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4MY7
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BU of 4my7 by Molmil
frog M ferritin iron-loaded under anaerobic environment
分子名称: CHLORIDE ION, FE (II) ION, Ferritin, ...
著者Mangani, S, Di Pisa, F, Pozzi, C, Turano, P, Lalli, D.
登録日2013-09-27
公開日2014-09-17
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.48 Å)
主引用文献Time-lapse anomalous X-ray diffraction shows how Fe(2+) substrate ions move through ferritin protein nanocages to oxidoreductase sites.
Acta Crystallogr.,Sect.D, 71, 2015
6GCK
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BU of 6gck by Molmil
Trypanosoma brucei PTR1 in complex with inhibitor 1e (F206)
分子名称: 4-[(2-azanyl-1,3-benzothiazol-6-yl)oxymethyl]benzenecarbonitrile, GLYCEROL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
著者Pozzi, C, Landi, G, Mangani, S.
登録日2018-04-18
公開日2019-04-03
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.14 Å)
主引用文献Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections.
J.Med.Chem., 62, 2019
6GCQ
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BU of 6gcq by Molmil
Trypanosoma brucei PTR1 in complex with inhibitor 2b (F192)
分子名称: 6-(trifluoromethylsulfanyl)-1,3-benzothiazol-2-amine, ACETATE ION, DIMETHYL SULFOXIDE, ...
著者Pozzi, C, Landi, G, Mangani, S.
登録日2018-04-18
公開日2019-04-03
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.58 Å)
主引用文献Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections.
J.Med.Chem., 62, 2019
6GCP
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BU of 6gcp by Molmil
Trypanosoma brucei PTR1 in complex with inhibitor 2d (F186)
分子名称: 6-[(3,4-dichlorophenyl)methylsulfanyl]-1,3-benzothiazol-2-amine, ACETATE ION, GLYCEROL, ...
著者Pozzi, C, Landi, G, Mangani, S.
登録日2018-04-18
公開日2019-04-03
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.52 Å)
主引用文献Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections.
J.Med.Chem., 62, 2019
6GDP
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BU of 6gdp by Molmil
Trypanosoma brucei PTR1 in complex with inhibitor 4l (F162)
分子名称: 2-azanyl-~{N}-(diphenylmethyl)-1,3-benzothiazole-6-carboxamide, ACETATE ION, GLYCEROL, ...
著者Pozzi, C, Landi, G, Mangani, S.
登録日2018-04-24
公開日2019-04-03
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.52 Å)
主引用文献Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections.
J.Med.Chem., 62, 2019
6GEX
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BU of 6gex by Molmil
Trypanosoma brucei PTR1 in complex with inhibitor 2h (F246)
分子名称: 4-[(2-azanyl-1,3-benzothiazol-6-yl)sulfanylmethyl]-~{N}-(phenylmethyl)benzamide, ACETATE ION, GLYCEROL, ...
著者Pozzi, C, Landi, G, Mangani, S.
登録日2018-04-27
公開日2019-04-03
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.78 Å)
主引用文献Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections.
J.Med.Chem., 62, 2019
7O6A
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BU of 7o6a by Molmil
Crystal structure of human mitochondrial ferritin (hMTF) Fe(II)-loaded for 5 minutes under anaerobic environment
分子名称: CHLORIDE ION, FE (II) ION, Ferritin, ...
著者Pozzi, C, Ciambellotti, S, Tassone, G, Turano, P, Mangani, S.
登録日2021-04-09
公開日2021-10-13
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Iron Binding in the Ferroxidase Site of Human Mitochondrial Ferritin.
Chemistry, 27, 2021
7O64
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BU of 7o64 by Molmil
Crystal structure of human mitochondrial ferritin (hMTF) Fe(II)-loaded for 1 minute.
分子名称: CHLORIDE ION, FE (II) ION, Ferritin, ...
著者Pozzi, C, Ciambellotti, S, Tassone, G, Turano, P, Mangani, S.
登録日2021-04-09
公開日2021-10-13
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献Iron Binding in the Ferroxidase Site of Human Mitochondrial Ferritin.
Chemistry, 27, 2021
7O66
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BU of 7o66 by Molmil
Crystal structure of human mitochondrial ferritin (hMTF) Fe(II)-loaded for 60 minutes showing either a dioxygen or a superoxide anion coordinated to iron ions in the ferroxidase site
分子名称: CHLORIDE ION, FE (II) ION, Ferritin, ...
