2QIV
 
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2QIA
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1XXE
 | | RDC refined solution structure of the AaLpxC/TU-514 complex | | 分子名称: | 1,5-ANHYDRO-2-C-(CARBOXYMETHYL-N-HYDROXYAMIDE)-2-DEOXY-3-O-MYRISTOYL-D-GLUCITOL, UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ZINC ION | | 著者 | Coggins, B.E, McClerren, A.L, Jiang, L, Li, X, Rudolph, J, Hindsgaul, O, Raetz, C.R.H, Zhou, P. | | 登録日 | 2004-11-04 | | 公開日 | 2004-11-23 | | 最終更新日 | 2022-03-02 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Refined Solution Structure of the LpxC-TU-514 Complex and pK(a) Analysis of an Active Site Histidine: Insights into the Mechanism and Inhibitor Design
Biochemistry, 44, 2005
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1MM5
 | | Solution NMR structure of the outer membrane enzyme PagP in OG micelles | | 分子名称: | CrcA protein | | 著者 | Hwang, P.M, Choy, W.-Y, Lo, E.I, Chen, L, Forman-Kay, J.D, Raetz, C.R.H, Prive, G.G, Bishop, R.E, Kay, L.E. | | 登録日 | 2002-09-03 | | 公開日 | 2002-09-13 | | 最終更新日 | 2022-02-23 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution Structure and Dynamics of the Outer Membrane Enzyme PagP by NMR
Proc.Natl.Acad.Sci.USA, 99, 2002
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1MM4
 | | Solution NMR structure of the outer membrane enzyme PagP in DPC micelles | | 分子名称: | CrcA protein | | 著者 | Hwang, P.M, Choy, W.-Y, Lo, E.I, Chen, L, Forman-Kay, J.D, Raetz, C.R.H, Prive, G.G, Bishop, R.E, Kay, L.E. | | 登録日 | 2002-09-03 | | 公開日 | 2002-09-13 | | 最終更新日 | 2022-02-23 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution Structure and Dynamics of the Outer Membrane Enzyme PagP by NMR
Proc.Natl.Acad.Sci.USA, 99, 2002
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1YUC
 | | Human Nuclear Receptor Liver Receptor Homologue-1, LRH-1, Bound to Phospholipid and a Fragment of Human SHP | | 分子名称: | GLYCEROL, L-ALPHA-PHOSPHATIDYL-BETA-OLEOYL-GAMMA-PALMITOYL-PHOSPHATIDYLETHANOLAMINE, Nuclear receptor 0B2, ... | | 著者 | Ortlund, E.A, Yoonkwang, L, Solomon, I.H, Hager, J.M, Safi, R, Choi, Y, Guan, Z, Tripathy, A, Raetz, C.R.H, McDonnell, D.P, Moore, D.D, Redinbo, M.R. | | 登録日 | 2005-02-13 | | 公開日 | 2005-03-01 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP
Nat.Struct.Mol.Biol., 12, 2005
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2BLN
 | | N-terminal formyltransferase domain of ArnA in complex with N-5- formyltetrahydrofolate and UMP | | 分子名称: | ACETATE ION, N-{[4-({[(6R)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]carbonyl}-L-glutamic acid, PROTEIN YFBG, ... | | 著者 | Williams, G.J, Breazeale, S.D, Raetz, C.R.H, Naismith, J.H. | | 登録日 | 2005-03-07 | | 公開日 | 2005-04-08 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | Structure and Function of Both Domains of Arna, a Dual Function Decarboxylase and a Formyltransferase, Involved in 4-Amino-4-Deoxy-L-Arabinose Biosynthesis.
J.Biol.Chem., 280, 2005
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2BLL
 | | Apo-structure of the C-terminal decarboxylase domain of ArnA | | 分子名称: | PROTEIN YFBG | | 著者 | Williams, G.J, Breazeale, S.D, Raetz, C.R.H, Naismith, J.H. | | 登録日 | 2005-03-07 | | 公開日 | 2005-04-08 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structure and Function of Both Domains of Arna, a Dual Function Decarboxylase and a Formyltransferase, Involved in 4-Amino-4-Deoxy-L- Arabinose Biosynthesis.
