5IN5

Crystal Structure of GDP-mannose 4,6 dehydratase in complex with natural inhibitor GDP-Fucose

Summary for 5IN5

• Entry DOI: 10.2210/pdb5in5/pdb
• Related: 5IN4
• Descriptor: GDP-mannose 4,6 dehydratase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, ... (6 entities in total)
• Functional Keywords: gdp-mannose 4, 6 dehydratase, fucosylation, lyase-inhibitor complex, lyase/inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 173796.56

Authors

Sickmier, E.A. (deposition date: 2016-03-07, release date: 2016-08-17, Last modification date: 2024-03-06)

• Primary citation: Allen, J.G.,Mujacic, M.,Frohn, M.J.,Pickrell, A.J.,Kodama, P.,Bagal, D.,San Miguel, T.,Sickmier, E.A.,Osgood, S.,Swietlow, A.,Li, V.,Jordan, J.B.,Kim, K.W.,Rousseau, A.C.,Kim, Y.J.,Caille, S.,Achmatowicz, M.,Thiel, O.,Fotsch, C.H.,Reddy, P.,McCarter, J.D.; Facile Modulation of Antibody Fucosylation with Small Molecule Fucostatin Inhibitors and Cocrystal Structure with GDP-Mannose 4,6-Dehydratase.; Acs Chem.Biol., 11:2734-2743, 2016; PubMed: 27434622; DOI: 10.1021/acschembio.6b00460

Experimental method

X-RAY DIFFRACTION (1.9 Å)