3CV9
 
 | | Crystal structure of vitamin D hydroxylase cytochrome P450 105A1 (R73A/R84A mutant) in complex with 1alpha,25-dihydroxyvitamin D3 | | Descriptor: | 5-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANE-1,3-DIOL, Cytochrome P450-SU1, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Hayashi, K, Sugimoto, H, Shinkyo, R, Yamada, M, Ikeda, S, Ikushiro, S, Kamakura, M, Shiro, Y, Sakaki, T. | | Deposit date: | 2008-04-18 | | Release date: | 2008-11-04 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structure-based design of a highly active vitamin D hydroxylase from Streptomyces griseolus CYP105A1
Biochemistry, 47, 2008
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3CV8
 | | Crystal structure of vitamin D hydroxylase cytochrome P450 105A1 (R84F mutant) | | Descriptor: | Cytochrome P450-SU1, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Hayashi, K, Sugimoto, H, Shinkyo, R, Yamada, M, Ikeda, S, Ikushiro, S, Kamakura, M, Shiro, Y, Sakaki, T. | | Deposit date: | 2008-04-18 | | Release date: | 2008-11-04 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structure-based design of a highly active vitamin D hydroxylase from Streptomyces griseolus CYP105A1
Biochemistry, 47, 2008
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5X7E
 | | Crystal structure of vitamin D hydroxylase cytochrome P450 105A1 (R84A mutant) in complex with 1,25-dihydroxyvitamin D2 | | Descriptor: | (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5S)-5,6-dimethyl-6-oxidanyl-hept-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydr o-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol, PROTOPORPHYRIN IX CONTAINING FE, Vitamin D3 dihydroxylase | | Authors: | Hayashi, K, Yasuda, K, Shiro, Y, Sugimoto, H, Sakaki, T. | | Deposit date: | 2017-02-25 | | Release date: | 2017-05-10 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Production of an active form of vitamin D2 by genetically engineered CYP105A1
Biochem. Biophys. Res. Commun., 486, 2017
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9KW5
 | | Crystal structure of CYP105A1 R84A, diclofenac and lanoconazole complex | | Descriptor: | (2~{E})-2-[(4~{R})-4-(2-chlorophenyl)-1,3-dithiolan-2-ylidene]-2-imidazol-1-yl-ethanenitrile, 2-[2,6-DICHLOROPHENYL)AMINO]BENZENEACETIC ACID, PROTOPORPHYRIN IX CONTAINING FE, ... | | Authors: | Hirano, Y, Yoneda, S, Yasuda, K, Takimoto-Kamimura, M, Sakaki, T, Tamada, T. | | Deposit date: | 2024-12-05 | | Release date: | 2025-05-21 | | Last modified: | 2025-05-28 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Cooperative inhibition in cytochrome P450 between a substrate and an apparent noncompetitive inhibitor.
J.Biol.Chem., 301, 2025
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9KW4
 | | Crystal structure of CYP105A1 R84A and miconazole complex | | Descriptor: | 1-[(2S)-2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, PROTOPORPHYRIN IX CONTAINING FE, ... | | Authors: | Hirano, Y, Yoneda, S, Yasuda, K, Takimoto-Kamimura, M, Sakaki, T, Tamada, T. | | Deposit date: | 2024-12-05 | | Release date: | 2025-05-21 | | Last modified: | 2025-05-28 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Cooperative inhibition in cytochrome P450 between a substrate and an apparent noncompetitive inhibitor.
J.Biol.Chem., 301, 2025
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9KW3
 | | Crystal structure of CYP105A1 R84A and lanoconazole complex | | Descriptor: | (2~{E})-2-[(4~{R})-4-(2-chlorophenyl)-1,3-dithiolan-2-ylidene]-2-imidazol-1-yl-ethanenitrile, PROTOPORPHYRIN IX CONTAINING FE, Vitamin D3 dihydroxylase | | Authors: | Hirano, Y, Yoneda, S, Yasuda, K, Takimoto-Kamimura, M, Sakaki, T, Tamada, T. | | Deposit date: | 2024-12-05 | | Release date: | 2025-05-21 | | Last modified: | 2025-05-28 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Cooperative inhibition in cytochrome P450 between a substrate and an apparent noncompetitive inhibitor.
J.Biol.Chem., 301, 2025
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9KW2
 | | Crystal structure of CYP105A1 R84A and ketoconazole complex | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CIS-1-ACETYL-4-(4-((2-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-1-YLMETHYL)-1,3-DIOXOLAN-4-YL)METHOXY)PHENYL)PIPERAZINE, PROTOPORPHYRIN IX CONTAINING FE, ... | | Authors: | Hirano, Y, Yoneda, S, Yasuda, K, Takimoto-Kamimura, M, Sakaki, T, Tamada, T. | | Deposit date: | 2024-12-05 | | Release date: | 2025-05-21 | | Last modified: | 2025-05-28 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Cooperative inhibition in cytochrome P450 between a substrate and an apparent noncompetitive inhibitor.
