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Structure of U2AF65 variant with polyuridine tract
分子名称:	1,4-DIETHYLENE DIOXIDE, 5'-R(PUPUPUPUPUPUP*U)-3', Splicing factor U2AF 65 kDa subunit
著者	Sickmier, E.A, Kielkopf, C.L.
登録日	2006-02-21
公開日	2006-07-25
最終更新日	2023-08-30
実験手法	X-RAY DIFFRACTION (2.5 Å)
主引用文献	Structural basis of polypyrimidine tract recognition by the essential splicing factor U2AF65. Mol.Cell, 23, 2006

1XCB

X-ray Structure of a Rex-Family Repressor/NADH Complex from Thermus Aquaticus
分子名称:	CALCIUM ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Redox-sensing transcriptional repressor rex
著者	Sickmier, E.A, Brekasis, D, Paranawithana, S, Bonanno, J.B, Burley, S.K, Paget, M.S, Kielkopf, C.L, New York SGX Research Center for Structural Genomics (NYSGXRC)
登録日	2004-09-01
公開日	2004-09-28
最終更新日	2021-02-03
実験手法	X-RAY DIFFRACTION (2.9 Å)
主引用文献	X-Ray Structure of a Rex-Family Repressor/NADH Complex: Insights into the Mechanism of Redox Sensing Structure, 13, 2005

1RIF

Crystal structure of the UvsW helicase from Bacteriophage T4
分子名称:	DNA helicase uvsW, GOLD ION, MAGNESIUM ION
著者	Sickmier, E.A, White, S.W, Kreuzer, K.N.
登録日	2003-11-17
公開日	2003-11-25
最終更新日	2024-02-14
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	The Crystal Structure of the UvsW Helicase from Bacteriophage T4. Structure, 12, 2004

5SX5

Crystal Structure of panitumumab in complex with epidermal growth factor receptor domain 3 mutant S468R.
分子名称:	1,2-ETHANEDIOL, Epidermal growth factor receptor, GLYCEROL, ...
著者	Sickmier, E.A.
登録日	2016-08-09
公開日	2016-10-05
最終更新日	2023-10-04
実験手法	X-RAY DIFFRACTION (2.5 Å)
主引用文献	The Panitumumab EGFR Complex Reveals a Binding Mechanism That Overcomes Cetuximab Induced Resistance. Plos One, 11, 2016

5SX4

Crystal Structure of panitumumab in complex with epidermal growth factor receptor domain 3.
分子名称:	1,2-ETHANEDIOL, Epidermal growth factor receptor, GLYCEROL, ...
著者	Sickmier, E.A, Kurzeja, R.J.M, Michelsen, K, Mukta, V, Yang, E, Tasker, A.S.
登録日	2016-08-09
公開日	2016-10-05
最終更新日	2023-10-04
実験手法	X-RAY DIFFRACTION (2.8 Å)
主引用文献	The Panitumumab EGFR Complex Reveals a Binding Mechanism That Overcomes Cetuximab Induced Resistance. Plos One, 11, 2016

4Z7P

X-ray structure of racemic ShK Q16K toxin
分子名称:	Potassium channel toxin kappa-stichotoxin-She1a, SULFATE ION
著者	Sickmier, E.A.
登録日	2015-04-07
公開日	2015-09-09
最終更新日	2015-09-23
実験手法	X-RAY DIFFRACTION (1.2 Å)
主引用文献	Pharmaceutical Optimization of Peptide Toxins for Ion Channel Targets: Potent, Selective, and Long-Lived Antagonists of Kv1.3. J.Med.Chem., 58, 2015

4DUS

Structure of Bace-1 (Beta-Secretase) in complex with N-((2S,3R)-1-(4-fluorophenyl)-3-hydroxy-4-((6'-neopentyl-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)butan-2-yl)acetamide
分子名称:	Beta-secretase 1, GLYCEROL, IODIDE ION, ...
著者	Sickmier, E.A.
登録日	2012-02-22
公開日	2012-10-10
最終更新日	2014-07-02
実験手法	X-RAY DIFFRACTION (2.5 Å)
主引用文献	A Potent and Orally Efficacious, Hydroxyethylamine-Based Inhibitor of beta-Secretase. ACS Med Chem Lett, 3, 2012

