6L3G
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![BU of 6l3g by Molmil](/molmil-images/mine/6l3g) | Structural Basis for DNA Unwinding at Forked dsDNA by two coordinating Pif1 helicases | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent DNA helicase, DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*CP*GP*CP*GP*CP*GP*CP*GP*CP*GP*TP*TP*TP*T)-3'), ... | Authors: | Su, N, Bharath, S.R, Song, H. | Deposit date: | 2019-10-10 | Release date: | 2019-12-11 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Structural basis for DNA unwinding at forked dsDNA by two coordinating Pif1 helicases. Nat Commun, 10, 2019
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7WKS
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![BU of 7wks by Molmil](/molmil-images/mine/7wks) | Apo state of AtPIN3 | Descriptor: | Auxin efflux carrier component 3 | Authors: | Su, N. | Deposit date: | 2022-01-11 | Release date: | 2022-08-10 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structures and mechanisms of the Arabidopsis auxin transporter PIN3. Nature, 609, 2022
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7WKW
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![BU of 7wkw by Molmil](/molmil-images/mine/7wkw) | NPA bound state of AtPIN3 | Descriptor: | 2-(naphthalen-1-ylcarbamoyl)benzoic acid, Auxin efflux carrier component 3 | Authors: | Su, N. | Deposit date: | 2022-01-11 | Release date: | 2022-08-10 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (2.62 Å) | Cite: | Structures and mechanisms of the Arabidopsis auxin transporter PIN3. Nature, 609, 2022
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7XEM
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![BU of 7xem by Molmil](/molmil-images/mine/7xem) | Cholesterol bound state of mTRPV2 | Descriptor: | CHOLESTEROL, Transient receptor potential cation channel subfamily V member 2 | Authors: | Su, N. | Deposit date: | 2022-03-31 | Release date: | 2022-08-17 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (3.17 Å) | Cite: | Structural mechanisms of TRPV2 modulation by endogenous and exogenous ligands. Nat.Chem.Biol., 19, 2023
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7XEO
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![BU of 7xeo by Molmil](/molmil-images/mine/7xeo) | MbetaCD treated state of mTRPV2 | Descriptor: | Transient receptor potential cation channel subfamily V member 2 | Authors: | Su, N. | Deposit date: | 2022-03-31 | Release date: | 2022-08-17 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (2.89 Å) | Cite: | Structural mechanisms of TRPV2 modulation by endogenous and exogenous ligands. Nat.Chem.Biol., 19, 2023
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7XEV
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![BU of 7xev by Molmil](/molmil-images/mine/7xev) | Structure of mTRPV2_2-APB | Descriptor: | 2-aminoethyl diphenylborinate, Transient receptor potential cation channel subfamily V member 2 | Authors: | Su, N. | Deposit date: | 2022-03-31 | Release date: | 2022-08-17 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.27 Å) | Cite: | Structural mechanisms of TRPV2 modulation by endogenous and exogenous ligands. Nat.Chem.Biol., 19, 2023
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7XEU
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![BU of 7xeu by Molmil](/molmil-images/mine/7xeu) | Structure of mTRPV2_E2 | Descriptor: | CHOLESTEROL, Transient receptor potential cation channel subfamily V member 2 | Authors: | Su, N. | Deposit date: | 2022-03-31 | Release date: | 2022-08-17 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (2.77 Å) | Cite: | Structural mechanisms of TRPV2 modulation by endogenous and exogenous ligands. Nat.Chem.Biol., 19, 2023
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7XEW
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![BU of 7xew by Molmil](/molmil-images/mine/7xew) | Structure of mTRPV2_Q525F | Descriptor: | Transient receptor potential cation channel subfamily V member 2 | Authors: | Su, N. | Deposit date: | 2022-03-31 | Release date: | 2022-08-17 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (2.59 Å) | Cite: | Structural mechanisms of TRPV2 modulation by endogenous and exogenous ligands. Nat.Chem.Biol., 19, 2023
