9M5O

Plasmodium vivax aspartyl-tRNA synthetase in complex with aspartyl sulfamoyl adenosine (Asp-AMS) Complex

Summary for 9M5O

• Entry DOI: 10.2210/pdb9m5o/pdb
• Descriptor: aspartate--tRNA ligase, 5'-O-(L-alpha-aspartylsulfamoyl)adenosine, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: aminoacylation, aminoacyl-trna synthetase, trna-binding, atp-binding, malaria, inhibitor, ligase
• Biological source: Plasmodium vivax (malaria parasite P. vivax)
• Total number of polymer chains: 2
• Total formula weight: 125277.66

Authors

Sharma, V.K.,Manickam, Y.,Sharma, A.,Bagale, S.,Pradeepkumar, P.I. (deposition date: 2025-03-06, release date: 2025-06-04)

• Primary citation: Ketprasit, N.,Tai, C.W.,Sharma, V.K.,Manickam, Y.,Khandokar, Y.,Ye, W.,Dogovski, C.,Hilko, D.H.,Morton, C.,Braun, A.S.C.,Leeming, M.,Bagale, S.,Pradeepkumar, P.I.,Panjikar, S.,Poulsen, S.A.,Griffin, M.D.W.,Sharma, A.,Tilley, L.,Xie, S.C.; Natural product-mediated reaction hijacking mechanism validates Plasmodium aspartyl-tRNA synthetase as an antimalarial drug target; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.839 Å)