4DH6

Structure of Bace-1 (Beta-Secretase) in Complex with (2R)-N-((2S,3R)-1-(benzo[d][1,3]dioxol-5-yl)-3-hydroxy-4-((S)-6'-neopentyl-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridine]-4'-ylamino)butan-2-yl)-2-methoxypropanamide
分子名称:	(2R)-N-[(2S,3R)-1-(1,3-benzodioxol-5-yl)-4-{[(4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl]amino}-3-hydroxybutan-2-yl]-2-methoxypropanamide, Beta-secretase 1, GLYCEROL, ...
著者	Sickmier, E.A.
登録日	2012-01-27
公開日	2012-04-18
最終更新日	2013-07-03
実験手法	X-RAY DIFFRACTION (2.5 Å)
主引用文献	Design and preparation of a potent series of hydroxyethylamine containing beta-secretase inhibitors that demonstrate robust reduction of central beta-amyloid. J.Med.Chem., 55, 2012

3RSV

Structure of Bace-1 (Beta-Secretase) in complex with (R)-3-(2-amino-6-o-tolylquinolin-3-yl)-N-((R)-2,2-dimethyltetrahydro-2H-pyran-4-yl)-2-methylpropanamide
分子名称:	(2R)-3-[2-amino-6-(2-methylphenyl)quinolin-3-yl]-N-[(4R)-2,2-dimethyltetrahydro-2H-pyran-4-yl]-2-methylpropanamide, Beta-secretase 1, GLYCEROL, ...
著者	Sickmier, E.A.
登録日	2011-05-02
公開日	2011-08-31
最終更新日	2023-09-13
実験手法	X-RAY DIFFRACTION (2.5 Å)
主引用文献	From Fragment Screening to In Vivo Efficacy: Optimization of a Series of 2-Aminoquinolines as Potent Inhibitors of Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1). J.Med.Chem., 54, 2011

3RTH

Structure of Bace-1 (Beta-Secretase) in Complex with 6-(2-(3,3-Dimethylbut-1-ynyl)phenyl)quinolin-2-amine
分子名称:	6-[2-(3,3-dimethylbut-1-yn-1-yl)phenyl]quinolin-2-amine, Beta-secretase 1, IODIDE ION
著者	Sickmier, E.A.
登録日	2011-05-03
公開日	2011-08-31
最終更新日	2017-11-08
実験手法	X-RAY DIFFRACTION (2.7 Å)
主引用文献	From Fragment Screening to In Vivo Efficacy: Optimization of a Series of 2-Aminoquinolines as Potent Inhibitors of Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1). J.Med.Chem., 54, 2011

3RTN

Structure of Bace-1 (Beta-Secretase) in Complex with 3-(2-Amino-6-o-tolylquinolin-3-yl)-N-cyclohexylpropanamide
分子名称:	3-[2-amino-6-(2-methylphenyl)quinolin-3-yl]-N-cyclohexylpropanamide, Beta-secretase 1, GLYCEROL, ...
著者	Sickmier, E.A.
登録日	2011-05-03
公開日	2011-08-31
実験手法	X-RAY DIFFRACTION (2.7 Å)
主引用文献	From Fragment Screening to In Vivo Efficacy: Optimization of a Series of 2-Aminoquinolines as Potent Inhibitors of Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1). J.Med.Chem., 54, 2011

5IN4

Crystal Structure of GDP-mannose 4,6 dehydratase bound to a GDP-fucose based inhibitor
分子名称:	GDP-mannose 4,6 dehydratase, GUANOSINE-5'-DIPHOSPHATE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
著者	Sickmier, E.A.
登録日	2016-03-07
公開日	2016-08-17
最終更新日	2024-03-06
実験手法	X-RAY DIFFRACTION (1.6 Å)
主引用文献	Facile Modulation of Antibody Fucosylation with Small Molecule Fucostatin Inhibitors and Cocrystal Structure with GDP-Mannose 4,6-Dehydratase. Acs Chem.Biol., 11, 2016