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7XER
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![BU of 7xer by Molmil](/molmil-images/mine/7xer) | Structure of mTRPV2_Q525T | Descriptor: | CHOLESTEROL, Transient receptor potential cation channel subfamily V member 2 | Authors: | Su, N. | Deposit date: | 2022-03-31 | Release date: | 2022-08-17 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (2.47 Å) | Cite: | Structural mechanisms of TRPV2 modulation by endogenous and exogenous ligands. Nat.Chem.Biol., 19, 2023
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7XXB
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![BU of 7xxb by Molmil](/molmil-images/mine/7xxb) | IAA bound state of AtPIN3 | Descriptor: | 1H-INDOL-3-YLACETIC ACID, Auxin efflux carrier component 3 | Authors: | Su, N. | Deposit date: | 2022-05-29 | Release date: | 2022-08-10 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (2.93 Å) | Cite: | Structures and mechanisms of the Arabidopsis auxin transporter PIN3. Nature, 609, 2022
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7YEP
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![BU of 7yep by Molmil](/molmil-images/mine/7yep) | 2-APB bound state of mTRPV2 | Descriptor: | 2-aminoethyl diphenylborinate, Transient receptor potential cation channel subfamily V member 2 | Authors: | Su, N. | Deposit date: | 2022-07-06 | Release date: | 2022-08-17 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (2.83 Å) | Cite: | Structural mechanisms of TRPV2 modulation by endogenous and exogenous ligands. Nat.Chem.Biol., 19, 2023
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8W9T
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![BU of 8w9t by Molmil](/molmil-images/mine/8w9t) | |
8W9V
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![BU of 8w9v by Molmil](/molmil-images/mine/8w9v) | |
8W9O
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![BU of 8w9o by Molmil](/molmil-images/mine/8w9o) | |
8W9N
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![BU of 8w9n by Molmil](/molmil-images/mine/8w9n) | |
1WP8
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![BU of 1wp8 by Molmil](/molmil-images/mine/1wp8) | crystal structure of Hendra Virus fusion core | Descriptor: | Fusion glycoprotein F0,Fusion glycoprotein F0 | Authors: | Xu, Y, Liu, Y, Lou, Z, Su, N, Bai, Z, Gao, G.F, Rao, Z. | Deposit date: | 2004-08-31 | Release date: | 2005-11-15 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structures of Nipah and Hendra virus fusion core proteins FEBS J., 273, 2006
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1WP7
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![BU of 1wp7 by Molmil](/molmil-images/mine/1wp7) | crystal structure of Nipah Virus fusion core | Descriptor: | fusion protein | Authors: | Xu, Y, Liu, Y, Lou, Z, Su, N, Bai, Z, Gao, G.F, Rao, Z. | Deposit date: | 2004-08-31 | Release date: | 2005-11-15 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of Nipah Virus fusion core To be Published
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4W6E
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![BU of 4w6e by Molmil](/molmil-images/mine/4w6e) | Human Tankyrase 1 with small molecule inhibitor | Descriptor: | 2-(4-{6-[(3S)-3,4-dimethylpiperazin-1-yl]-4-methylpyridin-3-yl}phenyl)-8-(hydroxymethyl)quinazolin-4(3H)-one, Tankyrase-1, ZINC ION | Authors: | Kazmirski, S.L, Johannes, J, Boriack-Sjodin, P.A, Howard, T. | Deposit date: | 2014-08-20 | Release date: | 2015-05-13 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Pyrimidinone nicotinamide mimetics as selective tankyrase and wnt pathway inhibitors suitable for in vivo pharmacology. Acs Med.Chem.Lett., 6, 2015
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5KU9
