6RNU
BCL-XL in a complex with a covalent small molecule inhibitor
Summary for 6RNU
Entry DOI | 10.2210/pdb6rnu/pdb |
Descriptor | Bcl-2-like protein 1, 4-(4-fluorophenyl)-3-fluorosulfonyl-benzoic acid, BROMIDE ION, ... (4 entities in total) |
Functional Keywords | bcl-xl, signaling protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 41445.17 |
Authors | Hargreaves, D. (deposition date: 2019-05-09, release date: 2019-10-02, Last modification date: 2019-11-20) |
Primary citation | Mukherjee, H.,Su, N.,Belmonte, M.A.,Hargreaves, D.,Patel, J.,Tentarelli, S.,Aquila, B.,Grimster, N.P. Discovery and optimization of covalent Bcl-xL antagonists. Bioorg.Med.Chem.Lett., 29:126682-126682, 2019 Cited by PubMed: 31606346DOI: 10.1016/j.bmcl.2019.126682 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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