1FYV
| CRYSTAL STRUCTURE OF THE TIR DOMAIN OF HUMAN TLR1 | Descriptor: | TOLL-LIKE RECEPTOR 1 | Authors: | Xu, Y, Tao, X, Shen, B, Horng, T, Medzhitov, R, Manley, J.L, Tong, L. | Deposit date: | 2000-10-03 | Release date: | 2000-11-22 | Last modified: | 2018-01-31 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural basis for signal transduction by the Toll/interleukin-1 receptor domains. Nature, 408, 2000
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1FYX
| CRYSTAL STRUCTURE OF P681H MUTANT OF TIR DOMAIN OF HUMAN TLR2 | Descriptor: | TOLL-LIKE RECEPTOR 2 | Authors: | Xu, Y, Tao, X, Shen, B, Horng, T, Medzhitov, R, Manley, J.L, Tong, L. | Deposit date: | 2000-10-03 | Release date: | 2000-11-22 | Last modified: | 2021-11-03 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural basis for signal transduction by the Toll/interleukin-1 receptor domains. Nature, 408, 2000
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1FYW
| CRYSTAL STRUCTURE OF THE TIR DOMAIN OF HUMAN TLR2 | Descriptor: | TOLL-LIKE RECEPTOR 2 | Authors: | Xu, Y, Tao, X, Shen, B, Horng, T, Medzhitov, R, Manley, J.L, Tong, L, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2000-10-03 | Release date: | 2000-11-22 | Last modified: | 2018-01-31 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural basis for signal transduction by the Toll/interleukin-1 receptor domains. Nature, 408, 2000
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8G5T
| Crystal structure of apo TnmK2 | Descriptor: | TnmK2 | Authors: | Liu, Y.-C, Gui, C, Shen, B. | Deposit date: | 2023-02-14 | Release date: | 2023-10-18 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.846 Å) | Cite: | Cofactorless oxygenases guide anthraquinone-fused enediyne biosynthesis. Nat.Chem.Biol., 20, 2024
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8G5U
| Crystal structure of TnmK2 complexed with TNM B | Descriptor: | TnmK2, methyl (2E)-3-[(1aS,11S,11aS,14Z,18R)-3,18-dihydroxy-4,9-dioxo-4,9,10,11-tetrahydro-11aH-11,1a-hept[3]ene[1,5]diynonaphtho[2,3-h]oxireno[c]quinolin-11a-yl]but-2-enoate | Authors: | Liu, Y.-C, Gui, C, Shen, B. | Deposit date: | 2023-02-14 | Release date: | 2023-10-18 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.804 Å) | Cite: | Cofactorless oxygenases guide anthraquinone-fused enediyne biosynthesis. Nat.Chem.Biol., 20, 2024
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8G5S
| Crystal structure of apo TnmJ | Descriptor: | TnmJ | Authors: | Liu, Y.-C, Li, G, Gui, C, Shen, B. | Deposit date: | 2023-02-14 | Release date: | 2023-10-18 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Cofactorless oxygenases guide anthraquinone-fused enediyne biosynthesis. Nat.Chem.Biol., 20, 2024
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1I3A
| RNASE HII FROM ARCHAEOGLOBUS FULGIDUS WITH COBALT HEXAMMINE CHLORIDE | Descriptor: | COBALT HEXAMMINE(III), RIBONUCLEASE HII | Authors: | Chapados, B.R, Chai, Q, Hosfield, D.J, Qiu, J, Shen, B, Tainer, J.A. | Deposit date: | 2001-02-13 | Release date: | 2001-04-11 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Structural biochemistry of a type 2 RNase H: RNA primer recognition and removal during DNA replication. J.Mol.Biol., 307, 2001
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1I39
| RNASE HII FROM ARCHAEOGLOBUS FULGIDUS | Descriptor: | RIBONUCLEASE HII | Authors: | Chapados, B.R, Chai, Q, Hosfield, D.J, Qiu, J, Shen, B, Tainer, J.A. | Deposit date: | 2001-02-13 | Release date: | 2001-04-11 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structural biochemistry of a type 2 RNase H: RNA primer recognition and removal during DNA replication. J.Mol.Biol., 307, 2001
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6BBX
| Crystal structure of TnmS3 in complex with TNM C | Descriptor: | Glyoxalase/bleomycin resisance protein/dioxygenase, methyl (2R,3R)-2,3-dihydroxy-3-[(1aS,11S,11aR,14Z,18R)-3,7,8,18-tetrahydroxy-4,9-dioxo-4,9,10,11-tetrahydro-11aH-11,1a-hept[3]ene[1,5]diynonaphtho[2,3-h]oxireno[c]quinolin-11a-yl]butanoate | Authors: | Chang, C.Y, Chang, C, Nocek, B, Rudolf, J.D, Joachimiak, A, Phillips Jr, G.N, Shen, B, Enzyme Discovery for Natural Product Biosynthesis (NatPro), Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2017-10-19 | Release date: | 2018-07-04 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Resistance to Enediyne Antitumor Antibiotics by Sequestration. Cell Chem Biol, 25, 2018