著者Pozzi, C, Ciambellotti, S, Tassone, G, Turano, P, Mangani, S.
登録日2021-04-09
公開日2021-10-13
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Iron Binding in the Ferroxidase Site of Human Mitochondrial Ferritin.
Chemistry, 27, 2021
7O68
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BU of 7o68 by Molmil
Crystal structure of human mitochondrial ferritin (hMTF) Fe(II)-loaded for 120 minutes showing either a dioxygen or a superoxide anion coordinated to iron ions in the ferroxidase site.
分子名称: CHLORIDE ION, FE (II) ION, Ferritin, ...
著者Pozzi, C, Ciambellotti, S, Tassone, G, Turano, P, Mangani, S.
登録日2021-04-09
公開日2021-10-13
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.68 Å)
主引用文献Iron Binding in the Ferroxidase Site of Human Mitochondrial Ferritin.
Chemistry, 27, 2021
7O6C
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BU of 7o6c by Molmil
Crystal structure of human mitochondrial ferritin (hMTF) Fe(II)-loaded for 15 minutes under anaerobic environment
分子名称: CHLORIDE ION, FE (II) ION, Ferritin, ...
著者Pozzi, C, Ciambellotti, S, Tassone, G, Turano, P, Mangani, S.
登録日2021-04-09
公開日2021-10-13
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Iron Binding in the Ferroxidase Site of Human Mitochondrial Ferritin.
Chemistry, 27, 2021
7O63
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BU of 7o63 by Molmil
High resolution crystal structure of human mitochondrial ferritin (hMTF)
分子名称: CHLORIDE ION, Ferritin, mitochondrial, ...
著者Pozzi, C, Ciambellotti, S, Tassone, G, Turano, P, Mangani, S.
登録日2021-04-09
公開日2021-10-13
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.16 Å)
主引用文献Iron Binding in the Ferroxidase Site of Human Mitochondrial Ferritin.
Chemistry, 27, 2021
7O65
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BU of 7o65 by Molmil
Crystal structure of human mitochondrial ferritin (hMTF) Fe(II)-loaded for 90 minutes showing either a dioxygen or a superoxide anion coordinated to iron ions in the ferroxidase site
分子名称: CHLORIDE ION, FE (II) ION, Ferritin, ...
著者Pozzi, C, Ciambellotti, S, Tassone, G, Turano, P, Mangani, S.
登録日2021-04-09
公開日2021-10-13
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Iron Binding in the Ferroxidase Site of Human Mitochondrial Ferritin.
Chemistry, 27, 2021
7O67
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BU of 7o67 by Molmil
Crystal structure of human mitochondrial ferritin (hMTF) Fe(II)-loaded for 15 minutes showing either a dioxygen or a superoxide anion coordinated to iron ions in the ferroxidase site
分子名称: CHLORIDE ION, FE (II) ION, Ferritin, ...
著者Pozzi, C, Ciambellotti, S, Tassone, G, Turano, P, Mangani, S.
登録日2021-04-09
公開日2021-10-13
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献Iron Binding in the Ferroxidase Site of Human Mitochondrial Ferritin.
Chemistry, 27, 2021
7O69
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BU of 7o69 by Molmil
Crystal structure of human mitochondrial ferritin (hMTF) Fe(II)-loaded for 5 minutes showing a peroxide anion as bridging species of iron ions in the ferroxidase site
分子名称: CHLORIDE ION, FE (II) ION, Ferritin, ...
著者Pozzi, C, Ciambellotti, S, Tassone, G, Turano, P, Mangani, S.
登録日2021-04-09
公開日2021-10-13
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Iron Binding in the Ferroxidase Site of Human Mitochondrial Ferritin.
Chemistry, 27, 2021
7O6D
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BU of 7o6d by Molmil
Crystal structure of human mitochondrial ferritin (hMTF) Fe(II)-loaded for 3 minutes under anaerobic environment
分子名称: CHLORIDE ION, FE (II) ION, Ferritin, ...
著者Pozzi, C, Ciambellotti, S, Tassone, G, Turano, P, Mangani, S.
登録日2021-04-09
公開日2021-10-13
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.47 Å)
主引用文献Iron Binding in the Ferroxidase Site of Human Mitochondrial Ferritin.
