9M5M
 
 | | Crystal structure of Plasmodium vivax aspartyl-tRNA synthetase (PvDRS) | | Descriptor: | 1,2-ETHANEDIOL, SULFATE ION, aspartate--tRNA ligase | | Authors: | Sharma, V.K, Manickam, Y, Bagale, S, Pradeepkumar, P.I, Sharma, A. | | Deposit date: | 2025-03-06 | | Release date: | 2025-06-04 | | Method: | X-RAY DIFFRACTION (2.06 Å) | | Cite: | Natural product-mediated reaction hijacking mechanism validates Plasmodium aspartyl-tRNA synthetase as an antimalarial drug target
To Be Published
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9M5N
 | | Plasmodium vivax aspartyl-tRNA synthetase in complex with aspartyl-adenylate (Asp-AMP) Complex. | | Descriptor: | ACETATE ION, ASPARTYL-ADENOSINE-5'-MONOPHOSPHATE, GLYCEROL, ... | | Authors: | Sharma, V.K, Manickam, Y, Sharma, A, Bagale, S, Pradeepkumar, P.I. | | Deposit date: | 2025-03-06 | | Release date: | 2025-06-04 | | Method: | X-RAY DIFFRACTION (2.14 Å) | | Cite: | Natural product-mediated reaction hijacking mechanism validates Plasmodium aspartyl-tRNA synthetase as an antimalarial drug target
To Be Published
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9M5O
 | | Plasmodium vivax aspartyl-tRNA synthetase in complex with aspartyl sulfamoyl adenosine (Asp-AMS) Complex | | Descriptor: | 5'-O-(L-alpha-aspartylsulfamoyl)adenosine, MAGNESIUM ION, aspartate--tRNA ligase | | Authors: | Sharma, V.K, Manickam, Y, Sharma, A, Bagale, S, Pradeepkumar, P.I. | | Deposit date: | 2025-03-06 | | Release date: | 2025-06-04 | | Method: | X-RAY DIFFRACTION (1.839 Å) | | Cite: | Natural product-mediated reaction hijacking mechanism validates Plasmodium aspartyl-tRNA synthetase as an antimalarial drug target
To Be Published
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5W2C
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5W2A
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4Q44
 | | Polymerase-Damaged DNA Complex | | Descriptor: | 5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]thymidine, DNA (5'-D(*TP*CP*TP*AP*(RDG)P*GP*GP*TP*CP*CP*TP*AP*GP*GP*AP*CP*CP*C)-3'), DNA polymerase IV, ... | | Authors: | Nair, D.T, Kottur, J, Sharma, A. | | Deposit date: | 2014-04-13 | | Release date: | 2015-05-06 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.71 Å) | | Cite: | Unique structural features in DNA polymerase IV enable efficient bypass of the N2 adduct induced by the nitrofurazone antibiotic
Structure, 23, 2015
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4Q43
 | | Polymerase-damaged DNA complex | | Descriptor: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA (5'-D(*T*CP*TP*AP*GP*GP*GP*TP*CP*CP*TP*AP*GP*GP*AP*CP*CP*C)-3'), DNA (5'-D(*TP*CP*TP*(RDG)P*GP*GP*GP*TP*CP*CP*TP*AP*GP*GP*AP*CP*CP*C)-3'), ... | | Authors: | Kottur, J, Sharma, A, Nair, D.T. | | Deposit date: | 2014-04-13 | | Release date: | 2015-05-06 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.45 Å) | | Cite: | Unique structural features in DNA polymerase IV enable efficient bypass of the N2 adduct induced by the nitrofurazone antibiotic
Structure, 23, 2015
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4Q45
 | | DNA Polymerase- damaged DNA complex | | Descriptor: | 5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]thymidine, DNA (5'-D(*TP*CP*TP*A*GP*GP*GP*TP*CP*CP*TP*AP*GP*GP*AP*CP*CP*C)-3'), DNA (5'-D(*TP*CP*TP*AP*GP*GP*(RDG)P*TP*CP*CP*TP*AP*GP*GP*AP*CP*CP*C)-3'), ... | | Authors: | Kottur, J, Sharma, A, Nair, D.T. | | Deposit date: | 2014-04-13 | | Release date: | 2015-05-06 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.176 Å) | | Cite: | Unique structural features in DNA polymerase IV enable efficient bypass of the N2 adduct induced by the nitrofurazone antibiotic
Structure, 23, 2015
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