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6OMR
| Crystal structure of PtmU3 complexed with PTN substrate | Descriptor: | ACETATE ION, MANGANESE (II) ION, PtmU3, ... | Authors: | Liu, Y.C, Dong, L.B, Shen, B. | Deposit date: | 2019-04-19 | Release date: | 2019-07-24 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Characterization and Crystal Structure of a Nonheme Diiron Monooxygenase Involved in Platensimycin and Platencin Biosynthesis. J.Am.Chem.Soc., 141, 2019
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6OMP
| Crystal structure of apo PtmU3 | Descriptor: | ACETATE ION, MANGANESE (II) ION, PtmU3 | Authors: | Liu, Y.C, Dong, L.B, Shen, B. | Deposit date: | 2019-04-19 | Release date: | 2019-07-24 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Characterization and Crystal Structure of a Nonheme Diiron Monooxygenase Involved in Platensimycin and Platencin Biosynthesis. J.Am.Chem.Soc., 141, 2019
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6OMQ
| Crystal structure of PtmU3 complexed with PTM substrate | Descriptor: | ACETATE ION, MANGANESE (II) ION, PtmU3, ... | Authors: | Liu, Y.C, Dong, L.B, Shen, B. | Deposit date: | 2019-04-19 | Release date: | 2019-07-24 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Characterization and Crystal Structure of a Nonheme Diiron Monooxygenase Involved in Platensimycin and Platencin Biosynthesis. J.Am.Chem.Soc., 141, 2019
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6XE0
| Cryo-EM structure of NusG-CTD bound to 70S ribosome (30S: NusG-CTD fragment) | Descriptor: | 16s rRNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | Authors: | Washburn, R, Zuber, P, Sun, M, Hashem, Y, Shen, B, Li, W, Harvey, S, Acosta-Reyes, F.J, Knauer, S.H, Frank, J, Gottesman, M.E. | Deposit date: | 2020-06-11 | Release date: | 2020-07-29 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (6.8 Å) | Cite: | Escherichia coli NusG Links the Lead Ribosome with the Transcription Elongation Complex. Iscience, 23, 2020
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4LQ0
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4LOX
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5UMY
| Crystal structure of TnmS3 in complex with tiancimycin | Descriptor: | (1aS,11S,11aR,14Z,18R)-3,8,18-trihydroxy-11a-[(1R)-1-hydroxyethyl]-7-methoxy-11,11a-dihydro-4H-11,1a-hept[3]ene[1,5]diynonaphtho[2,3-h]oxireno[c]quinoline-4,9(10H)-dione, Glyoxalase/bleomycin resisance protein/dioxygenase | Authors: | Chang, C.Y, Chang, C, Nocek, B, Rudolf, J.D, Joachimiak, A, Phillips Jr, G.N, SHen, B, Enzyme Discovery for Natural Product Biosynthesis (NatPro), Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2017-01-29 | Release date: | 2018-07-04 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | Resistance to Enediyne Antitumor Antibiotics by Sequestration. Cell Chem Biol, 25, 2018
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5UMQ
| Crystal structure of TnmS1, an antibiotic binding protein from Streptomyces sp. CB03234 | Descriptor: | Glyoxalase/bleomycin resisance protein/dioxygenase | Authors: | Chang, C.Y, Chang, C, Nocek, B, Rudolf, J.D, Joachimiak, A, Phillips Jr, G.N, Shen, B, Enzyme Discovery for Natural Product Biosynthesis (NatPro), Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2017-01-29 | Release date: | 2018-07-04 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Resistance to Enediyne Antitumor Antibiotics by Sequestration. Cell Chem Biol, 25, 2018
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5UMX
| Crystal structure of TnmS3 in complex with riboflavin | Descriptor: | Glyoxalase/bleomycin resisance protein/dioxygenase, RIBOFLAVIN | Authors: | Chang, C.Y, Chang, C, Nocek, B, Rudolf, J.D, Joachimiak, A, Phillips Jr, G.N, Shen, B, Enzyme Discovery for Natural Product Biosynthesis (NatPro), Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2017-01-29 | Release date: | 2018-07-04 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.59 Å) | Cite: | Resistance to Enediyne Antitumor Antibiotics by Sequestration. Cell Chem Biol, 25, 2018
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5UMP
