5IN4
Crystal Structure of GDP-mannose 4,6 dehydratase bound to a GDP-fucose based inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | GDP-mannose 4,6 dehydratase | polymer | 364 | 41650.2 | 4 | UniProt (O60547) Pfam (PF16363) In PDB | Homo sapiens (Human) | GDP-D-mannose dehydratase,GMD |
2 | A, B, C, D | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 4 | Chemie (NAP) | |||
3 | A, B, C, D | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 4 | Chemie (GDP) | |||
4 | A, B, C, D | [(2R,3S,4R,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,3S,4R,5S,6R)-3,4,5-trihydroxy-6-(trifluoromethyl)tetrahydro-2H-pyran-2-yl dihydrogen diphosphate (non-preferred name) | non-polymer | 643.3 | 4 | Chemie (6CK) | |||
5 | water | water | 18.0 | 1420 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 23 - 372 (UniProt: O60547)
PDB | External Database | Details |
---|---|---|
Met -35 | - | expression tag |
His -34 | - | expression tag |
His -33 | - | expression tag |
His -32 | - | expression tag |
His -31 | - | expression tag |
His -30 | - | expression tag |
His -29 | - | expression tag |
Glu -28 | - | expression tag |
Asn -27 | - | expression tag |
Leu -26 | - | expression tag |
Tyr -25 | - | expression tag |
Phe -24 | - | expression tag |
Gln -23 | - | expression tag |
Gly -22 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 166600.7 | |
Non-Polymers* | Number of molecules | 12 |
Total formula weight | 7319.7 | |
All* | Total formula weight | 173920.3 |