5IN4
Crystal Structure of GDP-mannose 4,6 dehydratase bound to a GDP-fucose based inhibitor
Summary for 5IN4
Entry DOI | 10.2210/pdb5in4/pdb |
Related | 5IN5 |
Descriptor | GDP-mannose 4,6 dehydratase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, ... (5 entities in total) |
Functional Keywords | gdp-mannose 4, 6 dehydratase, antibody fucosylation, lyase-inhibitor complex, lyase/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 173920.35 |
Authors | Sickmier, E.A. (deposition date: 2016-03-07, release date: 2016-08-17, Last modification date: 2024-03-06) |
Primary citation | Allen, J.G.,Mujacic, M.,Frohn, M.J.,Pickrell, A.J.,Kodama, P.,Bagal, D.,San Miguel, T.,Sickmier, E.A.,Osgood, S.,Swietlow, A.,Li, V.,Jordan, J.B.,Kim, K.W.,Rousseau, A.C.,Kim, Y.J.,Caille, S.,Achmatowicz, M.,Thiel, O.,Fotsch, C.H.,Reddy, P.,McCarter, J.D. Facile Modulation of Antibody Fucosylation with Small Molecule Fucostatin Inhibitors and Cocrystal Structure with GDP-Mannose 4,6-Dehydratase. Acs Chem.Biol., 11:2734-2743, 2016 Cited by PubMed: 27434622DOI: 10.1021/acschembio.6b00460 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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