.
Biochemistry, 59, 2020
6NKT
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BU of 6nkt by Molmil
Ternary complex crystal structure of K289M variant of DNA polymerase Beta with beta-gamma difluoro analogue of dGTP
Descriptor: 2'-DEOXY-5'-O-[({[DIFLUORO(PHOSPHONO)METHYL](HYDROXY)PHOSPHORYL}OXY)(HYDROXY)PHOSPHORYL]GUANOSINE, DNA (5'-D(*CP*CP*GP*AP*CP*CP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DOC))-3'), ...
Authors:Batra, V.K, Wilson, S.H.
Deposit date:2019-01-07
Release date:2020-01-08
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Revealing an Internal Stabilization Deficiency in the DNA Polymerase beta K289M Cancer Variant through the Combined Use of Chemical Biology and X-ray Crystallography.
Biochemistry, 59, 2020
6NKY
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BU of 6nky by Molmil
Ternary complex crystal structure of K289M variant of DNA polymerase Beta with "hot-spot sequence" with beta-gamma CHF analogue of dGTP
Descriptor: 2'-DEOXY-5'-O-[(R)-{[(R)-[(R)-FLUORO(PHOSPHONO)METHYL](HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]GUANOSINE, CHLORIDE ION, DNA (5'-D(*CP*CP*GP*AP*AP*CP*AP*AP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ...
Authors:Batra, V.K, Wilson, S.H.
Deposit date:2019-01-07
Release date:2020-01-08
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.094 Å)
Cite:Revealing an Internal Stabilization Deficiency in the DNA Polymerase beta K289M Cancer Variant through the Combined Use of Chemical Biology and X-ray Crystallography.
Biochemistry, 59, 2020
6NKV
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BU of 6nkv by Molmil
Ternary complex crystal structure of DNA polymerase Beta with "hot-spot sequence" with beta-gamma CHF analogue of dGTP
Descriptor: 2'-DEOXY-5'-O-[(R)-{[(R)-[(R)-FLUORO(PHOSPHONO)METHYL](HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]GUANOSINE, CHLORIDE ION, DNA (5'-D(*CP*CP*GP*AP*AP*CP*AP*AP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ...
Authors:Batra, V.K, Wilson, S.H.
Deposit date:2019-01-07
Release date:2020-01-08
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Revealing an Internal Stabilization Deficiency in the DNA Polymerase beta K289M Cancer Variant through the Combined Use of Chemical Biology and X-ray Crystallography.
Biochemistry, 59, 2020
6NKR
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BU of 6nkr by Molmil
Ternary complex crystal structure of K289M variant of DNA polymerase Beta with dGTP
Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, DNA (5'-D(*CP*CP*GP*AP*CP*CP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ...
Authors:Batra, V.K, Wilson, S.H.
Deposit date:2019-01-07
Release date:2020-01-08
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Revealing an Internal Stabilization Deficiency in the DNA Polymerase beta K289M Cancer Variant through the Combined Use of Chemical Biology and X-ray Crystallography.
Biochemistry, 59, 2020
6NKU
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BU of 6nku by Molmil
Ternary complex crystal structure of DNA polymerase Beta with "hot-spot sequence" with dGTP
Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, DNA (5'-D(*CP*CP*GP*AP*AP*CP*AP*AP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ...
Authors:Batra, V.K, Wilson, S.H.
Deposit date:2019-01-07
Release date:2020-01-08
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Revealing an Internal Stabilization Deficiency in the DNA Polymerase beta K289M Cancer Variant through the Combined Use of Chemical Biology and X-ray Crystallography.
Biochemistry, 59, 2020
6NKS
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BU of 6nks by Molmil
Ternary complex crystal structure of K289M variant of DNA polymerase Beta with beta-gamma CHF analog of dGTP
Descriptor: 2'-DEOXY-5'-O-[(R)-{[(R)-[(R)-FLUORO(PHOSPHONO)METHYL](HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]GUANOSINE, CHLORIDE ION, DNA (5'-D(*CP*CP*GP*AP*CP*CP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ...
Authors:Batra, V.K, Wilson, S.H.
Deposit date:2019-01-07
Release date:2020-01-08
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.349 Å)
Cite:Revealing an Internal Stabilization Deficiency in the DNA Polymerase beta K289M Cancer Variant through the Combined Use of Chemical Biology and X-ray Crystallography.
Biochemistry, 59, 2020

 

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