5IN5

Crystal Structure of GDP-mannose 4,6 dehydratase in complex with natural inhibitor GDP-Fucose
分子名称:	GDP-mannose 4,6 dehydratase, GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, ...
著者	Sickmier, E.A.
登録日	2016-03-07
公開日	2016-08-17
最終更新日	2024-03-06
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	Facile Modulation of Antibody Fucosylation with Small Molecule Fucostatin Inhibitors and Cocrystal Structure with GDP-Mannose 4,6-Dehydratase. Acs Chem.Biol., 11, 2016

3RSX

Structure of Bace-1 (Beta-Secretase) in Complex with 6-(Thiophen-3-yl)quinolin-2-amine
分子名称:	6-(thiophen-3-yl)quinolin-2-amine, Beta-secretase 1, IODIDE ION
著者	Sickmier, E.A.
登録日	2011-05-02
公開日	2011-08-31
実験手法	X-RAY DIFFRACTION (2.48 Å)
主引用文献	From Fragment Screening to In Vivo Efficacy: Optimization of a Series of 2-Aminoquinolines as Potent Inhibitors of Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1). J.Med.Chem., 54, 2011

3RTM

Structure of Bace-1 (Beta-Secretase) in Complex with 3-(2-Aminoquinolin-3-yl)-N-cyclohexyl-N-methylpropanamide
分子名称:	3-(2-aminoquinolin-3-yl)-N-cyclohexyl-N-methylpropanamide, Beta-secretase 1, GLYCEROL, ...
著者	Sickmier, E.A.
登録日	2011-05-03
公開日	2011-08-31
実験手法	X-RAY DIFFRACTION (2.76 Å)
主引用文献	From Fragment Screening to In Vivo Efficacy: Optimization of a Series of 2-Aminoquinolines as Potent Inhibitors of Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1). J.Med.Chem., 54, 2011

3RU1

Structure of Bace-1 (Beta-Secretase) in Complex with 3-(2-Aminoquinolin-3-yl)-N-(cyclohexylmethyl)propanamide
分子名称:	3-(2-aminoquinolin-3-yl)-N-(cyclohexylmethyl)propanamide, Beta-secretase 1, GLYCEROL, ...
著者	Sickmier, E.A.
登録日	2011-05-04
公開日	2011-08-31
最終更新日	2023-09-13
実験手法	X-RAY DIFFRACTION (2.3 Å)
主引用文献	From Fragment Screening to In Vivo Efficacy: Optimization of a Series of 2-Aminoquinolines as Potent Inhibitors of Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1). J.Med.Chem., 54, 2011

3RVI

Structure of Bace-1 (Beta-Secretase) in Complex with 2-((2-Amino-6-o-tolylquinolin-3-yl)methyl)-N-(cyclohexylmethyl)pentanamide
分子名称:	(2R)-2-{[2-amino-6-(2-methylphenyl)quinolin-3-yl]methyl}-N-(cyclohexylmethyl)pentanamide, Beta-secretase 1, GLYCEROL, ...
著者	Sickmier, E.A.
登録日	2011-05-06
公開日	2011-08-31
実験手法	X-RAY DIFFRACTION (2.65 Å)
主引用文献	From Fragment Screening to In Vivo Efficacy: Optimization of a Series of 2-Aminoquinolines as Potent Inhibitors of Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1). J.Med.Chem., 54, 2011

2HZC

Crystal structure of the N-terminal RRM of the U2AF large subunit
分子名称:	HEXAETHYLENE GLYCOL, Splicing factor U2AF 65 kDa subunit, ZINC ION
著者	Thickman, K.R, Sickmier, E.A, Kielkopf, C.L.
登録日	2006-08-08
公開日	2006-08-29
最終更新日	2024-02-21
実験手法	X-RAY DIFFRACTION (1.47 Å)
主引用文献	Alternative Conformations at the RNA-binding Surface of the N-terminal U2AF(65) RNA Recognition Motif. J.Mol.Biol., 366, 2007