J.Biol.Chem., 280, 2005
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4J6E
 | | Structure of LPXI D225A Mutant | | 分子名称: | (2R,3R,4R,5S,6R)-2-{[(S)-{[(S)-{[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methoxy}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]oxy}-5-hydroxy-6-(hydroxymethyl)-3-{[(3R)-3-hydroxytetradecanoyl]amino}tetrahydro-2H-pyran-4-yl (3R)-3-hydroxytetradecanoate, UDP-2,3-diacylglucosamine pyrophosphatase LpxI | | 著者 | Metzger IV, L.E, Lee, J.K, Finer-Moore, J.S, Raetz, C.R.H, Stroud, R.M, Center for Structures of Membrane Proteins (CSMP) | | 登録日 | 2013-02-11 | | 公開日 | 2013-05-08 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.52 Å) | | 主引用文献 | LpxI structures reveal how a lipid A precursor is synthesized.
Nat.Struct.Mol.Biol., 19, 2012
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3T57
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8T0J
 | | Salmonella Typhimurium ArnD | | 分子名称: | Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD | | 著者 | Sousa, M.C, Munoz-Escudero, D, Lee, M. | | 登録日 | 2023-06-01 | | 公開日 | 2023-10-18 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | | 主引用文献 | Structure and Function of ArnD. A Deformylase Essential for Lipid A Modification with 4-Amino-4-deoxy-l-arabinose and Polymyxin Resistance.
Biochemistry, 62, 2023
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6HY2
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2JT2
 | | Solution Structure of the Aquifex aeolicus LpxC- CHIR-090 complex | | 分子名称: | N-{(1S,2R)-2-hydroxy-1-[(hydroxyamino)carbonyl]propyl}-4-{[4-(morpholin-4-ylmethyl)phenyl]ethynyl}benzamide, UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ZINC ION | | 著者 | Barb, A.W, Jiang, L, Raetz, C.R.H, Zhou, P. | | 登録日 | 2007-07-18 | | 公開日 | 2007-12-04 | | 最終更新日 | 2021-10-20 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding
Proc.Natl.Acad.Sci.Usa, 104, 2007
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5YKA
 | | Crystal structure of the Kdo hydroxylase KdoO, a non-heme Fe(II) alphaketoglutarate dependent dioxygenase in complex with cobalt(II) | | 分子名称: | ACETATE ION, CHLORIDE ION, COBALT (II) ION, ... | | 著者 | Chung, H.S, Pemble, C.W, Joo, S.H, Raetz, C.R. | | 登録日 | 2017-10-12 | | 公開日 | 2018-09-05 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.448 Å) | | 主引用文献 | Biochemical and Structural Insights into an Fe(II)/ alpha-Ketoglutarate/O2-Dependent Dioxygenase, Kdo 3-Hydroxylase (KdoO).
J. Mol. Biol., 430, 2018
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5YVZ
 | | Crystal structure of the Kdo hydroxylase KdoO, a non-heme Fe(II) alphaketoglutarate dependent dioxygenase in complex with alphaketoglutarate and Fe(III) | | 分子名称: | 2-OXOGLUTARIC ACID, ACETATE ION, FE (III) ION, ... | | 著者 | Chung, H.S, Pemble, C.W, Joo, S.H, Raetz, C.R. | | 登録日 | 2017-11-28 | | 公開日 | 2018-09-05 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Biochemical and Structural Insights into an Fe(II)/ alpha-Ketoglutarate/O2-Dependent Dioxygenase, Kdo 3-Hydroxylase (KdoO).
J. Mol. Biol., 430, 2018
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5YW0
 | | Crystal structure of the Kdo hydroxylase KdoO, a non-heme Fe(II) alphaketoglutarate dependent dioxygenase in complex with succinate and Fe(III) | | 分子名称: | ACETATE ION, FE (III) ION, GLYCEROL, ... | | 著者 | Chung, H.S, Pemble, C.W, Joo, S.H, Raetz, C.R. | | 登録日 | 2017-11-28 | | 公開日 | 2018-09-05 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | | 主引用文献 | Biochemical and Structural Insights into an Fe(II)/ alpha-Ketoglutarate/O2-Dependent Dioxygenase, Kdo 3-Hydroxylase (KdoO).
