3O0U
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3OVX
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3OVZ
| Cathepsin K in complex with a covalent inhibitor with a ketoamide warhead | Descriptor: | Cathepsin K, N-[(1S)-3-amino-1-ethyl-2,3-dioxopropyl]-2-chloro-4-(pyridin-2-ylmethoxy)-3-(trifluoromethyl)benzamide, SULFATE ION | Authors: | Fradera, X, van Zeeland, M, Uitdehaag, J.C.M. | Deposit date: | 2010-09-17 | Release date: | 2010-12-22 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.02 Å) | Cite: | Trifluoromethylphenyl as P2 for ketoamide-based cathepsin S inhibitors. Bioorg.Med.Chem.Lett., 20, 2010
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3N3G
| 4-(3-Trifluoromethylphenyl)-pyrimidine-2-carbonitrile as cathepsin S inhibitors: N3, not N1 is critically important | Descriptor: | (E)-1-(6-{4-[3-(4-methylpiperazin-1-yl)propoxy]-3-(trifluoromethyl)phenyl}pyridin-2-yl)methanimine, 6-{4-[3-(4-methylpiperazin-1-yl)propoxy]-3-(trifluoromethyl)phenyl}pyridine-2-carbonitrile, Cathepsin S, ... | Authors: | Fradera, X, Uitdehaag, J.C.M, van Zeeland, M. | Deposit date: | 2010-05-20 | Release date: | 2010-07-14 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | 4-(3-Trifluoromethylphenyl)-pyrimidine-2-carbonitrile as cathepsin S inhibitors: N3, not N1 is critically important. Bioorg.Med.Chem.Lett., 20, 2010
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2AXI
| HDM2 in complex with a beta-hairpin | Descriptor: | 3[N-MORPHOLINO]PROPANE SULFONIC ACID, SULFATE ION, Ubiquitin-protein ligase E3 Mdm2, ... | Authors: | Mittl, P.R.E, Fasan, R, Robinson, J, Gruetter, M.G. | Deposit date: | 2005-09-05 | Release date: | 2006-03-21 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Structure-Activity Studies in a Family of beta-Hairpin Protein Epitope Mimetic Inhibitors of the p53-HDM2 Protein-Protein Interaction. Chembiochem, 7, 2006
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2FLG
| Solution structure of an EGF-LIKE domain from the Plasmodium falciparum merozoite surface protein 1 | Descriptor: | Merozoite surface protein 1 | Authors: | James, S, Moehle, K, Pluschke, G, Robinson, J. | Deposit date: | 2006-01-06 | Release date: | 2006-02-21 | Last modified: | 2022-03-09 | Method: | SOLUTION NMR | Cite: | Synthesis, solution structure and immune recognition of an epidermal growth factor-like domain from Plasmodium falciparum merozoite surface protein-1. Chembiochem, 7, 2006
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2KX5
| Recognition of HIV TAR RNA by peptide mimetic of Tat protein | Descriptor: | Cyclic peptide mimetic of Tat protein, HIV TAR RNA | Authors: | Davidson, A, Patora-Komisarska, K, Robinson, J, Varani, G. | Deposit date: | 2010-04-26 | Release date: | 2010-07-07 | Last modified: | 2011-07-13 | Method: | SOLUTION NMR | Cite: | Essential structural requirements for specific recognition of HIV TAR RNA by peptide mimetics of Tat protein. Nucleic Acids Res., 39, 2011
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2RLL
| CCR5 Nt(7-15) | Descriptor: | 9-mer from C-C chemokine receptor type 5 | Authors: | Bewley, C.A, Lam, S.N. | Deposit date: | 2007-07-21 | Release date: | 2007-09-25 | Last modified: | 2023-11-15 | Method: | SOLUTION NMR | Cite: | Structures of the CCR5 N terminus and of a tyrosine-sulfated antibody with HIV-1 gp120 and CD4 Science, 317, 2007
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2N8X
| Solution structure of LptE from Pseudomonas Aerigunosa | Descriptor: | LPS-assembly lipoprotein LptE | Authors: | Moehle, K, Kocherla, H, Jurt, S, Robinson, J, Zerbe, O, Zerbe, K, Bacsa, B. | Deposit date: | 2015-10-28 | Release date: | 2016-05-25 | Last modified: | 2016-06-29 | Method: | SOLUTION NMR | Cite: | Solution Structure and Dynamics of LptE from Pseudomonas aeruginosa. Biochemistry, 55, 2016
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3FRG
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2Q2B
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