1KAF

DNA Binding Domain Of The Phage T4 Transcription Factor MotA (AA105-211)
分子名称:	Transcription regulatory protein MOTA
著者	Li, N, Sickmier, E.A, Zhang, R, Joachimiak, A, White, S.W.
登録日	2001-11-01
公開日	2001-11-21
最終更新日	2022-12-21
実験手法	X-RAY DIFFRACTION (1.6 Å)
主引用文献	The MotA transcription factor from bacteriophage T4 contains a novel DNA-binding domain: the 'double wing' motif. Mol.Microbiol., 43, 2002

8SZQ

Cat DHX9 bound to ADP
分子名称:	1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
著者	Lee, Y.-T, Sickmier, E.A, Grigoriu, S, Boriack-Sjodin, P.A.
登録日	2023-05-30
公開日	2023-08-02
最終更新日	2023-11-08
実験手法	X-RAY DIFFRACTION (2.711 Å)
主引用文献	Crystal structures of the DExH-box RNA helicase DHX9. Acta Crystallogr D Struct Biol, 79, 2023

8SZP

Human DHX9 bound to ADP
分子名称:	1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, ATP-dependent RNA helicase A, ...
著者	Lee, Y.-T, Sickmier, E.A, Grigoriu, S, Boriack-Sjodin, P.A.
登録日	2023-05-30
公開日	2023-08-02
最終更新日	2023-11-08
実験手法	X-RAY DIFFRACTION (2.62 Å)
主引用文献	Crystal structures of the DExH-box RNA helicase DHX9. Acta Crystallogr D Struct Biol, 79, 2023

8SZR

Dog DHX9 bound to ADP
分子名称:	ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, RNA helicase, ...
著者	Lee, Y.-T, Sickmier, E.A, Grigoriu, S, Boriack-Sjodin, P.A.
登録日	2023-05-30
公開日	2023-08-02
最終更新日	2023-11-08
実験手法	X-RAY DIFFRACTION (2.97 Å)
主引用文献	Crystal structures of the DExH-box RNA helicase DHX9. Acta Crystallogr D Struct Biol, 79, 2023

8SZS

Cat DHX9 bound to GDP
分子名称:	1,2-ETHANEDIOL, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
著者	Lee, Y.-T, Sickmier, E.A, Boriack-Sjodin, P.A.
登録日	2023-05-30
公開日	2023-09-06
最終更新日	2023-12-27
実験手法	X-RAY DIFFRACTION (2.38 Å)
主引用文献	Development of assays to support identification and characterization of modulators of DExH-box helicase DHX9. Slas Discov, 28, 2023

5IE1

Crystal structure of BACE1 in complex with 3-(2-amino-6-(o-tolyl)quinolin-3-yl)-N-(3,3-dimethylbutyl)propanamide
分子名称:	3-[2-amino-6-(2-methylphenyl)quinolin-3-yl]-N-(3,3-dimethylbutyl)propanamide, Beta-secretase 1, GLYCEROL, ...
著者	Jordan, J.B, Whittington, D.A, Bartberger, M.D, Sickmier, E.A, Chen, K, Cheng, Y, Judd, T.
登録日	2016-02-24
公開日	2016-03-30
最終更新日	2024-04-03
実験手法	X-RAY DIFFRACTION (2.298 Å)
主引用文献	Fragment-Linking Approach Using (19)F NMR Spectroscopy To Obtain Highly Potent and Selective Inhibitors of beta-Secretase. J.Med.Chem., 59, 2016

5VBL

Structure of apelin receptor in complex with agonist peptide
分子名称:	(2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Apelin receptor,Rubredoxin,Apelin receptor Chimera, ZINC ION, ...
著者	Ma, Y, Yue, Y, Ma, Y, Zhang, Q, Zhou, Q, Song, Y, Shen, Y, Li, X, Ma, X, Li, C, Hanson, M.A, Han, G.W, Sickmier, E.A, Swaminath, G, Zhao, S, Stevems, R.C, Hu, L.A, Zhong, W, Zhang, M, Xu, F.
登録日	2017-03-29
公開日	2017-05-31
最終更新日	2023-11-15
実験手法	X-RAY DIFFRACTION (2.6 Å)
主引用文献	Structural Basis for Apelin Control of the Human Apelin Receptor Structure, 25, 2017

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