J. Mol. Biol., 430, 2018
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4EHY
 | | Crystal structure of LpxK from Aquifex aeolicus in complex with ADP/Mg2+ at 2.2 angstrom resolution | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, GLYCEROL, ... | | 著者 | Emptage, R.P, Daughtry, K.D, Pemble IV, C.W, Raetz, C.R.H. | | 登録日 | 2012-04-04 | | 公開日 | 2012-08-29 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.199 Å) | | 主引用文献 | Crystal structure of LpxK, the 4'-kinase of lipid A biosynthesis and atypical P-loop kinase functioning at the membrane interface.
Proc.Natl.Acad.Sci.USA, 109, 2012
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1LXA
 | | UDP N-ACETYLGLUCOSAMINE ACYLTRANSFERASE | | 分子名称: | UDP N-ACETYLGLUCOSAMINE O-ACYLTRANSFERASE | | 著者 | Roderick, S.L. | | 登録日 | 1995-10-07 | | 公開日 | 1995-12-07 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | A left-handed parallel beta helix in the structure of UDP-N-acetylglucosamine acyltransferase.
Science, 270, 1995
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4EHX
 | | Crystal structure of LpxK from Aquifex aeolicus at 1.9 angstrom resolution | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLYCEROL, ... | | 著者 | Emptage, R.P, Daughtry, K.D, Pemble IV, C.W, Raetz, C.R.H. | | 登録日 | 2012-04-04 | | 公開日 | 2012-08-29 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Crystal structure of LpxK, the 4'-kinase of lipid A biosynthesis and atypical P-loop kinase functioning at the membrane interface.
Proc.Natl.Acad.Sci.USA, 109, 2012
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4EHW
 | | Crystal structure of LpxK from Aquifex aeolicus at 2.3 angstrom resolution | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, GLYCEROL, Tetraacyldisaccharide 4'-kinase | | 著者 | Emptage, R.P, Daughtry, K.D, Pemble IV, C.W, Raetz, C.R.H. | | 登録日 | 2012-04-04 | | 公開日 | 2012-08-29 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystal structure of LpxK, the 4'-kinase of lipid A biosynthesis and atypical P-loop kinase functioning at the membrane interface.
Proc.Natl.Acad.Sci.USA, 109, 2012
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3FID
 | | LpxR from Salmonella typhimurium | | 分子名称: | GLYCEROL, PENTAETHYLENE GLYCOL MONODECYL ETHER, Putative outer membrane protein (LpxR), ... | | 著者 | Rutten, L, Gros, P. | | 登録日 | 2008-12-11 | | 公開日 | 2009-02-10 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Active-site architecture and catalytic mechanism of the lipid A deacylase LpxR of Salmonella typhimurium
Proc.Natl.Acad.Sci.USA, 106, 2009
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3EH0
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5F42
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6A2E
 | | Apo structure of the Kdo hydroxylase KdoO, a non-heme Fe(II) alphaketoglutarate dependent dioxygenase | | 分子名称: | ACETATE ION, Kdo hydroxylase, KdoO, ... | | 著者 | Chung, H.S, Pemble, C.W, Joo, S.H. | | 登録日 | 2018-06-11 | | 公開日 | 2018-09-05 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.939 Å) | | 主引用文献 | Biochemical and Structural Insights into an Fe(II)/ alpha-Ketoglutarate/O2-Dependent Dioxygenase, Kdo 3-Hydroxylase (KdoO).
J. Mol. Biol., 430, 2018
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4IHF
 | | Chasing Acyl Carrier Protein Through a Catalytic Cycle of Lipid A Production | | 分子名称: | Acyl carrier protein, CHLORIDE ION, S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] (3R)-3-hydroxytetradecanethioate, ... | | 著者 | Masoudi, A, Raetz, C.R.H, Pemble, C.W. | | 登録日 | 2012-12-18 | | 公開日 | 2013-11-13 | | 最終更新日 | 2017-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Chasing acyl carrier protein through a catalytic cycle of lipid A production.
Nature, 505, 2014
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