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4QXU
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BU of 4qxu by Molmil
Novel Inhibition Mechanism of Membrane Metalloprotease by an Exosite-Swiveling Conformational antibody
分子名称: Matrix metalloproteinase-14, SULFATE ION, anti_MT1-MMP Heavy chain, ...
著者Udi, Y, Grossman, M, Solomonov, I, Dym, O, Rozenberg, H, Moreno, v, Cuiniasse, P, Dive, V, Arroyo, A.G, Sagi, I, Israel Structural Proteomics Center (ISPC)
登録日2014-07-22
公開日2014-12-17
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Inhibition mechanism of membrane metalloprotease by an exosite-swiveling conformational antibody.
Structure, 23, 2015
4IJO
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BU of 4ijo by Molmil
Unraveling hidden allosteric regulatory sites in structurally homologues metalloproteases
分子名称: CALCIUM ION, Macrophage metalloelastase, ZINC ION
著者Udi, Y, Fragai, M, Grossman, M, Mitternacht, S, Arad-Yellin, R, Calderone, V, Melikian, M, Toccafondi, M, Berezovsky, I.N, Luchinat, C, Sagi, I.
登録日2012-12-22
公開日2013-05-01
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Unraveling hidden regulatory sites in structurally homologous metalloproteases
J.Mol.Biol., 425, 2013
1AAF
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BU of 1aaf by Molmil
NUCLEOCAPSID ZINC FINGERS DETECTED IN RETROVIRUSES: EXAFS STUDIES ON INTACT VIRUSES AND THE SOLUTION-STATE STRUCTURE OF THE NUCLEOCAPSID PROTEIN FROM HIV-1
分子名称: HIV-1 NUCLEOCAPSID PROTEIN, ZINC ION
著者Summers, M.F, Henderson, L.E, Chance, M.R, Bess Junior, J.W, South, T.L, Blake, P.R, Sagi, I, Perez-Alvarado, G, Sowder, R.C, Hare, D.R, Arthur, L.O.
登録日1992-04-06
公開日1994-01-31
最終更新日2024-04-10
実験手法SOLUTION NMR
主引用文献Nucleocapsid zinc fingers detected in retroviruses: EXAFS studies of intact viruses and the solution-state structure of the nucleocapsid protein from HIV-1.
Protein Sci., 1, 1992
3MA2
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BU of 3ma2 by Molmil
Complex membrane type-1 matrix metalloproteinase (MT1-MMP) with tissue inhibitor of metalloproteinase-1 (TIMP-1)
分子名称: CALCIUM ION, Matrix metalloproteinase-14, Metalloproteinase inhibitor 1, ...
著者Grossman, M, Tworowski, D, Dym, O, Lee, M.-H, Levy, Y, Sagi, I.
登録日2010-03-23
公開日2010-06-30
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献The Intrinsic Protein Flexibility of Endogenous Protease Inhibitor TIMP-1 Controls Its Binding Interface and Affects Its Function.
Biochemistry, 49, 2010
3UTZ
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BU of 3utz by Molmil
Endogenous-like inhibitory antibodies targeting activated metalloproteinase motifs show therapeutic potential
分子名称: Metalloproteinase, heavy chain, light chain, ...
著者Sela-Passwell, N, Kikkeri, R, Dym, O, Rozenberg, H, Margalit, R, Arad-Yellin, R, Eisenstein, M, Brenner, O, Shoham, T, Danon, T, Shanzer, A, Sagi, I, Israel Structural Proteomics Center (ISPC)
登録日2011-11-27
公開日2011-12-14
最終更新日2017-03-15
実験手法X-RAY DIFFRACTION (2.18 Å)
主引用文献Antibodies targeting the catalytic zinc complex of activated matrix metalloproteinases show therapeutic potential.
NAT.MED. (N.Y.), 18, 2012
4P3C
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BU of 4p3c by Molmil
MT1-MMP:Fab complex (Form I)
分子名称: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ACETATE ION, ...
著者Rozenberg, H, Udi, Y, Sagi, I.