Chemistry, 27, 2021
7OWY
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BU of 7owy by Molmil
Crystal structure of human mitochondrial ferritin (hMTF) Fe(II)-loaded for 3 minutes showing a peroxide anion as bridging species of iron ions in the ferroxidase site
分子名称: CHLORIDE ION, FE (II) ION, Ferritin, ...
著者Pozzi, C, Ciambellotti, S, Tassone, G, Turano, P, Mangani, S.
登録日2021-06-21
公開日2021-10-13
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Iron Binding in the Ferroxidase Site of Human Mitochondrial Ferritin.
Chemistry, 27, 2021
4KPW
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BU of 4kpw by Molmil
Crystal structure of His-tagged human thymidylate synthase R175A mutant
分子名称: 1,2-ETHANEDIOL, SULFATE ION, Thymidylate synthase
著者Pozzi, C, Mangani, S.
登録日2013-05-14
公開日2014-05-14
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献Hotspots in an obligate homodimeric anticancer target. Structural and functional effects of interfacial mutations in human thymidylate synthase.
J.Med.Chem., 58, 2015
4O1X
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BU of 4o1x by Molmil
Crystal structure of human thymidylate synthase double mutant C195S-Y202C
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, SULFATE ION, ...
著者Pozzi, C, Mangani, S.
登録日2013-12-16
公開日2015-01-21
最終更新日2023-03-01
実験手法X-RAY DIFFRACTION (2.32 Å)
主引用文献Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth.
Elife, 11, 2022
4O1U
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BU of 4o1u by Molmil
Crystal structure of human thymidylate synthase mutant Y202C
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, SULFATE ION, ...
著者Pozzi, C, Mangani, S.
登録日2013-12-16
公開日2015-01-21
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.26 Å)
主引用文献Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth.
Elife, 11, 2022
6TS0
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BU of 6ts0 by Molmil
Crystal structure of human L ferritin (HuLf) triple variant E60A-E61A-E64A Fe(III)-loaded for 30 minutes
分子名称: CADMIUM ION, FE (III) ION, Ferritin light chain, ...
著者Pozzi, C, Ciambellotti, S, Turano, P, Mangani, S.
登録日2019-12-19
公開日2020-02-19
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Iron Biomineral Growth from the Initial Nucleation Seed in L-Ferritin.
Chemistry, 26, 2020
6TSX
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BU of 6tsx by Molmil
Crystal structure of horse L ferritin (HoLf) Fe(III)-loaded for 30 minutes
分子名称: CADMIUM ION, CHLORIDE ION, FE (III) ION, ...
著者Pozzi, C, Ciambellotti, S, Turano, P, Mangani, S.
登録日2019-12-21
公開日2020-02-19
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.021 Å)
主引用文献Iron Biomineral Growth from the Initial Nucleation Seed in L-Ferritin.
Chemistry, 26, 2020
6I36
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BU of 6i36 by Molmil
SIXTY MINUTES IRON LOADED FROG M FERRITIN
分子名称: CHLORIDE ION, FE (II) ION, Ferritin, ...
著者Mangani, S, Di Pisa, F, Pozzi, C, Turano, P, Lalli, D.
登録日2018-11-05
公開日2018-12-12
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.59 Å)
主引用文献Time-Lapse Anomalous X-Ray Diffraction Shows How Fe(2+) Substrate Ions Move Through Ferritin Protein Nanocages To Oxidoreductase Sites.
Acta Crystallogr.,Sect.D, 71, 2015
6TR9
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BU of 6tr9 by Molmil
Crystal structure of human L ferritin (HuLf) triple variant E60A-E61A-E64A
分子名称: CADMIUM ION, Ferritin light chain
著者Pozzi, C, Ciambellotti, S, Turano, P, Mangani, S.
登録日2019-12-18
公開日2020-02-19
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.46 Å)
主引用文献Iron Biomineral Growth from the Initial Nucleation Seed in L-Ferritin.
Chemistry, 26, 2020
6TS1
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BU of 6ts1 by Molmil
Crystal structure of human L ferritin (HuLf) triple variant E60A-E61A-E64A Fe(III)-loaded for 60 minutes
分子名称: CADMIUM ION, FE (III) ION, Ferritin light chain, ...
著者Pozzi, C, Ciambellotti, S, Turano, P, Mangani, S.
登録日2019-12-19
公開日2020-02-19
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Iron Biomineral Growth from the Initial Nucleation Seed in L-Ferritin.
Chemistry, 26, 2020

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