J.Biol.Chem., 301, 2025
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9JI6
 | | CYP105A1 R84A complexed with diclofenac (DIF) | | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-[2,6-DICHLOROPHENYL)AMINO]BENZENEACETIC ACID, ... | | Authors: | Mikami, B, Takita, T, Sakaki, T, Yasuda, K, Wada, M, Yasukawa, K. | | Deposit date: | 2024-09-11 | | Release date: | 2025-04-23 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Structure-Function Analysis of Streptomyces griseolus CYP105A1 in the Metabolism of Nonsteroidal Anti-inflammatory Drugs.
Biochemistry, 64, 2025
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9JIP
 | | CYP105A1 R84A complexed with flufenamic acid (FLF) | | Descriptor: | 1,2-ETHANEDIOL, 2-[[3-(TRIFLUOROMETHYL)PHENYL]AMINO] BENZOIC ACID, PROTOPORPHYRIN IX CONTAINING FE, ... | | Authors: | Mikami, B, Takita, T, Sakaki, T, Yasuda, K, Wada, M, Yasukawa, K. | | Deposit date: | 2024-09-12 | | Release date: | 2025-04-23 | | Method: | X-RAY DIFFRACTION (1.68 Å) | | Cite: | Structure-Function Analysis of Streptomyces griseolus CYP105A1 in the Metabolism of Nonsteroidal Anti-inflammatory Drugs.
Biochemistry, 64, 2025
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9JHW
 | | CYP105A1 complexed with diclofenac (DIF) | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-[2,6-DICHLOROPHENYL)AMINO]BENZENEACETIC ACID, PROTOPORPHYRIN IX CONTAINING FE, ... | | Authors: | Mikami, B, Takita, T, Sakaki, T, Yasuda, K, Wada, M, Yasukawa, K. | | Deposit date: | 2024-09-10 | | Release date: | 2025-04-23 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Structure-Function Analysis of Streptomyces griseolus CYP105A1 in the Metabolism of Nonsteroidal Anti-inflammatory Drugs.
Biochemistry, 64, 2025
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9JI1
 | | CYP105A1 complexed with flufenamic acid (FLF) | | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-[[3-(TRIFLUOROMETHYL)PHENYL]AMINO] BENZOIC ACID, ... | | Authors: | Mikami, B, Takita, T, Sakaki, T, Yasuda, K, Wada, M, Yasukawa, K. | | Deposit date: | 2024-09-11 | | Release date: | 2025-04-23 | | Method: | X-RAY DIFFRACTION (1.47 Å) | | Cite: | Structure-Function Analysis of Streptomyces griseolus CYP105A1 in the Metabolism of Nonsteroidal Anti-inflammatory Drugs.
Biochemistry, 64, 2025
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2ZBX
 | | Crystal structure of vitamin D hydroxylase cytochrome P450 105A1 (wild type) with imidazole bound | | Descriptor: | Cytochrome P450-SU1, IMIDAZOLE, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Sugimoto, H, Shinkyo, R, Hayashi, K, Yoneda, S, Yamada, M, Kamakura, M, Ikushiro, S, Shiro, Y, Sakaki, T. | | Deposit date: | 2007-10-30 | | Release date: | 2008-04-08 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Crystal Structure of CYP105A1 (P450SU-1) in Complex with 1alpha,25-Dihydroxyvitamin D3
Biochemistry, 47, 2008
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2ZBZ
 | | Crystal structure of vitamin D hydroxylase cytochrome P450 105A1 (R84A mutant) in complex with 1,25-dihydroxyvitamin D3 | | Descriptor: | 5-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANE-1,3-DIOL, Cytochrome P450-SU1, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Sugimoto, H, Shinkyo, R, Hayashi, K, Yoneda, S, Yamada, M, Kamakura, M, Ikushiro, S, Shiro, Y, Sakaki, T. | | Deposit date: | 2007-10-30 | | Release date: | 2008-04-08 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal Structure of CYP105A1 (P450SU-1) in Complex with 1alpha,25-Dihydroxyvitamin D3
Biochemistry, 47, 2008
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2ZBY
 | | Crystal structure of vitamin D hydroxylase cytochrome P450 105A1 (R84A mutant) | | Descriptor: | Cytochrome P450-SU1, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Sugimoto, H, Shinkyo, R, Hayashi, K, Yoneda, S, Yamada, M, Kamakura, M, Ikushiro, S, Shiro, Y, Sakaki, T. | | Deposit date: | 2007-10-30 | | Release date: | 2008-04-08 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Crystal Structure of CYP105A1 (P450SU-1) in Complex with 1alpha,25-Dihydroxyvitamin D3
Biochemistry, 47, 2008
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