登録日2014-03-06
公開日2014-12-17
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.943 Å)
主引用文献Inhibition mechanism of membrane metalloprotease by an exosite-swiveling conformational antibody.
Structure, 23, 2015
4P3D
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BU of 4p3d by Molmil
MT1-MMP:Fab complex (Form II)
分子名称: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, ...
著者Rozenberg, H, Udi, Y, Sagi, I.
登録日2014-03-07
公開日2014-12-17
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.949 Å)
主引用文献Inhibition mechanism of membrane metalloprotease by an exosite-swiveling conformational antibody.
Structure, 23, 2015
5H0U
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BU of 5h0u by Molmil
Crystal structure of the catalytic domain of membrane type 1 matrix metalloproteinase
分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CALCIUM ION, GLYCEROL, ...
著者Ogata, H, Decaneto, E, Lubitz, W.
登録日2016-10-07
公開日2017-10-04
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.239 Å)
主引用文献Solvent water interactions within the active site of the membrane type I matrix metalloproteinase.
Phys Chem Chem Phys, 19, 2017
6FBJ
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BU of 6fbj by Molmil
monoclonal antibody targeting Matrix metalloproteinase 7
分子名称: Heavy Chain, Light chain
著者Dym, O.
登録日2017-12-19
公開日2019-01-30
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Novel monoclonal antibody targeting Matrix metalloproteinase 7 shows therapeutic potential against pancreatic cancer
To Be Published
4OUU
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BU of 4ouu by Molmil
anti-MT1-MMP monoclonal antibody
分子名称: anti_MT1-MMP Heavy chain, anti_MT1-MMP light chain
著者Udi, Y, Grossman, M, Solomonov, I, Dym, O, Rozenberg, H, Koziol, A, Cuniasse, P, Dive, V, Arroyo, A.G, Irit, S, Israel Structural Proteomics Center (ISPC)
登録日2014-02-19
公開日2014-12-17
最終更新日2015-01-28
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Inhibition mechanism of membrane metalloprotease by an exosite-swiveling conformational antibody.
Structure, 23, 2015
1HVO
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BU of 1hvo by Molmil
ZINC-AND SEQUENCE-DEPENDENT BINDING TO NUCLEIC ACIDS BY THE N-TERMINAL ZINC FINGER DOMAIN OF THE HIV-1 NUCLEOCAPSID PROTEIN: NMR STRUCTURE OF THE COMPLEX WITH THE PSI-SITE ANALOG, D/ACGCC
分子名称: DNA (5'-D(P*AP*CP*GP*CP*C)-3'), Hiv-1 Nucleocapsid Zinc Finger, ZINC ION
著者South, T.L, Summers, M.F.
登録日1992-12-08
公開日1994-01-31
最終更新日2022-02-23
実験手法SOLUTION NMR
主引用文献Zinc- and sequence-dependent binding to nucleic acids by the N-terminal zinc finger of the HIV-1 nucleocapsid protein: NMR structure of the complex with the Psi-site analog, dACGCC.
Protein Sci., 2, 1993
1HVN
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BU of 1hvn by Molmil
ZINC-AND SEQUENCE-DEPENDENT BINDING TO NUCLEIC ACIDS BY THE N-TERMINAL ZINC FINGER DOMAIN OF THE HIV-1 NUCLEOCAPSID PROTEIN: NMR STRUCTURE OF THE COMPLEX WITH THE PSI-SITE ANALOG, D/ACGCC
分子名称: DNA (5'-D(P*AP*CP*GP*CP*C)-3'), Hiv-1 Nucleocapsid Zinc Finger, ZINC ION
著者South, T.L, Summers, M.F.
登録日1992-12-08
公開日1994-01-31
最終更新日2022-02-23
実験手法SOLUTION NMR
主引用文献Zinc- and sequence-dependent binding to nucleic acids by the N-terminal zinc finger of the HIV-1 nucleocapsid protein: NMR structure of the complex with the Psi-site analog, dACGCC.
Protein Sci., 2, 1993

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