| Crystal structure of TnmS3, an antibiotic binding protein from Streptomyces sp. CB03234 | Descriptor: | Glyoxalase/bleomycin resisance protein/dioxygenase | Authors: | Chang, C.Y, Chang, C, Nocek, B, Rudolf, J.D, Joachimiak, A, Phillips Jr, G.N, Shen, B, Enzyme Discovery for Natural Product Biosynthesis (NatPro), Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2017-01-29 | Release date: | 2018-07-04 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.08 Å) | Cite: | Resistance to Enediyne Antitumor Antibiotics by Sequestration. Cell Chem Biol, 25, 2018
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5UMW
| Crystal structure of TnmS2, an antibiotic binding protein from Streptomyces sp. CB03234 | Descriptor: | Glyoxalase/bleomycin resisance protein/dioxygenase, RIBOFLAVIN | Authors: | Chang, C.Y, Chang, C, Nocek, B, Rudolf, J.D, Joachimiak, A, Phillips Jr, G.N, Shen, B, Enzyme Discovery for Natural Product Biosynthesis (NatPro), Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2017-01-29 | Release date: | 2018-07-04 | Last modified: | 2020-09-23 | Method: | X-RAY DIFFRACTION (2.27 Å) | Cite: | Resistance to Enediyne Antitumor Antibiotics by Sequestration. Cell Chem Biol, 25, 2018
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5W27
| Crystal structure of TnmS3 in complex with tiancimycin (TNM B) | Descriptor: | Glyoxalase/bleomycin resisance protein/dioxygenase, methyl (2E)-3-[(1aS,11S,11aS,14Z,18R)-3,18-dihydroxy-4,9-dioxo-4,9,10,11-tetrahydro-11aH-11,1a-hept[3]ene[1,5]diynonaphtho[2,3-h]oxireno[c]quinolin-11a-yl]but-2-enoate | Authors: | Chang, C.Y, Chang, C, Nocek, B, Rudolf, J.D, Joachimiak, A, Phillips Jr, G.N, SHen, B, Enzyme Discovery for Natural Product Biosynthesis (NatPro), Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2017-06-05 | Release date: | 2018-06-06 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of TnmS3 in complex with tiancimycin (TNM B) To Be Published
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4OQJ
| Streptomcyes albus JA3453 oxazolomycin ketosynthase domain OzmQ KS1 | Descriptor: | GLYCEROL, PHOSPHATE ION, PKS, ... | Authors: | Nocek, B, Mack, J, Endras, M, Babnigg, G, Bingman, C.A, Yennamalli, R, Lohman, J.R, Ma, M, Shen, B, Phillips Jr, G.N, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro) | Deposit date: | 2014-02-09 | Release date: | 2014-03-19 | Last modified: | 2016-11-02 | Method: | X-RAY DIFFRACTION (1.904 Å) | Cite: | Structural and evolutionary relationships of "AT-less" type I polyketide synthase ketosynthases. Proc.Natl.Acad.Sci.USA, 112, 2015
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1XX5
| Crystal Structure of Natrin from Naja atra snake venom | Descriptor: | ETHANOL, Natrin 1 | Authors: | Wang, J, Shen, B, Lou, X.H, Guo, M, Teng, M.K, Niu, L.W. | Deposit date: | 2004-11-04 | Release date: | 2005-06-14 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Blocking effect and crystal structure of natrin toxin, a cysteine-rich secretory protein from Naja atra venom that targets the BKCa channel Biochemistry, 44, 2005
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6DA6
| Crystal structure of the TtnD decarboxylase from the tautomycetin biosynthesis pathway of Streptomyces griseochromogenes, apo form at 2.6 A resolution (P212121) | Descriptor: | GLYCEROL, MAGNESIUM ION, UNKNOWN LIGAND, ... | Authors: | Han, L, Rudolf, J.D, Chang, C.-Y, Miller, M.D, Soman, J, Phillips Jr, G.N, Shen, B, Enzyme Discovery for Natural Product Biosynthesis (NatPro) | Deposit date: | 2018-05-01 | Release date: | 2018-10-03 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.59 Å) | Cite: | Biochemical and Structural Characterization of TtnD, a Prenylated FMN-Dependent Decarboxylase from the Tautomycetin Biosynthetic Pathway. ACS Chem. Biol., 13, 2018
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6DA7
| Crystal structure of the TtnD decarboxylase from the tautomycetin biosynthesis pathway of Streptomyces griseochromogenes with apo form at 1.83 A resolution (I222) | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLYCEROL, SODIUM ION, ... | Authors: | Han, L, Rudolf, J.D, Chang, C.-Y, Miller, M.D, Soman, J, Phillips Jr, G.N, Shen, B, Enzyme Discovery for Natural Product Biosynthesis (NatPro) | Deposit date: | 2018-05-01 | Release date: | 2018-10-03 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | Biochemical and Structural Characterization of TtnD, a Prenylated FMN-Dependent Decarboxylase from the Tautomycetin Biosynthetic Pathway. ACS Chem. Biol., 13, 2018
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