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![BU of 5ku9 by Molmil](/molmil-images/mine/5ku9) | Crystal structure of MCL1 with compound 1 | Descriptor: | (3~{S})-3-azanyl-4-(4-bromophenyl)-~{N}-[(3~{S})-1-[2-[[(2~{R})-1-(3,4-dichlorophenyl)-4-(methylamino)-4-oxidanylidene-butan-2-yl]amino]-2-oxidanylidene-ethyl]-2-oxidanylidene-4,5-dihydro-3~{H}-1-benzazepin-3-yl]butanamide, Induced myeloid leukemia cell differentiation protein Mcl-1, SODIUM ION | Authors: | Ferguson, A.D. | Deposit date: | 2016-07-13 | Release date: | 2017-01-11 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl-1 Inhibitors. ACS Med Chem Lett, 8, 2017
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5ECE
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![BU of 5ece by Molmil](/molmil-images/mine/5ece) | Tankyrase 1 with Phthalazinone 1 | Descriptor: | 1,2-ETHANEDIOL, 2-[4-[3-[(4-oxidanylidene-3~{H}-phthalazin-1-yl)methyl]phenyl]carbonylpiperazin-1-yl]pyridine-3-carbonitrile, ACETATE ION, ... | Authors: | Kazmirski, S.L, Johannes, J, Read, J.A, Howard, T, Larsen, N.A, Ferguson, A.D. | Deposit date: | 2015-10-20 | Release date: | 2015-11-25 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clustering. Bioorg.Med.Chem.Lett., 25, 2015
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5EBT
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![BU of 5ebt by Molmil](/molmil-images/mine/5ebt) | Tankyrase 1 with Phthalazinone 2 | Descriptor: | (R,R)-2,3-BUTANEDIOL, 4-[bis(fluoranyl)-[3-[[(6~{S})-6-methyl-3-(trifluoromethyl)-6,8-dihydro-5~{H}-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]carbonyl]phenyl]methyl]-2~{H}-phthalazin-1-one, Tankyrase-1, ... | Authors: | Kazmirski, S.L, Johannes, J. | Deposit date: | 2015-10-19 | Release date: | 2016-03-02 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.24 Å) | Cite: | Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clustering. Bioorg.Med.Chem.Lett., 25, 2015
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8RPO
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![BU of 8rpo by Molmil](/molmil-images/mine/8rpo) | BFL1 in complex with a reversible covalent ligand | Descriptor: | (~{E})-2-cyano-3-(2-dimethylphosphorylphenyl)-~{N}-[[1-[4-(trifluoromethyl)phenyl]cyclopropyl]methyl]prop-2-enamide, Bcl-2-related protein A1 | Authors: | Hargreaves, D. | Deposit date: | 2024-01-16 | Release date: | 2024-07-03 | Method: | X-RAY DIFFRACTION (1.791 Å) | Cite: | Identification and Evaluation of Reversible Covalent Binders to Cys55 of Bfl-1 from a DNA-Encoded Chemical Library Screen. Acs Med.Chem.Lett., 15, 2024
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4W5S
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![BU of 4w5s by Molmil](/molmil-images/mine/4w5s) | Tankyrase in complex with compound | Descriptor: | 8-(hydroxymethyl)-2-[4-(1-methyl-1H-pyrazol-4-yl)phenyl]quinazolin-4(3H)-one, GLYCEROL, Tankyrase-1, ... | Authors: | Johannes, J, Kazmirski, S.L, Boriack-Sjodin, P.A, Howard, T. | Deposit date: | 2014-08-18 | Release date: | 2015-05-13 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Pyrimidinone nicotinamide mimetics as selective tankyrase and wnt pathway inhibitors suitable for in vivo pharmacology. Acs Med.Chem.Lett., 6, 2015
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6LG2
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![BU of 6lg2 by Molmil](/molmil-images/mine/6lg2) | VanR bound to Vanillate | Descriptor: | 4-HYDROXY-3-METHOXYBENZOATE, Predicted transcriptional regulators | Authors: | He, Y, Bharath, S.R, Song, H. | Deposit date: | 2019-12-04 | Release date: | 2020-02-12 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Developing a highly efficient hydroxytyrosol whole-cell catalyst by de-bottlenecking rate-limiting steps. Nat Commun, 11, 2020
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6RNU
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![BU of 6rnu by Molmil](/molmil-images/mine/6rnu) | BCL-XL in a complex with a covalent small molecule inhibitor | Descriptor: | 4-(4-fluorophenyl)-3-fluorosulfonyl-benzoic acid, BROMIDE ION, Bcl-2-like protein 1 | Authors: | Hargreaves, D. | Deposit date: | 2019-05-09 | Release date: | 2019-10-02 | Last modified: | 2019-11-20 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Discovery and optimization of covalent Bcl-xL antagonists. Bioorg.Med.Chem.Lett., 29, 2019
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